1725 replies to this topic

[Reformed-Redan]

Its just that from novpchem you get the compound at a lower cost and quicker since by the time we get the money the compound will already be synthesized

[Mr. Pink]

Id rather get from Novochemy because they have what we are looking for and I dont need that much of the compound.

Id rather get from Novochemy because they have what we are looking for and I dont need that much of the compound.

i thought the problem with them is that it is backordered - which would mean that they do NOT have what we want. i'm down with going with Novochemy if that means we get it faster.

[Reformed-Redan]

Id rather get from Novochemy because they have what we are looking for and I dont need that much of the compound.

Id rather get from Novochemy because they have what we are looking for and I dont need that much of the compound.

i thought the problem with them is that it is backordered - which would mean that they do NOT have what we want. i'm down with going with Novochemy if that means we get it faster.

novochemy should be having the compoind soon. Im up from getting from them.

[krsna]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

[KoolK3n]

I'm not sure if this was already mentioned but Nikolaus Hansl (one of the authors of the study) died two years ago but his wife? Adele? Adele Hansl is still alive. Maybe someone can call her and ask her for more info? The number: 402-391-3743

Edited by KoolK3n, 07 April 2013 - 01:51 AM.

[MrHappy]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

I am unsure of the actual mechanism of action of PRL-8-53. It works on prolactin, hence the designation PRL-#-#.

TBH, the side-effects are more likely to involve sexual dysfunction, mood issues, breast growth, lactation and tumorigenesis.

I wouldn't expect seizures or blackouts.

During pregnancy, prolactin levels increase up to 20 times normal levels.

That being said, I'm not sure PRL-8-53 increases prolactin - it may in fact modify the mechanism in which prolactin stimulates g-protein encoding. If that's the case, the risk of side-effects would be a lot lower, in my limited opinion on this substance.

I would really love to see some more research done, but unless a university decides to explore it, I don't see that happening any time soon.

In the meantime, I can see a group of 70kg rats picking up the research. I would like to see some documentation and testing protocols agreed to, for consistency.

[Izan]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

I am unsure of the actual mechanism of action of PRL-8-53. It works on prolactin, hence the designation PRL-#-#.

TBH, the side-effects are more likely to involve sexual dysfunction, mood issues, breast growth, lactation and tumorigenesis.

I wouldn't expect seizures or blackouts.

During pregnancy, prolactin levels increase up to 20 times normal levels.

That being said, I'm not sure PRL-8-53 increases prolactin - it may in fact modify the mechanism in which prolactin stimulates g-protein encoding. If that's the case, the risk of side-effects would be a lot lower, in my limited opinion on this substance.

I would really love to see some more research done, but unless a university decides to explore it, I don't see that happening any time soon.

In the meantime, I can see a group of 70kg rats picking up the research. I would like to see some documentation and testing protocols agreed to, for consistency.

it does not work on prolactin, where the heck did you get this info from? prl stands for pacific research Laboratories, dr hansl worked there.

I'm not sure if this was already mentioned but Nikolaus Hansl (one of the authors of the study) died two years ago but his wife? Adele? Adele Hansl is still alive. Maybe someone can call her and ask her for more info? The number: 402-391-3743

i am in contact with this woman, i am waiting for her to reply. she is a very old woman now, please be patient. and yes, it already has been mentioned.

Edited by izan82, 07 April 2013 - 02:10 AM.

[MrHappy]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

I am unsure of the actual mechanism of action of PRL-8-53. It works on prolactin, hence the designation PRL-#-#.

TBH, the side-effects are more likely to involve sexual dysfunction, mood issues, breast growth, lactation and tumorigenesis.

I wouldn't expect seizures or blackouts.

During pregnancy, prolactin levels increase up to 20 times normal levels.

That being said, I'm not sure PRL-8-53 increases prolactin - it may in fact modify the mechanism in which prolactin stimulates g-protein encoding. If that's the case, the risk of side-effects would be a lot lower, in my limited opinion on this substance.

