809 replies to this topic

[canz]

Do you mean this stack?

• Forskolin 10-20mg - Once Daily
• Artichoke Extract 500mg - Once Daily
• Stimulant or Precursor (Amino Acid)

10-20 mg of forkolin 100% extract or 20% extract?

Yes that stack. If you can find 100% that would probably be best, but others have had great results in the range of 1%-20% from the thread that zbarnes posted above.

[Nootr]

The 100% can't be found. The stongest sold on net is 20%. But i want to be sure if i should take 20 mg of 20% or 100 mg of 20% to get net 20 mg of the substance. Anyway i think they meant 20 mg of 20% extract coz it is impossible to buy 100% extract anywhere.

[canz]

The 100% can't be found. The stongest sold on net is 20%. But i want to be sure if i should take 20 mg of 20% or 100 mg of 20% to get net 20 mg of the substance. Anyway i think they meant 20 mg of 20% extract coz it is impossible to buy 100% extract anywhere.

You are correct.

[Steve_86]

The 100% can't be found. The stongest sold on net is 20%. But i want to be sure if i should take 20 mg of 20% or 100 mg of 20% to get net 20 mg of the substance. Anyway i think they meant 20 mg of 20% extract coz it is impossible to buy 100% extract anywhere.

You are correct.

I got 95 or 98% extract (i forget). It can be found on the net.

[Nootr]

According to the thread devoted to the stack you should take 10 mg of pure forskolin. So 100 mg of 10% forskolin should be taken. For example, here they sell pills http://www.lef.org/V.../Forskolin.html containing 10 mg of forskolin in 100 mg pills.

[Nootr]

Etifoxine is as strong as benzos but without withdrawal. Looks tempting.

[DaneV]

Etifoxine is as strong as benzos but without withdrawal. Looks tempting.

The drug is developed in the sixties... If it was really interesting, i think it would be used a bit more by now.

[zoopants]

first off i would really like to thank Science Guy for his very thorough post which started this thread, it was / is extremely helpful. Sam-e ( 400mg x 1 a day ) has worked well for me ( general energy & improved sense of well being ) , my only concern is i also take curcumin ( 400mg bcm 95 l.e.f brand x 1 a day ) and i found out it is considered a maoi . I take l theanine and alcar also , but there doesn't seem to be any worries with their interactions . does anyone have any insight ?

[Nootr]

I found out that anxyolitics cause mental decline. I now have problems with concentration on work. I have read that prolonged use of phenibut causes encephalopathy. Probably, it's better to take large doses of nootropics like noopept, phenyl-piracetam, piracetam than anxyolitics or at least combine them. Curcumin seems to be MAOI according to my feelings but the question is if it is good enough compared to tianeptine for example? Coz tianeptine also creates protective sheild causing edorphine release. it must be mentioned that the feeling of happiness is not only high serotonin, dopamine and norepinephrine levels but mostly high levels of endorphines (endogenic morphines). They are produced from: sex, sport, power over people or creative work like arts or science. Because most of this thread users are likely to have sex diffeciency, lack of power over other people, lack of sports and low level of creative achievement they(we) lack endorphines which results in low mood. Restoration of neuromediators to normal level cannot provide happy state without normal level of endorphines. So low level of endorphines causes depression and decline of mental abilities together with gradual decay of EGO structure. All the chemicals mentioned here do not work enough well to raise endorphines level. They effect is temporary. You will get accustomed (phsychologocal tolerance) to them and will find yourself in depression again. At least this is my experience.

[Nootr]

About L-theanine:
L-theanine has been shown to increase brain GABA levels, however it is a NMDA agonist and may actually induce withdrawal. I'd surmise that its effects are based on an inverse U dose-response curve. Lower doses (25-100 mg) - stimulating, higher doses (1-2 grams) - depressing.

[hanzsolo]

Very interesting, thanks so much to Science Guy for all the research and great finds !!

I am interested in trying Curcumin after your success with it - and have some L.E.F. BCM-95 400mg - would this be ok at 1 capsule per day ?
This is the description;
BCM-95® Bio-Curcumin® (Curcuma longa) 25:1 extract (root) [std. to 95% Total Curcuminoids Complex with Essential Oils of Turmeric Rhizome by HPLC (380 mg)]
400 mg
Or should I stick with curcumin powder sprinkled on foods ??
Also any idea if curcumin will upset my intestine (I have colitis)

Thanks

[hanzsolo]

I am also interested in trying Magnesium Malate.
I have tried other forms but they have too much of a laxative effect at higher dosages...
Any brand or company you can recommend for the Mag Malate ??

Would I need to take Calcium with it ??

