303 replies to this topic

[perplex]

I posted the following on the 'noopept - sexual sides thread' but thought I would share it here in an attempt to involve more people in the discussion.

I love Noopept. Unfortunately like many I suffered noticable sexual sides while on it. More specifically both sex drive and EQ were considerably reduced. Seeing as I enjoy this noot and its effects so much I'm determined to find a way to reverse these ill effects

Once I stopped my Noopept trial it took me sometime to get my Libido back on track. With the help of several members of our community we discussed several different theories/approaches on how to solve this issue; namely:

(1) Supplement Nitric Oxide drivers - (e.g) Artichoke extract
(2) Supplement on natural testosterone boosters- ashgawhanda
(3) Supplement on choline - Lecithin etc

Although some of the above helped treat the problem temporarily what really re-established my Libido to its normal mid-twenties prowess was when I tried (3). However, it was a specific source of choline that helped. I tried eggs and lecithin before to very little effect - it was only once I started supplementing with CDP choline that my sex switch turned back on.

It is well known around the community that CDP Choline provides Uridine which in turn helps regulate dopamine production and increase dopamine receptor densities. I've seen several people mix Mr. Happy's Uridine stack with Noopept and report good results with limited sides. In addition I've seen 'EPIQ noopept complex' already comes with uridine and cdp-choline. All the above seem to point to one conclusion:

Noopept and it's negative sexual side effects are a dopamine related issue which could in turn be mitigated through co-ordinating simultaneous use of dopaminergic normalizing supplements such as citicoline (cdp) and/or Uridine.

for the more experienced users of noopept, what's your take on this?

Edited by perplex, 26 November 2013 - 07:14 PM.

[Godof Smallthings]

^Interesting theory that bears replicating to see if it works for others than you. I'll try it during my next noopept trial.

[machete234]

• Noopept will trip you out. It will trance you out if you are in a flow of life which supports trancing. For example, the 9-5 grind: this is a trance, and taking Noopept will reinforce it.

Its was often like taking a weak pot cookie in the morning or so and I couldn see how people would think this improves them intellectually.
In my experience this is like going to work stoned, sure you can have benefits like better out of the box thinking etc but how good is the success rate really going to be?

As a recreational thing this was pretty nice for example for sports, cinema or taking your surroundings in with great detail, it was like a constant psychedelic come up with no peak.

Left out the spirulina today to check if the excessive compounded psycho-stimulative effects would subside a bit and it seems to have worked.

What is in spirulina apart from some amino acids and protein? (tastes like chicken too hehe)
It makes things a little better in my experience for example racetams+ spirulina is often better than racetams or spirulina alone.

Since having it in bulk I have real trouble getting that stuff in and so I dont take it anymore.
If you want to try spirulina for gods sake get the pressed tablets because they go down so smoothly compared to the powder.

Edited by machete234, 27 November 2013 - 12:41 PM.

[robosapiens]

Good Theory! Thank you.
I`ve got a second question. Are there people that used Noopept for a long time and then stopped using?
Did your brains keep working above baseline when you stopped using? Any side effects?
I started using Noopept because I want to restore my braincapacity like before there was any damage..
Thanks for the response

I did a several month run on it, and then six weeks off, and I feel permanently enhanced from it at this time. I'm now starting another cycle with it.

[Climactic]

Noopept and it's negative sexual side effects are a dopamine related issue which could in turn be mitigated through co-ordinating simultaneous use of dopaminergic normalizing supplements such as citicoline (cdp) and/or Uridine.

If uridine is what your brain needs, doesn't it make more sense to supplement triacetyluridine? Afaik, it is much more powerful than other providers of uridine. If you do try it, go easy with it. I am not asking you to discontinue the citicoline - it is good in its own right.

Also, it'd probably be worthwhile for you to know your baseline testosterone level (without any possible influence of noopept, citicoline, etc.).

Edited by Climactic, 28 November 2013 - 02:35 AM.

[mission780]

Please recommend me a reliable shop in Europe (preferably EU) where I can order good quality Noopept.

[mission780]

Can anybody compare the effects of Noopept to the nootropic (very low) doses of psychedelics?
What are the similarities and differences?

[Frankee026]

It makes my vocab recall much sharper and more appropriate, and I am so jazzed to be social, but I definitely tend to space on simple things like clocking out from work. Also, my throat gets scratchy and sore no matter what, from any and every dose.

