304 replies to this topic

[Mind]

Reason reviews a recent study about C60 and olive oil.

 

https://www.longecit...ife-in-rodents/

[ambivalent]

 A great major scientific breakthroughs have been accidental in nature; the Baati study appeared to be one of those dramatic instances. The disinterest from the scientific community seemed to result from a vain allegiance to the scientific method. As scientific snobbery and elitism has escalated,  so its spirit and tradition of adventure and inquiry has waned. The complaint over sample size, is a seems to be a non-thinking trained response born out of the reputational risk averseness which seems endemic within the scientific community.

Sample size can't explain away huge effects: something was unquestioningly going on - accuracy is the only casuality of the meagre rodent enrollment, not certainty. And when the effect is close to doubling the lifespan, with the life-extended group achieving well beyond life expectation of the studied species, neither can poor experimental design: if so we need to capture that design error.

The response of the scientific community should have been to view the study like a prospector finding a nugget in a stream: if its not iron pyrite then shovel-up.  Money should have been immediately thrown into numerous parallel studies, one of which should be a large scale replication of Baati.  Science still can't trust in luck, even a 10% chance the study wasn't a fluke, would merit tens of millions of dollars of investment for mankind, but, of course, it wasn't a patented drug.  The heart and traditions of science inquiry is found on amateur communites, not in journals.

Nine years on we have to my knowedge yet to carry out a study upon the species in which the effects were observed while the work has been rather discredited through inter-species studies.

Around seven or eight years, I found a study and posted on longecity which showed at least when it comes to fasting at least rats aren't mice.

https://www.ncbi.nlm...les/PMC3119327/

https://pubmed.ncbi....h.gov/21410319/

There is too, other critical data, which has never been accumulated. When the longecity forum was alive with c60 users  there were some weirdly remarkable and seemingly independently observed effects, which experienced hackers and novices had never previously observed - such as burn healing, extreme alcohol intolerance.  That longecity data is an important validation of the study, but because it couldn't be accurately counted, then it is assumed not to count. However, after all, in life we take anecdotal evidence as evidence, especially when its harmful.

 (Unable to post on FA website)

Edited by ambivalent, 27 April 2021 - 08:00 AM.

[resveratrol_guy]

https://www.longecit...dents/?p=908415

[jroseland]

I've used C60, from different vendors, for months and the experiential effects for me were pretty subtle compared with a lot of the harder-hitting Nootropics I've tried. But, as Teo reports here, it can make an appreciable difference in the quality of life for older folks.

 

Watch: C60 Olive Oil is Making this 67-year-old Biohacker Great Again!

[Empiricus]

100mg of PQQ is a lot.  I suggest easing into such high-dose PQQ.  I experienced ringing-in-ears last time I went there:

 

https://www.longecit...a/#entry770959 

Edited by Empiricus, 24 May 2024 - 09:32 AM.