253 replies to this topic

[msbost]

To me noopept was very potent, try to take 5-10 mg of noopept sublingually. I find sublingual administration to work better than ingesting than ingesting the nootropic.
Make sure you use low doses... the first couple of days you will feel extremly relaxed(to the point of sleeping), but after that you will get the good effects..such as decrease in mental fatigue(main reason why we want nootropic ) and better motivation. I noticed a decrease in libido and I am very happy with this effect .

[Sasha_]

To be fair, I don't really understand why people compare noopept and piracetam that way, in my experience their respective effects differ quite a bit.
I feel kinda wired and prone to make more "mistakes" while on a large piracetam dose whereas 5 to 10mg of noopept makes me feel rather serene and clear minded, more open and emotional, where piracetam would turn me in a bit of a jerk !

Just to say I don't find them comparable...

[Nujabes]

It sounds like many people are taking this product in improper dosages or for less than the recommended period of time and than saying thumbs down. Shouldn't this product betaken A) In the morning or ~2x a day with small doses ~10-20mg and B) Be taken with a meal since the drug is fat soluble?

I'm not one hundred percent sure if my information is correct but I think it is how the drug should be taken. The drug should also be taken orally, not sublingually based off of Russian translations from the noopept main site. It should also be cycled 2-3 months on, 1 month off.

Only after using it the proper way can you give the drug a proper evaluation which is why I will wait to post my thoughts on the nootropric Noopept.

Edit: I wanted to do some research on Noopept and stumbled across an article from the Journal of Melcular Biology. This one is interesting! http://www.sciencedi...022283611010849

Haven't read the whole thing but here is the abstract (it focuses on patients with neurlogical disorders i.e. Parkinson's, and Alzheimers:

"Parkinson's disease is a common neurodegenerative disorder characterized by α-synuclein (α-Syn)-containing Lewy body formation and selective loss of dopaminergic neurons in the substantia nigra. We have demonstrated the modulating effect of noopept, a novel proline-containing dipeptide drug with nootropic and neuroprotective properties, on α-Syn oligomerization and fibrillation by using thioflavin T fluorescence, far-UV CD, and atomic force microscopy techniques. Noopept does not bind to a sterically specific site in the α-Syn molecule as revealed by heteronuclear two-dimensional NMR analysis, but due to hydrophobic interactions with toxic amyloid oligomers, it prompts their rapid sequestration into larger fibrillar amyloid aggregates. Consequently, this process rescues the cytotoxic effect of amyloid oligomers on neuroblastoma SH-SY5Y cells as demonstrated by using cell viability assays and fluorescent staining of apoptotic and necrotic cells and by assessing the level of intracellular oxidative stress. The mitigating effect of noopept against amyloid oligomeric cytotoxicity may offer additional benefits to the already well-established therapeutic functions of this new pharmaceutical."

I personally am ignorant to the toxic effect of amyloid oligomers so I found a pubmed article adressing the topic found here http://www.ncbi.nlm....pubmed/22403391

Here's the abstract:

"Amyloid diseases, including Alzheimer's, Parkinson's, and the prion conditions, are each associated with a particular protein in fibrillar form. These amyloid fibrils were long suspected to be the disease agents, but evidence suggests that smaller, often transient and polymorphic oligomers are the toxic entities. Here, we identify a segment of the amyloid-forming protein αB crystallin, which forms an oligomeric complex exhibiting properties of other amyloid oligomers: β-sheet-rich structure, cytotoxicity, and recognition by an oligomer-specific antibody. The x-ray-derived atomic structure of the oligomer reveals a cylindrical barrel, formed from six antiparallel protein strands, that we term a cylindrin. The cylindrin structure is compatible with a sequence segment from the β-amyloid protein of Alzheimer's disease. Cylindrins offer models for the hitherto elusive structures of amyloid oligomers."

Another good article with how Amyloid toxins / oligomers play a role in pathogenesis (disease development). Found this through Google Scholar led me to this website http://www.neurology...ppl_1/S74.short

Abstract:

"Recent findings indicate that soluble amyloid oligomers may represent the primary pathologic species in degenerative diseases. These amyloid oligomers share common structural features and the ability to permeabilize membranes, suggesting that they also share a common primary mechanism of pathogenesis. Membrane permeabilization by amyloid oligomers may initiate a common group of downstream pathologic processes, including intracellular calcium dyshomeostasis, production of reactive oxygen species, altered signaling pathways, and mitochondrial dysfunction that represent key effectors of cellular dysfunction and cell death in amyloid-associated degenerative disease, such as sporadic inclusion-body myositis."

