3585 replies to this topic

[zorba990]

Any advice before I apply to half of my head using a needle roller?

Take before pics.

[HappyPhysicist]

I'm upping my dose from 10 mg/day to 50 mg/day.

I weigh about 90 kg so that would be 0.56 mg/kg.

I am using a 0.5 kg/L C60 OO solution and drinking 100 mL/day. I started a couple days ago.

No noticeable side effects or benefits.

[Rob Wegner]

Would you argue that the added strength is comparable to steroids, which can suppress the immune system? I bring this up in light of Japanese researchers learning that the protein C1q is responsible for aging -- and that suppressing C1q suppresses the immune system and improves longevity. See: Scientists discover protein responsible of ageing in Japan

[Anthony_Loera]

Hi Rob,

I wish I could compare, but I have never taken steroids.
I haven't been sick either, and I had taken a full week of C60oo sometime before my trip that I had just came back from.

A

[Rob Wegner]

I don't think there is any way that a single protein could be called "responsible [for] aging". That makes it sound like the sole cause. Maybe it's related in some minor way.

I agree. For example, a recent study revealed that spaceflight suppressed accumulation of toxic proteins that normally accumulate within aging muscle in C. elegans worms. "When these genes were supressed in Earth-bound worms, longer lifespans would result." See: Study reveals space travel may slow ageing process and Spaceflight may extend the lifespan of microscopic worm.
‎

[Hebbeh]

Unfortunately, the C60 didn't confer any UV protection for me. I spent 6 hours climbing between 10,000 and 14,000 feet in the Colorado Mtns today. At that altitude, the air is thin and the sun and UV intense. I've spent many similar weekends in the mountains this summer and have a solid tan on arms, neck and face...however, today was the first of the season wearing shorts...and my legs used to be white...now they are burning red. And even my neck which is very tan feels slightly sunburned. I've been averaging 4.5 to 6 mg C60 for 3 weeks now and dosed 6mg this morning before heading out.

[Turnbuckle]

I'd previously reported on mixed fullerenes here, and I've now taken the preparation twice more at a fullerene dose of 1.25 mg and once at 2.5 mg. There was no immediate effect at all, and as for other effects it was hard to tell since the effects of the initial doses of C60 in April and May were so dramatic and long lasting.

There are two practical advantages of mixed fullerenes--they are cheaper since there is no extra processing to separate them out, and they go into solution faster because the crystals are imperfect.

Edited by Turnbuckle, 15 July 2012 - 12:55 PM.

[Hebbeh]

Unfortunately, the C60 didn't confer any UV protection for me. I spent 6 hours climbing between 10,000 and 14,000 feet in the Colorado Mtns today. At that altitude, the air is thin and the sun and UV intense. I've spent many similar weekends in the mountains this summer and have a solid tan on arms, neck and face...however, today was the first of the season wearing shorts...and my legs used to be white...now they are burning red. And even my neck which is very tan feels slightly sunburned. I've been averaging 4.5 to 6 mg C60 for 3 weeks now and dosed 6mg this morning before heading out.

Update: In retrospect, even though I did sustain a sunburn on my previously white and unexposed legs yesterday...it's probably amazing that it is not much more severe considering that my legs had no previous sun this year, I used no sun block, and with time on the summit, was actually exposed for a good 7 hours of intense sun at high altitude. I should probably have severe sunburn but it's definitely less than severe...but maybe a little more than mild. We will see if I peel in the next 3 or 4 days.

[sapentia]

After two weeks of C60-OO exposure I can report that I noticed no effects in any of the aforementioned areas. To recap, I took 10mL of 0.8mg C60/mL EVOO as provided by the C60 guy (retailer) at 2-5 mL doses per day for 8 days after which I began taking 2-5mL doses one day per week. I also dermaneedled ~ 1mL of the C60-OO solution into my frontal scalp 3 times to experiment with hair regrowth potential as mentioned by Turnbuckle. To date I have noticed no physical improvements in workout capacity, stamina, increased libido, hair regrowth, skin improvement, cognitive improvement or any other type effect. Believe me that I wanted to see some of the effects mentioned by fellow contributors, but I am unable to confirm them in this N=1 experiment. Of course, hair regrowth benefits can't be fully assessed at two weeks, but hairfall has remained the same which leaves me skeptical as to any possible efficacy in this area. Ultimately, the desired effect is longevity which is impossible to assess in the context of my self.

