• Log in with Facebook Log in with Twitter Log In with Google      Sign In    
  • Create Account
  LongeCity
              Advocacy & Research for Unlimited Lifespans

Photo
* * * * * 13 votes

PRL-8-53; was: PRL 8-147: The Most Powerful Memory Enhancer?


  • Please log in to reply
1725 replies to this topic

#1291 Q did it!

  • Member
  • 354 posts
  • 89
  • Location:United States

Posted 31 October 2013 - 06:05 PM

These things we know and are why we getting this compound synthesized. We want the answers and there's only one way to get them.

As far as the lab goes I can personally vouch for it and ScienceGuy may be getting a sample tested for purity as he seeming always does ;)


1) "We want the answers and there's only one way to get them." Wrong. Most of the people that participated in the group-buy are consumers--not producers, i.e. those who are not knowledgeable about conducting scientific investigations and not trained to use proper protocols. They don't know how to evaluate primary literature or even do basic literature searches. You won't get legitimate answers from amateur pharmacologists on this forum who only contribute their anecdotal evidence. Additionally, the sample size is too small to draw any conclusions about short- or long-term effects.

2) What is the name of the laboratory that is synthesizing this compound? Provide their contact information so I can research their qualifications and credentials. Every group-buy should be entirely transparent, especially with the nature of the product being sold.

3) Have you ever met "ScienceGuy" in real life before? What kind of credentials does he have? Does he work for a reputable institution? How do you know that these group-buys are not motivated by money and self-interest? You don't. It's entirely possible that he was quoted 500 dollars total for the entire synthesis, and he is making an extravagant profit off of each and every one of you for his own personal gain.

The people in this community should be asking questions like these and raising concerns. The process should be entirely transparent.



“"We want the answers and there's only one way to get them." Wrong.”
Sorry you may have misunderstood me here.
What I trying to say (been rushed for time) is what you have stated, Testing, Further Research, Data, Analysis etc. is needed. There is not any real conclusive evidence for this compound. No real studies are going to be done on this compound. 1.) No patent 2.) As you say it dates back to pre-1975 and 3.) What kind of market would this have other than that of nootropic value? Maybe Alzheimer's or memory impairment? But once again there is no room for profit by drug companies so why even bother. (Could go on but there are entire books on this topic)

The point know by all participants here is that this is not any real/professional/USDA controlled CLINICAL TRIAL. It is simply put a group of persons putting their funds together for the purchases of a compound that they alone could not afford, in this case PRL-8-53, that they can test/judge for themselves on effectiveness.

Yes most of the people here are consumers (hence why this is a GROUP BUY not a CLINICAL TRIAL). Even with true scientific testing one does not know if a drug is going to work till it be personally trialed (Though trials due help with finding risks and dangers associated with). What works for one person may not work for another.

The sample size it not to “SMALL” it is more than enough for a good testing period by participants to see if this compound even works and if it does then it is and always has been the idea to get more. (NSN will be stocking this soon)

As far as exposing the lab this I will not due. They have remained private due to the risk of it being know by their “AVERAGE” client that they dabble in nootropics/what’s happening here… (Yes I know who they are, have communicated with and verified them but I really do not wish to get involved with this much more then I already have).

Yes group buys should be more/completely* transparent and I wish this one was but we are trying to protect people’s privacy here Participants and Suppliers alike (this is a PUBLIC forum after all ;)).

I don’t know why I am evening answering this but… no I have not met ScienceGuy personally nor have you me ;) but I assure you I am real (A real internet human I am. Sorry had to say it, sigh) Sometimes you have to give people the benefit of the doubt (online communities :~).

Edit:

Second everything SG wrote.

Edited by Q did it!, 31 October 2013 - 06:12 PM.

