• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 1 votes

Mixing / Stacking RACETAMS

racetam piracetam oxiracetam aniracetam pramiracetam nefiracetam nootropic memory cognitive racetams

  • Please log in to reply
38 replies to this topic

#1 ScienceGuy

  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 12 January 2012 - 01:36 PM


I have had a number of people enquire about my RACETAM STACK, so I thought it best to post this as a new topic.

FYI - My RACETAM STACK that I take daily currently comprises the following:

1) PIRACETAM: 5g twice daily, with 3+ hours in-between doses (TOTAL: 10g daily)

2) OXIRACETAM: 300mg once daily

3) PRAMIRACETAM: 100mg once daily

Other NOOTROPICS that I take in addition to this include:

4) Hydergine (Ergoloid Mesylates): 1mg once daily

5) Choline (as choline orthosilicic acid): 100mg twice daily (total 200mg)

6) Phosphatidylserine (as isolate): 100mg once daily

7) Quercetin (as Chalcone): 250mg twice daily

8) Gerovital H3: 3.6ml via IM Injection once daily

You got me thinking about mixing them racetams.. How do you go about it [?]


I would recommend firstly trialling each of the various RACETAMS (e.g. PIRACETAM, PRAMIRACETAM, ANIRACETAM, OXIRACETAM, NEFIRACETAM) individually BY THEMSELVES to ascertain the following:

1. How you personally respond to the particular RACETAM.

2. What is the MAXIMUM dosage (up to 5g twice daily) FOR YOU of PIRACETAM that you are able to tolerate without manifestation of side effects (N.B. You will to ensure that you do not misconstrue Racetam induced Choline Deficiency symptoms as PIRACETAM side effects, so you will need to play around with your CHOLINE dosage as such – e.g. if you get a headache or brain fog, try increasing your CHOLINE dosage a bit, and if the headache and/or brain fog diminishes then it’s the lack of CHOLINE, NOT the PIRACETAM causing them). NOTE: YOUR required CHOLINE dosage can be anything from ZERO to 500+ mg.

3. What is the MINIMUM dosage FOR YOU for the other RACETAMs which yield the desired therapeutic beneficial effects of the particular RACETAM; this will be the appropriate dosage for you to include in YOUR stack.

THEN try adding the other RACETAMS to the PIRACETAM one-by-one at the respective dosages established in (3) above.

Please be aware that for some of the various RACETAMs individual response varies considerably; for example, some people find ANIRACETAM to be great, whereas others don’t get on with it at all; and the same goes for OXIRACETAM. N.B. It appears from user feedback (this is not scientifically substantiated but is my own observation) that those who DON’T respond well to ANIRACETAM DO respond well to OXIRACETAM and vice versa.

and what functions those different racetams have in the stack?


All the RACETAMS that I have listed potentiate each other and there appears to be considerable synergy between them. Aside from their contributing additive overall nootropic effects MY PERSONAL OBSERVATIONS relating to the individual RACETAMs are as follows:

PIRACETAM – At above a high enough dosage provides ANTI-DEPRESSANT (MOOD ENHANCEMENT) and non-sedating ANXIOLYTIC effects in addition to its NOOTROPIC effects.

PRAMIRACETAM – Significantly enhanced mental clarity and sharpness; and increased motivation. N.B. TAKE WITH FAT (as fat soluble)

OXIRACETAM – Auditory perception enhancement (e.g. music sounds better). Improvement in overall MEMORY storage and recall (much more so than provided by PIRACETAM, which tends to primarily enhance working and short-term memory)

ANIRACETAM – Provides a potent ANXIOLYTIC effect at much lower doses than PIRACETAM, but with the tendency to induce FATIGUE, BRAIN FOG and AMOTIVATION (N.B. This does NOT mean it will do the same with you – you will need to try it for yourself to see how you respond to it). The NOOTROPIC effects are very short-lived, lasting only circa 2 hours. N.B. TAKE WITH FAT (as fat soluble)

NEFIRACETAM – For me personally NEFIRACETAM was somewhat a double-edged sword with both POSITIVES and NEGATIVES, but with the NEGATIVES outweighing the POSITIVES. I found it to yield a strong ANXIOLYTIC effect AT ANY DOSAGE (even 25mg) akin to ANIRACETAM, but WITHOUT any of the undesirable side effects of ANIRACETAM (fatigue, brain fog, amotivation etc.); and VERY strong nootropic effects… However, I also experienced the following UNDESIRABLE SIDE EFFECTS: INCREASED anxiety; SEXUAL SIDES (reduced libido, reduced seminal volume); SLEEP DISRUPTION; IRRITABILITY; MOOD DISRUPTION; DEPRESSION; LOSS OF SELF-CONFIDENCE; and AMOTIVATION.