Edited by caliban, 06 January 2014 - 11:12 AM.

[golden1]

Can anybody compare the effects of Noopept to the nootropic (very low) doses of psychedelics?
What are the similarities and differences?

its not really close

[thomasthomas]

It makes my vocab recall much sharper and more appropriate, and I am so jazzed to be social, but I definitely tend to space on simple things like clocking out from work. Also, my throat gets scratchy and sore no matter what, from any and every dose.

That's really funny, because I kind of get the same thing. My throat doesn't get scratchy, but I get a very
mild lump in my throat. Every time.

I thought I was the only one. I wonder what is the cause of this.

Edited by caliban, 06 January 2014 - 11:13 AM.

[Even_Smarter]

I kind of have the feeling that noopept has a negative effect on short term memory, whereas old memories pop up in my mind. Normal?

Edited by caliban, 06 January 2014 - 11:12 AM.

[mission780]

Any more people would like to share their experiences with Noopept?

How much you take, how often and what are good and bad effects for you?

Are Noopept effects much more real/intense than other most popular nootropics?

[Force]

I have cycled noopept since July 2012. It is my favorite nootropic. It greatly enhances my memory, vocabulary, hand-eye coordination, spacial memory, motivation and creativity. It reversed learned helplessness.

It synergizes well with caffeine and theanine. The rest of my stack consists of:

• 1g EPA/DHA (fish oil)
• CDP Choline (citocholine)
• Uridine UMP
• Multivitamin
• Sometimes: Theanine(2nd favorite noot), Caffeine, Sunifiram, Phenylpiracetam, Aniracetam, Nicotine, B-complex, Magnesium.citrate

To discern the effects, started off with Noopept by itself. It worked best for recovering from synthetic cannabinoid use. The duration and dosing of each noopept cycle varies considerably. I have taken 2 month breaks and 1 week breaks.

30mg is too much. When I trialed this dose, I noticed short-term memory deficits and spaciness. Sublingual dosing hits me too suddenly. I can may remedy this by splitting into 3 smaller doses, but for now I am sticking with 20mg orally (puts me at the top of the bell-shaped curve with no side effects).

Edited by Force, 03 December 2013 - 06:21 PM.

[mission780]

I have cycled noopept since July 2012. It is my favorite nootropic. It greatly enhances my memory, vocabulary, hand-eye coordination, spacial memory, motivation and creativity. It reversed learned helplessness.

It synergizes well with caffeine and theanine. The rest of my stack consists of:

• 1g EPA/DHA (fish oil)
• CDP Choline (citocholine)
• Uridine UMP
• Multivitamin
• Sometimes: Theanine(2nd favorite noot), Caffeine, Sunifiram, Phenylpiracetam, Aniracetam, Nicotine, B-complex, Magnesium.citrate

To discern the effects, started off with Noopept by itself. It worked best for recovering from synthetic cannabinoid use. The duration and dosing of each noopept cycle varies considerably. I have taken 2 month breaks and 1 week breaks.

30mg is too much. When I trialed this dose, I noticed short-term memory deficits and spaciness. Sublingual dosing hits me too suddenly. I can may remedy this by splitting into 3 smaller doses, but for now I am sticking with 20mg orally (puts me at the top of the bell-shaped curve with no side effects).

Thank you!

BTW do you happen to know if Noopept make effects of cannabis less pronounced, weaker?

I have such an impression with selegiline (Jumex) that I've tried a few times recently - it made me NOT want to smoke or it weakened its effects, I suspect.

Edited by mission780, 03 December 2013 - 06:51 PM.

[robosapiens]

Can anybody compare the effects of Noopept to the nootropic (very low) doses of psychedelics?
What are the similarities and differences?

Sort of... it doesn't get you 'high' but it has a perception expanding effect, a mild psychedelic but NOT a hallucinatory or dissociative, so lends itself to deep philosophical or creative thinking along with visual acuity enhancement, it also blunts fear and helplessness somewhat.

The alleged short term memory 'brain fog' effects with noopept aren't - it's more that we go into an alpha state and 'trance out' vs zone out, this can be quite useful once you get comfortable working with it..

For me, unifram works well to add a bit more focus or vigilance to it.