  • like x 3
  • dislike x 1

#1292 catalase

  • Guest
  • 6 posts
  • -10
  • Location:Unknown
  • NO

Posted 31 October 2013 - 07:46 PM

Firstly, welcome to LONGECITY :)

Secondly, it is abundantly clear that your information level is woefully insufficient to be making such posts. I suggest you might like to read through threads properly and ensure that both your information level is complete and all of your facts are correct and accurate before making such bold sweeping statements, and especially insinuations that someone might be acting immorally; wherein, if you read through this thread you will see that pretty much all of your concerns have in fact been discussed previously in this thread, and my actions to date with respect to this forum, which includes posting a copy of the invoice for the respective custom synthesis on the respective thread, and in fact the manner in which I became involved in this particular Group Buy, demonstrates that your insinuations are misguided to the absolute degree ;)



Thank you for taking the time to welcome me to LONGECITY.

1) My information is based on all of the facts provided by primary literature--which is peer reviewed, placebo controlled, double blind, (but NOT randomized, thus no minimization of allocation bias). This study is questionable to begin with as I have previously stated, but it is the only REAL science in this thread. Furthermore, there is only one published study that included human trials.

2) If you were even remotely educated in the scientific disciplines, you would know that if you wrote a grant proposal to any group with ONE study referenced in your work, that institution would laugh in your face and likely preclude you from ever receiving future funding.

3) Regarding the "bold sweeping statements" that you refer to as "insinuations that someone might be acting immorally," perhaps you should take the time to address my concerns rather than becoming completely defensive when the issue is raised. You have nothing to lose here, it will only add to your "credibility".

4) Reply to this post with the invoice from the company for your "custom synthesis" that includes the contact deals of the company. This will let us know if the answers to the following questions that I posted above:

"What are the credentials of the individuals synthesizing this compound for the group-buy? What level of standards is their laboratory held to? Who monitors the laboratory and holds them accountable for violations of regulations? Are they a reputable source that acquires their reagents from other reputable sources?"

I'm not the only only individual that has asked this question. No one has given a sufficient answer thus far, and it almost seems as if those who are organizing this group-buy are trying to purposefully conceal the identity of the laboratory because perhaps it doesn't meet the highest standards for synthesis of materials safe for consumption.

4a) I'm sure they would appreciate additional business from other clients, not just yourself.

5) You should probably learn to use a punctuation mark known as the "period" in your run-on paragraph. You're not William Faulkner (he's deceased as well), so don't try to write the world's longest sentence.

6) I will make sure that your are held personally responsible if the amateur/ignorant/uneducated participants in your pseudo-study are harmed in any way by this compound.
  • dislike x 7
  • like x 1

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#1293 catalase

  • Guest
  • 6 posts
  • -10
  • Location:Unknown
  • NO

Posted 31 October 2013 - 07:50 PM

These things we know and are why we getting this compound synthesized. We want the answers and there's only one way to get them.

As far as the lab goes I can personally vouch for it and ScienceGuy may be getting a sample tested for purity as he seeming always does ;)


1) "We want the answers and there's only one way to get them." Wrong. Most of the people that participated in the group-buy are consumers--not producers, i.e. those who are not knowledgeable about conducting scientific investigations and not trained to use proper protocols. They don't know how to evaluate primary literature or even do basic literature searches. You won't get legitimate answers from amateur pharmacologists on this forum who only contribute their anecdotal evidence. Additionally, the sample size is too small to draw any conclusions about short- or long-term effects.

2) What is the name of the laboratory that is synthesizing this compound? Provide their contact information so I can research their qualifications and credentials. Every group-buy should be entirely transparent, especially with the nature of the product being sold.

3) Have you ever met "ScienceGuy" in real life before? What kind of credentials does he have? Does he work for a reputable institution? How do you know that these group-buys are not motivated by money and self-interest? You don't. It's entirely possible that he was quoted 500 dollars total for the entire synthesis, and he is making an extravagant profit off of each and every one of you for his own personal gain.

The people in this community should be asking questions like these and raising concerns. The process should be entirely transparent.