Edited by ScienceGuy, 29 January 2012 - 03:54 PM.

  • like x 6

#2 1thoughtMaze1

  • Guest
  • 335 posts
  • -127
  • Location:Toronto

Posted 12 January 2012 - 07:26 PM

So? How is the stack working for you??

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#3 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 12 January 2012 - 07:44 PM

So? How is the stack working for you??


VERY well! :-D

ALL the following are SIGNIFICANTLY improved versus baseline:

Mental clarity / sharpness, focus / concentration, processing of new information, working memory, short-term memory, multi-tasking ability, motivation, productivity, working efficiency, stamina, speed of executing tasks... :cool:

#4 1thoughtMaze1

  • Guest
  • 335 posts
  • -127
  • Location:Toronto

Posted 12 January 2012 - 07:52 PM

Very nice!

#5 Reformed-Redan

  • Guest
  • 2,200 posts
  • -9
  • Location:Thousand Oaks, CA

Posted 12 January 2012 - 09:38 PM

How about Noopept?

#6 skypower

  • Guest
  • 42 posts
  • 0
  • Location:earth

Posted 12 January 2012 - 11:08 PM

Thanks for sharing.

#7 absent minded

  • Guest
  • 99 posts
  • 13

Posted 13 January 2012 - 01:43 AM

have you noticed anything significant with regards to full or empty stomach for piracetam?

#8 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 13 January 2012 - 10:12 AM

How about Noopept?


FYI - I posted my comprehensive feedback on my personal experiences with NOOPEPT in another thread which you can read here: http://www.longecity...__fromsearch__1
  • like x 1

#9 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 13 January 2012 - 10:44 AM

have you noticed anything significant with regards to full or empty stomach for piracetam?


I always take PIRACETAM with food (specifically with breakfast and lunch)

I personally find there is no noticable difference whatsoever in PIRACETAM's therapeutic effects whether taken with or without food, but taking it on an empty stomach can cause STOMACH UPSET which is avoided entirely by taking it with food. ;)

Edited by ScienceGuy, 13 January 2012 - 10:45 AM.


#10 Baten

  • Guest
  • 785 posts
  • 57
  • Location:Belgium

Posted 13 January 2012 - 11:12 AM

I think 5g piracetam doses are way too high. Rest of your stack seems promising though.

#11 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 13 January 2012 - 09:55 PM

I think 5g piracetam doses are way too high. Rest of your stack seems promising though.


You will find that circa 5g PIRACETAM dosages TWICE DAILY have been used in a number of human clinical studies... just sayin' ;)

Oh and they work GREAT for me! :-D

Edited by ScienceGuy, 13 January 2012 - 09:56 PM.


#12 Baten

  • Guest
  • 785 posts
  • 57
  • Location:Belgium

Posted 13 January 2012 - 10:12 PM

Hmm have you tried methylene blue? Seems like something that would fit with the rest.

#13 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 14 January 2012 - 01:11 AM

PIRACETAM – Makes me irritable. Dose dependant that is noticable starting and 500mg and is really bad at 2g. Really didn't notice any positives.

PRAMIRACETAM – Ditto. Significantly enhanced mental clarity and sharpness; and increased motivation. No irritibility issue.

OXIRACETAM – I have it ordered just so I can say I've tried it. It is super expensive so it will have to really impress me.

ANIRACETAM – Provides a potent ANXIOLYTIC effect. I find it demotivating and makes me get bad double vision (which I'm prone to if I drink alcohol or if I'm staring at a monitor for too long). Greatly enhances my perceived color saturation (moreso than the other racetams). If it was cheaper I might experiment more with it just taking it before bed for the AMPA upregulation.

#14 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 14 January 2012 - 09:14 AM

Hmm have you tried methylene blue? Seems like something that would fit with the rest.


Nice one Baten! ;)

FYI - I've quite a long list of substances that I intend to comprehensively research and personal try out; and funnily enough METHYLENE BLUE is almost next on the list...

After all, anything with the potential added bonus of turning your pee green most certainly warrants trialling... :cool:

#15 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 14 January 2012 - 09:31 AM

PIRACETAM – Makes me irritable. Dose dependant that is noticable starting and 500mg and is really bad at 2g. Really didn't notice any positives.

