143 replies to this topic

[Bushi]

400mg seems to be the sweet spot for dosing. Also, the shelf life on this stuff is ridiculously low, even in the freezer. Weeks, it seems.

How do you know it is so low? Does it say it on the bottle, or did you notice it was no longer effective?

I too, would like to know. According to the manufacturers MSDS , this extract is very stable and lifetime is 2+ years if stored correctly.

[Cow]

I'm currently suffering from benzo and z drug withdrawal and am ordering a sample pack to test if it has any beneficial effect on withdrawal. Any ideas? If this can help relieve any sympton of gaba related withdrawal it would be extremely useful.

Hi cow,

Did you ever get to try it DHM in this capacity? Thanks!

Unfortunately my sample pack was a little small and I didn't have enough to really evaluate it. The first time trying it my anxiety appeared to get worse, but oddly enough trying today it seemed to help with it. My anxiety was still there but I felt a bit more relaxed, kind of like a deep breath. The previous post about the shelf life has me worried because I was considering ordering a kg to actually give a real test but don't need a large batch going bad.

If anyone can find anything about shelf life that states otherwise I'll place a large order so I can run a much more proper test.

Edited by Cow, 08 May 2013 - 04:15 AM.

[Bushi]

I'm currently suffering from benzo and z drug withdrawal and am ordering a sample pack to test if it has any beneficial effect on withdrawal. Any ideas? If this can help relieve any sympton of gaba related withdrawal it would be extremely useful.

Hi cow,

Did you ever get to try it DHM in this capacity? Thanks!

Unfortunately my sample pack was a little small and I didn't have enough to really evaluate it. The first time trying it my anxiety appeared to get worse, but oddly enough trying today it seemed to help with it. My anxiety was still there but I felt a bit more relaxed, kind of like a deep breath. The previous post about the shelf life has me worried because I was considering ordering a kg to actually give a real test but don't need a large batch going bad.

If anyone can find anything about shelf life that states otherwise I'll place a large order so I can run a much more proper test.

http://www.selleckch...optin-MSDS.html
Stability: stable if stored as directed; avoid strong oxidizing agents Thermal decomposition / conditions to be avoided: protect from light and heat

[MrHappy]

Personal experience: 4-6 weeks. Don't bulk purchase. Others had the same experience, frozen or not,

[maxwatt]

Don't freeze it; There is residual moisture in the powder, and the freeze/thaw process could possibly induce decomposition. DHM itself is stable if stored not above 20 degrees celsius. Most available extracts from Chinese vine tea are 80%DHM, the rest other compounds found in the plant. Whether this is a factor I can but guess. Kingherbs has stored stock for over 6 months, still tests for DHM, unchanged. The standard COA the Chinese give you lists shelf-life at two to three years stored in the dark and stable temperature, but this may be only a reasonable assumption.

Samples I have had for over 6 months still work.

[MrHappy]

Don't freeze it; There is residual moisture in the powder, and the freeze/thaw process could possibly induce decomposition. DHM itself is stable if stored not above 20 degrees celsius. Most available extracts from Chinese vine tea are 80%DHM, the rest other compounds found in the plant. Whether this is a factor I can but guess. Kingherbs has stored stock for over 6 months, still tests for DHM, unchanged. The standard COA the Chinese give you lists shelf-life at two to three years stored in the dark and stable temperature, but this may be only a reasonable assumption.

Samples I have had for over 6 months still work.

Ouch, so I may have killed my stock by trying to preserve it.

[maxwatt]

I hope not.

[Braindeadjoe]

Could this naturally upregulate gaba activity(antagonize) for GAD, SA, panic, ect

[VultureCulture]

If anyone can find anything about shelf life that states otherwise I'll place a large order so I can run a much more proper test.

I've had a bottle for a couple months now, stored at room temperature. I haven't noticed any loss of potency.

Has anyone here tried this vendor?

http://www.dhmdepot.com/

This is where I ordered from, vendor is definately legit.