“"We want the answers and there's only one way to get them." Wrong.”
Sorry you may have misunderstood me here.
What I trying to say (been rushed for time) is what you have stated, Testing, Further Research, Data, Analysis etc. is needed. There is not any real conclusive evidence for this compound. No real studies are going to be done on this compound. 1.) No patent 2.) As you say it dates back to pre-1975 and 3.) What kind of market would this have other than that of nootropic value? Maybe Alzheimer's or memory impairment? But once again there is no room for profit by drug companies so why even bother. (Could go on but there are entire books on this topic)

The point know by all participants here is that this is not any real/professional/USDA controlled CLINICAL TRIAL. It is simply put a group of persons putting their funds together for the purchases of a compound that they alone could not afford, in this case PRL-8-53, that they can test/judge for themselves on effectiveness.

Yes most of the people here are consumers (hence why this is a GROUP BUY not a CLINICAL TRIAL). Even with true scientific testing one does not know if a drug is going to work till it be personally trialed (Though trials due help with finding risks and dangers associated with). What works for one person may not work for another.

The sample size it not to “SMALL” it is more than enough for a good testing period by participants to see if this compound even works and if it does then it is and always has been the idea to get more. (NSN will be stocking this soon)

As far as exposing the lab this I will not due. They have remained private due to the risk of it being know by their “AVERAGE” client that they dabble in nootropics/what’s happening here… (Yes I know who they are, have communicated with and verified them but I really do not wish to get involved with this much more then I already have).

Yes group buys should be more/completely* transparent and I wish this one was but we are trying to protect people’s privacy here Participants and Suppliers alike (this is a PUBLIC forum after all ;)).

I don’t know why I am evening answering this but… no I have not met ScienceGuy personally nor have you me ;) but I assure you I am real (A real internet human I am. Sorry had to say it, sigh) Sometimes you have to give people the benefit of the doubt (online communities :~).

Edit:

Second everything SG wrote.


1) Any reputable vendor would NOT mind having their identity revealed so that they can acquire more clients.

2) Any reputable vendor would make their credentials known to the public.

3) There is no reason for you to conceal the identity of a reputable laboratory, so please enlighten us all.
  • dislike x 9

#1294 Nattzor

  • Guest
  • 549 posts
  • 103
  • Location:Sweden

Posted 31 October 2013 - 08:05 PM

1) Any reputable vendor would NOT mind having their identity revealed so that they can acquire more clients.

2) Any reputable vendor would make their credentials known to the public.

3) There is no reason for you to conceal the identity of a reputable laboratory, so please enlighten us all.


1. Uhm, isn't there a problem with labs selling to individuals?

2. Same as 1.

3. Same as 1.
  • like x 2
  • dislike x 1

#1295 Q did it!

  • Member
  • 354 posts
  • 89
  • Location:United States

Posted 31 October 2013 - 08:14 PM

I'm going to go ahead and declair troll on catalase and sugest that everyone ignore any further post or comments made by him.
  • like x 6

#1296 Q did it!

  • Member
  • 354 posts
  • 89
  • Location:United States

Posted 31 October 2013 - 09:59 PM

Does anybody else recognize a strange pattern of people attacking ScienceGuy on this forum as of resent?
  • like x 4

#1297 sunshinefrost

  • Guest
  • 455 posts
  • 84
  • Location:Pandora

Posted 31 October 2013 - 10:18 PM

Firstly, welcome to LONGECITY :)

Secondly, it is abundantly clear that your information level is woefully insufficient to be making such posts. I suggest you might like to read through threads properly and ensure that both your information level is complete and all of your facts are correct and accurate before making such bold sweeping statements, and especially insinuations that someone might be acting immorally; wherein, if you read through this thread you will see that pretty much all of your concerns have in fact been discussed previously in this thread, and my actions to date with respect to this forum, which includes posting a copy of the invoice for the respective custom synthesis on the respective thread, and in fact the manner in which I became involved in this particular Group Buy, demonstrates that your insinuations are misguided to the absolute degree ;)



Thank you for taking the time to welcome me to LONGECITY.

