1725 replies to this topic

[Amorphous]

ScienceGuy,
Is there a possibility to ask the custom synthesis lab to try making prl 8-147 instead? How difference is the molecules?
If it is not difficult to convert prl 8-53 to 8-147, maybe the lab would do it.......I am just asking..... or we can start the next group-buy?

[Nattzor]

ScienceGuy,
Is there a possibility to ask the custom synthesis lab to try making prl 8-147 instead? How difference is the molecules?
If it is not difficult to convert prl 8-53 to 8-147, maybe the lab would do it.......I am just asking..... or we can start the next group-buy?

We know 0% about PRL-8-147, so no, we cannot produce it.

[Reformed-Redan]

Important to remember that the biggest gains were seen in information retained for a week, not short term memory.

This,

the primary benefit from this compound that differentiated it from everything else I have tried is the retention component. I can still recall the conversation very vividly in terms of verbal memory with my dad over Facebook. It's a subjective report nevertheless; but, its the only thing that really stands out. Apart from that I don't even know if IDRA-21 really helped at all. I only noticed a slight weird antidepressant effect from IDRA-21 and a headache in the lower part of my head.

[researchist]

I have not been following this thread like I should. I know there is one buy in manufacturing now. Is there a second buy? I would definitely like to get in on prl-8-147 rather than prl-8-53 if that is going to happen!

[jly1986]

I have not been following this thread like I should. I know there is one buy in manufacturing now. Is there a second buy? I would definitely like to get in on prl-8-147 rather than prl-8-53 if that is going to happen!

You can order it from Newstar Nootropics.

[MangekyōPeter]

I have not been following this thread like I should. I know there is one buy in manufacturing now. Is there a second buy? I would definitely like to get in on prl-8-147 rather than prl-8-53 if that is going to happen!

You can order it from Newstar Nootropics.

Actually you CAN'T get prl-8-147 from NSN as they don't have it.

Edited by marekso, 08 November 2013 - 09:19 PM.

[Artificiality]

Important to remember that the biggest gains were seen in information retained for a week, not short term memory.

This,

the primary benefit from this compound that differentiated it from everything else I have tried is the retention component. I can still recall the conversation very vividly in terms of verbal memory with my dad over Facebook. It's a subjective report nevertheless; but, its the only thing that really stands out. Apart from that I don't even know if IDRA-21 really helped at all. I only noticed a slight weird antidepressant effect from IDRA-21 and a headache in the lower part of my head.

Sorry, just checking, but did you mean PLR 8-53 when you said IDRA-21, or are you actually referring to IDRA-21?

[jly1986]

<p>

<br />

<br />

<br />
I have not been following this thread like I should. I know there is one buy in manufacturing now. Is there a second buy? I would definitely like to get in on prl-8-147 rather than prl-8-53 if that is going to happen!<br />

<br />
<br />
You can order it from Newstar Nootropics.<br />

<br />
<br />
Actually you CAN'T get prl-8-147 from NSN as they don't have it.<br />

<br />
<br />
</p>

I was referring to PRL 8-53.
To my knowledge, that's the only one.
There is no PRL 8-147. Someone somewhere at some point in time used the number 8-147 when he meant 8-53.

Edited by jly1986, 08 November 2013 - 11:15 PM.

[Nattzor]

I was referring to PLR 8-53.
To my knowledge, that's the only one.
There is no PLR 8-147. Someone somewhere at some point in time used the number 8-147 when he meant 8-53.

There is PRL (it's PRL, not PLR) 8-147 afaik.

"A similar substance created by the same creator Dr. Nikolas R Hanis, called PRL 8-147, was studied in the early 1980’s at the University of Colorado at Boulder. Though not as widely-tested (PRL 8-147 never passed rodent testing), it is similar in function and structure."

[jly1986]

I was referring to PLR 8-53.
To my knowledge, that's the only one.
There is no PLR 8-147. Someone somewhere at some point in time used the number 8-147 when he meant 8-53.

There is PRL (it's PRL, not PLR) 8-147 afaik.

