Tell me you're using an Omega 3 Oil... EPA/DHA... My response would be a positive one...
That would also be a long chain fatty acid, like olive oil. So it should mostly be processed through the lymph system, bathing a lot of tissues of the body along the way with C60. My understanding is that MCT oil would not.
Are there other purified long chain fatty acid choices out there (along the lines of MCT oil, a purified medium chain fatty acid)?
Thanks for this comment stephen_b... You're right...
... the best way to ensure Buckyball delivery to the "systemic circulation" is to dissolve them in a PUFA oil. A great way to limit the tissues that get exposed to the Buckyballs is to use an MCT OIl.--------------------------
Lipid-based delivery systems and intestinal lymphatic drug transport: A mechanistic updateAfter oral administration, the majority of drug molecules are absorbed across the small intestine and enter the systemic circulation via the portal vein and the liver. For some highly lipophilic drugs (typically log P > 5, lipid solubility > 50 mg/g), however, association with lymph lipoproteins in the enterocyte leads to transport to the systemic circulation via the intestinal lymph. The attendant delivery benefits associated with lymphaticdrug transport include a reduction in first-pass metabolism and lymphatic exposure to drug concentrations orders of magnitude higher than that attained in systemic blood. In the current review we briefly describe the mechanisms by which drug molecules access the lymph and the formulation strategies that may be utilised to enhance lymphatic drug transport. Specific focus is directed toward recent advances in understanding regarding the impact of lipid source (both endogenous and exogenous) and intracellular lipid trafficking pathways on lymphatic drug transport and enterocyte-based first-pass metabolism.--------------------------
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...MCT's energy sustaining powers can be explained as follows: when MCT oil is metabolized in the body, it behaves more like a carbohydrate than a fat. Remember that the fuel of preference for the body is carbohydrate. Unlike other fats, MCT oil does not go through the lymphatic system. Instead, it is transported directly to the liver where it is metabolized so it releases energy like a carbohydrate and creates lots of ketones (which can be used for fuel) in the process.
http://www.bodybuild.../fun/issa23.htm--------------------------
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Supporting study reference...
medium-chain triacylglyerols (MCT) are edible oils composed of triacylglycerols with saturated medium-chain fatty acids (MCFA) moieties of six to ten C atoms. These have been introduced into clinical nutrition programmes because of their rapid absorption and solubility (Seaton et al. 1986). MCT are metabolized differently from LCT. They are transported to the liver directly via hepatic portal circulation and are oxidized to ketones, whereas LCT are absorbed via the intestinal lymphatic ducts and transported in chylomicrons through the thoracic duct to reach the systemic circulation (Bach & Babyan, 1982; Senior 1990).
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niner... After reviewing the above links, do you still maintain the position that deviating from the Buckyball study protocol by using an MCT Oil vs. the study choice of a PUFA is a choice of no consequence? If you do still maintain that position, please provide the rationale and supporting study link support for your view...
Edited by wccaguy, 17 May 2012 - 12:15 PM.