1) My information is based on all of the facts provided by primary literature--which is peer reviewed, placebo controlled, double blind, (but NOT randomized, thus no minimization of allocation bias). This study is questionable to begin with as I have previously stated, but it is the only REAL science in this thread. Furthermore, there is only one published study that included human trials.

2) If you were even remotely educated in the scientific disciplines, you would know that if you wrote a grant proposal to any group with ONE study referenced in your work, that institution would laugh in your face and likely preclude you from ever receiving future funding.

3) Regarding the "bold sweeping statements" that you refer to as "insinuations that someone might be acting immorally," perhaps you should take the time to address my concerns rather than becoming completely defensive when the issue is raised. You have nothing to lose here, it will only add to your "credibility".

4) Reply to this post with the invoice from the company for your "custom synthesis" that includes the contact deals of the company. This will let us know if the answers to the following questions that I posted above:

"What are the credentials of the individuals synthesizing this compound for the group-buy? What level of standards is their laboratory held to? Who monitors the laboratory and holds them accountable for violations of regulations? Are they a reputable source that acquires their reagents from other reputable sources?"

I'm not the only only individual that has asked this question. No one has given a sufficient answer thus far, and it almost seems as if those who are organizing this group-buy are trying to purposefully conceal the identity of the laboratory because perhaps it doesn't meet the highest standards for synthesis of materials safe for consumption.

4a) I'm sure they would appreciate additional business from other clients, not just yourself.

5) You should probably learn to use a punctuation mark known as the "period" in your run-on paragraph. You're not William Faulkner (he's deceased as well), so don't try to write the world's longest sentence.

6) I will make sure that your are held personally responsible if the amateur/ignorant/uneducated participants in your pseudo-study are harmed in any way by this compound.

There are many compounds which have ZERO human studies at all such as DM-232, DM-235 (UNIFIRAM,SUNIFIRAM), which theoretically could be WORSE than PLR-8-53. Why are you not sounding alarm for these as well? People like ScienceGuy should be commended if anything for his work, diligence, and time put forth toward various projects. I find it absolutely reprehensible and disgusting that you would go so far as to threaten him.


Distgusting indeed... The nerves !!
  • like x 1

#1298 PWAIN

  • Guest
  • 1,288 posts
  • 241
  • Location:Melbourne

Posted 31 October 2013 - 11:01 PM

That was my thought too... seems we have a troll in our midst. Catalase comes along with posting history of 4 after joining up yesterday and launches into a full scale attack. Really wish people would learn to look for the signs and "Not feed the Trolls". There is no reasoning that will placate a troll and of course they pick up on an issue that is so nearly true except when you look at it in detail.

Does anybody else recognize a strange pattern of people attacking ScienceGuy on this forum as of resent?


  • like x 1

#1299 samohT

  • Guest
  • 36 posts
  • 16
  • Location:USA

Posted 31 October 2013 - 11:59 PM

Hey the thought just occurred to me; did anyone ever get ahold of any of the original researchers to an extent in which we ascertained supplemental motive to pursue 8-53? Why the company decided to shut it down? Or any other anecdotal information on the chemical...?

Obviously, as y'all have discussed, a lot can be gained with just a few short questions to one of the researchers on their personal accounts and opinions with the drug.


Sorry if the answer's buried somewhere in the 44 thread pages and I missed it...

#1300 p3x888

  • Guest
  • 133 posts
  • 16
  • Location:USA
  • NO

Posted 01 November 2013 - 12:31 AM

Aren't the two main researches already dead?

