1725 replies to this topic

[polarbears]

Just a recap... I have spent a month now of direct 10-20mg/day prl-8-53 usage

prl is a h1 or h3 inverse agonist no doubt, tolerance builds rapidly, and the SAR could be judged as similar to a few current histamine inverse agonists out atm..pm for questions

I ruined the effects the second week by combining IDRA-21 with it( horrible time, even with 4mg).

Definitely ruins working/short term memory but GREATLY improves task related memory on retention related activities, i.e studying and then examinations.

Not the most powerful but still interesting. Just don't take it daily, I've been taking 2-3 days off lately but its a really great compound- however it can numb you from reality..

[gnappi]

Definitely ruins working/short term memory but GREATLY improves task related memory on retention related activities, i.e studying and then examinations.

So it would not be better to take the prl-8-53 at bedtime?

[Nattzor]

prl is a h1 or h3 inverse agonist no doubt, tolerance builds rapidly, and the SAR could be judged as similar to a few current histamine inverse agonists out atm..pm for questions

No evidence of that. Isochroma changed his mind when we were on irc, he was talking about pitlosant (or something like that). What's SAR btw?

Definitely ruins working/short term memory but GREATLY improves task related memory on retention related activities, i.e studying and then examinations.

Everyone else seem to have no improvement/slight improvement in WM, looks like you're unique.

[mait]

Hello,

My update! 2 weeks in with 5-7 mg per day dosing. I have not seen the buildup of tolerance. Rather the opposite is true for me - the positive gains seem to be cumulative. The positive gains in my case are related to improved LTM and having more "consistent" WM performance. When I played games on Gambridge BrainSciences page before I could reach to my record results in memory tests usually 10-20% of times. Now I seem to be able to perform at my record levels more consistently (over half of the times). Still I haven't seen consistent gains in the absolute performance levels with PRL-8-53 (I haven't made "a jump" in my records). So I will wait until my Coluracetam from NewMind arrives and hope that Colu + PRL-8-53 would give me a lift needed to improve my WM performance at absolute terms.

[leftside]

I've been using PRL-8-53 for a week and a half now, with a break at the weekend. I started with 5mg twice a day, but only take 5mg in the morning now. I'm really liking the mild additional concentration and focus at work. I'm also now finding it be a very mild stimulant, which is another reason I only take it in the morning. Please note that I am quite sensitive to most stimulants.

I also feel it makes other substances that contain caffeine (coffee, tea, yerba mate, etc) to feel a little stronger. I can "feel it" in the center of my head. It's not a headache, but it is something I'm aware of. I'll take a week off it soon.

I haven't had too much success with most racetam's in the past, but I'm liking this new substance.

[DjDerek10]

After a couple glasses of wine, I tried 10 Mg of PRL-8-53 for the first time. I had already taken Piracetam (1600Mg), Oxiracetam (1600 Mg), Aniracetam (1600 Mg), Centrophenoxine (1000Mg) and 10 Mg of Sunifiram about 2 and half hours before the PRL Dose. I do electronic music production and was already feeling pretty in tune from the stack I had taken earlier. When the PRL Kicked in I got a little bit of anxiety (Pretty much made me feel like I should of been dancing or working out or something lol) that subsided after about 20 mins and from there on out I felt very clear headed and extremely focused. I was hearing music in ways Ive never heard before, able to hear every frequency in the sound spectrum with ease and clarity. I was so focused on my productiont that I did a 4 hour session that just flew by and I was able to finish the song I had started and it turned out to be my best one yet. I will have to say that out of all nootropics I have tried, I definitely like this one the best and can not wait to try it with Coluracetam which I have on order. Cheers!

[deadkenny64]

It's a shame that the initial effects start to wane with subsequent doses. It still helps my concentration but nowhere near the crystal clarity I had the first time. Even with a week off I can't recapture the magic. I take hydergine daily (1 mg) so I haven't gone past 7 mg as hydergine seems to potentiate most of what I take. Maybe it's time to up the dose...

Edited by deadkenny64, 06 December 2013 - 02:53 AM.

[igorpanarin]

Im in the process of buying. Im waiting for customs. Can anyone tell me if they had good experience. Ps what were the side effects. Did anyone get super smart. Did anyone have tolerance buildup, etc. What were the effects?

[middpanther88]

Didn't really react to Coluracetam+PRL. Maybe I'm doing something wrong?

[phil8462643]

there s not much real info available but one conclusion of the study was that it worked less on individuals with better memory

[3AlarmLampscooter]

there s not much real info available but one conclusion of the study was that it worked less on individuals with better memory

Study was methodologically flawed in that respect though. The memory task was possible to complete without drug assistance (in other words too easy), and that seriously limited possible gains from PRL-8-53 in already high performers. The memory task for my case report got around this problem by being way too hard to come close to completing without drug help.

