1755 replies to this topic

[niner]

Are we sure that alcohol is functioning as a preservative here? Are we sure it isn't for something else, like enhancing absorption?

[1todd960]

Still waiting on word from China? This is taking forever

[Dreamer]

I find it interesting that you have my email address, and we have communicated via email regarding the Direct Buy Group order as recently as a few days ago, that I explained that all communications regarding the group order would be by email to keep this kind of clutter off the board, and yet you choose the board to express your unhappiness with the progress of getting all the elements of a group order together and the order placed. Your whining accomplishes nothing positive, todd.

Perhaps you would prefer to withdraw from the group order?

[Dreamer]

A general update on the Direct Buy Group order for AGAG/AEDG/Epitalon.

There are a total of 14 individuals participating in the group buy. Most are 1 gram orders, 1 half gram and a couple 2 gram orders.

Invoices have been sent out this afternoon. If you are participating and did not get an invoice, please PM or email me.

If you have not signed up to participate in the group order but would like to, please PM me with the amount you want, name, shipping address, how you want it aliquoted (100mg/tube is standard - 50mg/tube is an additional $20/gram), and your email address as all communications regarding the group order will be via email to keep the clutter off the board.

The cost is $253/gram plus shipping charges and billing charges.

[meatsauce]

Big thanks to Dreamer.

I was the thinking that we could drop the peptide solution into our noses rather than under our tongue for a better and more complete absorption. I would be worried that sublingual drops might wash away with bad technique and dropping nasally would solve this.

[hav]

Big thanks to Dreamer.

I was the thinking that we could drop the peptide solution into our noses rather than under our tongue for a better and more complete absorption. I would be worried that sublingual drops might wash away with bad technique and dropping nasally would solve this.

I've tried that but my wife didn't like the burning sensation that can develop as it seeps from the nasal area into the back of the throat. For myself, I only noticed that happening to me if I took it right before lying down and going to bed. If I took it a half hour earlier, I didn't get any nasal drip. I used a sprayer from an old bottle of Astepro using it's indicated 4 ml capacity for 22 metered sprays as a mixing guide going for 1 spray in each nostril per dose.

Howard

[smithx]

i had the same problem and made my sterile water i used tap water brought it to the boil in a small stainless saucepan and left it simmering for about 30 minutes,

AFAIK water is sterile 1 second after it reaches boiling. There is no need to boil for 30 minutes.

Edited by smithx, 21 June 2013 - 08:36 PM.

[AdamI]

My dad that has been taking AGAG about 400 mg and I think he got another 100 mg to go, finished he's yearly cycling race 300 kilometers (vättern rundan). That is around a lake.

He trained a little less this year compare to last year. He cycled on the same time as last year but he made one extra break and also the wind was very bad. So 3 things slowed him down wind and that extra wind and not as much training as the year before.

He did say that he felt alot more fresh in the legs this time.

Last year 10h 36 min

This year 10h 41min

So everything points to that AGAG had an effect...

[solarfingers]

I don't know, any chemistry majors out there... Just how difficult could this be done at home? Perhaps we should create a cookbook?

http://chem24h.com/d.../xttpmmwbv.html

Epithalon;Epitalon
Description of the Scheme

The title compound was obtained by solution-phase peptide synthesis. Acylation of L-aspartic acid beta-benzyl ester (II) with the succinimidyl ester of N-Boc-gamma-benzyl-L-glutamic acid (I) led to the protected dipeptide (III). Removal of the Boc protecting group of (III) by means of trifluoroacetic acid afforded amine (IV), which was subsequently condensed with N-Cbz-L-alanine succinimidyl ester (V) to furnish tripeptide (VI). Coupling of (VI) with glycine benzyl ester (VII) using DCC and HOBt gave the fully protected peptide (VIII). The N-Cbz and benzyl ester groups of (VIII) were finally removed by catalytic hydrogenation over Pd/C to provide the target tetrapeptide.