Thanks

[zoopants]

the recommended dose is 1 cap ( 400mg ) per day ( L.E.F brand bcm -95 ) . i believe it is more bioavailable than tumeric powder . i do not know about its effect on colitis , but i think i read it may be helpful for preventing relapses. i should add, i take curcumin as a general preventative ( anti -inflammatory ) & so i havent noticed benefits or problems either way . i think the nature of mag at high doses is laxative , i dont know a particular brand ,i think there are some time released mag products & maybe that would lessen laxative effect .

[magta39]

How about magnesium aspartate? I take 5 or 600 mgs per day. ..Sometimes 150 mgs on empty stomach and never have any stomach problems from it.

[noos]

How about magnesium aspartate? I take 5 or 600 mgs per day. ..Sometimes 150 mgs on empty stomach and never have any stomach problems from it.

For anxiety? aspartates are excitatory .

[magta39]

How about magnesium aspartate? I take 5 or 600 mgs per day. ..Sometimes 150 mgs on empty stomach and never have any stomach problems from it.

For anxiety? aspartates are excitatory .

Hmmm....seems like my anxiety is under control but I wish I could sleep better. I will not take it at night for awhile and see what happens....maybe try a different form of Mg at night.....?

[Perek]

Try Afobazole.
I didn't read all the posts but if you need a knock-down, take a benzo.
A more pro-life approach is to take Afobazole. Especially great for SAD.
I've taken it for 4 years and it works wonders, often most.

[noos]

How about magnesium aspartate? I take 5 or 600 mgs per day. ..Sometimes 150 mgs on empty stomach and never have any stomach problems from it.

For anxiety? aspartates are excitatory .

Hmmm....seems like my anxiety is under control but I wish I could sleep better. I will not take it at night for awhile and see what happens....maybe try a different form of Mg at night.....?

I would. Maybe Mg sulphate bath?

A ref. re:aspartates
http://www.ncbi.nlm....books/NBK28252/

[noos]

Try Afobazole.
I didn't read all the posts but if you need a knock-down, take a benzo.
A more pro-life approach is to take Afobazole. Especially great for SAD.
I've taken it for 4 years and it works wonders, often most.

Any memory problems as reported here?
http://www.longecity...post__p__507713

The OP is opposed to gabaergics.IIRC.

[nupi]

Anecdotally, low dose (5mg at the moment) Escitalopram works quite well (and quite quickly so, less than a week on it now). Its not benzo knock down territory but seems much more sustainable (that is, if that numb headache subsides)

[Nootr]

Try Afobazole.
A more pro-life approach is to take Afobazole. Especially great for SAD.
I've taken it for 4 years and it works wonders, often most.

Do you make any breaks in taking afobazole? And if yes how long are they?

[Perek]

Try Afobazole.
I didn't read all the posts but if you need a knock-down, take a benzo.
A more pro-life approach is to take Afobazole. Especially great for SAD.
I've taken it for 4 years and it works wonders, often most.

Any memory problems as reported here?
http://www.longecity...post__p__507713

The OP is opposed to gabaergics.IIRC.

I have never experienced any kind of cognitive side-effects with Afobazole. Usual dosage is 3 x 10-20mg per day and the long term effect sets in after a couple of weeks. It's a benign drug though I know of people finding it to be a bit too activatiing in the first week or so. I was surprised to read about such a reaction at such a small dosage but we are all different.

[Perek]

Try Afobazole.
A more pro-life approach is to take Afobazole. Especially great for SAD.
I've taken it for 4 years and it works wonders, often most.

Do you make any breaks in taking afobazole? And if yes how long are they?

I've only taken breaks when running out of pills. Happened 2-3 times over they years and I could really tell the difference after a week or so. After continuation it takes 1-2 weeks for the effect to set in again.

It mainly helps me with social anxiety. Stamina !
I can also say that since I started Afobazole I hardly EVER get any hangovers, though I am quite a drinker at times...

Try Afobazole.
A more pro-life approach is to take Afobazole. Especially great for SAD.
I've taken it for 4 years and it works wonders, often most.

Do you make any breaks in taking afobazole? And if yes how long are they?

I've only taken breaks when running out of pills. Happened 2-3 times over they years and I could really tell the difference after a week or so. After continuation it takes 1-2 weeks for the effect to set in again.

It mainly helps me with social anxiety. Stamina !
I can also say that since I started Afobazole I hardly EVER get any hangovers, though I am quite a drinker at times...

[DaneV]

Afobazole sounds interesting... You guys all get it at Pharmacy1010 or are there better sources out there ?

Edited by DaneV, 12 September 2012 - 12:32 PM.

