1725 replies to this topic

[Synaesthesiac]

I received one gram of PRL-8-53 from New Star 2 days ago. I have tried 5mg 2x daily for the first day and am into my second day today (one 5mg dose so far). It is pertinent to note that I am also taking Oxi (600mg), Prami (150mg), Noopept (10mg), Colu (10mg), Suni (5mg), and Uni (5mg) all twice a day with this as well, as it is crunch-time at work and I do not have the luxury of time and/or the ability to sustain the slight loss of focus that a washout and full-cessation of my current stack would inevitably lead to. In regard to what others have suspected, I can confirm through my own observations that PRL seems to have a nice synergy with Coluracetam. I feel a definitive improvement in mood, seemingly dopaminergic in nature, as well as a noticeable subjective improvement in recall and my ability to sustain attention and plan out what I need to get done for the day (it's as if I'm actively and somewhat effortlessly planning my actions several steps ahead, being able to anticipate work needs and situations well before they arise. I do not feel any side-effects at this point whatsoever. It's also worthy to note that I take ALCAR and NAC to help mitigate any potential toxicity in my stack, although I don't believe this is a primary, secondary, or even tertiary issue. So far so good, I just wanted to add my experience of this compound still in it's experiential nascency.

Edited by Synaesthesiac, 10 November 2013 - 01:01 AM.

[Amorphous]

It doesn't seem like Prl 8-53 would improve dual n-back game in a short term administration (in this case also WM). What is the chance for it to improve WM in longer term basis? Subjectively, I feel like PRL make my thinking easier and smoother. I am thinking to try it for a longer term while practicing n-bank, but I am not sure. Basically, this drug has no study for using longer term except on mice that show no sign of teratogenicity.

[3AlarmLampscooter]

Got the first hard data on PRL-8-53 improving long term memory. I felt like the clinical trial was poorly designed to assess gains in higher performing individuals. I came up with a modified version of it.

Had a friend generate two lists of 100 pseudorandom 6 letter words, with a 50-word sublist for each. Made two pills, one with 5mg PRL-8-53 mixed with baking soda, the other only baking soda.

On the first day, I took pill A and waited an hour. Then was studied 50 word sublist A for 5 minutes. At 24h after, I tried to pick out the 50 words on the sublist out of 100 item wordlist A. I correctly identified 21 of them.

After waiting another day, I repeated the procedure with pill B and sublist+wordlist B, again trying to pick out the words at t=24h. This time I scored 48.

I'll let you guess which one was placebo

Protip: Placebo does not result in 228% of baseline performance on memory retention

I'll have to repeat this study with larger doses, and larger wordlists/different datasets.

Edit: Should add this was still on 5mg Selegiline daily. This may be effecting results to some degree.
Should also add I ran tests on short term memory for digit retention. Scored 11 on placebo and 12 on PRL. Clearly I'm a high preformer, and clearly PRL isn't doing much if anything there. Had much better results with Sunifiram on improving digit retention.

Edited by 3AlarmLampscooter, 10 November 2013 - 05:24 AM.

[phil8462643]

3 alarm! well done! Thats the type of post I joined longecity for!

[Nattzor]

Very nice experiment! We need more people doing that!

[Amorphous]

Wow, 3alarm, even your picture changed after this experiment, it must be something significant. What an improvement!.....I mean,,,your picture.
Seriously 228% improvement on verbal recall does show the effectiveness of this compound or something else in this experimentation. Good job!

[Nattzor]

Wow, 3alarm, even your picture changed after this experiment, it must be something significant. What an improvement!.....I mean,,,your picture.
Seriously 228% improvement on verbal recall does show the effectiveness of this compound or something else in this experimentation. Good job!

It was a 128% improvement to be exact, 228% of baseline (but "just" 128% more than baseline).

[megatron]

How far away from completing the synthesis are they?

[Nattzor]

How much did it cost to join the group buy and how much will you get?

(I know it's full a long time ago, just want to know)

[Amorphous]

Wow, 3alarm, even your picture changed after this experiment, it must be something significant. What an improvement!.....I mean,,,your picture.
Seriously 228% improvement on verbal recall does show the effectiveness of this compound or something else in this experimentation. Good job!