http://chem24h.com/d...69/110369_1.wmf

benzyl 2-aminoacetate; Glycine benzyl ester hydrochloride (VII)
benzyl (1S)-2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethylcarbamate (V)
benzyl (4S)-4-[(tert-butoxycarbonyl)amino]-5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-5-oxopentanoate (I)
(2S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid (II)
(2S)-4-(benzyloxy)-2-({(2S)-5-(benzyloxy)-2-[(tert-butoxycarbonyl)amino]-5-oxopentanoyl}amino)-4-oxobutanoic acid (III)
(2S)-2-{[(2S)-2-amino-5-(benzyloxy)-5-oxopentanoyl]amino}-4-(benzyloxy)-4-oxobutanoic acid (IV)
(5S,8S,11S)-11-[2-(benzyloxy)-2-oxoethyl]-8-[3-(benzyloxy)-3-oxopropyl]-5-methyl-3,6,9-trioxo-1-phenyl-2-oxa-4,7,10-triazadodecan-12-oic acid (VI)
benzyl (5S,8S,11S)-11-[2-(benzyloxy)-2-oxoethyl]-8-[3-(benzyloxy)-3-oxopropyl]-5-methyl-3,6,9,12-tetraoxo-1-phenyl-2-oxa-4,7,10,13-tetraazapentadecan-15-oate (VIII)

I shot off an email to a friend who teaches college chemistry. Let's see what he has to say. Any chemists out there seeing new light bulbs turning on?

[niner]

The total cost of the intermediates will probably be pretty high... Higher than the commercial cost of the equivalent amount of epitalon? Don't know, but it wouldn't surprise me. Then you have to consider what the yield would be. After all the various steps and purifications, you might only have 10% of the theoretical yield. The peptide companies use solid state synthesis, which is essentially robotic and much simpler. I think you'll have a hard time beating their price with a solution phase synthesis.

[solarfingers]

Let me see I and II leads to III

benzyl (4S)-4-[(tert-butoxycarbonyl)amino]-5-[(2,5-dioxo-1-pyrrolidinyl)oxy]-5-oxopentanoate (I)
(2S)-2-amino-4-(benzyloxy)-4-oxobutanoic acid (II)

III - IV

(2S)-2-{[(2S)-2-amino-5-(benzyloxy)-5-oxopentanoyl]amino}-4-(benzyloxy)-4-oxobutanoic acid (IV)

condensed by V furnished VI

benzyl (1S)-2-[(2,5-dioxo-1-pyrrolidinyl)oxy]-1-methyl-2-oxoethylcarbamate (V)

VI + VII = VIII

benzyl 2-aminoacetate; Glycine benzyl ester hydrochloride (VII)
+ DCC ?
+ HOBt ?

VIII - N-Cbz = Epitalon

I have no idea what all that means but it looks like a process one could follow. The only question is what quantities? That's likely a question my chemist friend could answer. It might be too costly but it is worth investigating don't you think? It would be worth it if the yield was 1/4 or more less the cost of buying it from a synthesis company. The question of purity is one I will also leave up to my chemist friend. I guess that is related to how accurate the quantities were to ensure there were no left over chemicals that did not end up as Epitalon. I don't know.

[Dreamer]

An update on the direct Buy Group order.

We had 13 members sign up and pay their invoices.

The order was placed with GenScript this morning.

I am hopeful we will be learning more from the participants what their experiences are as time goes by.

My wife and I continue to take the peptide and feel quite well and have noticed no side effects.

[Logic]

Dreamer

Can you plz share you and your wife's experiences of Epitalon?
Has it made you look younger? skin & hair?
Has it improved energy, mood, cognition and sleep?
Any other observations?

[solarfingers]

Dreamer

Can you plz share you and your wife's experiences of Epitalon?
Has it made you look younger? skin & hair?
Has it improved energy, mood, cognition and sleep?
Any other observations?

Yes, before and after pics would be appreciated.

[Dreamer]

Experiences with Epitalon/AGAG/AEDG...

We both take various supplements, mostly to ensure sufficient nutrients and some to correct certain concerns. I am 72 Kath is 66. We both have good health and we feel we both look a bit younger than others our ages.

I used to have some problem sleeping well through the night and began using melatonin. Now I take 9 mg melatonin before bedtime and 3 mg of AGAG sublingually, Kath does not take melatonin and only takes 1 mg AGAG. We both sleep well through the night and dream actively and wake up rested.

Energy is good for both of us, as is mood, cognition and interest in things. I have noticed improvements in my skin and hair, and my nails seem to grow much faster. Some of this could be and probably is, due to the MSM, magnesium and other supplements we take..

In any event, we do not intend to change what we are doing including taking AGAG.

Sorry, I don't do photos or Facebook. I prefer my privacy.

[Logic]

Thx Dreamer.

[daouda]

Emphasis in Dreamer's quoted posts is mine.

To all those interested in buying some AGAG for their personal use, you might want to wait a bit before committing to the ongoing saga of the current group buy.

