I have been taking Oxiracetam on and off lately. I'm not sure about its effects; but, there is something working in the backgroud. I feel even younger again in cognitive functioning. Like I can pick up on thoguhts more easily. Like my brain is more receptive. But, I had an argument yesterday after taking oxiracetam. I woke up with this swishy swashy feeling. Like a litle bit after a hangover.
After reading about the most probable mechanism of action I am lead to believe that Piracetam "sensitizes" the brain (NMDA receptors) through permeability and "modulation of ion channels (i.e., Na+, K+))". Thus, I figured that neurotoxicity (excitotoxicity) in already young and more receptive brains might be of concern.
Excitotoxicity can occur from substances produced within the body (endogenous excitotoxins). Glutamate is a prime example of an excitotoxin in the brain, and it is also the major excitatory neurotransmitter in the mammalian CNS.[9] During normal conditions, glutamate concentration can be increased up to 1mM in the synaptic cleft, which is rapidly decreased in the lapse of milliseconds.[10] When the glutamate concentration around the synaptic cleft cannot be decreased or reaches higher levels, the neuron kills itself by a process called apoptosis.[11] [12]
JUst someething worth mentioning.
Edited by redan, 15 January 2012 - 07:25 PM.