6 replies to this topic

[Allen Walters]

I've Been taking large doses of DIM for a couple weeks now for slight gyno I have had sense I was a teenager. it has Help it quite a bit, but I have noticed my skin looks smoother and younger. I also have noticed a more positive attitude about things in general, and better focus. I also have chronic back pain that has all but vanished. I've been taking 4 gr a day, with grape seed oil but now I think I'll switch it to olive oil.

[Allen Walters]

Oh, and it has cleared up all my acne that I've had my entire adult life as well.

[Raphy]

I've Been taking large doses of DIM for a couple weeks now for slight gyno I have had sense I was a teenager. it has Help it quite a bit, but I have noticed my skin looks smoother and younger. I also have noticed a more positive attitude about things in general, and better focus. I also have chronic back pain that has all but vanished. I've been taking 4 gr a day, with grape seed oil but now I think I'll switch it to olive oil.

What is DIM?

[Allen Walters]

The following definition of diindolylmethane was taken from
the National Cancer Institute:

diindolylmethane
A phytonutrient and plant indole found in cruciferous vegetables including broccoli, brussels sprouts, cabbage, cauliflower and kale, with potential antiandrogenic and antineoplastic activities. As a dimer of indole-3-carbinol, diindolylmethane (DIM) promotes beneficial estrogen metabolism in both sexes by reducing the levels of 16-hydroxy estrogen metabolites and increasing the formation of 2-hydroxy estrogen metabolites, resulting in increased antioxidant activity. Although this agent induces apoptosis in tumor cells in vitro, the exact mechanism by which DIM exhibits its antineoplastic activity in vivo is unknown. Check for active clinical trials using this agent. (NCI Thesaurus)

US brand name: BioResponse DIM
Abbreviation: DIM

[Allen Walters]

There are people who claim that it has anti aging properties, but others say it is due to having the healthy hormone balance of a young person.

[Kevnzworld]

Both I3C and DIM help promote healthy metabolism of estrogen by influencing the ratio of beneficial 2-hydroxyestrone to unfavorable 16-alpha-hydroxyestrone.48,50 An increased ratio of these estrogen metabolites is associated with a decreased risk of breast and other cancers.39,47-53 A placebo-controlled, double-blind study of women at increased risk for breast cancer found that four weeks of supplementation with I3C promoted favorable changes in the urinary estrogen metabolite ratio of 2-hydroxy-estrone to 16-alpha-hydroxyestrone.50
( from LEF )

I take I3C and DIM because I use DHEA and Testosterone creams. As men age they naturally convert more testosterone into estrogen. It is thought that this increase in estrogen and some of it's harmful metabolites contribute to prostate cancer.

[zm3thod]

The only thing I really noticed with DIM was that it improved my skin, particularly acne, at 200-400mg a day (the most I tried taking). I'm a mid-twenties male.