142 replies to this topic

[MrHappy]

In a nutshell:
250-350mg, by weight, of UMP, orally (see my latest comment - the "250mg scoop" from SN is actually 350mg for UMP)
250mg choline
>800mg DHA
>400mg EPA
500IU of Vitamin E (mixed tocopherols or tocotrienols, for preference)
a *GOOD* balanced multi B vitamin, which includes the RDI of folate, B12 and trace minerals

If you do pick this up, I'd recommend starting with that for 1-2 weeks and make any adjustments from there.

[tritium]

So, say that you are already near baseline. Then, you take Adderall, which downregulates dopamine receptors, but at the same time take UMP, which upregulates receptors. Would it be a feasible idea that you would stay near baseline using this regimen and thus prevent the rapid tolerance to Adderall?

[MrHappy]

So, say that you are already near baseline. Then, you take Adderall, which downregulates dopamine receptors, but at the same time take UMP, which upregulates receptors. Would it be a feasible idea that you would stay near baseline using this regimen and thus prevent the rapid tolerance to Adderall?

There are a couple of people on here who have PM'd me various success messages in mixing with that class of stimulant, but I've never tried it.

[Raza]

Going from theory, uridine at night should both help reduce amphetamine resistance and lessen the insomnia associated with its use. If I wanted to take daily amphs for any reason it's the first thing I'd try, over the usual magnesium/inositol/taurine night combo even.

Although, y'know, those are significantly cheaper and approach the issue over different angles, so no reason not to do both.

Edited by Raza, 03 August 2012 - 10:50 AM.

[MrHappy]

Going from theory, uridine at night should both help reduce amphetamine resistance and lessen the insomnia associated with its use. If I wanted to take daily amphs for any reason it's the first thing I'd try, over the usual magnesium/inositol/taurine night combo even.

Although, y'know, those are significantly cheaper and approach the issue over different angles, so no reason not to do both.

I bought 1kg of uridine for slightly over $200, shipped..

[malden]

Do you want to share your cource?

( im on uridine for 1 week now.. the results are verry plesant!)

[Hebbeh]

Do you want to share your cource?

( im on uridine for 1 week now.. the results are verry plesant!)

• 
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• Location:Australia

Posted 22 February 2012 - 11:01 PM
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Here's the contact info:

Lucy Zhang
Sales manager
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ZICHUAN DISTRICT,ZIBO CITY,SHANDONG PROVINCE,CHINA
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MSN:lucyzhang727@hotmail.com
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SKYPE: lulu7278
E-mail:2-kssh@163.com
www.ksxc.cn

[Raza]

Going from theory, uridine at night should both help reduce amphetamine resistance and lessen the insomnia associated with its use. If I wanted to take daily amphs for any reason it's the first thing I'd try, over the usual magnesium/inositol/taurine night combo even.

Although, y'know, those are significantly cheaper and approach the issue over different angles, so no reason not to do both.

I bought 1kg of uridine for slightly over $200, shipped..

Now that is a lot better than SN's price.

What is negotiating purchases over email with these asian chemical companies like?

[MrHappy]

Going from theory, uridine at night should both help reduce amphetamine resistance and lessen the insomnia associated with its use. If I wanted to take daily amphs for any reason it's the first thing I'd try, over the usual magnesium/inositol/taurine night combo even.

Although, y'know, those are significantly cheaper and approach the issue over different angles, so no reason not to do both.

I bought 1kg of uridine for slightly over $200, shipped..

Now that is a lot better than SN's price.

What is negotiating purchases over email with these asian chemical companies like?

Mine arrived next day. Good to deal with, too.

[neuropill]

Low dose Amisulpride works great for me to upregulate my D receptors.

[welp]

Can anyone advise on the use of drugs like risperdal or haldol to upregulate receptors. Especially for sex drive. I have masturbated and watched porn so excessively that my dopamine receptors are very low and I have ED. I want to use risperdal as an antagonist to block dopamine from reaching the D2 receptors and perhaps some others that come into play ( I dont know which ). Here are the receptors that are blocked if you scroll down the page to where it says Pharmacology

http://en.wikipedia....iki/Risperidone

So basically I want to use it for a period of time. For example 3 months, upregulate my receptors and then quit. What do you all think? Will this increase my sex drive after quitting.

