253 replies to this topic

[Peak]

Thank you for taking the trouble to do this.

I never had a significant effect from Noopept.

There's something there, but so what?

I don't think it's recognizable in a blind test. 

 

The ones that are immediately noticeable for me and I'm

confident I could spot blind are

 

Ladasten 50mg tab: thickness, yellow and green colors pop. Long lasting.

   25mg or less is quite sufficient for me. Anxiolytic effect that is claimed to persist

   after month of daily regimen, and that seems credible. I think that's scary. 

 

Phenotropil (Phenylpiracetam) 100mg tab: stim of ephedrine/bupropion type.

   In fact 100 mg is too much for me, 25-50 mg is what I'd take. Don't like it. 

 

Somewhat certain I can blind-spot

Adrafinil 300 mg : mellow stim at level of 50 mg caffeine. Metabolized to Modafinil.

   This one can be useful. Daily use is followed by depression. And it's hard on the 

   liver. 

 

 

Piracetam 1000mg : I only notice when I don't take it, I get more foggy and forgetful. 

Edited by Peak, 01 November 2015 - 12:02 AM.

[deeptrance]

Thank you for taking the trouble to do this.
I never had a significant effect from Noopept.
There's something there, but so what?
I don't think it's recognizable in a blind test.

What you said about piracetam, that you only notice it when you DON'T take it, is true for me about noopept. I've taken noopept daily for at least 2 years and am completely habituated to it. On the few days when I've forgotten to take my morning dose, I'll find myself wondering what's "off" about me sometime around mid-day. Could be coincidence, I don't know. But I did have a pretty intense noopept experience the first time I took 50 mg. I just didn't think the positive effects were worth the extreme impatience and irritation I felt toward the world. It felt like everyone else had become stupid because they weren't seeing things as I was seeing them, which presumes I saw them correctly and of course that's a very dangerous point of view to live by!
 

Ladasten 50mg tab: thickness, yellow and green colors pop. Long lasting.
   25mg or less is quite sufficient for me. Anxiolytic effect that is claimed to persist
   after month of daily regimen, and that seems credible. I think that's scary.

This has me very intrigued because I tend to be very sensitive to every kind of drug, and I've been really curious about bromantane. The fact that you get something out of such a small dose is encouraging, because it indicates that some people can get a lot more out of their purchase. Otherwise, it just seemed too expensive to mess with, given the 200mg+ dosages that broscience researchers talk about on Bluelight and reddit. But those folks ALWAYS dose about 5 to 10 times higher than I do for just about every drug I've ever tried.
 
[

Phenotropil (Phenylpiracetam) 100mg tab: stim of ephedrine/bupropion type.
   In fact 100 mg is too much for me, 25-50 mg is what I'd take. Don't like it.

Yup, I never got anywhere near even 100 mg because at tiny doses I still felt too anxious and wired on it. Very potent stuff for those of us who respond to it. I tossed my sample after a couple of trials around 20-25 mg.
 

Somewhat certain I can blind-spot
Adrafinil 300 mg : mellow stim at level of 50 mg caffeine. Metabolized to Modafinil.

I can't handle adrafanil. I tried 100 mg a couple times, taken when I first woke up, and it gave me insomnia and heart palpitations on those nights. It really surprised me that it would have such persistent effects. Maybe it was interacting with other things. I tossed that substance too. In fact, I toss a LOT of substances, mostly drugs and RCs. Maybe I should get in touch with the Austin members of this forum so they can have a free source for the items I don't want.

[Peak]

Ladasten is the only psychoactive I've run into that claims to bring about long term changes.

 

Psychoanalysis and religious/political conversion are the only previous candidates. 

 

The very idea of a patient being "cured" by a period of treatment is contrary to the way neuropharmacology works.

You CAN cure an infection with antibiotics, but the whole premise of neuropharmacology is that it temporarily

alters some receptors in the nervous system, and temporarily shifts some things around. The very idea of say

an antidepressant making you permanently cheerful is unthinkable. Or a pain reliever taking away your chronic

pain forever, no way. On the contrary, we EXPECT opposite rebound. Because that's how equilibria work.

 

Now imagine a drug that makes you all better for months after you stop taking it !? That implies that the

whole machine has been altered. Some receptors no longer being synthesized?  The very DNA or its expression

being modified ? We don't have anything like that in our pharmacopoeia. And yet that's what they say. That

patients after a month long treatment with Ladasten are all better for months afterwards? THAT's scary, and

one reason I stopped taking even small doses after a couple of days. And yes, something persisted for days. 

