1725 replies to this topic

[jrmp]

Is there any spot left to be on the groupbuy? I'm very late, but if there is a spot, could i be in?

[Q did it!]

Everyone I PM the PAYITSQUARE information to, you know who you are, could you hold off with 3x and 4x quantities. A few persons were confused on what was written (It was a bit confusing I must admit). The maximum you can order right now if 2x. If you were in the original group buy then it is 1x. Recall you still have your other 1x received from the original group buy.


Thanks for understanding

[mait]

Seems like the available amount of PRL-8-53 is sold off if I am not mistaken? The PayItSquare link shows no available doses left. So the funding phase of this group-buy has been successful.

Edited by mait, 19 August 2013 - 02:28 PM.

[sunshinefrost]

I'll check, its a setting issue

[sunshinefrost]

Alright you should be good to go

[kevinseven11]

I'm curious about this compounds pharmacology.
A serotonin inhibitor, and a dopamine potentiator, AND a cholinergic agonist or modulator.
Is there any possibility that we could do research into the exact subtypes?

[Nattzor]

I'm curious about this compounds pharmacology.
A serotonin inhibitor, and a dopamine potentiator, AND a cholinergic agonist or modulator.
Is there any possibility that we could do research into the exact subtypes?

I've already posted a bit on that, but got 0 feedback on it. Posts should be 1-3 pages back or so.

[kevinseven11]

sorry I missed that! You ended up no where though M4 activation leads to less motor activity, but less memory. Do you think its any other M subtype? If it released NGF I think that would cause less movement.
I think we should be able to do our own in vitro studies of receptor activation? Any where to buy them?

[Nattzor]

sorry I missed that! You ended up no where though M4 activation leads to less motor activity, but less memory. Do you think its any other M subtype? If it released NGF I think that would cause less movement.
I think we should be able to do our own in vitro studies of receptor activation? Any where to buy them?

Remember that I'm a layman and really don't have much of an education (except wiki and reading studies). If we take a look at the muscarinic receptors (their functions) we see this:

Nicotinic receptors on the postganglionic neuron are responsible for the initial fast depolarization (Fast EPSP) of that neuron. As a consequence of this, nicotinic receptors are often cited as the receptor on the postganglionic neurons at the ganglion. However, the subsequent hyperpolarization (IPSP) and slow depolarization (Slow EPSP) that represent the recovery of the postganglionic neuron from stimulation are actually mediated by muscarinic receptors, types M₂ and M₁ respectively (discussed below).

Thus (if PRL-8-53 works the M1 subtype) it would probably be synergystic with a nicotinic agnoist.

But to add more relevant stuffs: I just added the "possible M4 receptor because of the placement" due to it being in the CNS (and because of this: "Muscarinic acetylcholine receptors possess a regulatory effect on dopaminergic neurotransmission."), I do however believe it's more likely M1-receptor.
Bit more for M1:

Furthermore, 77-LH-28-1, but not AC-42, acted as an agonist at rat hippocampal M1 receptors, as demonstrated by its ability to increase cell firing and initiate gamma frequency network oscillations

http://www.ncbi.nlm.nih.gov/pubmed/18454168

I'm guessing an M1 receptor agonist (maybe not selective) and some non-selective dopamine/serotonin agonist/antagonist.

PRL-8-53 will most likely be ready in a few weeks from what my source tells me, but no idea how we're suppose to do an in-vitro study.

[mait]

sorry I missed that! You ended up no where though M4 activation leads to less motor activity, but less memory. Do you think its any other M subtype? If it released NGF I think that would cause less movement.
I think we should be able to do our own in vitro studies of receptor activation? Any where to buy them?

Remember that I'm a layman and really don't have much of an education (except wiki and reading studies). If we take a look at the muscarinic receptors (their functions) we see this:

Nicotinic receptors on the postganglionic neuron are responsible for the initial fast depolarization (Fast EPSP) of that neuron. As a consequence of this, nicotinic receptors are often cited as the receptor on the postganglionic neurons at the ganglion. However, the subsequent hyperpolarization (IPSP) and slow depolarization (Slow EPSP) that represent the recovery of the postganglionic neuron from stimulation are actually mediated by muscarinic receptors, types M₂ and M₁ respectively (discussed below).