PRAMIRACETAM – Ditto. Significantly enhanced mental clarity and sharpness; and increased motivation. No irritibility issue.

OXIRACETAM – I have it ordered just so I can say I've tried it. It is super expensive so it will have to really impress me.

ANIRACETAM – Provides a potent ANXIOLYTIC effect. I find it demotivating and makes me get bad double vision (which I'm prone to if I drink alcohol or if I'm staring at a monitor for too long). Greatly enhances my perceived color saturation (moreso than the other racetams). If it was cheaper I might experiment more with it just taking it before bed for the AMPA upregulation.


Thanks for sharing! :)

Your feedback is most interesting and is yet further indication of the apparent randomness of the individual response to the particular RACETAMS; and hence the need to each and every person to try each by themselves to see how THEY personally respond to each of the particular RACETAMS.

Especially interesting that you also, find ANIRACETAM to be demotivating; it makes me completely amotivated, so I steer WELL clear of it...

It will also be especially interesting to see how you get on with the OXIRACETAM and whether or not your response to that particular RACETAM fits my observation that individuals who don't respond well to ANIRACETAM, such as yourself, DO respond will to OXIRACETAM.

I would recommend you try stacking the OXIRACETAM with the PRAMIRACETAM, with the PRAMI at whatever dosage you find best when taken as monotherapy, and start with the OXI at a dosage of just 300mg once daily, then increase dosage gradually by say 100mg each day, and perhaps add in a second dosage 3+ hours after the first once if needed. Since oyu are quite right that OXI is annoyingly expensive you should ascertain what is the MINIMUM dosage that yields the desired therapeutic beneficial effects. I personally find that 300mg is all I need, which helps keep costs down; but please note that is the dosage that is right FOR ME, which does NOT necessarily mean you will respond well to this dosage as well; some users have reported great effects at dosages of OXI as high as 800mg multiple times per day; the only bummer with that is the hefty price tag... :sad:

Please do post feedback regarding how you get on with the OXIRACETAM ;)

#16 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 16 January 2012 - 06:32 PM

My Oxi came in the mail yesterday.

I took my first dose (300mg of Oxi) along with my normal 300mg of Pram (along with my other nootropics).

I'm not sure if I really noticed anything. A bit more focus and maybe a bit of emotional dulling (I felt focused in a robotic kind of way). Very subtle.

Since the effect was subtle, I wanted to try a more normal dose so I can notice what the Oxi is doing. So after only 2 hours I did a 500mg dose. This seems like it is too much.

I'm going to continue the trial but tomorrow will stick with 300mg of Oxi and 300mg of Pram

PIRACETAM – Makes me irritable. Dose dependant that is noticable starting and 500mg and is really bad at 2g. Really didn't notice any positives.

PRAMIRACETAM – Ditto. Significantly enhanced mental clarity and sharpness; and increased motivation. No irritibility issue.

OXIRACETAM – I have it ordered just so I can say I've tried it. It is super expensive so it will have to really impress me.

ANIRACETAM – Provides a potent ANXIOLYTIC effect. I find it demotivating and makes me get bad double vision (which I'm prone to if I drink alcohol or if I'm staring at a monitor for too long). Greatly enhances my perceived color saturation (moreso than the other racetams). If it was cheaper I might experiment more with it just taking it before bed for the AMPA upregulation.


Thanks for sharing! :)

Your feedback is most interesting and is yet further indication of the apparent randomness of the individual response to the particular RACETAMS; and hence the need to each and every person to try each by themselves to see how THEY personally respond to each of the particular RACETAMS.

Especially interesting that you also, find ANIRACETAM to be demotivating; it makes me completely amotivated, so I steer WELL clear of it...

It will also be especially interesting to see how you get on with the OXIRACETAM and whether or not your response to that particular RACETAM fits my observation that individuals who don't respond well to ANIRACETAM, such as yourself, DO respond will to OXIRACETAM.

I would recommend you try stacking the OXIRACETAM with the PRAMIRACETAM, with the PRAMI at whatever dosage you find best when taken as monotherapy, and start with the OXI at a dosage of just 300mg once daily, then increase dosage gradually by say 100mg each day, and perhaps add in a second dosage 3+ hours after the first once if needed. Since oyu are quite right that OXI is annoyingly expensive you should ascertain what is the MINIMUM dosage that yields the desired therapeutic beneficial effects. I personally find that 300mg is all I need, which helps keep costs down; but please note that is the dosage that is right FOR ME, which does NOT necessarily mean you will respond well to this dosage as well; some users have reported great effects at dosages of OXI as high as 800mg multiple times per day; the only bummer with that is the hefty price tag... :sad:

Please do post feedback regarding how you get on with the OXIRACETAM ;)



#17 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 16 January 2012 - 07:18 PM

My Oxi came in the mail yesterday.