[Mr. Pink]

UPDATE:

Hi Everyone,

I just received word back from the lab; this is what they have said:

I'm sorry for being late again but I must be 100% sure about quality of chemicals we provide, I hope we finish this week.

I asked them what was the cause of the delay and they confirmed that they have in fact carried out the synthesis twice as the first batch did not pass their strict quality control protocol, so they discarded it. They have informed me that are confident the second batch should do so. It is apparently a difficult substance to synthesize and because SODIUM CYANIDE is used as a reagent it is obviously extremely important that the synthesis and purification processes are carried out properly and thoroughly. So hopefully not long now!

thank you for the update, ScienceGuy. Do you know if they finished that week as they had hoped? It's about 2 weeks since then, any further info? I'm sorry for my impatience, just i'm in my crunch time right now for a huge exam in January

[ScienceGuy]

thank you for the update, ScienceGuy. Do you know if they finished that week as they had hoped? It's about 2 weeks since then, any further info? I'm sorry for my impatience, just i'm in my crunch time right now for a huge exam in January

I have sent a message to the lab asking for an update. I will post here just as soon as I receive a reply.

However, I strongly advise against taking experimental drugs for the first time prior to an important exam... you have no idea whether you will be a positive responder and as with any drug there is always the risk of ADVERSE EFFECTS... you would be taking a huge gamble and it is just not worth the risk... my advice is to test out any substance for the first time when it doesn't matter if you respond badly to it... if you respond positively then use it for your next set of exams... but that's just my opinion

Edited by ScienceGuy, 16 December 2013 - 09:24 PM.

[Mr. Pink]

thank you for the update, ScienceGuy. Do you know if they finished that week as they had hoped? It's about 2 weeks since then, any further info? I'm sorry for my impatience, just i'm in my crunch time right now for a huge exam in January

I have sent a message to the lab asking for an update. I will post here just as soon as I receive a reply.

However, I strongly advise against taking experimental drugs for the first time prior to an important exam... you have no idea whether you will be a positive responder and as with any drug there is always the risk of ADVERSE EFFECTS... you would be taking a huge gamble and it is just not worth the risk... my advice is to test out any substance for the first time when it doesn't matter if you respond badly to it... if you respond positively then use it for your next set of exams... but that's just my opinion

that's a good point...that was my original plan when this was getting going last spring. but now i'll have to reconsider. thanks for sending them an update request for me.

[megatron]

thank you for the update, ScienceGuy. Do you know if they finished that week as they had hoped? It's about 2 weeks since then, any further info? I'm sorry for my impatience, just i'm in my crunch time right now for a huge exam in January

I have sent a message to the lab asking for an update. I will post here just as soon as I receive a reply.

However, I strongly advise against taking experimental drugs for the first time prior to an important exam... you have no idea whether you will be a positive responder and as with any drug there is always the risk of ADVERSE EFFECTS... you would be taking a huge gamble and it is just not worth the risk... my advice is to test out any substance for the first time when it doesn't matter if you respond badly to it... if you respond positively then use it for your next set of exams... but that's just my opinion

Would you perhaps ask how the ISRIB synthesis is going as well?

[ScienceGuy]

UPDATE:

Hi Everyone,

I have been chasing the lab regards ETA on their completing the synthesis and this is their reply:

I'm very sorry but there are still some issues on large scale. I was unable to keep up with correspondence due to personal reasons and I'm sorry for not informing you directly.

I understand your dissatisfaction, but I will continue work on this project until I succeed or you decide to not continue with this order.

To which I then asked them to provide a definitive confirmed completion date for the synthesis; wherein they has responded as follows:

First week of January is best I can think of.

I'm aware of other suppliers carrying PRL made in China. Different story, they have everything easily available and don't monitor for heavy metal contamination, don't require certificates for every substrate batch.

I'm deeply sorry for this situation.

I have responded making clear that the first week of January will need to be the absolute deadline and there must be no further delays or I will have no choice but to cancel the order. Worst case scenario if it comes to that (which I am hoping it won't) then I will refund everyone's money to them, and since the sum I have received is less then the sum paid (due to PAYPAL fees etc.) I would agree to repay everyone in full the sum that they paid, meaning I would personally take the hit for the PAYPAL fees (even though I did not in fact commence this GROUP BUY, but agreed to take it over from the person who started it at their request to help them out). However, I am very much hoping that it won't come to that; and to date this particular supplier has a track record of being 100% reliable. So watch this space and let's see what transpires first week in January...

And Happy Christmas everyone!

Would you perhaps ask how the ISRIB synthesis is going as well?