[Bushi]

Hey guys, founder of Claritypill.com here. I just launched full scale this Monday. I want to give everyone here a free 4 pack sample (150mg per tablet) as long as you can give me feedback. Bonus, A video testimonial on YouTube after you try it out and I'll give you a free 30 count bottle. Doesn't matter if it's positive or not. I just really want to get this into people's hands where it can benefit them. Just shoot me an email: support AT clarity pill.com with the address you want it sent.

If this is against the rules let me know and I'll take this post off. Thanks guys.

[thegodsmustbecrazy]

I ordered 100g bulk powder from China. If it works I am going to sell most of it via local classified ads as a hangover cure. I would be hesitant to tell anyone it works WHILE you are drinking, because they would tend to overdose on alcohol. For me, it is another potentially useful substance for my tickle trunk. I'll report back once I get a chance to test it. Am not a big drinker though.

[Adamzski]

I would like to order some and get it ASAP. I am in Australia right now but will leave the country in less than 14 days. Could you DHL me 8 tablets? How much?
I would use this often. I have not been drinking a lot recently but I am not using Wellbutrin only because the danger of getting out of control drunk after a few beers is too much

[Bushi]

Adamzski, unfortunately I'm in the US and it will cost a minimum of 45$ to get it to Australia, especially in the time frame you specify. Are you traveling to the US? Maybe we can set something up?

[Adamzski]

I am going to Korea but might be in the states sometime soon. I will research a few places to buy but how much usps to Seoul South Korea? Amazon is usually $15 or less for small items and takes about 2 weeks.

[maxwatt]

I ordered 100g bulk powder from China. If it works I am going to sell most of it via local classified ads as a hangover cure. I would be hesitant to tell anyone it works WHILE you are drinking, because they would tend to overdose on alcohol. For me, it is another potentially useful substance for my tickle trunk. I'll report back once I get a chance to test it. Am not a big drinker though.

I doubt that; my experience taking just before drinking is that alcohol-induced euphoria doesn't happen, so the nasty effects of drinking are not masked. Felt stick to my stomach, uncoordinated and no desire to continue drinking when I'd reached my limit, versus otherwise being happily able to down another few drinks.

YMMV. Any one else have actual observations?

[Vanerlin]

There's a cheap US source for dihydromyricetin on eBay that ships internationally.

Unbelievable how much some companies are charging for this stuff.

[thegodsmustbecrazy]

A while back, I recieved 100 grams of this stuff from China. I paid about 90.00 shipped here. Observations are: When drunk, before bed, take 1/8tsp (650mg) and you will regain much of your mental capacity. You are still uncoordinated, and if you are way too drunk, will still feel the need to puke. If taken the morning after, it clears your head up, and seems to relieve the symptoms of a hangover. I am unsure of upping the dosage though to see if it has a greater effect. I am wary of toxicity effects, and am unable to find a reference to a safe dosage. I will be selling these locally before Christmas in 650mg gel caps as a hangover cure.

[wanderlust]

tested it   a week ago  l played games  luminosity as i do every day  to test  and improve  my problem-solving skills ,reflex times & mental flexibly  my score was along the bell curve of improvement seen for the last 3 months. then  i drank half a glass of whisky waited 15mins and attempted to play the same games on luminosity t (i am quite sensitive to alcohol as rarely drink ) and in fact found the games to be confusing and taxing and gave up without finishing them simply as i could not continue them or see why i would wish to .. as this point i was also having trouble walking in a straight line and my speech of slurred . so (with prompting  from others )i  took two 750mg tablets of dhm extract and waited an additional 20mins 

 

i then reattempted the luminosity exercises i was below my usual scores by about 30% in flexibility, 15% in attention, reflex times and 12 % in attention i was able to perform and complete the games. though i still felt  intoxicated (warm feeling in body and extremely relaxed) the  short-term  cognitive deficits caused by the consumption  of alcohol was significantly reduced .  and hour and a half later i felt sober. and my scores were less than 10% from normal.

 

my tummy was not entirely sure about the whole event but this simply might be the half pint glass of neat whisky i drank

,

alchol produces an entirely present sensation  of inebriation  and there were moments where the dhm was quickly  stripping that away was  not really that enjoyable but it was alright  .