[neuropill]

Can anyone advise on the use of drugs like risperdal or haldol to upregulate receptors. Especially for sex drive. I have masturbated and watched porn so excessively that my dopamine receptors are very low and I have ED. I want to use risperdal as an antagonist to block dopamine from reaching the D2 receptors and perhaps some others that come into play ( I dont know which ). Here are the receptors that are blocked if you scroll down the page to where it says Pharmacology

http://en.wikipedia....iki/Risperidone

So basically I want to use it for a period of time. For example 3 months, upregulate my receptors and then quit. What do you all think? Will this increase my sex drive after quitting.

Horrible choices as they are not very selective for dopamine receptors compared to other available drugs.

[welp]

so what would you recommend?

[neuropill]

My suggestion above which again works again for me and is far more selective.

[welp]

Oh Im sorry I didnt see your post about Amisulpride. How much should I take every day and is it good for sex drive. That is what I will be taking it for. Also Should I cycle it?

[Thorsten3]

Doesn't low dose ami increase prolactin levels? I've read of long term anecdotals where people just complain of being 'off', after a while. Prolactin increase isn't a good thing for health.

[neuropill]

Oh Im sorry I didnt see your post about Amisulpride. How much should I take every day and is it good for sex drive. That is what I will be taking it for. Also Should I cycle it?

I wouldn't use it everyday nor do I think i need to. I use low doses 25-50 usually depending on how I feel for like 4-5 days and if I want to reset my receptors I go up to 400 mg on occasion. Low doses raise dopamine while higher doses inhibit it in the short term. If you need to reset your receptors which will up-regulate them you're need a higher dose for a short period like a week or so depending on why your receptors are down-regulated.

Doesn't low dose ami increase prolactin levels? I've read of long term anecdotals where people just complain of being 'off', after a while. Prolactin increase isn't a good thing for health.

No but high doses daily will which is not something i think anyone needs to take unless you're schizo or something.

For me it's one the of the best compounds I've used for resetting my dopamine receptors. I also like cycling Piribedil at times.

[welp]

I use low doses 25-50 usually depending on how I feel for like 4-5 days and if I want to reset my receptors I go up to 400 mg on occasion.

So do you take the drug everyday or for 4-5 days? Whatabout the 400mg do you take it for 4-5 days or for how long?
Thanks

[neuropill]

I use low doses 25-50 usually depending on how I feel for like 4-5 days and if I want to reset my receptors I go up to 400 mg on occasion.

So do you take the drug everyday or for 4-5 days? Whatabout the 400mg do you take it for 4-5 days or for how long?
Thanks

I take it in response to when I take other compounds that raise or release dopamine to counter balance my receptors. Usually this is a monthly occurrence.

The 400 mg dose I take anywhere from 1 day to a few days pulsed for a week. Have not found it needed to take more or longer doses.

I use a similar approach with naltrexone, rimonabant,tianeptine, cyproheptadine, etc for maintaining ideal receptor up-regulation.

[tritium]

Seems like all the beneficial medications are not approved for use in the U.S. while the harmful ones are.

[chrisp2]

I just realized Yohimbine is a DA2 antagonist.

I'm wondering if a relatively low dose might also help improve DA2 receptor density...

[protoject]

Oh Im sorry I didnt see your post about Amisulpride. How much should I take every day and is it good for sex drive. That is what I will be taking it for. Also Should I cycle it?

I wouldn't use it everyday nor do I think i need to. I use low doses 25-50 usually depending on how I feel for like 4-5 days and if I want to reset my receptors I go up to 400 mg on occasion. Low doses raise dopamine while higher doses inhibit it in the short term. If you need to reset your receptors which will up-regulate them you're need a higher dose for a short period like a week or so depending on why your receptors are down-regulated.

Doesn't low dose ami increase prolactin levels? I've read of long term anecdotals where people just complain of being 'off', after a while. Prolactin increase isn't a good thing for health.

No but high doses daily will which is not something i think anyone needs to take unless you're schizo or something.