I did not place that order, so no can do. My involvement in the ISRIB GROUP BUY is solely assisting with the SHIPPING.

[3AlarmLampscooter]

So now that we're all accustomed to PRL-8-53, anyone have any progress on identifying the structure of PRL-8-147?

I ended up looking up most of Hansl's other patented molecules in pubchem, and failed to get any remotely relevant hits.

[Nattzor]

So now that we're all accustomed to PRL-8-53, anyone have any progress on identifying the structure of PRL-8-147?

I ended up looking up most of Hansl's other patented molecules in pubchem, and failed to get any remotely relevant hits.

His relative said he left behind three (!) garages filled with boxes of papers and the relative has not been able to look through everything (and it's Christmas now, doubt it'll be done now).

[mait]

Still. Even if we cant get PRL 8-147 synthesized the effects of Coluracetam + PRL 8-147 have outclassed anything else I have tried before in the field of nootropics. And I have tried almost all racetams class drugs available on internet.

[3AlarmLampscooter]

So now that we're all accustomed to PRL-8-53, anyone have any progress on identifying the structure of PRL-8-147?

I ended up looking up most of Hansl's other patented molecules in pubchem, and failed to get any remotely relevant hits.

His relative said he left behind three (!) garages filled with boxes of papers and the relative has not been able to look through everything (and it's Christmas now, doubt it'll be done now).

Geez, and I thought I had a lot of stuff in my basement...

Still. Even if we cant get PRL 8-147 synthesized the effects of Coluracetam + PRL 8-147 have outclassed anything else I have tried before in the field of nootropics. And I have tried almost all racetams class drugs available on internet.

Oh, we'll get PRL-8-147 one way or another, sooner or later. We've at least got the patent, and I'm assuming it was part of the same series and covered, therefor somewhere in there. It'll definitely be worth expending some serious capital on synthesis and animal testing if needed, assuming the claims of PRL-8-147 prove as true as those of PRL-8-53. From there, I so no reason someone can't pick up Hansl's work with all the technology and research for rational drug design that has come out in the intervening decades and move on to even more potent compounds.

Of course it would really help if we knew what exactly PRL-8-53 targeted...

[xks201]

That's if his family doesn't throw away all his papers.

[Nattzor]

That's if his family doesn't throw away all his papers.

They wont, they're also interested in finding PRL-8-147. I've almost considered giving them some money so they can hire someone to index everything digitally.

[xks201]

You could probably start a fund here if they actually will accept that offer.

[Reformed-Redan]

UPDATE:

Hi Everyone,

I have been chasing the lab regards ETA on their completing the synthesis and this is their reply:

I'm very sorry but there are still some issues on large scale. I was unable to keep up with correspondence due to personal reasons and I'm sorry for not informing you directly.

I understand your dissatisfaction, but I will continue work on this project until I succeed or you decide to not continue with this order.

To which I then asked them to provide a definitive confirmed completion date for the synthesis; wherein they has responded as follows:

First week of January is best I can think of.

I'm aware of other suppliers carrying PRL made in China. Different story, they have everything easily available and don't monitor for heavy metal contamination, don't require certificates for every substrate batch.

I'm deeply sorry for this situation.

I have responded making clear that the first week of January will need to be the absolute deadline and there must be no further delays or I will have no choice but to cancel the order. Worst case scenario if it comes to that (which I am hoping it won't) then I will refund everyone's money to them, and since the sum I have received is less then the sum paid (due to PAYPAL fees etc.) I would agree to repay everyone in full the sum that they paid, meaning I would personally take the hit for the PAYPAL fees (even though I did not in fact commence this GROUP BUY, but agreed to take it over from the person who started it at their request to help them out). However, I am very much hoping that it won't come to that; and to date this particular supplier has a track record of being 100% reliable. So watch this space and let's see what transpires first week in January...

And Happy Christmas everyone!

Would you perhaps ask how the ISRIB synthesis is going as well?

I did not place that order, so no can do. My involvement in the ISRIB GROUP BUY is solely assisting with the SHIPPING.

I see the the supplier is having a hard time with suppliers delivering things on time. I'd like to request that the ISRIB be cancelled alongside the PRL synthesis. I'm sorry. The existing participants will still get ISRIB albeight from a different supplier. Thanks.

[sparkk51]

UPDATE:

Hi Everyone,

I have been chasing the lab regards ETA on their completing the synthesis and this is their reply:

I'm very sorry but there are still some issues on large scale. I was unable to keep up with correspondence due to personal reasons and I'm sorry for not informing you directly.

I understand your dissatisfaction, but I will continue work on this project until I succeed or you decide to not continue with this order.

To which I then asked them to provide a definitive confirmed completion date for the synthesis; wherein they has responded as follows:

First week of January is best I can think of.