#1301 kevinseven11

  • Guest
  • 385 posts
  • 40
  • Location:Texas

Posted 01 November 2013 - 03:30 AM

I plan on researching on my chickens before I ingest this myself. I will post my results if you guys are interested. Sorry for random output. ;)

#1302 xks201

  • Guest
  • 839 posts
  • 25
  • Location:USA

Posted 01 November 2013 - 03:58 AM

Mait. Plz be quiet. Thanks.

#1303 catalase

  • Guest
  • 6 posts
  • -10
  • Location:Unknown
  • NO

Posted 01 November 2013 - 05:24 AM

1) Any reputable vendor would NOT mind having their identity revealed so that they can acquire more clients.

2) Any reputable vendor would make their credentials known to the public.

3) There is no reason for you to conceal the identity of a reputable laboratory, so please enlighten us all.


1. Uhm, isn't there a problem with labs selling to individuals?

2. Same as 1.

3. Same as 1.


LOL. Are you implying that ScienceGuy is not an individual? ScienceGuy is an institution? THE SCIENCEGUY INSTITUTION FOR NOOTROPICS. LMAO.

This lab is selling to ScienceGuy--an individual--who does not have any legitimate academic credentials. Oh wait, "Uhm, isn't there a problem with labs selling to individuals?". That sounds familiar doesn't it? This uneducated/amateur/ignorant individual is then going to make a handsome profit off of each and every one of you. Downvote me all you want, but it's simply the truth. If you can personally verify ScienceGuy's academic credentials, then please enlighten me, otherwise, take your downvotes elsewhere.

Effectively, this lab, which could be run in the back of someone's home recreational vehicle, is selling an experimental drug that was studied ONCE, and you are all willing to consume it because you think it will endow you with magical super powers, oh and of course, the ability to double your verbal recall capacity. You can't even verify the conditions of this laboratory or the academic credentials of the individual who runs it. You'll never know if that vial of tetrodotoxin that was synthesized for the another synthesis customer managed to make its way into the batch of PRL-8-53 that ScienceGuy is supposed to distribute to all of you--because if it did, you'd be dead in less than 24 hours after consuming the first dose. It is not wise to consume these experimental drugs to begin with, and surely not wise to consume these drugs from laboratories whose identities are concealed from the public because the individuals running them do not have proper academic credentials that certify their expertise and use of proper laboratory techniques.

Do any of you even have a legitimately diagnosed medical condition that even warrants some kind of experimental drug, because after exhausting all other treatments you cannot find relief for your symptoms? Probably not. Most of you just have expendable cash and are bored enough to ingest this substance.

Before you speak next time, grow a brain. And btw, PRL-8-53 won't help you with that.
  • dislike x 10

#1304 samohT

  • Guest
  • 36 posts
  • 16
  • Location:USA

Posted 01 November 2013 - 05:30 AM

Dude, we're hobbyists. Can you please please just shut the fuck up and consider us hobbyists? I'm all for playing devils advocate and erring on the side of caution but you're just being an asshat. PLUR, man.

"THE SCIENCEGUY INSTITUTION FOR NOOTROPICS" happens to have thus far completed multiple batch chemical synthesis orders and group buys to my knowledge and comes off as if he known damned well what he's talking about. If ScienceGuy kills us all well that was the inherent risk wasn't it? (I'm sure he's going to test it out himself within minutes of unwrapping the package.) Regardless of whatever personality conflicts he has with anyone here, he HAS an upstanding reputation here. You DO NOT. You're posting on some anonymous throwaway account you made just to troll on the integrity of this entire endeavor. Very spineless.
I wish one of the more proactive admins here will run your IP through the list of known IP/username pairs to find matches and expose you (if you're not proxied), that's what I'd do on my forum, but I can only dream.

Nobody's acting like this substance is safe. In fact everyone here is being quite rational in stating that both this substances short and long term effects and safety are generally unknown beyond what the somewhat dated study states. At least I hope everybody understands that.

Edited by samohT, 01 November 2013 - 05:39 AM.