I would really love to see some more research done, but unless a university decides to explore it, I don't see that happening any time soon.

In the meantime, I can see a group of 70kg rats picking up the research. I would like to see some documentation and testing protocols agreed to, for consistency.

it does not work on prolactin, where the heck did you get this info from? prl stands for pacific research Laboratories, dr hansl worked there.

Interesting, was something I read while googling. I'll see if I can find the article.

I the meantime, I'll withdraw my comment until I can find the link.

[Izan]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

from the study; ''The compound may be taken orally, and it is active over a period of several hours. The drug is not a stimulant, andin the experimental animal toxicity appears only after it is given a dose more than one thousand times as large as the projected human dose''

[sparkk51]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

from the study; ''The compound may be taken orally, and it is active over a period of several hours. The drug is not a stimulant, andin the experimental animal toxicity appears only after it is given a dose more than one thousand times as large as the projected human dose''

You mean that point where food cant pass through the rat's intestines because its stuffed with PRL 8-147?

[Izan]

is anyone interested to write to the Nebraska academy of sciences? apparently they have much more information about dr hansl's work. http://nebraskaacade...ildapricot.org/ ; nebacad@unl.edu

[krsna]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

from the study; ''The compound may be taken orally, and it is active over a period of several hours. The drug is not a stimulant, andin the experimental animal toxicity appears only after it is given a dose more than one thousand times as large as the projected human dose''

Animal toxicity studies have their merit, but of course you can't put complete faith in them either. Unless something has undergone some real phase 1 clinical trials you are going to be taking risks. I don't know what studies have or have not taken place on this substance but the fact it was never pursued further would give me pause for some caution. I have guinea pigged myself professionally and they don't take chances, there is medical personnel there observing you for the duration of the drugs activity; heart rate, blood pressure, temperature is all regularly monitored. This is the proper setting for experimenting with little studied compounds.. not getting a chinese (or whichever is decided upon) chemical company to synthesize something and then taking it at home as you watch tv in your underwear. But hey, it's your health, do with it as you please, as I said, I decided to do the same in the past, except I had the advantage of medical personnel and professional protocols in place, plus I was getting paid rather than paying

Edited by bowleaf, 07 April 2013 - 02:49 AM.

[krsna]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

[Hebbeh]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

You come across as being very condescending. Implying you are more intelligent and therefor feel a need to tell the forum members how reckless and apparently stupid they must be.

As such, you insult the intelligence of virtually every member and then have the audacity to question it?

And as virtually every substance discussed on this forum is experimental for the most part, and virtually everybody has already assumed the risks associated with self experimentation, why are you even here?

[Reformed-Redan]

You all be brave (or very foolhardy). The eagerness to experiment with a little-studied compound is interesting, this forum seems to encourage this sort of reckless behaviour, terms like 'pioneering' are tossed around casually, infecting imaginations with ideas of important work being undertaken. I don't discourage this behaviour, I benefit from it after all, but I do worry that some people may be wandering into dangerous territory because group-hype is fooling them into thinking what they are considering undertaking is safe in any way. It's russian roulette at the end of the day, with the barrel of the gun pointed at your mental and physical health. I hope anyone actually willing to ingest this stuff will take some minor precautions. For starters, I would go to a local hospital with an emergency room, sit in the lobby and ingest a small amount of the substance, wait at least an hour before heading home. Or, for those less cautious, at the very least have someone near you for the first hour of ingestion to respond to any crisis which may arise and be able to get medical attention to you quickly. Good luck and looking forward to what might come of this.

I appreciate your concern; but, I think were going to give this compound a tryout anyway.

[Reformed-Redan]

Q, how are the funds coming along? Are you going for the 100g? If so, just let me know. This is a group buy and everyone gets a say.

[krsna]

believe it or not it just disturbs me to read some 20 something person saying they want to ingest this stuff in order to save some time studying. or some of the other things I've read in this thread. no condescension, just an expression of healthy skepticism. also, world of difference experimenting with piracetam vs this.

heart failure, brain damage, or any of the other lovely possibilities.. are they worth risking.. to save you time studying?