It was a 128% improvement to be exact, 228% of baseline (but "just" 128% more than baseline).

It was 228% improved performance to be exact, 128% performance improvement from baseline to be accurate
Thanks

[megatron]

How much did it cost to join the group buy and how much will you get?

(I know it's full a long time ago, just want to know)

I believe the initial price was $80 for 4g (Novochemy?), but I don't remember after the first company failed synthesizing it and we had to switch to another manufacturer.

[Nootropic Milk Hotel]

I took 5mg PRL-8-53 sublingually/buccally about two hours ago (my third time taking it). Today I have also taken 15mg Adderall IR, some ALCAR and Lion's Mane, fish oil and a multi. I'm feeling extremely stimulated, much more so than when I take Adderall alone. I am feeling fantastic and I have been motivated to do a whole bunch of important and productive things today. What has been really cool is that I haven't even thought about them or doubted them; I have just put my mind on getting things done and then done them. I haven't felt any negative aspects of stimulation, except for a rapid heartbeat and high body temperature, which are normal for me on Adderall.
Has anyone else tried this stuff alongside stimulants? It's fantastic, but I have to worry a bit about how healthy or sustainable it is. PRL 8-53 has rapidly become one of my favorite nootropics, but the fact that we still really don't know its long-term effects or even mechanism of action (as far as I know) is a bit unsettling.

[therein]

I took 5mg PRL-8-53 sublingually/buccally about two hours ago (my third time taking it). Today I have also taken 15mg Adderall IR, some ALCAR and Lion's Mane, fish oil and a multi. I'm feeling extremely stimulated, much more so than when I take Adderall alone. I am feeling fantastic and I have been motivated to do a whole bunch of important and productive things today. What has been really cool is that I haven't even thought about them or doubted them; I have just put my mind on getting things done and then done them. I haven't felt any negative aspects of stimulation, except for a rapid heartbeat and high body temperature, which are normal for me on Adderall.
Has anyone else tried this stuff alongside stimulants? It's fantastic, but I have to worry a bit about how healthy or sustainable it is. PRL 8-53 has rapidly become one of my favorite nootropics, but the fact that we still really don't know its long-term effects or even mechanism of action (as far as I know) is a bit unsettling.

I wouldn't really call PRL 8-53 a nootropic. There is just too little information out there to say that. When you say that you are feeling fantastic, even better than Adderall alone, it brings the excitotoxicity question to mind. There is also potential neurotransmitter depletion and receptor downregulation. It is good to hear that you are enjoying the effects but paradoxically, the fact that you are enjoying it this much means that you should be more careful.

[dare2winit]

Sometimes I get really worried reading about all these people mixing PRL-8-53 with tons of other stuff on the first day or even week of their first dose. I really hope nothing bad happens but even more so I'm bummed that not many people are willing to thoroughly test this. I had high hopes for lots of like minded people testing and logging the effects. Yet I see more people describing physical feelings as if this was a some kind of high (not wrong in of itself) I was hoping for more.
3Alarm is on the right track and I hope others will take note.

So heres my plan, feel free to critique it...

Me and a friend are both participating in this and will log our results. We will be filling up each others capsules with equal amounts of PRL-8-53 and placing the pills in random envelopes with a day of the week written on them. We will do this with pills of baking soda as well and then log what days have PRL and which days have baking soda. Now we will swap envelopes so the other person doesn't know when they will be taking a placebo or PRL-8-53 capsule. The goal is to have 5 days of placebo and 5 of PRL-8-53.
We will follow 3Alarms lead and use a list of 6 letter words ( http://www.easysurf.cc/list6.htm ) and each day at an exact time we will read a list of 50 words (maybe 2 or 3 times, any input?) and take a capsule. Exactly 24 hours later we will then try to pick out the 50 words we saw yesterday from a list of 100 words. After that we'll dose again, and store the list of the words we picked out of the 100 in a file (no grading until after 10 days)

Now my big question is... How long should we wait after dosing to read the daily list of 50 words? I don't know how long it takes to hit the "sweet spot" of PRL-8-53. I'd appreciate any input.