[Hebbeh]

Sapentia, do you mind sharing your age, health, and fitness level? I'm wondering if the people seeing effects are older and/or have possible health issues? If already young and healthy, it probably doesn't get any better....other than possibly to help maintain your youthful profile?

[robert1]

When renaming forums, how about a heads-up page instead of error pages, at least for a little while...

[sapentia]

Sapentia, do you mind sharing your age, health, and fitness level? I'm wondering if the people seeing effects are older and/or have possible health issues? If already young and healthy, it probably doesn't get any better....other than possibly to help maintain your youthful profile?

No problem; I gave some of that info. before. I am a 35 y/o caucasian male with no serious health issues in good physical conditioning; I both resistence train and partake in endurance activities such as trail running and hiking mountains. I don't subscribe to BMI, but my height is 5'-10" and my bodyweight is 175 lbs. Interestingly, I did deadlifts yesterday which is one of the exercises I've used to gauge any strength effects. This week marks one week that I've been off the C60-OO everyday routine. Well, while I did the same weight for deadlifts yesterday (just 225 lbs.), it felt considerably more difficult than it had the week before even though I did the same number of reps. I only did one set at this weight as opposed to two last week as this isn't an exercise I'm willing to overexert myself in; I value my back too much for that. Nothing else varied to my knowledge and obviously it is likely that placebo effect played a role, but it's still interesting to consider that C60 may have had an effect and I just didn't notice it. At some point I may retest by supplementing daily for a full week again.

[abelard lindsay]

This is the reply I got:
You are right, C60 itself does not smell. To get C60 as pure as possible, it goes through a process that requires organic solvents for the separation. Traces of this solvent, ortho-dichlorobenzene, may stay behind to a 0.01% extend (hence the light smell).

FYI, ortho-dichlorobenzene is some really toxic stuff. You don't want to get even a little of that in your sample if you are going to ingest it. See below:

http://www.sciencela...?msdsId=9923721

[rwac]

This is the reply I got:
You are right, C60 itself does not smell. To get C60 as pure as possible, it goes through a process that requires organic solvents for the separation. Traces of this solvent, ortho-dichlorobenzene, may stay behind to a 0.01% extend (hence the light smell).

FYI, ortho-dichlorobenzene is some really toxic stuff. You don't want to get even a little of that in your sample if you are going to ingest it. See below:

http://www.sciencela...?msdsId=9923721

Potential Chronic Health Effects:
Very hazardous in case of skin contact (irritant), of eye contact (irritant), of ingestion. Hazardous in case of skin
contact (permeator), of inhalation. CARCINOGENIC EFFECTS: Not available. MUTAGENIC EFFECTS: Not available.
TERATOGENIC EFFECTS: Not available. DEVELOPMENTAL TOXICITY: Not available. The substance is toxic to kidneys,
liver, mucous membranes. Repeated or prolonged exposure to the substance can produce target organs damage. Repeated
or prolonged inhalation of vapors may lead to chronic respiratory irritation.

[Lufega]

I don't think there is any way that a single protein could be called "responsible [for] aging". That makes it sound like the sole cause. Maybe it's related in some minor way.

I agree. For example, a recent study revealed that spaceflight suppressed accumulation of toxic proteins that normally accumulate within aging muscle in C. elegans worms. "When these genes were supressed in Earth-bound worms, longer lifespans would result." See: Study reveals space travel may slow ageing process and Spaceflight may extend the lifespan of microscopic worm.
‎

In worms perhaps but in humans, spending time in space seems to accelerate aging, partly due to increased loss of magnesium.

Correcting magnesium deficiencies may prolong life.

Rowe WJ.

