Do not believe I am troubled. I have learned to control my emotions. Time is utterly meaningless. We exist in consciousness, automatically proceeding. I've transcended dwelling on the past. Do not pity me or feel sad for me, while I sit here and laugh. 
Ha! Nice to meet you. Can't personally relate to controlling emotions or to "I sit here and laugh" but the rest of it is way outside the Matrix.
A very good antidepressant for example is Stablon (tianeptine), it affects NMDA and AMPA instead of serotonin and increases NGF. It improves libido and elevates mood instead of dulling it. Initially it might cause some insomnia, but eventually it also improves sleep onset and quality. It's also neuroprotective and a respiratory stimulant.
It's been shown to have greater efficacy than SSRIs in both anxiety and depressive disorders, it's tolerable in bipolar depression and doesn't cause weight gain. It is also a mild anticonvulsant and an atypical analgesic. Tianeptine improves neuropathic pain, fibromyalgia and OCD.
Wow, I had not heard of this med yet. I've been put on 6 different SSRIs and had to stop them before I completed a week of the starter dose because I felt like I was on bad acid. The 6th and final time, I followed the urging of my temporary psych (in a recovery hospital after suicide attempt) who said my symptoms meant the celexa was "just about to work." A few days later, during which time I became increasingly incapable of functioning in physical, social and emotional realms, I had a grand mal seizure, slammed my head against the corner of a coffee table and was presumed dead by a friend who witnessed the whole thing. I came to a couple days later in a hospital. There were some interesting cosmic aspects to this experience which go beyond the scope of this thread and forum, but we can communicate privately if you're interested (hint: the psychiatrist in question was Hindu and had a devious smile when he said it was just about to work.)
The upshot of this is that even in the short run, some people are hyper-sensitive to SSRIs and/or other monoaminergic drugs.
The info about AMPA and NMDA receptors coincides with new info I was reading last night from the NIH website, which summarized recent trends away from monoaminergics and toward the glutame system. Prospects look very good for further research and development of treatment by these means. The studies suggest that SSRIs might even have their effect due to downstream impact on glutamate activity.
- Piracetam (can worsen depression initially or at low doses when taken without fish oil, later a permanent improvement can be observed)
- Hydergine (do not use in delusional bipolar or schizophrenia, NGF booster. works in refractory depression)
- Bacopa Monnieri 20% bacosides (anxiolytic, regenerates the same parts of the brain as antidepressants)
- Vitamin D (deficiencies can exacerbate depression)
- Fish Oil (mood stabilizing, reduces suicidal behaviour)
I have read on many forums about combining piracetam with choline, but you don't mention choline and you suggest fish oil WITH the piracetam? Just checking to see what you've learned about these combinations.
I take all the above minus hydergine and plus about a dozen other things such as rhodiola, ginkgo, d,l-phenylalanine, acacia catechu, green tea extract, vinpocetine, and more. I know that I'm playing with fire and wasting money at the same time but it's a new form of addiction for me. I especially enjoy the research and online shopping for bulk sources (internet shopping addiction pertaining to only one product category!)
So, against the statement in the title of this thread, I am randomly mixing MANY supplements. It's not entirely random because I do research things thoroughly and I try to watch out for interaction effects, but I know I'm lacking a lot of information that is crucial to making better-informed choices about what to take and in what doses. I tend to take lower-than-suggested doses in order to play it safe, and this might simply render some supplements ineffective and a pointless expenditure. Who knows... my kidneys probably aren't too happy about all this. One way I justify the herbal use (along with root powders such as maca) is that they are essentially FOOD sources; we evolved eating much more bitter, nutrient-dense leaves and roots, not the watered-down hybridized stuff that we currently find in the produce section. Fortunately there are options like watercress, dandelion greens, arugula and several others that are increasingly showing up in higher-end grocery stores, and these are closer to their ancestral source, complete with the bitter and sometimes astringent flavors characteristic of antioxidants, catechins, tannins, psychoactives, and other bioactive compounds.
Edited by deeptrance, 27 April 2012 - 04:50 PM.