  • like x 5

#1305 catalase

  • Guest
  • 6 posts
  • -10
  • Location:Unknown
  • NO

Posted 01 November 2013 - 06:11 AM

Dude, we're hobbyists. Can you please please just shut the fuck up and consider us hobbyists? I'm all for playing devils advocate and erring on the side of caution but you're just being an asshat. PLUR, man.

"THE SCIENCEGUY INSTITUTION FOR NOOTROPICS" happens to have thus far completed multiple batch chemical synthesis orders and group buys to my knowledge and comes off as if he known damned well what he's talking about. If ScienceGuy kills us all well that was the inherent risk wasn't it? (I'm sure he's going to test it out himself within minutes of unwrapping the package.) Regardless of whatever personality conflicts he has with anyone here, he HAS an upstanding reputation here. You DO NOT. You're posting on some anonymous throwaway account you made just to troll on the integrity of this entire endeavor. Very spineless.
I wish one of the more proactive admins here will run your IP through the list of known IP/username pairs to find matches and expose you (if you're not proxied), that's what I'd do on my forum, but I can only dream.

Nobody's acting like this substance is safe. In fact everyone here is being quite rational in stating that both this substances short and long term effects and safety are generally unknown beyond what the somewhat dated study states. At least I hope everybody understands that.


Just because someone disagree's with you doesn't make them a "troll." Too many people continue to use this term without understanding its actual meaning. I've raised a fair number of valid points about the study behind this drug, but you continue to ignore them.
  • dislike x 3

#1306 Q did it!

  • Member
  • 354 posts
  • 89
  • Location:United States

Posted 01 November 2013 - 07:20 AM

So only 3 more weeks untill the lab finishes the synthesis and ships the chemical to SG. Will be so happy when this is all said and done... then on to the next compound :)

#1307 ScienceGuy

  • Life Member
  • 851 posts
  • 1,131
  • Location:UK

Posted 01 November 2013 - 08:04 AM

I'm going to go ahead and declair troll on catalase and sugest that everyone ignore any further post or comments made by him.


I feel the need to point out that I was in fact only brought into assist with this particular GROUP BUY by the organizers at a late stage; wherein this was in fact my very first post regarding it:

Hats off to Q for all his hard work on this! :)

I'm going to be extremely interested in seeing how this pans out...


The fact of the matter is that all the credit should be awarded to Q DID IT!, YADAYADA, and SUNSHINEFROST, who are in fact the ones responsible for making this GROUP BUY happen and all of whom should be commended for their considerable time invested in organizing everything and in bringing it to fruition. :)

Since my role in this has in fact been secondary after being asked by these guys to help out obviously it is absolutely misguided and wholly inappropriate to single me out as the target of these attacks... Furthermore, there is not one single instance of anything that has not been already discussed and/or answered previously in this thread and/or other related threads on LONGECITY... Also, it should be noted that the individual who is CATALASE has in fact set up a brand new account then immediately proceeded with launching these antagonistic attacks... AND it is crystal clear that even if one were to spend the considerable time composing a fully comprehensive reply to address everything he has posted he would still not be placated...

For all these reasons it is indeed abundently clear the that said individual is most certainly a TROLL and everyone should IGNORE HIM... and BTW saying you are not a TROLL does not make it so... ACTIONS speak louder than words... If you don't want to be called out as being a TROLL, stop acting like one :)

If ANYONE feels that any of his questions and/or false accusations actually warrrant answering please say so via a post in this thread and I will be very happy to do so... What I do not want to do is derail or clutter up this thread any further than it has been, by addressing matters that have already been addressed previously unless there is a GENUINE requirement to do so... so I put it out to all you fine ladies and gentlemen, is there anything raised by this guy that you would like me to answer? Like I said, I am very happy to do so if necessary, but don't want to waste precious time doing so unless necessary... let me know ;)

And as an illustration of how there is not anything here that has not already been covered previously please kindly note the following post from earlier in the thread which I feel to be quite relevant:

How many times does it have to be said?