Source

Medical University of Ohio at Toledo, Ohio, USA. rowerun@aol.com

Abstract

The International Space Station provides an extraordinary facility to study the accelerated aging process in microgravity, which could be triggered by significant reductions in magnesium (Mg) ion levels with, in turn, elevations of catecholamines and vicious cycles between the two. With space flight there are significant reductions of serum Mg (P < 0.0001) that have been shown in large studies of astronauts and cosmonauts. The loss of the functional capacity of the cardiovascular system with space flight is over ten times faster than the course of aging on Earth. Mg is an antioxidant and calcium blocker and in space there is oxidative stress, insulin resistance, and inflammatory conditions with evidence in experimental animals of significant endothelial injuries and damage to mitochondria. The aging process is associated with progressive shortening of telomeres, repetitive DNA sequences, and proteins that cap and protect the ends of chromosomes. Telomerase can elongate pre-existing telomeres to maintain length and chromosome stability. Low telomerase triggers increased catecholamines while the sensitivity of telomere synthesis to Mg ions is primarily seen for the longer elongation products. Mg stabilizes DNA and promotes DNA replication and transcription, whereas low Mg might accelerate cellular senescence by reducing DNA stability, protein synthesis, and function of mitochondria. Telomerase, in binding to short DNAs, is Mg dependent. On Earth, in humans, a year might be required to detect changes in telomeres, but in space there is a predictably much shorter duration required for detection, which is therefore more reasonable in time and cost. Before and after a space mission, telomere lengths and telomerase enzyme activity can be determined and compared with age-matched control rats on Earth. The effect of Mg supplementation, both on maintaining telomere length and extending the life span, can be evaluated. Similar studies in astronauts would be fruitful.

[Chook12]

I have been taking my homebrew potion for 3 weeks, 1.67mg of c60 per day. Pictures of the brew are in the chook thread.

Feeling well, possibly more energy, skin good, hair possibly more body. No change to number of grey hairs. Nothing really concrete to report.

My husband is taking the brew alongside me. We have our personal reasons for taking this risk, we are adult people and make this choice.

Now giving the Sarah Vaughter potion a try (first dose this morning). The chooks will still get the homebrew stuff.

Edited by chicken12, 22 July 2012 - 02:04 AM.

[Junk Master]

See, I'm not the only one reporting good hair days. For what it's worth, I haven't experienced any loss of grey hair. But my dose of 1.6-2.4 mg per day is pretty small.

[tintinet]

See, I'm not the only one reporting good hair days. For what it's worth, I haven't experienced any loss of grey hair. But my dose of 1.6-2.4 mg per day is pretty small.

I guess we're both at the conservative end of the dose range. I've been taking 4.5 mg/day. I think it's a bit early to really know much about effects on my hair, but I'll be monitoring it.

[Anthony_Loera]

Sorry guys,
No change in hair... Even at 140mg a day.

Cheers
A

[Logan]

See, I'm not the only one reporting good hair days. For what it's worth, I haven't experienced any loss of grey hair. But my dose of 1.6-2.4 mg per day is pretty small.

I would imagine that new hair growing in colored that used to be grey would take some time. How long have you been taking C60?

[Junk Master]

I've been taking the C60 two weeks now.

As for strength gains, mine are more endurance related. I would not compare C60/OO to steroids at all, at least not at the dose I'm taking.

[Anthony_Loera]

Im taking C60 in oo daily for a week, then skipping 2 to 3 weeks... Then taking another 140mg daily for a week in oo (which is close to a cup of oo a day). .. And then skipping a few weeks... Im probably going to start on my next batch soon.

Im obviously alive and not doing the suggested 1/6 dose reduction for humans, im taking the full rat dose.

I also do not look like Captain America or Magic Mike... Unfortunatly..

A

[maxwatt]

I think the 1/6 scaling may not apply, if the action depends on permeating every cell and staying there, rather than being something that is metabolic eliminated by before having full effect. In that case, relative mass would be the scaling factor. But again we don't know, nor do we know if the rat dose was ideal.

Edited by maxwatt, 23 July 2012 - 05:12 PM.

[niner]

I think the 1/6 scaling may not apply, if the action depends on permeating every cell and staying there, rather than being something that is metabolic eliminated by before having full effect. In that case, relative mass would be the scaling factor. But again we don't know, nor do we know if the rat dose was ideal.

My thinking was that superoxide production would be directly proportional to rate of respiration/OxPhos, which would justify the allometric scaling. But the unknowns are still large, as you note.