I'm aware of other suppliers carrying PRL made in China. Different story, they have everything easily available and don't monitor for heavy metal contamination, don't require certificates for every substrate batch.

I'm deeply sorry for this situation.

I have responded making clear that the first week of January will need to be the absolute deadline and there must be no further delays or I will have no choice but to cancel the order. Worst case scenario if it comes to that (which I am hoping it won't) then I will refund everyone's money to them, and since the sum I have received is less then the sum paid (due to PAYPAL fees etc.) I would agree to repay everyone in full the sum that they paid, meaning I would personally take the hit for the PAYPAL fees (even though I did not in fact commence this GROUP BUY, but agreed to take it over from the person who started it at their request to help them out). However, I am very much hoping that it won't come to that; and to date this particular supplier has a track record of being 100% reliable. So watch this space and let's see what transpires first week in January...

And Happy Christmas everyone!

Would you perhaps ask how the ISRIB synthesis is going as well?

I did not place that order, so no can do. My involvement in the ISRIB GROUP BUY is solely assisting with the SHIPPING.

I see the the supplier is having a hard time with suppliers delivering things on time. I'd like to request that the ISRIB be cancelled alongside the PRL synthesis. I'm sorry. The existing participants will still get ISRIB albeight from a different supplier. Thanks.

Why don't we just wait until the first week of January. That doesn't seem that far off.

[Nattzor]

You could probably start a fund here if they actually will accept that offer.

I asked them if they were willing to accept it to hire someone to digitalize it. Will update.

[ScienceGuy]

I see the the supplier is having a hard time with suppliers delivering things on time. I'd like to request that the ISRIB be cancelled alongside the PRL synthesis. I'm sorry. The existing participants will still get ISRIB albeight from a different supplier. Thanks.

Why don't we just wait until the first week of January. That doesn't seem that far off.

The right course of action here is to wait until the absolute deadline, namely close of business on 7th JANUARY 2014, has been reached and not to act prematurely. This is the proper way to act and as such is what will be happening here.

If the lab fails to complete the synthesis by close of business on 7th JANUARY 2014, then the order will be cancelled and I will be refunding everyone's money and personally will take the hit for all of the PAYPAL FEES (even though I did not in fact start this GROUP BUY but took it over when asked to by the person who did).

I have previously found this lab to deliver orders as per the requirement in every single instance, and in that respect they have to date been 100% reliable. Therefore, they deserve to be given the chance to complete the order.

Even so, I should point out that if this particular lab fails to deliver by the absolute deadline I for one will not be personally nor recommending anyone else use them ever again for any custom synthesis; and I have already told them this.

YADAYADA - Regards the ISRIB Group Buy, since you are managing that particular Group Buy it is entirely up to you how you wish to proceed. Whatever action you choose, please kindly note that I will still be very happy to assist you by managing the shipping. All I will require is the ISRIB bulk quantity, the participant list (including names and mailing addresses where to mail the individual samples), and the total shipping costs (= $145).

[Major Legend]

Hey I never received my batch of PRL...was it ever mailed to me?

Also I would add China is the biggest world producer of vitamin c, as well as countless other supplements and drugs, if they are really putting heavy metal in everything then alot of people would be dead or disabled by now.

China is a developing country and that means alot of issues remain unregulated, but the fact is they are world's manufacturer for pretty much everything, and most of the time they seem to be able to keep their standards consistent.

Edited by Major Legend, 24 December 2013 - 05:56 PM.

[sparkk51]

Hey I never received my batch of PRL...was it ever mailed to me?

Also I would add China is the biggest world producer of vitamin c, as well as countless other supplements and drugs, if they are really putting heavy metal in everything then alot of people would be dead or disabled by now.

China is a developing country and that means alot of issues remain unregulated, but the fact is they are world's manufacturer for pretty much everything, and most of the time they seem to be able to keep their standards consistent.

the PRL-8-53 from the group buy? Do you not read? No one has received theirs.

[Mr. Pink]

I have responded making clear that the first week of January will need to be the absolute deadline and there must be no further delays or I will have no choice but to cancel the order. Worst case scenario if it comes to that (which I am hoping it won't) then I will refund everyone's money to them, and since the sum I have received is less then the sum paid (due to PAYPAL fees etc.) I would agree to repay everyone in full the sum that they paid, meaning I would personally take the hit for the PAYPAL fees (even though I did not in fact commence this GROUP BUY, but agreed to take it over from the person who started it at their request to help them out). However, I am very much hoping that it won't come to that; and to date this particular supplier has a track record of being 100% reliable. So watch this space and let's see what transpires first week in January...

well, at least we'll know 1st week of next year, one way or another. guess i'll order the chinese crap. thanks science guy