 

Is there any reason to think it's a highly lipid-soluble agent that has lipid-soluble active metabolites that could

be stored in body fat and leeched out for a long time? If not, then it's screwing with some fundamentals, and

that's a new and frightening mechanism. How about an agent that causes indifference, or lack of empathy, like

an SSRI, but PERMANENTLY? What military or police wouldn't see applications for those kinds of drugs? 

 

But anyway, Ladasten doesn't cause anything like that. Even a quarter tablet, i.e. 12.5 mg, for me sublingually

is immediately noticeable. The lights are richer, yellows and greens look more saturated. A benign thickness

and lowering of anxiety, a bit of an improved mood, not wired, but liking doing things. After a couple of days

at 50mg divided up during the day, the feeling stayed with me and faded gradually. The visual thing is most

noticeable on first dosing. I wasn't comfortable taking it for longer than that. 

 

The reason I feel OK taking Piracetam every day is because of the way it's prescribed in Eastern Europe. That's

where I first ran into it. It was Rx'd for my father after a TIA. He took it for ~ 8 years and was sharp until he died

at age 93. 

 

There's another that had a bit of that color popping visual effect: AwakeBrain's N-Acetyl Semax. I took too

much the one time I tried it and it was uncomfortable. I'll dig out my protocol if you're interested. 

 

 

 

 

 

 

Edited by Peak, 02 November 2015 - 08:14 AM.

[Junk Master]

For me Noopept is a different animal when used intra-nasally v. orally.  Much more effective and noticeable intra-nasally.

[metabrain]

Noopept just spaced me out, I had the exact same reaction with Memantine.

[presently]

Thumbs up.  I would hazard a guess that some who had negative reactions to Noopept may have been taking too much, however little it may have seemed to be, relative to effective dosages of less potent nootropics.

 

I had a 5g mini-tub of Liftmode Noopept on the shelf for years, thinking it did nothing because my initial taste tests were meh.  Threads like this one made me curious enough to try again.  I tried a whole microscoop (which turns out to be a lot for me) a few days back and it felt as good as phenibut, even if the ladies weren't trying to tackle me.  I tried two microscoops the next day, and that was way too much.  I was thinking too fast and couldn't stop.  So, I took two days off and tried half a microscoop today, and that's about right.  Life's events are amusing, music is engrossing.  For me, aniracetam has great synergy with noopept, fasoracetam not so much.

 

For some people, Noopept is active at tiny dosages.  If the side effects were bad, maybe try taking less, even much less.  The positives may snap into focus and memories of the negatives may be converted into useful lessons on how to approach potentially beneficial molecules that happen to hit each person differently.  Metaphorical babies get thrown out with symbolic bathwater all the time.  Not saying that's you, and thanks for reading!

[Kinesis]

Thank you, presently ... excellent post.  The adage goes the dose makes the poison.  I have a favorite illustration to remind me of that.

A team of researchers undertakes a study of water ... as a novel substance.  It enrolls twelve rats in each of two groups; a control group which will receive none of the drug over the study period, and an active group which will receive one liter daily via a single intraperitoneal injection.  The dependent variable is total survival time. Our imaginary de novo researchers want to see whether the animals in the active group live longer or less long as a result of consuming the drug.  Of course, because we are not imaginary de novo researchers, we already have a very good idea what the study outcome will be.  All the rats in the control group survive for several days.  All the rats in the active group die within moments of receiving the drug.  The researchers conclude that water is a toxic, uniformly fatal substance.

In another part of the world, another team of researchers conducts exactly the same experiment, except the dosage of water is one milliliter.  The rats in the control group, as before, survive for several days.  In this case, however, the rats in the active group significantly outlive those in the control.  This group of researchers concludes that water is a miracle drug that has amazing life extension properties.

Those of you who are familiar with the concept of proof by contradiction may anticipate where we're going with this.  One study unambiguously proves that water is toxic, and another that it is a precious, life-giving substance.  The contradiction indicates there must be something wrong with our premises.

The flawed premise?  That a substance is either good or bad.  That an inanimate substance inherently possesses a quality of good or evil, when good and evil are only value judgments that we as humans project onto them.  And which may vary considerably depending on exactly how we meet up with them.  We have a tendency to adopt the mindset of the spaghetti western and put black hats on some characters and white hats on others.  In the real world, the hats are mostly shades of gray, or different colors, and some characters may not wear hats at all.

There are some substances that from the human health standpoint are pretty much uniformly black hatted.  Like, say, plutonium.  They are relatively few in number, but those that are uniformly white hatted are nonexistent.  Water, oxygen, what-have-you, there are a number of things known to be essential to human life, but that are all toxic at some level of exposure.  There is no such thing as merit independent of dose.