 

if one were to take a to lower dose of Dhm these negative effects may linger for a greater period of time or dominate the experience altogether.  in taking mescaline we use the term "threshold dose", for below this point the effects of mescaline are stomach cramps  and vomiting, above it the effects  are entirely different.   as far as i can tell its safe to take really high doses of Dhm and better for your liver to do so,

 

 

Edited by wanderlust, 11 July 2016 - 02:26 PM.

[wanderlust]

for the last two days i have taken 750mgs of DHM extract and not consumed alcohol ,

i already take a cocktail of noots daily 

including sodium valproate , nsi-189. prl-853 and idra-21 and a handful of piracetam taken  through out the day.

 

i am a very careful quite shy withdrawn person , working in a small office alone most days

i have found that since taking the 

dhm that my self-confidence and self-control has massively increased.

i feel the fearless confidence of my early 20s

 

i will exprement with removing the other noots to see if its an interaction between them or the dhm alone.

 

 

 

 

 

[natasjlp]

for the last two days i have taken 750mgs of DHM extract and not consumed alcohol ,

i already take a cocktail of noots daily 

including sodium valproate , nsi-189. prl-853 and idra-21 and a handful of piracetam taken  through out the day.

 

i am a very careful quite shy withdrawn person , working in a small office alone most days

i have found that since taking the 

dhm that my self-confidence and self-control has massively increased.

i feel the fearless confidence of my early 20s

 

i will exprement with removing the other noots to see if its an interaction between them or the dhm alone.

 

hi wanderlust, do you have any further experience to share?

[wanderlust]

sure thing.

iv have taken 750mgs every day for just over a month 

as i stopped taking sodium valproate

i  noticed a slow decline in its effect which is levelling off at 40% of what it was.

 

 

 

the most notable effect of long term use for me has been a disdain for altered states of consciousness,and addictive habits

i have read that long term use reduces the propensity and occurrence of binge drinking and even  drinking altogether .

 

its almost as if the desire for alterd states of cousiness are perhaps a chemical inblance  that it corrects

 

i am currently quitting dairly and caffine

 

the  massive boost in personal confidence has remined

 

yesterday

i was sitting in a pub with a group of  intellectuals

 

A month ago i would have needed to have a pint to feel confident enough to speak to such a smart crowd.

 

yesterday very sober .i was slaying  the offhand statment  that" rasicm is an apsect of capitalism,"hammer and tongue.

as two women drinking on another table kept glancing at me invitingly.

 

i plan to abuptly stop taking it at the end of this month  to check if its addictive(i could not stand that)

and to plot the curve of its effects wareing off.

 

i am giving thought to ordering a kilogram if anyone is intresting in going in with me

let me know.

 

 

 

 

 

 

 

 

 

[BieraK]

Well my harmful habit is drinking, I like to party from time to time I do not smoke and try to do not eat shitty food.

So I ordered 10 grams of this stuff for give it a try, before my alcohol hangover stack was:
4 to 6 pills of 250 mg Quercetin+250 mg ALCAR, that stack worked very well for me in the summer.

Whats about DHM?
Well I've discovered that this stuff works better if you take it before or at starting alcohol consumption, that was my error the first time, waiting to feel a bit drunk for using it. However I'm using lower doses for now, 500 mg per night, or 300 mg at starting the alcohol consumption.

Age: 27

For now I think that pills of this stuff with Quercetin could be a better approach for avoid or diminish harmful effects of alcohol, Quercetin makes me feel more alert and happy with alcohol.

Edited by BieraK, 17 August 2016 - 04:49 AM.

[wanderlust]

after testing dhm on Cambridge brain sciences and luminosity

i can say that for me at least it is a nootropic

 

DHM has a wonderful synergistic relationship piracetam .

750mgs of DHM and 750mgs of piracetam.

 

I have recently noticed that higher doses 1500mgs -2250mgs have caused a noticeable reduction in my appetite.

its of no concern to people taking it to block the effects of alcohol .but if you take it everyday it's worth taking note of

 

[treonsverdery]

[wanderlust] if you have more lumosity data to describe that could be very beneficial.  Variations on this molecule could prevent much drunk driving, as well as save lives.