Now I am still unfamiliar with plenty of the details regaring a lot that was mentioned in these articles, and I have NOT read these articles in full, however, the abstracts which are essentially summaries from these legitimate scientific journals carried out on humans lead me to suggest that there is MAJOR potential for long term positive effect / neuroproetection / cognitive enhancement by using Noopept properly.

Didn't spell check or read over anything for errors but I hope you guys find this information useful and have some input on it.

Cheers!

Edited by Nujabes, 06 January 2013 - 01:29 AM.

[Dissolvedissolve]

I agree with the oral, 10-20 mg, 2-3 months on, 1 off routine. That's what I've been doing and it's worked quite well. I've noted before that oral administration seems to provide the long-term benefits without the distracting acute effects that sublingual administration has.

I will just add that the bioavailability of noopept is extremely high regardless of what one eats it with. It's not a major concern whether you eat it with sources of fat or not. For this same reason, sublingual dosing doesn't accomplish much other than making the onset of effects more noticeable.

[sapaiderman]

For me oral administration of 10mg twice per day is much better than sublingual administration.
Everything was going well in my trial of Noopept until I tried the sublingual route, now on day 6 I have short term memory loss and confusion.

[stablemind]

Thumbs up, it's working great for me and my short term/ long term recall ability has improved significantly. I notice that I'm spending less time going over my flash cards and I'm able to recall it much faster when it is presented to me. On the first day I took it, I also noticed a significant improvement in mood at night, and nothing seemed to bother me. The next day, I no longer noticed this benefit although the cognitive effects were still present. This may be either due to tolerance, or the fact that I still had Pramiracetam in my system since I didn't have a washout period. I'll consider stacking this with Pramiracetam. My current dosage is 10-20 mg 2x/day.

Edited by stablemind, 09 January 2013 - 08:06 PM.

[health_nutty]

It sounds like many people are taking this product in improper dosages or for less than the recommended period of time and than saying thumbs down. Shouldn't this product betaken A) In the morning or ~2x a day with small doses ~10-20mg and B) Be taken with a meal since the drug is fat soluble?

I'm not one hundred percent sure if my information is correct but I think it is how the drug should be taken. The drug should also be taken orally, not sublingually based off of Russian translations from the noopept main site. It should also be cycled 2-3 months on, 1 month off.

Only after using it the proper way can you give the drug a proper evaluation which is why I will wait to post my thoughts on the nootropric Noopept.

You have a very good point about it's effects being long term. I've only tried one bottle of 50 10mg tabs. I took 10mg 3 times a day. I'm going to take a break and try again maybe at an even lower dose.

I'm going to try it again next time I order.

[stablemind]

Does Noopept make any of you irritable the next morning?

[sapaiderman]

Does Noopept make any of you irritable the next morning?

I'm only on day 9 of dosing 2x10mg per day and it's been quite an up and down ride. It does seem to make me more irritable sometimes,
but most of the time I seem to be in a good mood and I am able to take things in my stride much more easily...

[Sam375]

I took like 10mg this morning it seems to rise my pulse, I don't like it it makes me anxious, how long is it effective ?

[Sam375]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

[deh707]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

I only get that 1 hour of semi-panic whenever I take more than 30mg at a time.

Adding Aniracetam or L-Theanine seems to help with that, significantly.

[sapaiderman]

Noopept can make me feel anxious and a bit paranoid so I'm going to try and lower the dose to 5mg twice per day and see if that helps. I'm currently on day 11 taking 2x10mg, my sleep pattern is good, no loss of libido and memory and vision improving, the only issue is slight anxiety ...

I may add Aniracetam or theanine at some point in the future but for now I just want to try Noopept on its own

[@now]

Adding Alpha GPC with pramiracetam stabilizes mood for me. Probably personal neurochemistry, though.

[Sam375]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

I only get that 1 hour of semi-panic whenever I take more than 30mg at a time.

Adding Aniracetam or L-Theanine seems to help with that, significantly.

Do you have a history of panic attacks ? I mean before taking any nootropic

[deh707]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

I only get that 1 hour of semi-panic whenever I take more than 30mg at a time.

Adding Aniracetam or L-Theanine seems to help with that, significantly.

Do you have a history of panic attacks ? I mean before taking any nootropic

Negative.

[Sam375]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

I only get that 1 hour of semi-panic whenever I take more than 30mg at a time.