Stop derailing this thread with your warnings and sob stories, what we are trying to coordinate here is complicated enough without these distractions. Unless you have a ground breaking discovery regarding this substance or you are interested in being a part of this group purchase take your bag of well intentioned warnings and make your own thread.

Thank you kindly.


Edited by ScienceGuy, 01 November 2013 - 08:18 AM.

  • like x 3

#1308 xks201

  • Guest
  • 839 posts
  • 25
  • Location:USA

Posted 01 November 2013 - 12:35 PM

Catalase you do realize that people buy alll kinds of things all the time, drugs included, without the FDA approving them or the manufacturer?

Juuuust checkin bro. If someone wants to take a risk that's on them and last time I checked you weren't my mother. Dont you have a life to live or is talking shit your main hobby?

And who's to say some of us here don't have medical issues which make some of us more apt to try newer drugs? The prescription drug market for nootropics in the US is abysmal at best.

How about I tell you how to live your life and you do as I say? Perhaps you'd be better suited living in a dictatorship. Your stupid arguments aren't gonna gain any momentum here buddy so take them elsewhere. The average individual here is more intelligent than the bs you preach. I'm surprised you haven't been banned.

If you think that by telling everyone here to grow a brain is going to endeer you with an aura of intelligence, you probably should heed your own advice first.
  • like x 7

#1309 Nattzor

  • Guest
  • 549 posts
  • 103
  • Location:Sweden

Posted 01 November 2013 - 03:45 PM

LOL. Are you implying that ScienceGuy is not an individual? ScienceGuy is an institution? THE SCIENCEGUY INSTITUTION FOR NOOTROPICS. LMAO.

This lab is selling to ScienceGuy--an individual--who does not have any legitimate academic credentials. Oh wait, "Uhm, isn't there a problem with labs selling to individuals?". That sounds familiar doesn't it? This uneducated/amateur/ignorant individual is then going to make a handsome profit off of each and every one of you. Downvote me all you want, but it's simply the truth. If you can personally verify ScienceGuy's academic credentials, then please enlighten me, otherwise, take your downvotes elsewhere.

Effectively, this lab, which could be run in the back of someone's home recreational vehicle, is selling an experimental drug that was studied ONCE, and you are all willing to consume it because you think it will endow you with magical super powers, oh and of course, the ability to double your verbal recall capacity. You can't even verify the conditions of this laboratory or the academic credentials of the individual who runs it. You'll never know if that vial of tetrodotoxin that was synthesized for the another synthesis customer managed to make its way into the batch of PRL-8-53 that ScienceGuy is supposed to distribute to all of you--because if it did, you'd be dead in less than 24 hours after consuming the first dose. It is not wise to consume these experimental drugs to begin with, and surely not wise to consume these drugs from laboratories whose identities are concealed from the public because the individuals running them do not have proper academic credentials that certify their expertise and use of proper laboratory techniques.

Do any of you even have a legitimately diagnosed medical condition that even warrants some kind of experimental drug, because after exhausting all other treatments you cannot find relief for your symptoms? Probably not. Most of you just have expendable cash and are bored enough to ingest this substance.

Before you speak next time, grow a brain. And btw, PRL-8-53 won't help you with that.


I'm implying that the lab would not say "Lol, we synthesised drugs with patents to some individuals, #YOLO". You really should read what I write instead of attacking it all the time.

ScienceGuy is a med student (or is he done?) and have studied nutritional science before (afaik). If you check the thread and other group-buys you'll obv see that "we" have used labs that does synthesis for other companies before (we've used NSN (New Star Nootropics) supplier before I think, atleast gotten price checks from them + others).

Just because someone disagree's with you doesn't make them a "troll." Too many people continue to use this term without understanding its actual meaning. I've raised a fair number of valid points about the study behind this drug, but you continue to ignore them.


You're acting as a troll because you do personal attacks, attack straw men, etc.