[mait]

Hello! I ordered my C60 in EVO from Sarah Vaughter and I am at the end of my first bottle. Here are few observations I can make from my experiences (nothing really dramatic, but some slight changes still):

* My aerobic stamina seems to be improved a bit

* My short term memory seems to be a bit better

* Overall daily energy levels are higher

From my experience sublingual dosing is the way to go -it increases the effect of C60inEVO noticeably. Especially if I don't have opportunity to take C60 on completely empty stomach.

[sunshinefrost]

Hi !

i'm 32 and I started Taking C60 (99,95%) in OO yesterday. The nootropics/supplements i usually take are product B (telomerase enhancer) and cerebrolysin (neurotrophic neuropeptide for neurogenesis).

Is anybody familiar with cerebrolysin ? I received my order today and i'm wondering if i should combine all 3... they are all pretty amazing products.

The first dose of 1,5mg of OO gave me energy throughout the day, i was surprised. Wierd effect i had was a slight headach originating in the back of the skull. it subsided. Let's see what it will bring in the long run.

Did anybody else notice any memory enhancements yet?

[tintinet]

Hi !

i'm 32 and I started Taking C60 (99,95%) in OO yesterday. The nootropics/supplements i usually take are product B (telomerase enhancer) and cerebrolysin (neurotrophic neuropeptide for neurogenesis).

Is anybody familiar with cerebrolysin ? I received my order today and i'm wondering if i should combine all 3... they are all pretty amazing products.

The first dose of 1,5mg of OO gave me energy throughout the day, i was surprised. Wierd effect i had was a slight headach originating in the back of the skull. it subsided. Let's see what it will bring in the long run.

Did anybody else notice any memory enhancements yet?

At age 32 you expect memory enhancements? I'm older than that, and I can't recall not being able to recall things.

Cerebrolysin- IM? Ouch and out there, ISTM.

[sunshinefrost]

Hi !

i'm 32 and I started Taking C60 (99,95%) in OO yesterday. The nootropics/supplements i usually take are product B (telomerase enhancer) and cerebrolysin (neurotrophic neuropeptide for neurogenesis).

Is anybody familiar with cerebrolysin ? I received my order today and i'm wondering if i should combine all 3... they are all pretty amazing products.

The first dose of 1,5mg of OO gave me energy throughout the day, i was surprised. Wierd effect i had was a slight headach originating in the back of the skull. it subsided. Let's see what it will bring in the long run.

Did anybody else notice any memory enhancements yet?

At age 32 you expect memory enhancements? I'm older than that, and I can't recall not being able to recall things.

Cerebrolysin- IM? Ouch and out there, ISTM.

I never said i was unable to recall things
...but if you can't recall not being able to recall.... you may need something to help you recall ? joking

Edited by sunshinefrost, 24 July 2012 - 05:07 PM.

[mikey]

Turnbuckle... re: Curcumin... I've got two bottles with me all the time. One Curcumin 95, the other Curcumin C3. I take both just to be sure that I've taken both. I just became aware recently that Revgenetics sells Sky Curcumin. What do you recommend?

There are two liposomal curcumin products, which should absorb best.
http://www.swansonvi...1037/ItemDetail
and
http://www.drbvitami...cts.html?id=144

Mikey

[tintinet]

Hi !

i'm 32 and I started Taking C60 (99,95%) in OO yesterday. The nootropics/supplements i usually take are product B (telomerase enhancer) and cerebrolysin (neurotrophic neuropeptide for neurogenesis).

Is anybody familiar with cerebrolysin ? I received my order today and i'm wondering if i should combine all 3... they are all pretty amazing products.

The first dose of 1,5mg of OO gave me energy throughout the day, i was surprised. Wierd effect i had was a slight headach originating in the back of the skull. it subsided. Let's see what it will bring in the long run.

Did anybody else notice any memory enhancements yet?

At age 32 you expect memory enhancements? I'm older than that, and I can't recall not being able to recall things.

Cerebrolysin- IM? Ouch and out there, ISTM.

I never said i was unable to recall things
...but if you can't recall not being able to recall.... you may need something to help you recall ? joking

Nah, I live in the present- no need for recall!