I am in discussion with GS with regards to setting up arrangements for Longecity members to buy direct from them in smaller quantities for a direct relationship for payment and shipping, no middlemen and no risks as a result. You would be able to order directly from the producer and receive it directly from the producer.

I should have the information by end of day today and will post here for those interested.

I am in discussions today with GenScript to finalize the details of individual purchases of the AGAG peptide in quantities of 1 gram/order in 100 mg vials with the option of smaller size vials, perhaps smaller size total order, all handled directly between person ordering and GS. This assures accountability and provides recourse for any problems that may arise, and eliminates duplicate shipping and handling costs and efforts.

If you are interested in participating, please PM me with your email address and amount you are interested in buying from GS. No commitment is required at this time. I will provide updated information to those interested via email as I receive it from GS. I hope to have things worked out today, but it may take an extra day or so, depending on responses from GS.

I will not be receiving any compensation from anyone on any of these orders, nor will I even be involved outside of the coordination effort to the extent required to facilitate things.

I believe there may still be some confusion in what is going on with the 2 different group orders from GenScript.

I tried to bury the hatchet with daouda and combine efforts, but he was not interested and chose to remain confrontational, so there are two group orders. Everyone will have to decide what they want to do. It matters not one wit to me what anyone decides as I make nothing in any way, shape or form from any group buy from anyone.

Daouda's plan is to have all AGAG from a group bought by someone (the Organizer) in the group as a total in one order from GenScript, have each member of the group buy pay through PayItSquare to the person organizing the buy after that person determines the costs for packaging supplies and shipping so individual buyers can add it to the total for payment. After the Organizer pays GS, they will produce and ship it to the Organizer. The Organizer will divide up the shipment into individual orders, provide the packaging materials, pack each individual order, create invoices and packing slips (necessary for any customs or shipping inspections), deliver to shipper and pay. Each shipment should be insured IMO. The Organizer will be responsible to each individual buyer, not GenScript. All recourse will be through the Organizer.

I have been in the process of negotiating a group buy but with each individual buyer actually placing his portion of the group buy directly with GS and paying GS for product and shipping, GS would ship direct to each buyer and would be responsible to each buyer. This would keep the link between buyers/users and GenScript intact and eliminate duplicate shipping efforts. I'll call this the Direct Buy Group.

There are presently over 10 members ere that have expressed interest in buying through the Direct Buy Group, DBG, for at least 10 to 12 grams.

If anyone wants to add their name to the DBG, please PM me with your name (at least first name for now), email address, city, state, country, mail code, and quantity desired. I will be communicating all information to the DBG members via email in order to keep the clutter off this board.

I will continuing negotiations and clarifications with GS next week along with some other research. I hope to have all information assembled by end of next week and will communicate all info to the DBG members via email. After a suitable time (a few days?) to review all information by the DBG members, we can place the order(s).

I hope that clarifies how the two groups would operate.

Logic: I do not know where the orders would ship from. It's possible, since they will produce and package it at their lab in China, that they will also ship from China. Lots of possibilities.

BobSeitz: I do not have you in the DBG so if you want to join in, please pm me with all information as above requested.

So my plan was to organize a group order and make a long time trusted member (tintinet) the money recipient, and logistics officer, for safety and every participant's peace of mind.
You countered this plan with an alternative option, a "direct group order" which did seem to be better ( in particularly for all the reasons I highlighted above, and that you sure were very vocal about), so I naturally let go of my idea that I had been working very hard on.

Now for all this talk it seems everybody actually had to send the money to YOU, and not directly to GenScript...

Care to explain what happened there?

--
I'm not necessarily being confrontational here, but as someone whose money has been (indirecly) sent to you I truly feel this is something that absolutely demands at least some explanation. The difference between what you had been advertising for weeks and what actually finally happened cannot be left unexplained like that... I actually find it very strange that I'm the only one asking this right now (I've been waiting for someone to do it for days but quite astonishingly people seem to be content with the way things happened).

Edited by daouda, 30 June 2013 - 10:36 PM.

