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Can bacteria make you smarter?

mycobacterium vaccae

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#1 Now

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Posted 06 February 2012 - 10:08 PM


I just came across this article, might be interesting for some people. Maybe another reason to spend more time outdoors!

Can bacteria make you smarter?
Exposure to specific bacteria in the environment, already believed to have antidepressant qualities, could increase learning behavior according to research presented today at the 110th General Meeting of the American Society for Microbiology in San Diego.

"Mycobacterium vaccae is a natural soil bacterium which people likely ingest or breath in when they spend time in nature," says Dorothy Matthews of The Sage Colleges in Troy, New York, who conducted the research with her colleague Susan Jenks.

Previous research studies on M. vaccae showed that heat-killed bacteria injected into mice stimulated growth of some neurons in the brain that resulted in increased levels of serotonin and decreased anxiety.

"Since serotonin plays a role in learning we wondered if live M. vaccae could improve learning in mice," says Matthews.
Matthews and Jenks fed live bacteria to mice and assessed their ability to navigate a maze compared to control mice that were not fed the bacteria.

"We found that mice that were fed live M. vaccae navigated the maze twice as fast and with less demonstrated anxiety behaviors as control mice," says Matthews.

In a second experiment the bacteria were removed from the diet of the experimental mice and they were retested. While the mice ran the maze slower than they did when they were ingesting the bacteria, on average they were still faster than the controls.

A final test was given to the mice after three weeks' rest. While the experimental mice continued to navigate the maze faster than the controls, the results were no longer statistically significant, suggesting the effect is temporary.

"This research suggests that M. vaccae may play a role in anxiety and learning in mammals," says Matthews. "It is interesting to speculate that creating learning environments in schools that include time in the outdoors where M. vaccae is present may decrease anxiety and improve the ability to learn new tasks."

Provided by American Society for Microbiology
http://www.physorg.c...s193928997.html


There are scientists who believe that exposure to Mycobacterium vaccae may work as an antidepressant because it stimulates the generation of serotonin and norepinephrine in the brain. More specifically, it induces the neurogenesis of neurons that produce those two compounds. http://en.wikipedia....acterium_vaccae



#2 nito

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Posted 14 February 2012 - 03:49 AM

can you buy this kind of stuff in a bottle lol?

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#3 Now

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Posted 14 February 2012 - 09:37 AM

can you buy this kind of stuff in a bottle lol?


As an inhaler for a Mycobacterium vaccae induced high. :happy:

If you have some patience. They have injected it into mice with some promising results.

Research, as of 24 May 2010, has shown that when Mycobacterium vaccae was injected into mice, it stimulated some growth of neurons. It also increased levels of serotonin an decreased levels of anxiety. "We found that mice that were fed live M. vaccae navigated the maze twice as fast and with less demonstrated anxiety behaviors as control mice", says Dorothy Matthews of The Sage Colleges in Troy, New York, who conducted the research with her colleague Susan Jenks. http://en.wikipedia....acterium_vaccae

Edited by Now, 14 February 2012 - 09:38 AM.


#4 Marios Kyriazis

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Posted 14 February 2012 - 05:35 PM

There are better ways to stimulate your serotonin and neuronal growth. A more natural way is to perform some brain-specific exercises, which by the way, may increase other necessary factors such as BDNF and endorphins.
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#5 middpanther88

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Posted 14 February 2012 - 07:35 PM

Ya. It just seems that the increased learning is a product of reduced anxiety, which can be alleviated with serotonin-production (think 5-HTP/SSRIs).

#6 blind12

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Posted 04 December 2012 - 05:04 AM

Mycobacterium vaccae seems to have a much wider potential than serotonin production as it also normalizes abnormal immune responses and conditions, similarly to helminthic therapy.

So take my money and give it to me. I wonder why it's not sold already as a probiotic, like various lactic acid bacteria. It certainly is patented.

#7 Galaxyshock

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Posted 04 December 2012 - 11:47 AM

Interesting. The things we are missing when we grow away from nature.

#8 renfr

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Posted 13 June 2013 - 11:36 AM

Any news for this bacteria? I'm interested in doing a group buy if we can find a supplier of mycobacterium vaccae!

#9 renfr

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Posted 13 June 2013 - 11:45 AM

New study published in 2013 : http://www.ncbi.nlm....pubmed/23454729

#10 Metagene

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Posted 13 June 2013 - 01:33 PM

Any news for this bacteria? I'm interested in doing a group buy if we can find a supplier of mycobacterium vaccae!


Hell yeah! Sounds a lot better than chomping on sauerkraut everyday.

#11 Metagene

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Posted 13 June 2013 - 05:30 PM

I could only find the individual strain for sale.

http://www.atcc.org/.../all/15483.aspx

Seems like there would be interest in this stuff.

#12 telight

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Posted 18 June 2013 - 03:34 PM

I could only find the individual strain for sale.

http://www.atcc.org/.../all/15483.aspx

Seems like there would be interest in this stuff.


What is the difference between the one you posted and this one: http://www.lgcstanda.../all/23027.aspx

If someone with access to funds (Scienceguy :D) could purchase these bacteria, grow them, then send them out to members/anyone who wants them, I could see myself buying some from him. Though I understand there are regulations for mailing bacteria and it may not be legally possible. I am no biologist and have no expertise in this type of area. But looking at the studies I would be willing to ingest these bacteria, they seem to be safe and effective.