For me it's one the of the best compounds I've used for resetting my dopamine receptors. I also like cycling Piribedil at times.

Yes low doses will generally increase prolactin levels,even at 25-50mg , someone back me up here lol my lunch break is ending,

[gizmobrain]

' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/pubmed/16938372']
Amisulpride-induced hyperprolactinemia is reversible following discontinuation.


Source

Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Vas. Sofias Ave. 115 28 Athens, Greece. Thomas.Paparrigopoulos@iop.kcl.ac.uk

Abstract

BACKGROUND:

Although amisulpride is considered to be a prolactin-raising atypical antipsychotic drug, a limited number of studies have documented the extent of its prolactin-elevating properties. In the present study the effect of amisulpride on plasma levels of prolactin and the reversibility of this untoward side effect were investigated.
METHODS:

17 patients with various diagnoses received amisulpride (50-800 mg/day) or a combination of amisulpride plus other medication as needed. Plasma prolactin was determined 26.7+/-9.4 days (range: 13-50 days) after initiation of treatment and in 3 cases after a much longer period, and 14-51 days following its withdrawal.
RESULTS:

All patients on amisulpride had hyperprolactinemia (mean+/-S.D. prolactin levels: 62.5+/-33.0 ng/ml) with females exhibiting considerably higher prolactin levels than males. Following amisulpride discontinuation prolactin levels were significantly (p<000) reduced (mean+/-S.D. prolactin levels: 12.3+/-6.7 ng/ml). No significant correlation was detected between prolactin levels and either amisulpride dosage or duration of administration.
CONCLUSION:

Amisulpride has a pronounced prolactin-elevating effect which appears to be independent of dosage and duration of administration. Hyperprolactinemia rapidly reverses following amisulpride discontinuation. PMID: 16938372

→ source (external link)

' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/pubmed/22250612']
Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients.


Source

KARF Hospital, The Korean Alcohol Research Foundation, Goyang, South Korea.

Abstract

AIM:

Amisulpride at low dosages enhances dopaminergic neurotransmission by preferentially blocking presynaptic D2/D3 receptors. Thus, low dosages of amisulpride are expected not to increase prolactin levels. The aim of this study was to examine whether low dosages of amisulpride can increase serum levels of prolactin or not clinically in Korean patients.
METHOD:

Serum prolactin levels were measured in 20 Korean patients (12 men and eight women) with various diagnoses who were treated with less than 300 mg of amisulpride per day.
RESULTS:

The mean dosage of amisulpride was 195.0 ± 51.0 mg/day, and serum level of prolactin was 76.1 ± 43.4 ng/mL. The prolactin level was significantly higher in women (110.7 ± 49.3 ng/mL) than in men (53.1 ± 15.9 ng/mL) after administering amisulpride (P = 0.021), while the dosage of amisulpride did not differ significantly between men (200.0 ± 42.6 mg/day) and women (187.5 ± 64.1 mg/day) (P = 0.576).
CONCLUSIONS:

The low dosages of amisulpride elevate serum prolactin level in the majority of patients. This finding indicates that the dose-reduction of amisulpride has little effect to relieve amisulpride-induced hyperprolactinemia at therapeutic dosages. Clinicians should monitor serum prolactin level even when low dosages of amisulpride are administered.

© 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology.
PMID: 22250612

→ source (external link)

I was really interested in trialing a low-dosage of amisulpride until I saw the effect on prolactin. Anything that increases prolactin tends to turn me into a puddle of sleepy, worthless, unmotivated blob.

Edited by zrbarnes, 10 September 2012 - 09:30 PM.

[renfr]

What about sulbutiamine? It increases density of D1 receptors according to this study (retrieved from wikipedia) : http://www.ncbi.nlm....pubmed/10996447
However acute administration seems to be counterproductive.
Also phenylpiracetam is also said to upregulate massively dopamine.

[neuropill]

Oh Im sorry I didnt see your post about Amisulpride. How much should I take every day and is it good for sex drive. That is what I will be taking it for. Also Should I cycle it?