[qwestor]

In future u could have Genscript open a "bucket acct" in the Longecity groups name n people can send $ direct to GS n then everytime this acct has say 10 paid customers it will trigger GS to make a batch n parcel/ship it out to the individual participants in that particular order ....Subsequent new orders will go into the next group of 10

(Dreamer u can b out of the loop after setting up this INITIAL ongoing Longecity bucket acct w GS to receive/ship the individual orders)

Difference btw Daouda n Dreamers initial proposal was as Daouda outlined from Dreamers posts

Daouda...middleman receives funds AND ships

Dreamer...$ to n shipment DIRECT from GS

Dreamer "2"....middleman collects n GS ships direct...due to his explanation that GS wanted a "packaged quantity " order..

ok since Dreamer did the negotiation got this compromise intermediate solution 1/2 middleman 1/2 GS direct ship...it is in the spirit of community fair to trust this "middle way" was arranged in good faith

my suggestion above of n established ongoing bucket acct w a trigger in our collective name/behalf will in the future bypass the middleman requirement n make the direct pay to/ship from GS structure Dreamer initially proposed a reality

[Dreamer]

I'm not necessarily being confrontational here, but as someone whose money has been (indirecly) sent to you I truly feel this is something that absolutely demands at least some explanation.

Of course you are! You are being intentionately confrontational, rude and accusatory.

The solution to your problem is to simply refund your money so that you are no longer troubled by the arrangements. Of course, you could have made these inquiries discreetly before you sent in your money......but, you didn't.

So I will be refunding your money to your "agent". If you have any further questions, please contact him.

I see nothing good coming from continuing to try to deal with you so I won't be responding to you any further.

[Dreamer]

In future u could have Genscript open a "bucket acct" in the Longecity groups name n people can send $ direct to GS n then everytime this acct has say 10 paid customers it will trigger GS to make a batch n parcel/ship it out to the individual participants in that particular order ....Subsequent new orders will go into the next group of 10

The problem is that GS is not setup to deal with small orders like you suggest, qwestor. That may change in the future, but right now, I believe the group buy as we just went through is the best approach.

Perhaps, if and as, AGAG/AEDG becomes more popular and GS is producing it more frequently, that method of accumulating a group or batch of small orders would become feasible.

That is not to say that GS will not produce a gram for a private order, they will. But the cost will be much higher. I expect that as they produce more, that the price will come down. So things may change in the future.

[solarfingers]

Dreamer, I can see that you are providing a good service. Thank you.

[1todd960]

I would like to ask a question and hopefully I won't get scolded

I have 50mg bottles on the way. I've been told I need to pick up my own separate bottle with dropper for dosing. I plan on using wine for the alcohol part of the mixture.

Is it 50% sterile water and 50% wine?
The bottle/dropper that I buy should be a certain size? Are all droppers the same size?
Each drop = .25mg?

Okay more then one question. Thanks for the help.

[Dreamer]

You want about 7%~ alcohol so mix accordingly. If the wine is 14% then a 50/50 mix with water would yield 7%. It doesn't have to be exact.

Not all drops are the same size. The important thing is that you know how many drops of water/alcohol you mix with the peptide then you will know how many mg of peptide per drop. For example, 50 mg mixed with 100 drops of water will yield .5~ mg/drop. So determine how many mg you want to take and multiply by .5 for number of drops. Just an example to go by.

What ever mix you decide on, you can measure out the drops before hand and mark the bottle so you won't have to count each time. Just remember to mix with water only until fully disolved before adding the alcohol.

[1todd960]

Cool thx for the reply

[blood]

How was it determined that epitalon has anti-aging benefits that go above and beyond those of melatonin, given that epitalon induces release of melatonin?

[Dreamer]

How was it determined that epitalon has anti-aging benefits that go above and beyond those of melatonin, given that epitalon induces release of melatonin?

Based upon my prior research into epitalon/AGAG/AEDG, it enables/stimulates the production of telomerase.

Apparently, this was/is the function of the pineal gland. However, most of us suffer from calcification of the pineal gland and therefore also from reduced telomerase production as well as decreased melatonin production.

One can do some research for more information on the pineal gland, calcification, telomerase, telomeres, epitalon/epithalon to learn more.

I believe any benefits from taking the peptide will be gradual and accumulative. As such, I intend to continue to take it indefinetly unless I learn something different or better.

[daouda]

I'm not necessarily being confrontational here, but as someone whose money has been (indirecly) sent to you I truly feel this is something that absolutely demands at least some explanation.

Of course you are! You are being intentionately confrontational, rude and accusatory.

The solution to your problem is to simply refund your money so that you are no longer troubled by the arrangements. Of course, you could have made these inquiries discreetly before you sent in your money......but, you didn't.

So I will be refunding your money to your "agent". If you have any further questions, please contact him.

I see nothing good coming from continuing to try to deal with you so I won't be responding to you any further.

So it took you two days to come up with that answer? I see you're convenienly avoiding to adress my simple and clear question.

