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Best homemade transdermal delivery system?

transdermal drug delivery absorption bht herpes hsv

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#1 manic_racetam

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Posted 26 January 2012 - 04:48 PM


Trying to make an effective transdermal delivery system for BHT (Butylated hydroxytoluene) for herpes treatment.

I've tried mixing Vaseline brand body lotion and BHT in a blender, but it seems like it isn't absorbing into the skin very well (just a hunch)... The prescription acyclovir ointment is in a solution of polyethylene glycol (PEG) of different molecular weights, but according to this study it doesn't absorb very well. Any ideas on a good delivery system that would be easy enough to make at home?

Edited by manic_racetam, 26 January 2012 - 04:53 PM.


#2 Anthony_Loera

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Posted 26 January 2012 - 06:48 PM

hmm.. DMSO?

A

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#3 Mind

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Posted 26 January 2012 - 08:57 PM

Don't you have to be extremely careful with DMSO, because it is so efficient getting through the skin, anything that comes into touch with it will get absorbed into your skin when you apply it, so you have to use special gloves and a very clean environment (or so I have heard argued once or twice before).
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#4 manic_racetam

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Posted 26 January 2012 - 11:15 PM

Thanks! DMSO with an eye-dropper looks like it might be a pretty effective solution. You think the BHT molecule will be able to make it through the skin with the DMSO? (I can deal with garlic breath for a few hours if it works well)

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#5 PhaQ

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Posted 27 January 2012 - 02:50 AM

PLO Gel with some dmso in the polar phase. You can google how to make it. Its basically isopropyl myristate and lecithin emulsified with a polar phase containing whatever you want to absorb.





Also tagged with one or more of these keywords: transdermal, drug delivery, absorption, bht, herpes, hsv

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