Edited by bowleaf, 07 April 2013 - 01:41 PM.

[stablemind]

believe it or not it just disturbs me to read some 20 something person saying they want to ingest this stuff in order to save some time studying. or some of the other things I've read in this thread. no condescension, just an expression of healthy skepticism. also, world of difference experimenting with piracetam vs this.

heart failure, brain damage, or any of the other lovely possibilities.. are they worth risking.. to save you time studying?

I'm pretty sure the majority of those who are testing this substance have an intention other than to save time studying.

[megatron]

believe it or not it just disturbs me to read some 20 something person saying they want to ingest this stuff in order to save some time studying. or some of the other things I've read in this thread. no condescension, just an expression of healthy skepticism. also, world of difference experimenting with piracetam vs this.

heart failure, brain damage, or any of the other lovely possibilities.. are they worth risking.. to save you time studying?

To save some time studying? Are you kidding me? Intelligence defines how far you can reach academically, not discipline or time put in studying. If you have an IQ of 100, you can study yourself to death, but you will not manage to get a doctorate anyway. If this drug turns out to have any of the the promised effects, it could be the difference between a bachelor and a doctorate.

[arcticjoe]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

Don't worry, you talk sense, but youre probably wasting your time. most people here don't like to be told that their fairy-tale magic substance may do more harm than good. I was like that too, and now 10 years later I'm still feeling the negative effects of screwing around with one's brain chemistry.

Sent from my GT-I9300 using Tapatalk 2

[megatron]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

Don't worry, you talk sense, but youre probably wasting your time. most people here don't like to be told that their fairy-tale magic substance may do more harm than good. I was like that too, and now 10 years later I'm still feeling the negative effects of screwing around with one's brain chemistry.

Sent from my GT-I9300 using Tapatalk 2

It's just a matter of time before we find something that really, really works. And I want to be in on it when that day comes...

[Q did it!]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

Don't worry, you talk sense, but youre probably wasting your time. most people here don't like to be told that their fairy-tale magic substance may do more harm than good. I was like that too, and now 10 years later I'm still feeling the negative effects of screwing around with one's brain chemistry.

Sent from my GT-I9300 using Tapatalk 2

If people want to experiment and push the limits of the human mind let them. If humans never took any risks where would we be? The opportunity cost is pretty low all considered for this project.



redan

So far we have six persons.


If we were to go with NovoChemy I would suggest 8 persons for the 10g at $460.00. This would allow room for shipping cost but the 8 participants would receive 1.25g not 4g.
I must say that it is a bit to late in the game to start changing everything. But on a second thought if we did go with NovoChemy the 8 participants could sell part of their stocks but.... Man when PayPal screwed us the relay screwed us. And we could just buy three 10g samples and that would allow for 24 participants If we change everything this is our best bet. The only big change is from receiving 4g down to 1.25g which is still a lot. Also with the 3rd 10g sample I would have it mailed to a EU/UK resident for redistributing.

Also both Novo and SunShine have lead times. Novo and Sunshine only start to make the product after you place the order.

IS EVERYONE OK WITH SWITCHING SUPPLIERS? THE COST IS THE SAME JUST 1.25G NOT 4G.

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

Don't worry, you talk sense, but youre probably wasting your time. most people here don't like to be told that their fairy-tale magic substance may do more harm than good. I was like that too, and now 10 years later I'm still feeling the negative effects of screwing around with one's brain chemistry.

Sent from my GT-I9300 using Tapatalk 2

It's just a matter of time before we find something that really, really works. And I want to be in on it when that day comes...

Seconded

[arcticjoe]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

Don't worry, you talk sense, but youre probably wasting your time. most people here don't like to be told that their fairy-tale magic substance may do more harm than good. I was like that too, and now 10 years later I'm still feeling the negative effects of screwing around with one's brain chemistry.