I took my first dose (300mg of Oxi) along with my normal 300mg of Pram (along with my other nootropics).

I'm not sure if I really noticed anything. A bit more focus and maybe a bit of emotional dulling (I felt focused in a robotic kind of way). Very subtle.

Since the effect was subtle, I wanted to try a more normal dose so I can notice what the Oxi is doing. So after only 2 hours I did a 500mg dose. This seems like it is too much.

I'm going to continue the trial but tomorrow will stick with 300mg of Oxi and 300mg of Pram


For me anything above 400mg of OXIRACETAM = OVERSTIMULATION

For me the 300mg dose is spot on. Also, I experienced the same as you in that my first 300mg dose was subtle, but I noticed the effects relating to focus, memory and auditory enhancements to be cumulative in that the effect of the 300mg OXIRACETAM addition to my stack became more obvious as the days progressed. It will be interesting to hear whether it does the same for you. ;)

#18 dreth7

  • Guest
  • 47 posts
  • 1
  • Location:usa

Posted 16 January 2012 - 09:04 PM

any feedback on the nefiracetam?? Or still in trial phase.

#19 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 16 January 2012 - 09:17 PM

My Oxi came in the mail yesterday.

I took my first dose (300mg of Oxi) along with my normal 300mg of Pram (along with my other nootropics).

I'm not sure if I really noticed anything. A bit more focus and maybe a bit of emotional dulling (I felt focused in a robotic kind of way). Very subtle.

Since the effect was subtle, I wanted to try a more normal dose so I can notice what the Oxi is doing. So after only 2 hours I did a 500mg dose. This seems like it is too much.

I'm going to continue the trial but tomorrow will stick with 300mg of Oxi and 300mg of Pram


For me anything above 400mg of OXIRACETAM = OVERSTIMULATION

For me the 300mg dose is spot on. Also, I experienced the same as you in that my first 300mg dose was subtle, but I noticed the effects relating to focus, memory and auditory enhancements to be cumulative in that the effect of the 300mg OXIRACETAM addition to my stack became more obvious as the days progressed. It will be interesting to hear whether it does the same for you. ;)


Thanks for the feedback. Taking more wasn't at all what I expected (expected overstimulation and got brain fog)! I think I can elaborate more now that I'm out of the brainfogged state that the extra 500mg put me in (felt better after I came back from my run). I felt similar to how you described your 30mg NOPEPT experiment. It felt like my working memory was impared. I felt very sleepy actually. That could partly be because I didn't get a good night's sleep last night. But the sleepiness was much more pronounced after the 500mg dose. Moderation is the key... :)

#20 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 18 January 2012 - 07:25 PM

Moderation is the key... :)


Indeed it is! ;)

#21 scouser

  • Guest
  • 95 posts
  • 6
  • Location:Liverpool

Posted 19 January 2012 - 07:13 PM

Hello, I am completely new to the world of Nootropics and after reading the sticky here '10 months research' I was going to try the suggested stack of

Piracetam 4gm daily
CDP Choline 800mg daily
Picamilon 150mg daily

I have been looking online but as yet not found a supply of Piracetam.

After reading this thread, I am wondering if trying the cetams 1 by 1 may be the way to go.

I was looking at a supply of Pramiracetam. but I am willing to be guided here on my first steps. especially as science guy is in my neck of the woods and can maybe help me with decent suppliers.

If I took the Pramiracetam or other one by one to judge the effects, how log should I take them and at what dosages?

Thanks

#22 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 19 January 2012 - 07:20 PM

Oxi is a complete bust for me after a 3 day trial. I had high hopes for it, but it does nothing except make me tired. I've heard it motivates you, but I'm getting quite the opposite. I LOVE pramiracetam and am having much better results upping pram to 500mg in the morning and 250mg in the afternoon.

Maybe I will try OXI on it's own (not stacked with Pram) some weekend.

#23 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 19 January 2012 - 08:14 PM

any feedback on the nefiracetam??


I have now completed my comprehensive personal evaluations of both NEFIRACETAM and URIDINE.

My feedback is as follows:

RE: NEFIRACETAM:

Dosages used: 50mg, 25mg, and 10mg; all once daily per orally.