[wanderlust]

Please be aware that i take a cornucopia of noots

the only new one added recently is DHA daily

i work hard at luminosity for an hour everyday.

Change in Cognitive Area LPI (over the last 4 weeks )

1.  Speed 65^

      2 .attention 98^

games Played     Times Played     Highest Score      Game LPI
Speed             
Highway Hazards     6                       103280                 1444        Top 5

    
Memory             
Tidal Treasures     6                         12100                      768      Top 5

    
Attention             
Lost in Migration     6                      26500                        768        Top 5

    
Flexibility             
Disillusion                6                       28680                       751        Personal Best
Personal Best
    
Ebb and Flow          16                      23600                     1012            Personal Best
Personal Best

 

 

I hope that helps
    
          

Edited by wanderlust, 18 August 2016 - 01:16 AM.

[gizmobrain]

I am just more interested in what it tells us about inhibiting the effects of GABA on sober people.

 

So a long time coming, but as this substance is more available now, I think its time to revisit.

 

 

While perusing the wiki for Idiopathic hypersomnia, I read this:

Researchers have recently found an abnormal hypersensitivity to GABA (the major brain chemical responsible for sedation) in a subset of patients with central hypersomnia i.e.: idiopathic hypersomnia, narcolepsy without cataplexy and long sleepers. They have identified a small (500 to 3000 daltons) naturally occurring bioactive substance (most likely a peptide as it is trypsin-sensitive) in the CSF of afflicted patients. Although this substance requires further identification of its chemical structure, it is currently referred to as a "somnogen" because it has been shown to cause hyper-reactivity of GABA_A receptors, which leads to increased sedation or somnolence. In essence, it is as though these patients are chronically sedated with a benzodiazepine (medication which acts through the GABA system) such as Versed or Xanax, even though they do not take these medications.

 

 

Which got me thinking about if DHM would be a good fit for treating hypersomnia, even though I never did a whole lot of research into it. 

 

Which lead me to this patent for Compositions for sleeping disorders:

 

Compositions for sleeping disorders 
US 7935714 B2

 

ABSTRACT

Provided herein is a composition that contains an effective amount of one or more compounds for treating, preventing, or ameliorating a disorder such as insomnia or another sleeping disorder and using the composition.

1. Field of the Invention

This invention generally relates to a composition for treating, preventing or ameliorating insomnia and other sleeping disorders.

 

1. A composition comprising dihydromyricetin, myricetin, and myricitrin in a weight percentage ratio selected from the group consisting of 90.38:7.77:1.84, 95.14:3.69:1.23, and 75.46:23.26:1.27.

 

Weird. Will have to look into this later.

[maxwatt]

DHM binds to the GABA B receptor and blocks the ability of alcohol to bind to it and block it.  GABA are inhibitory receptors, and when they don't inhibit neurons the overreact, leading to the phenomena of drunkeness.  But DHM binds, yet does not completely inhibit GABA b, so (to simplify) you keep your wits about you and stay coordinated.  The dopamine releasing effects of alcohol do not seem to be blocked completely.  You aren't drunk, yet you are not sober either.

 

DHM does not affect GABA A receptors.  Those are the ones involved in depression, blocking them might be a bad idea.

 

DHM also stimulates SIRT3.  With resveratrol would be a good combination, I think better than quercetin at least for some purposes. 

 

At least in vitro, DHM has anti-cancer properties.   

 

Not bad stuff.

Edited by maxwatt, 19 August 2016 - 09:38 PM.

[normalizing]

this topic got lost on discussion. im still curious of any reports and i have to ask, i probably asked before for the blind to witness, whats the point taking things to block the euphoric effect of alcohol? its pointless to use a pill just for that while separately it seems to not even replace alcohol at all and it doesnt seem to have much else of use.

[maxwatt]

To quote my own post above, "The dopamine releasing effects of alcohol do not seem to be blocked completely.  You aren't drunk, yet you are not sober either."

 

 

[normalizing]

maxwatt, in all honestly, that sounds like shit. tolerance can do that too naturally!