Sent from my GT-I9300 using Tapatalk 2

It's just a matter of time before we find something that really, really works. And I want to be in on it when that day comes...

that may be true, but unfortunately the likelihood of first coming across something that causes some permanent damage is considerably higher.

[mait]

Lets wait for a week at least. i was told that the money transfer to Q would take around 3-7 working days by my bank and I made my payment last Friday as soon as Q gave me the bank details. (I am sending the money from EU and it cost me 30USD in fees and no faster alternative was available for me at this point).

[Hebbeh]

I love how someone negs me for suggesting people take some precautions when experimenting with things.. sort of goes to proving a lot of what I'm saying doesn't it? group-think recklessness. best of luck all.

Don't worry, you talk sense, but youre probably wasting your time. most people here don't like to be told that their fairy-tale magic substance may do more harm than good. I was like that too, and now 10 years later I'm still feeling the negative effects of screwing around with one's brain chemistry.

Sent from my GT-I9300 using Tapatalk 2

It's just a matter of time before we find something that really, really works. And I want to be in on it when that day comes...

that may be true, but unfortunately the likelihood of first coming across something that causes some permanent damage is considerably higher.

The activities discussed here are no more likely to cause permanent damage than any other activity we may be exposed to on a daily basis...including but not limited to:

Concussions from participating in sports and other activities.
Binge drinking alcohol on a regular basis....which appears to be a favorite weekend activity at many universities.
Exposure to any number of natural or man made environmental toxins through either water, air, or the food chain...or work environments.
Living life and aging in general.

How much of the negative effects you are claiming 10 years out are due to supposed nootropic use.....or to living and aging in general? I can assure you that you are at your peak mental and physical abilities in your early twenties and it is down hill from there. As you reach 30...40...50...60...etc, you'll never be as mental or physically sharp and quick as you were at twenty. Get used to it.

[arcticjoe]

its ok, - you want to justify consuming noots and i respect that. for me they did not work out, and i found out that in the end I function far better without noots then with them. i'm not saying you guys arent entitled to experimenting with your own bodies, i'm just urging some caution - esp when it comes to encouraging other people to take copious amounts of previously untested chems.

[Cuttlefish33]

its ok, - you want to justify consuming noots and i respect that. for me they did not work out, and i found out that in the end I function far better without noots then with them. i'm not saying you guys arent entitled to experimenting with your own bodies, i'm just urging some caution - esp when it comes to encouraging other people to take copious amounts of previously untested chems.

Who said anything about ingesting copious amounts?? And untested?? We do admit that there aren't many papers out there about PRL 8-53, but it definitely has been tested in humans before... Idk how much of this thread you've read but there's no peer pressure here; this is everyone's respective choice.

[Hebbeh]

its ok, - you want to justify consuming noots and i respect that. for me they did not work out, and i found out that in the end I function far better without noots then with them. i'm not saying you guys arent entitled to experimenting with your own bodies, i'm just urging some caution - esp when it comes to encouraging other people to take copious amounts of previously untested chems.

Nobody is justifying or encouraging anything. Everybody is expressing their own free will. And I agree, I've never used a racetam that impressed me...but that isn't stopping me from expressing my curiosity or desire at attempting to be at my best...whatever that takes.

And if nootropics didn't work out for you and you no longer desire to pursue that avenue, why are you hanging out on a nootropic forum and criticizing others?

[sparkk51]

Personally, I do not want to switch to Novochemy seeing as how I already sent $80. I just don't see why we would switch anyway.

[Q did it!]

Personally, I do not want to switch to Novochemy seeing as how I already sent $80. I just don't see why we would switch anyway.

With you on this. So its decided with carry through with the original plan and go with SunShine.


People we have allowed this thread to be come derailed can we please get it back on track. There is little use in speculating at this point. We need just get and test the compound for our selves. From there we can speculate but right know we are piratically arguing about what a particular cloud looks like from many perspective points.