After the trial I will post all results on here and neither of us will take any supplements during this time except for caffeine.

[middpanther88]

How long should the long term effects last? For example, you take the supplement and you remember the things you learned for the first hour, or do the memory effects bleed into the rest of the day(s)?

[dare2winit]

How long should the long term effects last? For example, you take the supplement and you remember the things you learned for the first hour, or do the memory effects bleed into the rest of the day(s)?

From my understanding the effects shouldn't bleed over into the next day, but its been months since I read the results of the original testing so I probably should double check.

[Potent]

Now my big question is... How long should we wait after dosing to read the daily list of 50 words? I don't know how long it takes to hit the "sweet spot" of PRL-8-53. I'd appreciate any input.

After the trial I will post all results on here and neither of us will take any supplements during this time except for caffeine.

The original hansl paper states that they took placebo or drug 2-2.5 hours "before the time." Which is a weird sentence. But I'm assuming it means they waited 2 hrs post dose to take their word list test.

[REBUILDER]

So is there a planned group-buy for this, or do we purchase it from someone in particular?

[Isochroma]

New Star has the 8-53.
Santa has the 8-147.

[gnappi]

New Star has the 8-53.
Santa has the 8-147.

What is Santa???

[spookytooth]

New Star has the 8-53.
Santa has the 8-147.

What is Santa???

Seriously? ^^

There you go: http://lmgtfy.com/?q=Santa

Edited by spookytooth, 11 November 2013 - 09:39 AM.

[gnappi]

New Star has the 8-53.
Santa has the 8-147.

What is Santa???

Seriously? ^^

There you go: http://lmgtfy.com/?q=Santa

Sorry, but I did not understand the joke.

[Breezey]

Great news about the 8-53. I will get on it soon enough. So, what is the method of getting hold of the 8-147? Any body have Santa's phone number?

[PWAIN]

Great news about the 8-53. I will get on it soon enough. So, what is the method of getting hold of the 8-147? Any body have Santa's phone number?

First you have to be a good boy or girl the whole year. Then you sit down and write him a nice letter. Address it to Santa c/o North Pole and drop it in the letter box. Finally you wait until 25 Dec (or 7 jan if you are in a orthodox country) and free delivery...don't forget to put out some milk and cookies for the delivery guy...

[PAM2]

Actually Santa delivers PRL-8-147, and other nootropics for well-behaving longecity forum members, but as I've heard, the ones answering stupid questions will fall out of the line..

Great news about the 8-53. I will get on it soon enough. So, what is the method of getting hold of the 8-147? Any body have Santa's phone number?

First you have to be a good boy or girl the whole year. Then you sit down and write him a nice letter. Address it to Santa c/o North Pole and drop it in the letter box. Finally you wait until 25 Dec (or 7 jan if you are in a orthodox country) and free delivery...don't forget to put out some milk and cookies for the delivery guy...

[Nattzor]

Great news about the 8-53. I will get on it soon enough. So, what is the method of getting hold of the 8-147? Any body have Santa's phone number?

We have no clue on PRL-8-147, so we can't get it.

Great news about the 8-53. I will get on it soon enough. So, what is the method of getting hold of the 8-147? Any body have Santa's phone number?

First you have to be a good boy or girl the whole year. Then you sit down and write him a nice letter. Address it to Santa c/o North Pole and drop it in the letter box. Finally you wait until 25 Dec (or 7 jan if you are in a orthodox country) and free delivery...don't forget to put out some milk and cookies for the delivery guy...

Bro, it's 24 December in Sweden/Scandinavia ;(

[5IMON]

When administering this orally, do you allow it to dissolve under the tongue?

[5IMON]

or swallow it...

[Particle]

When administering this orally, do you allow it to dissolve under the tongue?

Originally, 5 mg doses were given orally (swallowed). However, sublingual administration (dissolving the compound under the tongue) is also possible.

[Breezey]

This thread should come back to topic now the the group buy is over IMHO. I was just having dinner with the family and my Dad told me that Santa doesn't exist. Sorry guys, I guess we are going to have to come up with a new way.