Thus (if PRL-8-53 works the M1 subtype) it would probably be synergystic with a nicotinic agnoist.

But to add more relevant stuffs: I just added the "possible M4 receptor because of the placement" due to it being in the CNS (and because of this: "Muscarinic acetylcholine receptors possess a regulatory effect on dopaminergic neurotransmission."), I do however believe it's more likely M1-receptor.
Bit more for M1:

Furthermore, 77-LH-28-1, but not AC-42, acted as an agonist at rat hippocampal M1 receptors, as demonstrated by its ability to increase cell firing and initiate gamma frequency network oscillations

http://www.ncbi.nlm....pubmed/18454168

I'm guessing an M1 receptor agonist (maybe not selective) and some non-selective dopamine/serotonin agonist/antagonist.

PRL-8-53 will most likely be ready in a few weeks from what my source tells me, but no idea how we're suppose to do an in-vitro study.

PRL-8-53 might be a bit trickier to figure out because the effects of this compound might be related to bio active metabolite(s) of this compound. So simple in-vitro study wont be an all conclusive answer here. Although the creator of this compound itself attributed the effects of it mainly to acetylcholinergic function and secondarily to the modifying effects of monoaminergic neurotransmission, thus it would be really interesting to know the exact target of PRL-8-53 in Ach system (which may also help explain the monoaminergic modifying effects).

[kevinseven11]

So we would need rats, anesthesia(to kill?), and a way to inspect their brains with a microscope and some neuron stain? Only If legal/ethical of course. That is how real scientists would do it right?

[Jeremy Paul Stiles]

Hey guys, I have been following this thread since it started.

Just wondering if there were any spots left in the group buy?

Finally decided to see for myself.

[xks201]

Too late to get in on this?

[dereknel]

Too late to get in on this?

bump I want to know too

[Jeremy Paul Stiles]

All spots are taken in the group buy, looks like I missed out unfortunately.

I'm eager to hear everyones results though.

[garysh566]

I'm curious about this compounds pharmacology.
A serotonin inhibitor, and a dopamine potentiator, AND a cholinergic agonist or modulator.
Is there any possibility that we could do research into the exact subtypes?

I've already posted a bit on that, but got 0 feedback on it. Posts should be 1-3 pages back or so.

thanks ill check it out

[Q did it!]

Update

We still have a few spots available for those of you still interested in getting in on this group buy.

[MisterHero]

I'd like to join

[Balouk]

I'd like to join also, let me know where to pay

[Olorin]

I would also like to join, if possible.

[Turnbuckle]

I'm eager to hear everyones results though.

Or any results at all.

[kevinseven11]

We could do an in vitro study with both the chemical and the metabolites. That's assuming it's removed through urine..
Has this compounds excretion been mapped out in any studies?

[Wu Hang]

Overrated or not, I would like to know when this will be shipped, and clearly I would like to buy more for experimental purpose for sure.

[Wu Hang]

since it still shows 8 remaining in the payment page, I would like to know if I can get more. If so please reply.

[xks201]

I'm interested...PM me.

[Krabby]

Hi all,

An member on the forum has offered to test some for me, I am currently chatting to see what the 'thoroughness' of the testing is and will likely send a sample soon. While I want to identify the PLR, I also want to test and ensure there are no more nasty chemicals left behind.

rnapolymerase: If you'd be willing to conduct some testing to identify the compound and scan for any 'nasty' chemicals I'd glady send you some of my batch in exchange for the report.

I will keep everyone updated as news comes to hand, but sit tight as I'll likely have to send the stuff overseas so shipping alone will be a ~10 day turnaround time. If anyone has any advice on how to legally ship it as far as documentation etc goes, please shoot me a msg. I'd like to ship it legitemately to avoid any issues.

Oh, and if anyone has any colouracetam I'd gladly do a swap

Hey, any updates on what is going on?

[renfr]

Didn't follow anything since july, is there any updates? Someone already tested the compound or are you still having troubles with the supplier?

[xks201]

Pm me q. You got the email from yada in regards to me. I'd pm you today but it says as a basic member I uwed up my daily pm limit lol. Its a go.

[xks201]

PayitSquare is asking for an access code after payment. Anyone know what that is?

[xks201]

It's not processing my payment from this card and its memorial day so the bank is closed lol. Give me one more day to update the info. Thanks.