That being the case, I’m generally pretty open to trying new things when there is a reasonable expectation of net benefit, but especially when others’ experience with a substance isn’t uniformly benign, I prefer to start with an amount that is almost guaranteed to do nothing.  First do no harm.  For my first trial of Noopept I opened a 10 mg capsule and poured out about a quarter of the powder, then picked up a fraction of that with a fingertip.  So I estimate the dose at somewhere under 1.25 mg, certainly a microdose in this context.  This was a few hours ago, and I can’t say I noticed anything definitely due to the Noopept; nothing outside my normal range of variability.  No surprise there.  In accordance with the poll stipulations, I’ll withhold my vote for at least two weeks, but am mostly interested in much longer term results. My experience should add to that of the community since I don’t see any responses so far from anyone indicating they’re in my age range, which is late fifties.  After nearly six decades of wear and tear, I have some deficits to fill.  As this puts me pretty squarely in the target audience of the original developers, it should give it every chance to show a net benefit.
 

Edited by Kinesis, 03 October 2017 - 07:38 PM.

[Killing Joke]

I bought 60 x 30 mg Noopept  which were very cheap. They were tablets and smelled awful ,a bit like RC speed which is horrible. I dont know if these are actually Noopept GVS 111. N-Phenyl-N Prolyglycine  ethyl ester.  Dose 1 tab with a meal. I have been taking them now for about 3 wks and i cant say theres a huge difference in my mental clarity but i have been drinking a bottle of wine every day for the last month du to total boredom and the instant lift it gives me. No sexual probs, i feel a bit irritable and melancholic more than usual. They dont make me feel any more awake-mind you neither does two triple espressos. so i wonder if we are getting the actual proper product. I sometimes take Wakelert  _Adrafanil  which has a very noticeable effect on energy wakefulness and focussing but can cause a bit of dysphoria and make you want to redose but that does not bring u up again its best taken after a good nights sleep but even after a good sleep you still feel fog head and grumpy. Its stimulating but not like speed etc,but does affect your er..wood a bit. On or two pills are the most i would take. But Can any one say the noopept you get is real ? I dont feel its doing much and at such a cheap price which may lead to a high price to pay.    I notice my grammar is getting really bad. But i dont use spell check anymore  Any simple replies would be welcome, dont get too technical . Thanks  KJ

[John250]

I noticed a pretty decent boost in energy and focus the first few times I took it and then after that even after taking a break I never notice much at all.

[Killing Joke]

I want something for energy and daytime tired ness. Do you use steroids or stuff similar, as im thinking of tryin Dianabol and doing some weights. Sorry if yo dont use anything but your pic looks like you do.

[John250]

I want something for energy and daytime tired ness. Do you use steroids or stuff similar, as im thinking of tryin Dianabol and doing some weights. Sorry if yo dont use anything but your pic looks like you do.

You will not notice much energy from steroids. In fact many cause lethargy. Dianabol creates stress on the liver which can create fatigue. For what you were explaining you might benefit from Modafinil.

[Killing Joke]

Tried it. Its crap. Ephedra is better but a bit jerky. I do speed cycling ---on a bicycle---  and it gives me a surge. Im 51 but eat well  dont smoke or eat junk food and know i am lacking something You think snorting Noopept is a better hit.  Would you recommend any body building products as i lost some muscle mass due to a long term depression. but i can build fast.I also do kung fu mixed with yoga and tai chi. my reflexes are like a cat . But the tired feeling is killing me. Thanks for your answer. mate. I must say,i have not been as bad as i used to be. And i live on wild caught salmon,fruit veg nuts seeeds. etc. 

[John250]

Tried it. Its crap. Ephedra is better but a bit jerky. I do speed cycling ---on a bicycle--- and it gives me a surge. Im 51 but eat well dont smoke or eat junk food and know i am lacking something You think snorting Noopept is a better hit. Would you recommend any body building products as i lost some muscle mass due to a long term depression. but i can build fast.I also do kung fu mixed with yoga and tai chi. my reflexes are like a cat . But the tired feeling is killing me. Thanks for your answer. mate. I must say,i have not been as bad as i used to be. And i live on wild caught salmon,fruit veg nuts seeeds. etc.

I didn’t notice much of a difference from the capsules or intranasal spray. For you the first thing I recommend is to get your testosterone levels checked and then evaluate from there.

[mono]

The first time I took noopept I had an amazing experience. Mild euphoria, intense focus and visual enhancement like a low dose psychedelic, it was quite the ride. I took it before I had an exam one time and despite the profound effects it had on me it completely disabled my short term memory, I couldn't remember a thing, that was a strange feeling. A few years down the track I'm on new medication and I can't get it to work anymore, disappointing because I really enjoyed it.

Edited by mono, 07 January 2019 - 01:26 AM.