As a hypnotist, I find it quite interesting.

cheers

Edited by robosapiens, 03 December 2013 - 07:29 PM.

[riloal]

Nobody notices a crash in energy about four hours after taking noopept? Thanks

[mission780]

Nobody notices a crash in energy about four hours after taking noopept? Thanks

People here mention this crash from time to time. Some claim that if you take it after a meal you can avoid the crash or greatly reduce it.

[Geoffrey]

Yes, I get the crash, in fact I'm experiencing it right now, having taken Noopept earlier today (in the morning). I'm feeling totally lethargic, weak and lacking in motivation. I was debating whether to top up now, but as I'll be asleep in a couple of hours it doesn't seem worth it. So I just took some citicoline to replenish depleted stores. I wish I could get consistent results from nootropics. I never know on any one day whether they're going to fog me up, give me a headache and leave me drained, or whether I'm going to feel great, stimulated, motivated... Maybe I need a washout period.

[mission780]

Yes, I get the crash, in fact I'm experiencing it right now, having taken Noopept earlier today (in the morning). I'm feeling totally lethargic, weak and lacking in motivation. I was debating whether to top up now, but as I'll be asleep in a couple of hours it doesn't seem worth it. So I just took some citicoline to replenish depleted stores. I wish I could get consistent results from nootropics. I never know on any one day whether they're going to fog me up, give me a headache and leave me drained, or whether I'm going to feel great, stimulated, motivated... Maybe I need a washout period.

Is it only Noopept that gives you such inconsistent results or all nootropics you tried?

[Asteroceras]

I tried noopept, yesterday for the first time (supposedly 99% purity), and had quite an odd reaction. At approximately 12:00 p.m., Dec. 6, 2013, I used one 10-15 mg scoop to measure and take a sublingual dose of noopept. Any effect I received could have been attributed to placebo up until about 2 a.m., Dec.7, 2013. Throughout the day, there was an apparent anti-depressant effect, a shift in well being, and (later in the day) a minor shift in visual acuity.

In order to explain my odd reaction, a bit of background is required. Around the age of 15, I received a concussion approximately between the left parietal lobe/occipital lobe. Immediately after the incident, I began to experience symptoms of HPPD ( in particular: harsh visual static/permanent blue field entopic phenomena that covers everything - in daylight and nightlight, a substantial decrease in depth perception, a decrease in peripheral vision, an inability to comfortably look at much of anything - especially patterns, ghosting effect, lightburts, and others) which increased in severity for approximately 1 week after the incident, and eventually stabilized. My symptoms are no better than they were three years ago.

At approximately 2 a.m., Dec.7, 14 hours after my first dose, my visual static increased in severity to the point where I was nearly blinded in my left eye, and had trouble seeing in my right eye. I realized that there was nothing I could do to counteract the effect, I simply went to sleep. Currently, almost 13 hours later, the severity of the visual snow is substantially higher than normal, although not blinding.

From research, I've noticed that any anecdotal changes in vision are normally positive. I was surprised that noopept could have the opposite effect. My experience may seem a bit far fetched, but it is the truth. At this point, I'm holding off on taking another dose, and I'm at a loss in terms of what I should do. Any advice, theories, and help would be awesome. Thank you.

Edited by Asteroceras, 06 December 2013 - 07:59 PM.

[OpaqueMind]

This is purely speculation, but if people usually experience greater visual acuity on noopept that suggests an increase in the activity of the visual cortex. It sounds like you may have abnormalities in that particular region of your brain which cause these symptoms, so if what I said is true then it would make sense that noopept would also exacerbate these visual abnormalities. It's like if you have a balloon with a nipple on the end, if you blow up that balloon then the nipple will also become more pronounced. Haha oh dear, that was the worst analogy I've ever come up with, but you get the picture.

In regards to fixing the problem itself, a user BigPapa has had great success in fixing his HPPD symptoms by doing LLLT. It's also great for ameliorating issues arising from concussions and so forth. Check out LostFalco's thread, or search HPPD LLLT in the search engine.

[Asteroceras]

Thanks for the help OpaqueMind. From an EEG typology perspective, my head injury took place in close proximity of P3 (I think). I pulled up Lostfalco's thread, and it looks like I've got a bit of reading to do. Is it possible that LLLT could exacerbate or worsen the physiological abnormalities? Sorry to steer off-topic.