I wouldn't use it everyday nor do I think i need to. I use low doses 25-50 usually depending on how I feel for like 4-5 days and if I want to reset my receptors I go up to 400 mg on occasion. Low doses raise dopamine while higher doses inhibit it in the short term. If you need to reset your receptors which will up-regulate them you're need a higher dose for a short period like a week or so depending on why your receptors are down-regulated.

Doesn't low dose ami increase prolactin levels? I've read of long term anecdotals where people just complain of being 'off', after a while. Prolactin increase isn't a good thing for health.

No but high doses daily will which is not something i think anyone needs to take unless you're schizo or something.

For me it's one the of the best compounds I've used for resetting my dopamine receptors. I also like cycling Piribedil at times.

Yes low doses will generally increase prolactin levels,even at 25-50mg , someone back me up here lol my lunch break is ending,

If taken over a prolonged period of time in higher doses it will function more as a dopamine antagonist and thus inhibit Dopamine. At that dose (which will vary on the person's receptor settings) it's best to use for short term. I only use it for short periods and have not noticed any effects of increased prolactin which are obvious to most males.

' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/pubmed/16938372']
Amisulpride-induced hyperprolactinemia is reversible following discontinuation.


Source

Department of Psychiatry, Athens University Medical School, Eginition Hospital, 74, Vas. Sofias Ave. 115 28 Athens, Greece. Thomas.Paparrigopoulos@iop.kcl.ac.uk

Abstract

BACKGROUND:

Although amisulpride is considered to be a prolactin-raising atypical antipsychotic drug, a limited number of studies have documented the extent of its prolactin-elevating properties. In the present study the effect of amisulpride on plasma levels of prolactin and the reversibility of this untoward side effect were investigated.
METHODS:

17 patients with various diagnoses received amisulpride (50-800 mg/day) or a combination of amisulpride plus other medication as needed. Plasma prolactin was determined 26.7+/-9.4 days (range: 13-50 days) after initiation of treatment and in 3 cases after a much longer period, and 14-51 days following its withdrawal.
RESULTS:

All patients on amisulpride had hyperprolactinemia (mean+/-S.D. prolactin levels: 62.5+/-33.0 ng/ml) with females exhibiting considerably higher prolactin levels than males. Following amisulpride discontinuation prolactin levels were significantly (p<000) reduced (mean+/-S.D. prolactin levels: 12.3+/-6.7 ng/ml). No significant correlation was detected between prolactin levels and either amisulpride dosage or duration of administration.
CONCLUSION:

Amisulpride has a pronounced prolactin-elevating effect which appears to be independent of dosage and duration of administration. Hyperprolactinemia rapidly reverses following amisulpride discontinuation. PMID: 16938372

→ source (external link)

' class='bbc_url' title='External link' rel='nofollow external'>http://www.ncbi.nlm.nih.gov/pubmed/22250612']
Hyperprolactinemia induced by low-dosage amisulpride in Korean psychiatric patients.


Source

KARF Hospital, The Korean Alcohol Research Foundation, Goyang, South Korea.

Abstract

AIM:

Amisulpride at low dosages enhances dopaminergic neurotransmission by preferentially blocking presynaptic D2/D3 receptors. Thus, low dosages of amisulpride are expected not to increase prolactin levels. The aim of this study was to examine whether low dosages of amisulpride can increase serum levels of prolactin or not clinically in Korean patients.
METHOD:

Serum prolactin levels were measured in 20 Korean patients (12 men and eight women) with various diagnoses who were treated with less than 300 mg of amisulpride per day.
RESULTS:

The mean dosage of amisulpride was 195.0 ± 51.0 mg/day, and serum level of prolactin was 76.1 ± 43.4 ng/mL. The prolactin level was significantly higher in women (110.7 ± 49.3 ng/mL) than in men (53.1 ± 15.9 ng/mL) after administering amisulpride (P = 0.021), while the dosage of amisulpride did not differ significantly between men (200.0 ± 42.6 mg/day) and women (187.5 ± 64.1 mg/day) (P = 0.576).
CONCLUSIONS:

The low dosages of amisulpride elevate serum prolactin level in the majority of patients. This finding indicates that the dose-reduction of amisulpride has little effect to relieve amisulpride-induced hyperprolactinemia at therapeutic dosages. Clinicians should monitor serum prolactin level even when low dosages of amisulpride are administered.