You were a troll on longecity and irc yesterday, but acted sane in private chat. Now you're trolling again.

As I wrote today, don't view this community as a network of scientists, NO ONE is claiming it is. View it as people taking drugs because they feel like it.
  • like x 1

#1310 p3x888

  • Guest
  • 133 posts
  • 16
  • Location:USA
  • NO

Posted 01 November 2013 - 07:10 PM

I'm not a scientist, but I did stay at a Holiday Inn Express last night.

But back on mission. I know the status of the PLR-8-53 Group Buy, Is there anyone currently trying, contemplating, etc. a group by for PLR-8-147? Or are we waiting to see what 8-53 will do first? If not, I am game to help organize one for 8-147. I would also like to to do another ISRIB one since it is full.

#1311 middpanther88

  • Guest
  • 185 posts
  • -4

Posted 01 November 2013 - 07:35 PM

Why not just buy from new star nootropics?

#1312 p3x888

  • Guest
  • 133 posts
  • 16
  • Location:USA
  • NO

Posted 01 November 2013 - 09:15 PM

Buy what? 8-147 isn't availabe and hasn't been mentioned. Neither has ISRIB as far as I know. However, please correct me if I am wrong. I am aware of 8-53 being available soon at New Star, but I wasn't referring to those.

#1313 NG_F

  • Guest
  • 142 posts
  • 8
  • Location:Tweaking my Basal Ganglia

Posted 04 November 2013 - 03:40 AM

http://www.newstarno....com/prl853.php
  • like x 1

#1314 Reformed-Redan

  • Guest
  • 2,200 posts
  • -9
  • Location:Thousand Oaks, CA

Posted 04 November 2013 - 03:49 AM

http://www.newstarno....com/prl853.php

Wow, just wow! Love NSN! Can you ask them to get GTS-21?

#1315 unregistered_user

  • Guest
  • 721 posts
  • 169
  • Location:Washington DC

Posted 04 November 2013 - 03:53 AM

Now we can start getting some actual experience reports. I'll be waiting anxiously for updates from those who decide to trial PLR 8-147.

#1316 samohT

  • Guest
  • 36 posts
  • 16
  • Location:USA

Posted 04 November 2013 - 04:00 AM


Woah NSN what a huge surprise!!! Came to reality sooner than I thought.

Without me having to dig it up, can someone refresh me on the studied dosage? 170lb male. Not sure how much to order.

Edited by samohT, 04 November 2013 - 04:02 AM.


#1317 jly1986

  • Guest
  • 166 posts
  • 3
  • Location:Chicago

Posted 04 November 2013 - 04:25 AM

LD50 in mice is 860mg/kg.

The double-blind human trial used 5 mg per dose.

#1318 kevinseven11

  • Guest
  • 385 posts
  • 40
  • Location:Texas

Posted 04 November 2013 - 04:30 AM

Ill try some In vitro only studies with this compound soon.

#1319 jly1986

  • Guest
  • 166 posts
  • 3
  • Location:Chicago

Posted 04 November 2013 - 05:08 AM

Just ordered my 1/2 g.
My lucky bunny will be happy :-)

sponsored ad

  • Advert
Click HERE to rent this advertising spot for BRAIN HEALTH to support LongeCity (this will replace the google ad above).

#1320 samohT

  • Guest
  • 36 posts
  • 16
  • Location:USA

Posted 04 November 2013 - 05:28 AM

Anybody actually interested in comparing PRL to their personal baseline, it'd behoove you to start NOW on setting baseline result trends (preferably daily) on http://www.cambridgebrainsciences.com/ and of course share your results!
Of course, use whatever software or whatnot you feel like but.. The Cambridge tests are something we all have access to and is generally accepted as awesome. Is there any certain test we should be doing?

Edited by samohT, 04 November 2013 - 05:31 AM.

  • like x 1




49 user(s) are reading this topic

0 members, 48 guests, 0 anonymous users


    Bing (1)