Positive Effects Experienced: Increased mental clarity (though less so than PRAMIRACETAM at equal doses)

Side Effects Experienced: INCREASED anxiety; SEXUAL SIDES (reduced libido, reduced seminal volume); SLEEP DISRUPTION; IRRITABILITY; MOOD DISRUPTION; DEPRESSION; LOSS OF SELF-CONFIDENCE; AMOTIVATION

(N.B. Interestingly, I experienced ALL of these same side effects with NOOPEPT)

RE: URIDINE (UMP FORM):

Dosages used: 250mg, 100mg, 50mg, and 25mg; all once daily SUBLINGUALLY.

Positive Effects Experienced: Increased alertness with the 250mg sublingual dosage (only), but this was a very unpleasant 'wired' type of alertness which lasted 4 hours and was then immediately followed by severe brain fog.

Side Effects Experienced: NAUSEA; HEADACHE; FACIAL FLUSHING; MALAISE; IMPAIRED cognition; INCREASED anxiety; IRRITABILITY; MOOD DISRUPTION; LOSS OF SELF-CONFIDENCE; AMOTIVATION

In short I do not get on with EITHER of them AT ALL and hence will not be adding them to my stack (or at least re-trying them until I 100% eliminate my residual Encephalitis).

Therefore, my current RACETAM STACK comprises the following:

1) PIRACETAM: 5g twice daily, with 3+ hours in-between doses (TOTAL: 10g daily)

2) OXIRACETAM: 300mg once daily

3) PRAMIRACETAM: 100mg once daily

Other NOOTROPICS that I take in addition to this include:

4) Hydergine (Ergoloid Mesylates): 1mg once daily

5) Choline (as choline orthosilicic acid): 100mg once daily

6) Phosphatidylserine (as isolate): 100mg once daily

7) Quercetin (as Chalcone): 250mg twice daily

8) Gerovital H3: 3.6ml via IM Injection once daily

Edited by ScienceGuy, 20 January 2012 - 08:37 AM.


#24 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 19 January 2012 - 09:05 PM

Science guy, now that you mention depression I was getting a bit of depression and loss of self confidence during the time I was experimenting with OXI. It could be a coincidence. Pram on the other hand gives me more confidence and self esteem.

#25 ScienceGuy

  • Topic Starter
  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 20 January 2012 - 08:36 AM

Science guy, now that you mention depression I was getting a bit of depression and loss of self confidence during the time I was experimenting with OXI. It could be a coincidence. Pram on the other hand gives me more confidence and self esteem.


PRAMIRACETAM is AWESOME! ;)

#26 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 20 January 2012 - 04:36 PM

Science guy, now that you mention depression I was getting a bit of depression and loss of self confidence during the time I was experimenting with OXI. It could be a coincidence. Pram on the other hand gives me more confidence and self esteem.


PRAMIRACETAM is AWESOME! ;)


100% agree :)

#27 health_nutty

  • Guest
  • 2,410 posts
  • 94
  • Location:California

Posted 23 February 2012 - 06:39 PM

What is the best choline to use with racetams? Any benefits of using the more expensive ones such as alpha-gpc or cdp-choline.

Anything wrong with lecithin? I use lecithin and ALCAR.

#28 Baten

  • Guest
  • 785 posts
  • 57
  • Location:Belgium

Posted 24 February 2012 - 09:03 AM

I think lecithin + ALCAR definitely works. I like ALCAR.
Alpha GPC and CDP choline supposedly are stronger, cdp choline can also effect mood positively.

#29 unregistered_user

  • Guest
  • 721 posts
  • 169
  • Location:Washington DC

Posted 24 February 2012 - 02:56 PM

I take 1g of Royal Jelly which is the only natural source of pure acetylcholine and can naturally raise levels of acetylcholine. I'm not really sure if it is sufficient in terms of what my body needs when taking Piracetam but to me this seems like a good companion. Anyone have any thoughts?

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#30 lne

  • Guest
  • 10 posts
  • -1
  • Location:Brazil

Posted 18 March 2012 - 11:59 AM

ScienceGuy,

How long are you taking your stack ?
Noticed any tolerance ?
Do you have any experience with DMAE ?





Also tagged with one or more of these keywords: racetam, piracetam, oxiracetam, aniracetam, pramiracetam, nefiracetam, nootropic, memory, cognitive, racetams

10 user(s) are reading this topic

0 members, 10 guests, 0 anonymous users