I wanted to give an update on my visual static; it has dissipated to near-normal amounts, although, I'm having quite a bit of trouble reading.

Edited by Asteroceras, 09 December 2013 - 03:40 AM.

[OpaqueMind]

Ha yeah that thread has grown pretty massive, and been quite diluted in the process. LF has a run-down of the protocol on his user page though, if you decide to try it out. From my knowledge of the mechanisms of LLLT, it is very unlikely that it would worsen your condition. What it will do is essentially help you to speed up the recovery process, and even go beyond it somewhat, by rebuilding those parts of your brain.

When I started experimenting with nootropics, the physical and chemical structure of my nervous system was way out of balance, which is somewhat like the situation you have, so any chemical interventions ie nootropics, were generally ill-received, since I was interfering with an already unbalanced system. What my physiology needed was to regrow from within itself. The intelligence of the body is incredible, and it's manifestation in physical structure is very delicate in the process of recovery. The best way to recover is to engage and support the natural processes of the brain without enforcing change from the outside, which is essentially what LLLT does, by supercharging the mitochondria, the energy can then be used to carry out cellular processes which would usually occur but at an accelerated rate.

[mission780]

I've being trying Noopept for a week now. I take 10mg/day. I can feel a bit of stimulation from it and "something" is happening in my head, but I can't really say that I notice a clear cognitive enhancement. I'll be watching it for the next few days.

Are effects of Noopept so subtle that I may not see them clearly?

[ZHMike]

is anyone not cycling noopept? anyone that can comment on continuous long term use would be appreciated

[arboles]

Does Noopept produce any benefits that continue after supplementation has ceased?

[noopept-user-123]

Does Noopept produce any benefits that continue after supplementation has ceased?

Yes, it appears that it does according to anecdotal evidence. I hear that it seems to have beneficial effects for up to a month after cessation, and I've also read that some people experience a perceived "permanent" benefit.

[Epigenesis]

Does Noopept produce any benefits that continue after supplementation has ceased?

Yes, it appears that it does according to anecdotal evidence. I hear that it seems to have beneficial effects for up to a month after cessation, and I've also read that some people experience a perceived "permanent" benefit.

The studies have shown an increase BGNF, which would cause neurogenesis, so I think that does indicate there are benefits after supplementation is ceased(beyond just the anecdotal evidence).

Edited by Epigenesis, 13 February 2014 - 10:54 PM.

[jadamgo]

My experience with it is basically positive, though I do wish the Limitless effect would have stayed past the first week of using it. (Pipe dream I suppose.)

I get the crash before the beneficial effects. I feel drowsy and tired about an hour after taking it, and it lasts about 2 hours. Taking it first thing in the morning prevents this, though that may be because I do bright light therapy every morning. Taking it with a meal reduces it.

Interestingly, the crash is completely alleviated when I take it with strong cocoa. I mean with 2-3 tablespoons' worth of pure cocoa powder in a cup of hot chocolate. (Not the store-bought "hot chocolate" that's mostly sugar and whey powder.) Coffee and tea don't do this, so perhaps there's something special about the chocolate polyphenols or the theobromine? I'm just glad it works; I consider the crash problem solved.\

EDIT: Also, oxiracetam completely prevents the crash. Equally effective as cocoa, though less tasty and more expensive.

Edited by jadamgo, 13 February 2014 - 11:55 PM.

[Duchykins]

Noopept is fat soluble and takes a while for full effects to ramp up, you get some effects right away but others later. People taking it on empty stomachs may not be enabling noopept's efficacy. I had this crash thing too at first, then noticed that a vendor I buy other bulk powders from carries noopept and says is best to take with a bit of food. So I do that now, have a little something to eat with the pept.

This guy ^^^ up here read my mind. I stopped taking noopept by itself (which I did to see what would happen). I have a 70% cacao dark chocolate powder with tiny bit of caffeine (30mg) and green tea blend - I take half a scoop of nasty chocolate with noopept, with the 100mg theanine, 1.5g taurine, 100mg inositol, fish oil, 1g creatine, 400mg ALCAR I take most mornings and no crash, no irratibility. 2g lecithin, about 300mg choline bitartrate. Perfect. Sometimes another choline dose a few hours later is needed, or chocolate.