Adding Aniracetam or L-Theanine seems to help with that, significantly.

Do you have a history of panic attacks ? I mean before taking any nootropic

Negative.

Could you describe the physiological effects please ?

[deh707]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

I only get that 1 hour of semi-panic whenever I take more than 30mg at a time.

Adding Aniracetam or L-Theanine seems to help with that, significantly.

Do you have a history of panic attacks ? I mean before taking any nootropic

Negative.

Could you describe the physiological effects please ?

Of the Noopept >30mg panic? Sure.

I start to notice details too fast, like ANYTHING that moves, my eye catches it way too fast before I even realize it. It's interesting but not something I like. It's not that serious.

However, I remember one time I took 60mg, and that was worse. I just felt very irritated, like I was flooded with negative thoughts about everything, and for no legitimate reason. I just told myself to calm down, closed my eyes, took a deep breathe. That helped a bit, but it was still there.

Then I added about 300mg of L-Theanine, which helped dramatically within 15 minutes. I was in a very relaxed state of mind, while still being mentally "fast".

Don't think I'll ever be dosing more than 20mg Noopept again, though.

[blksith0]

I start to notice details too fast, like ANYTHING that moves, my eye catches it way too fast before I even realize it. It's interesting but not something I like. It's not that serious.

I noticed that too when taking Piracetam. Weird. Is that common?

[troubleis]

I start to notice details too fast, like ANYTHING that moves, my eye catches it way too fast before I even realize it. It's interesting but not something I like. It's not that serious.

I noticed that too when taking Piracetam. Weird. Is that common?

For some it is.. Effects of piracetam vary quite a bit as far as i have understood.

[health_nutty]

However, I remember one time I took 60mg, and that was worse. I just felt very irritated, like I was flooded with negative thoughts about everything, and for no legitimate reason. I just told myself to calm down, closed my eyes, took a deep breathe. That helped a bit, but it was still there.

That sounds like the irritibility from Piracetam. On noopept 10mg twice a day I didn't feel irritible. I tried 20mg at once and started noticing it. I always wondered what was causing it (on the neurochemical level).

[sapaiderman]

I had a panic attack that lasted something like an hour, rest of the day was fine, 12 hours later I still feel it. I really like it but I am concerned by the safety compared to piracetam.

I only get that 1 hour of semi-panic whenever I take more than 30mg at a time.

Adding Aniracetam or L-Theanine seems to help with that, significantly.

This morning I decided to add 200mg of Suntheanine to my 10mg dose of Noopept and this has alleviated the slight anxiety and irritability issues I was experiencing with Noopept on its own.

I also decided to add 200mg of Piracetam to the stack. I've tried the high doses before and they do not agree with me so I will try at a low dose twice a day.

Three weeks into to using Noopept twice a day at 10mg and it's still a thumbs up from me. I have more motivation and I am more social, but I'm still not sure what cognitive benefits I have experienced at this stage.

[leftside]

This is one of the few nootropics that I have to give a thumbs down to unfortunately. I tried different dosages of 10mg - 30mg, but unfortunately it consistently gave me brain fog.

[Azzidic]

For me at least, 30mg makes me feel pretty good. I have ADHD and it seems to help with the motivation, and a little with concentration. I actually prefer this as opposed to Stimulants like Adderall, Concerta, or Vyvanse. They effect my eating too much and make me feel way too slowed. Noopept doesn't have any negative side effects for me at least, just on the first few days it made me a bit tired, mentally worn out I guess.

[depo]

Guys, i recommend you to do the following test:
1) When you are in good mood and you are not under noopept effect start the software brain workshop and do several rounds for example 15 in automatic mode
2) When you are in good mood and under the effect of noopept do the same as in point 1)
3) The brain workshop graph will show you your progress/regress
4) Repeat points 1), 2) 3) several times to see the difference in your score beween "on noopept" and "not on noopept"
5) Finally figure out that noopept does not make your more smart

Do you have link to that software? Thanks

[Darkat]

Have been on noopept 10mg once daily for 3 weeks now. Anxiolitic effects are still there but not as pronounced as in the first few days. Noticed a distinct slight improvement in short term memory after 1 week, which has continued but not increased any more.
Have generally been stacking it with nefiracetam 150mg once daily, which definitely increases the anxiolitic effect. I have a couple of days a week off the nefiracetam, when I substitute in oxiracetam 500mg instead (any more of oxi gives me brain fog symptoms). The noopept + oxi does not have any synergism and in fact they seem to cancel each other out. I have considered re-trying aniracetam on the off days, but I have had problems with ani in the past - worked great at first, but after a couple of weeks it gave me a lot of anxiety, along with palpitations.