Please tell me how I'm being rude or accusatory. I am simply exposing facts and asking for some legitimately needed clarification. There is a huge discrepancy between what you had publicly advertised for weeks and what you actually asked for at the very last moment - in private - when the time came for participants to finally pay for their share. More importantly this discrepancy is on a very critical point (the direct payment relationship with the source), which you made the big selling point of your project, and which is the very reason why I abandonned my group buy project, so things wouldnt be confusing for everybody and that a maximum of people would benefit.

Now what kind of person are you whom won't tolerate any questioning on the way you've handled this collective operation? Your behavior is that of a paranoid fascist dictator... Asking a totally legitimate but challenging question is not only left unanswered but sanctionned by a "ban", plus accusations of deviant behavior?? Seriously?

There is also the absolute immorality of banning me, of all people, from this group buy. Again, I was the one initiating this whole endeavour on this board, contacting genscript and negociating this low price. Everything is crystal clear for anybody willing to read this thread starting there. You got the source and the price from a private conversation with me, which I shared privately with you out of trust, as a participant to my group buy. You did manage to have me give up my operation by apparently negociating some type of direct deal which I havent been able to pull off, so I cleared the way for you... Now it turns out this was all but a lie. Now my gut instinct tells me that you will eventually come through and honor your engagements with the participants, which will get you nothing but profuse thanks from everyone, as people couldn't care less about how they get good deal as long as they do get the goods at the end. But your character has definitely been exposed to anybody with common sense and some patience to actually read through the posts here.

Of course, you could have made these inquiries discreetly before you sent in your money......but, you didn't.

FYI, my "agent" had been sent my funds when it was crystal clear for me (and him) from all your posts AND PMs that the money was to be sent to GenScript at the end... With all your repeated posts and even personal messages about the DIRECT nature of the payment to GS, there was absolutely no reason for "inquiries" regarding this point... It was only after payment that my "agent" told me he had just in fact paypal'd the money to you. And it was too late for me to do anything about this.

Anyway, now that you've won your petty little war, I am left with no epitalon coming my way, for all the efforts I had put getting this deal and coordinating a group buy... Congratulations I guess. I had great hopes on Epitalon helping me with my tremendously difficult health conditions, so I will definitely try to get another group buy happening as soon as possible. Anybody interested please PM me.

Edited by daouda, 03 July 2013 - 05:41 PM.

[Dreamer]

I know I had promised this forum and myself to never respond to anything you posted again, daouda. However, you make a couple points that I cannot ignore.

1. Although I had previously contacted GenScript months ago re some AGAG/AEDG, it went nowhere for some reason, perhaps because I had a source for AGAG/AEDG. After my contact with you, I renewed my dialog with them and subsequently, information flowed and I was able to construct a Direct Group Buy with them. The only problem was they did not want to deal with a bunch of individual orders with the attendent invoicing, payments and customer service that would entail. So I "guaranteed" the order through my company for payment purposes and contact responsibility with the agreement that they would ship directly from their NJ facility to each individual around the world. That is the present structure of the Group Order.

2. You provided the catalyst that lead to the present group order.

For the above reasons, regardless of my personal feelings about you, I will honor the order you placed through your agent. I believe you deserve that.

Otherwise, I intend this to be my last response to you. The negative vibes simply are not worth it.

[daouda]

Dreamer, I'm glad I managed to (force)break through that weird, immensely negative persona within you that I had somehow "switched on" to finally reach the decent human being within. I just upvoted your post. That "number 1" point of yours is the kind of response I expected from my post which, if you reread it and think about it, was nothing but legitimate.

The negative vibes simply are not worth it.

I'm also glad to see you're as human as me as I rejoin you on this point. This has been absolutely exhausting and morally draining... I am immensely releived that these BS childish and petty "confrontations" are finally over. This is gonna sound cheesy like an ending to some Disney-produced Hollywood movie but I had truly lost some of my faith in humanity throughout this ordeal and I'm glad I finally got it back... Again, congratulations on letting your maturity and decency prevail.

[Dreamer]

For those of you that are interested, I just spoke with GenScript and we have a small window in time, until Monday morning, July 8, to make any increases in the group order for peptide quantity.

They also said that the shelf life in the freezer is at least a year and then at some point after that, it will gradually degrade.

So any of you that are already in the group order that want to increase your order quantity, you have an opportunity to do so. Please email me if you want to increase your order quantity.

For any of you that are not in the group order, please PM me with quantity wanted in grams, name, shipping address and email address (all communications regarding the group order will be via email to keep the clutter off this forum).

I believe this is last chance for this group order as they have already begun to produce the order.