© 2012 The Authors. Psychiatry and Clinical Neurosciences © 2012 Japanese Society of Psychiatry and Neurology.
PMID: 22250612

→ source (external link)

I was really interested in trialing a low-dosage of amisulpride until I saw the effect on prolactin. Anything that increases prolactin tends to turn me into a puddle of sleepy, worthless, unmotivated blob.

To truly upregulate dopamine some degree of antagonist action is required to reset the receptors. I would suggest starting with a low dose 25 mg for one day to see how you respond to it and go from there. I have taken other more potent dopamine antagonists and would not compare the effects unless you're taking higher doses.

[formergenius]

All I want to add here, is be really, really cautious with Iboga. It's not something to be taken lightly. I had an insanely bad trip on that stuff due to my own neglegence. I too thought, hell I'll just microdose. But I was impatient and took waaaay too much. I thought I was dying and my heart was beating extremely arythmnic and slow, and I had all kinds of scary visuals. I'll spare you the details. I mean I had many benefit's from Iboga, I also saw and felt wonderous things. But I was unguided and it turned out to be the scariest thing I've ever done. I lost my mind and gained it again, but I haven't been the same since. I'm not trying to be discouraging, I'm just saying that it should not be done without proper guidance.

Besides that I wish you the best of luck!

[Psionic]

Any findings how to modulate/upregulate specifically D2/D3 receptors? As these findings seems very promising:

Dr. Martinez and colleagues found that increased social status and increased social support correlated with the density of dopamine D2/D3 receptors in the striatum, a region of the brain that plays a central role in reward and motivation, where dopamine plays a critical role in both of these behavioral processes. This data suggests that people who achieve greater social status are more likely to be able to experience life as rewarding and stimulating because they have more targets for dopamine to act upon within the striatum. These data also may have implications for understanding the vulnerability to alcohol and substance abuse, as the work of Dr. Nora Volkow, the Director of the National Institute on Drug Abuse, and colleagues suggests that low levels of D2/D3 receptors may contribute to the risk for alcoholism among individuals who have family members who abuse alcohol. The current data suggest that vulnerable individuals with low D2/D3 receptors may be vulnerable to lower social status and social supports, and these social factors have previously been suggested as contributors to the risk for alcohol and substance use.

http://www.scienceda...tm<br /><br />recent findings:

- Uridine
- CDP Choline (probably counterproductive with Uridine))
- Inositol
- Amisulpride

- Not to take anything which raise dopamine levels
- Fasting/Meditation/Increasing BDNF or NGF

[welp]

Why would cdp choline be counter productive with uridine?

[rvdvaart]

I know this may sound silly and be easily dismissed by many, but its now scientifically proven that abstaining from watching porn/masturbating for 60-90 days dramatically increases dopamine receptors. If you're a male who watches internet porn (which is about 90% of us), you're brain has basically been reprogrammed to get stimulated by fewer and fewer sources and the dopamine receptors have downregulated.

When researches studied groups of men who gave up masturbating and watching porn for 60-90 days, they noticed their symptoms of brain fog, depression, anxiety, etc had completely disappeared. The brain essentially rewires itself and you're dopamine receptors upregulate. It's worth a watch for any male.

THE GREAT PORN EXPERIMENT

http://www.youtube.com/watch?v=wSF82AwSDiU

' class='bbc_url' title='External link' rel='nofollow external'>http://www.youtube.com/watch?v=wSF82AwSDiU']

→ source (external link)

After you watch this, read some of the testimonials from guys that gave up porn/masturbating. It almost sounds too good to be true....but it isn't

http://yourbrainonpo...-as-they-reboot

Edited by rvdvaart, 19 September 2012 - 03:44 AM.

[welp]

Thanks for the post
Im on that site already and know about Gary Wilson. Great guy.

I was just looking for extra substances that I can take with abstaining from PMO

Any information on the percentage of dopamine receptors that increase when abstaining for 60-90 days?

Edited by welp, 19 September 2012 - 03:37 AM.