Edited by telight, 18 June 2013 - 03:35 PM.


#13 Metagene

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Posted 18 June 2013 - 05:10 PM

I'm not entirely sure. The first one is a type strain isolated from dairy products and the other is isolated from Cow dung? Maybe you should PM Scienceguy lol.

#14 Logic

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Posted 18 June 2013 - 05:50 PM

Hmmm! Anyone know where I can get a miniature cow!? :-D

Its disgusting to consider, but wouldn't unpasteurised milk contain both?

#15 Metagene

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Posted 18 June 2013 - 06:10 PM

I think raw milk is great but there is only one supplier in my area and its expensive.

#16 maxwatt

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Posted 18 June 2013 - 06:10 PM

Try doing some gardening. Or living near a dairy farm.

#17 Logic

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Posted 18 June 2013 - 09:55 PM

Try doing some gardening. Or living near a dairy farm.


Nah; miniature cows are cuter! :)

http://www.mydairycow.com/

http://homestead.org...ows/MiniCow.htm

#18 maxwatt

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Posted 19 June 2013 - 02:54 AM

:|o doh!

#19 Destiny's Equation

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Posted 13 July 2018 - 09:19 PM

Preimmunization with a heat-killed preparation of Mycobacterium vaccae enhances fear extinction in the fear-potentiated startle paradigm.

 

Keywords: PTSD

 

https://www.ncbi.nlm...fear extinction



#20 Ruth

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Posted 15 July 2018 - 08:09 PM

https://pubs.acs.org...ssynbio.7b00399 Engineering the bacteria present in animal microbiomes promises to lead to breakthroughs in medicine and agriculture, but progress is hampered by a dearth of tools for genetically modifying the diverse species that comprise these communities. Here we present a toolkit of genetic parts for the modular construction of broad-host-range plasmids built around the RSF1010 replicon. Golden Gate assembly of parts in this toolkit can be used to rapidly test various antibiotic resistance markers, promoters, fluorescent reporters, and other coding sequences in newly isolated bacteria. We demonstrate the utility of this toolkit in multiple species of Proteobacteria that are native to the gut microbiomes of honey bees (Apis mellifera) and bumble bees (Bombus sp.). Expressing fluorescent proteins in Snodgrassella alvi, Gilliamella apicola, Bartonella apis, and Serratia strains enables us to visualize how these bacteria colonize the bee gut. We also demonstrate CRISPRi repression in B. apis and use Cas9-facilitated knockout of an S. alvi adhesion gene to show that it is important for colonization of the gut. Beyond characterizing how the gut microbiome influences the health of these prominent pollinators, this bee microbiome toolkit (BTK) will be useful for engineering bacteria found in other natural microbial communities.

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#21 Ruth

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Posted 16 July 2018 - 02:15 AM

The Mycobiome: A Neglected Component in the Microbiota-Gut-Brain Axis
Abstract: In recent years, the gut microbiota has been considered as a full-fledged actor of the gut–brain axis, making it possible to take a new step in understanding the pathophysiology of both neurological and psychiatric diseases. However, most of the studies have been devoted to gut bacterialmicrobiota,forgettingthenon-negligiblefungalflora. Inthisreview,weexposehowtherole of the fungal component in the microbiota-gut-brain axis is legitimate, through its interactions with both the host, especially with the immune system, and the gut bacteria. We also discuss published data that already attest to a role of the mycobiome in the microbiota-gut-brain axis, and the impact of fungi on clinical and therapeutic research

https://europepmc.or...ct/med/29973525

The present study evaluated the potential beneficial effect of kefir (KF) against fatigue. Furthermore, the composition of the gut microbiota is related to health benefits in the host; therefore, the study also investigated the effect of KF on the gut microbiota composition. Male ICR mice from four groups (n = 8 per group) were orally administered KF once daily for four weeks at 0, 2.15, 4.31, and 10.76 g/kg/day and were designated as the vehicle, KF-1X, KF-2X, and KF-5X groups, respectively. The gut microbiota was analyzed using 16S rRNA gene sequencing. The results showed a significant clustering of cecum after treatment in the vehicle, KF-1X, KF-2X, and KF-5X groups. The KF-2X and KF-5X groups showed a decreased Firmicutes/Bacteroidetes ratio compared with the vehicle group. In addition, anti-fatigue activity and exercise performance were evaluated on the basis of exhaustive swimming time, forelimb grip strength, and levels of serum lactate, ammonia, glucose, blood urea nitrogen (BUN), and creatine kinase (CK) after a swimming exercise. The exhaustive swimming time for the KF-1X, KF-2X, and KF-5X groups was significantly longer than that for the vehicle group, and the forelimb grip strength of the KF-1X, KF-2X, and KF-5X groups was also significantly higher than that of the vehicle group. KF supplementation also decreased serum lactate, ammonia, BUN, and CK levels after the swimming test. However, tissue glycogen content, an important energy source for exercise, increased significantly with KF supplementation. Thus, KF supplementation can alter the gut microbiota composition, improve performance, and combat physical fatigue.





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