[DaneV]

And I wonder why the official website states that Afobrazol should be used for up to three months. If the drug doesnt cause tolerance or dependance, why wouldn't you just use it for as long as you need it (which is often a lot more then a couple of months for most chronic anxiety sufferers) ?

http://translate.goo...ved=0CDEQ7gEwAA

[Perek]

And I wonder why the official website states that Afobrazol should be used for up to three months. If the drug doesnt cause tolerance or dependance, why wouldn't you just use it for as long as you need it (which is often a lot more then a couple of months for most chronic anxiety sufferers) ?

http://translate.goo...ved=0CDEQ7gEwAA

Here is a 6 months study
http://www.consilium...m/article/17123

I don't trust big pharmas long term safety studies anyway. Best evidence is from extensive clinical use and Afo been around for like 10 years now and being sold OTC in Russia. Haven't seen anything written on the net about serious side-effects.

[renfr]

About L-theanine:
L-theanine has been shown to increase brain GABA levels, however it is a NMDA agonist and may actually induce withdrawal. I'd surmise that its effects are based on an inverse U dose-response curve. Lower doses (25-100 mg) - stimulating, higher doses (1-2 grams) - depressing.

Any study saying L-theanine increase GABA levels? There are studies saying that L-theanine definitely doesn't act on GABA.

[Nootr]

Any study saying L-theanine increase GABA levels? There are studies saying that L-theanine definitely doesn't act on GABA.

I don't know. I just copied this about L-theanine from any topic of this forum. As for me I did not find L-theanine to be much of help as anxyolitic. If i took small doses like 200 mg the effect was weak. If i took one gram it became too sedating and causing brain-fog, though when drunk as 1 gram with coffee the negative thought just started without developing but probably due to the fact that mind became weaker from sedation. So actually I think I will stick to other chemicals. And why? Because I think that people with anxiousness (like me) also have low mood and depression and need something to activate them and increase motivation to do smth and to be more energectic. So L-theanine is quite enough for me in green tea which in its turn provides some energy benefits from caffeine and polyphenols.
Have purchased afobazol today and took three pills as required per day. It seems to give some alleviation and adds some energy. Will wait for its effect to develop within three weeks. Hope it will be the magic pill.

[protoject]

Recently I've been taking magnesium citrate. i find i can tolerate 3 teaspoons. Also just as a tip to anyone with sleep or anxiety problems, I found that magnesium citrate works way better if you dissolve it in the hot water [goes without saying... its on the instructions] and put it in a FULL big glass of water on a fairly empty stomach.. seems to work better than with less water or with food, settles in after a few hrs and lasts into the next day in a good way. It'sall thanks to this forum that I have any chance at sleeping.

[mycotheologist]

I just found this article on 2-methoxy-6-methylflavone:
http://onlinelibrary...1604.x/abstract

EXPERIMENTAL APPROACH We evaluated the effects of 2′-methoxy-6-methylflavone (2′MeO6MF) on native GABA_A receptors in new-born rat hippocampal neurons and determined specificity from 18 human recombinant GABA_A receptor subtypes expressed in Xenopus oocytes. We used ligand binding, two-electrode voltage clamp and patch clamp studies together with behavioural studies.


KEY RESULTS 2′MeO6MF potentiated GABA at α2β1γ2L and all α1-containing GABA_A receptor subtypes. At α2β2/3γ2L GABA_A receptors, however, 2′MeO6MF directly activated the receptors without potentiating GABA. This activation was attenuated by bicuculline and gabazine but not flumazenil indicating a novel site. Mutation studies showed position 265 in the β1/2 subunit was key to whether 2′MeO6MF was an activator or a potentiator. In hippocampal neurons, 2′MeO6MF directly activated single-channel currents that showed the hallmarks of GABA_A Cl^- currents. In the continued presence of 2′MeO6MF the single-channel conductance increased and these high conductance channels were disrupted by the γ2(381–403) MA peptide, indicating that such currents are mediated by α2/γ2-containing GABA_A receptors. In mice, 2′MeO6MF (1–100 mg·kg⁻¹; i.p.) displayed anxiolytic-like effects in two unconditioned models of anxiety: the elevated plus maze and light/dark tests. 2′MeO6MF induced sedative effects at higher doses in the holeboard, actimeter and barbiturate-induced sleep time tests. No myorelaxant effects were observed in the horizontal wire test.


CONCLUSIONS AND IMPLICATIONS 2′MeO6MF will serve as a tool to study the complex nature of the activation and modulation of GABA_A receptor subtypes.

It acts on GABA_a receptors so it won't work for benzo w/d symptoms but it may be a relatively non addictive and safe anxiolytic.