Remember, the extremely small tiny minuscule sample size from this study. I absolutely love this discussion, and can't wait to see where it leads, but if the study can't be replicated, don't be surprised.
I'll be surprised, not if it can't be replicated, but if something close or better can't be achieved in a study, thoughtfully designed and conducted by a smart and knowledgeable team with broad and deep knowledge of the aging and disease literature. Here's why.
We now have more data points than what the study itself contained. We now have the details of Turnbuckle's experience. The rats weren't able to tell us how they felt (although Anthony Loera's latest note implies that, if they could, it would be a story we'd be interested in). Turnbuckle's experience are n=1 data points obviously and completely useless for any effort to
prove something. But proving something isn't what this is about. We ought to be about the business of coming up with Explanations of the result in rats and the results for Turnbuckle.
- Turnbuckle's experience suggests the prospect of virtually immediate epigenetic changes taking place through, perhaps, the "stripping of methyl groups from mitochondrial dna." Olive Oil cannot achieve this result so we know the action of the Fullerene C60s has potentially profoundly healthful implications. This means that an "exercise 'Turnbuckle effect'" ought not be expected by those not having the same issues he has. It also means that, if you have other significant issues, you might expect a positive effect. (I've had one experience comparable to Turnbuckle's. I'll write about it soon.)
- They dosed those rats a single time with The Potion. What would have happened if they had done another Potion treatment, or three, or four, at regular intervals?
- We should have more confidence in the result because we now know, even if the study authors didn't, that their choice of Olive Oil was a good one. It has been specifically shown to Stimulate that physiological process (the Vagus/CAIP/HRV nexus) associated with what is currently defined to be Extreme Longevity in at least a three ways.
High HRV-->> Extreme Longevity: http://www.ncbi.nlm....pubmed/20381674
Vagal Control-->> HRV: http://www.jci.org/articles/view/30555
Positive Emotions-->> Extreme Longevity: http://www.impactagi...bs/100456a.html
Positive Emotions-->> Trigger the Vagus: http://www.ncbi.nlm....pubmed/20851735
Aerobic Exercise-->> Extreme Longevity: http://extremelongev...ds/sardinia.pdf
Aerobic Exercise-->> Vagus Activation: http://www.ncbi.nlm....pubmed/11560079
As the exponential growth of knowledge about aging and disease continues inexorably, we ought not be surprised that, at some point, with the publication of some specific study, maybe this one, the "S Curve" will turn up sharply. Is it This Study and This Potion? Dunno.
But I'm rolling around a design of what kinds of rat groups ought to be looked at in a follow on study. When a 1st cut at how the groups are defined is completed, I'll post it. Anyone else thinking about how rats should be organized into study groups to figure out what's going on? If you're not, why not? 8-)
I think WE should organize, design, solicit bids on, and fund the follow up study here. We have as much broad and deep
collective intelligence about the literature as these academics do.
If I'm the best, willing person to spearhead the effort to raise money to fund a study we collectively design, I'm ready to start working, in consultation with ImmInst leadership guidance and approval, to raise the cash. (And if I'm working on that, I'll be less bothersome about this Vagus stuff. That would be a benefit, eh? 8-))
In the meantime, how about we start putting some rat study group designs on the table, along with the study result explanations and hypotheses we would expect to test with those designs.
8-)
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Explanations that transform the world are the beginning of Infinity -- David Deutsch
Edited by wccaguy, 29 May 2012 - 03:45 PM.