Have not noticed any reduction in libido and no irritability. I do take a lot of other supplements though, so these might be protecting me from the libido problems that a few people are reporting.

Overall, I have to give noopept the thumbs up - way more effective that any of the racetams, with, perhaps, the exception of nefiracetam, which I find gives consistantly increased focus and good anti-anxiety effects.

[Daruman]

I have a couple of days a week off the nefiracetam, when I substitute in oxiracetam 500mg instead (any more of oxi gives me brain fog symptoms). The noopept + oxi does not have any synergism and in fact they seem to cancel each other out.

The fact that oxiracetam might cancel out noopept is interesting. I felt great effects from 20mg 2x/day orally, but when I was on my last few 100mgs I tried taking a few mega doses from 50-100mg. I noticed almost no effect from the large doses, but both those days I took oxiracetam too (normally I only take noopept + picamilon).

I also recommend more people take picamilon with noopept, I had great effects when taking them for a couple months.

[Sha-Ron S. Kushnir]

Noopept (Johnson Labs). 3 weeks in.

I must say that at first I was highly skeptical concerning Noopept, racetams, and the other accompanying Nootropics. But after weeks of some use, ranging from 1 dose of approximately 30mg to 2 doses, adding to approximately 50mg daily, certain noticeable effects began to occur.

The most noticeable of those effects are: the broadenging of perspective; hightened self awareness; simple realization; increased memory acquistion rate; and subtle self-empowerment.

With that, depending on ones level of self congruency, the mood that one feels from the increasing cognitive awareness that unfolds with Noopept, would naturally vary. If one's ego is dystonic with one's environment consisting of all of one's interpersonal interactions and associations, yes, Noopept would seem to me (at this early stage of experimentation), to cause irritability, aggression, impulsive action etc. Having said that, an important distinction is made here between what Noopept does on the level of cognitive processess, and its effect on the emotive system. In other words, it is not a chemical compound affecting "feelings". It is a compound that seems to me to directly effect the mechanical cognitive processess themselves. That is to say, Noopept seems to be comparable to oil, and the effect it has on an engine. The construct of that engine, its optimum speed, and the whereabout of its direction is entirely dependent on its physical construct, and above all the will of its driver. In other words, Noopept's psychological effects, at this present moment, appear to be ones that exert direct infuence on the actual cognitive process, not of emotions, sensual feelings or pleasures. It does seem to have an optimizing effect on the mechanical process of thoughts.

At present, it occurs to me that Noopept could do wanders in psychotherapy, since it brings with it increased levels of clarity precipitating heightened levels of self-awareness. The progessive realization factor propells one to discard nonsense thoughts and destructive thought patterns together with meaningless situation constructs, inspiring action, trigerring the activation in transformative processes. In that sense, I do predict that it may have negative as well as positive effects, depending on levels of dosage, and personage.

The bottom line is that Noopept is real. You may or will be changed by it.
I look fwd sharing with you my progress with Noopept.

Warmest wishes,
Sha-Ron Kushnir.

Edited by Sha-Ron S. Kushnir, 17 February 2013 - 03:58 AM.

[Suncatcher]

I think that without a doubt noopept is the best nootropic. It gives you the most bang for you buck

[johnj88]

Just wanted to chime in here to say:

At first, noopept was great and I experienced the positive effects stated by many:
1. Increased positive social cueing / more social awareness
2. Sense of calm
3. Increased analytical / reasoning abilities

Yet after many weeks of continued use and no days off, at dosages of 20-30 mg sublingual BID I experienced:
1. Irritability that I couldn't control anymore - never thought about trying prami to control this, which I'll now try
2. Too much social awareness - taking things other people said / did too personally and analyzing the "situation"
3. A weird sense of depression - didn't feel quite myself
4. Irritation of the sublingual mucosa - had to switch to oral dosing
5. To my dismay - a strong hit to my short term/working memory that was interfering with reading/academia
6. Diminished libido

Negative effects above could be due to confounding factors from other nootropics in my regimen, yet the negatives abolished with discontinued daily noopept use.

I have taken a break, and now decided to cycle noopept as I see fit. Also experimenting with 10 mg oral dosing at night to gain benefit from NGF/BDNF, although I have a feeling that noopept is interfering with my sleep in some way.

Edited by johnj88, 07 March 2013 - 05:18 AM.