"A similar substance created by the same creator Dr. Nikolas R Hanis, called PRL 8-147, was studied in the early 1980’s at the University of Colorado at Boulder. Though not as widely-tested (PRL 8-147 never passed rodent testing), it is similar in function and structure."

I believe whoever wrote that quote got his information from the errant website that mistakenly mixed up PRL 8-53 and 8-147. There are no published studies on "147" in rats or humans, only for 53.

[Nattzor]

I believe whoever wrote that quote got his information from the errant website that mistakenly mixed up PRL 8-53 and 8-147. There are no published studies on "147" in rats or humans, only for 53.

Nope, I'm talking to a relative of Dr. Hansl who said that he made a stronger compound a few years later. 1980 = few years later.

They do not claim any published studies, just studies. I'm fairly sure they did more studies on PRL-8-53 than 1 (or two), they got way more data than that. Iirc, I've also read about PRL-8-147 somewhere else, so it should exist.

[Reformed-Redan]

Important to remember that the biggest gains were seen in information retained for a week, not short term memory.

This,

the primary benefit from this compound that differentiated it from everything else I have tried is the retention component. I can still recall the conversation very vividly in terms of verbal memory with my dad over Facebook. It's a subjective report nevertheless; but, its the only thing that really stands out. Apart from that I don't even know if IDRA-21 really helped at all. I only noticed a slight weird antidepressant effect from IDRA-21 and a headache in the lower part of my head.

Sorry, just checking, but did you mean PLR 8-53 when you said IDRA-21, or are you actually referring to IDRA-21?

No, I was comparing IDRA-21 with PRL-8-53. As it stands PRL is a better nootropic IMHO; though I did get a headache the day after PRL use. Choline?

[mait]

I believe whoever wrote that quote got his information from the errant website that mistakenly mixed up PRL 8-53 and 8-147. There are no published studies on "147" in rats or humans, only for 53.

Nope, I'm talking to a relative of Dr. Hansl who said that he made a stronger compound a few years later. 1980 = few years later.

They do not claim any published studies, just studies. I'm fairly sure they did more studies on PRL-8-53 than 1 (or two), they got way more data than that. Iirc, I've also read about PRL-8-147 somewhere else, so it should exist.

Did they take the patent on this PRL 8-147 compound? Maybe this would lead us further? It seems that Dr Hansl has 2 patents:

https://www.google.c...ved=0CDkQ6AEwAA
https://www.google.c...ved=0CEAQ6AEwAQ

The first patent of two mentioned above describes in plural the benzoic acid amides that also includes PRL-8-53. So I would imagine that PRL-8-147 also hides somewhere in this patent.

But lets not get ahead of things here. We have new compound at hand and we should finish the things here first by answering:
a) how does PRL-8-53 change LTM, STM and WM, when quantitative tests are used (both the effects of acute and chronic dosing should be mapped);
b) are there any side-effects;
c) people here are using varying doses of PRL-8-53 so maybe we can derive some answer to the most effective dose.

Edited by mait, 09 November 2013 - 12:25 AM.

[telight]

Important to remember that the biggest gains were seen in information retained for a week, not short term memory.

This,

the primary benefit from this compound that differentiated it from everything else I have tried is the retention component. I can still recall the conversation very vividly in terms of verbal memory with my dad over Facebook. It's a subjective report nevertheless; but, its the only thing that really stands out. Apart from that I don't even know if IDRA-21 really helped at all. I only noticed a slight weird antidepressant effect from IDRA-21 and a headache in the lower part of my head.

Sorry, just checking, but did you mean PLR 8-53 when you said IDRA-21, or are you actually referring to IDRA-21?

No, I was comparing IDRA-21 with PRL-8-53. As it stands PRL is a better nootropic IMHO; though I did get a headache the day after PRL use. Choline?

Maybe it was a coincidence. I have tried PRL 8-53 and IDRA-21 and came to the same conclusions as you. IDRA-21 is a potent mood altering drug that produces consistent side effects (nearly everyone reported headaches when on IDRA-21). PRL 8-53 on the other hand is a subtle drug that improves recall significantly (will do some tests to quantify this). I wouldn't say that it increased my working memory very much but it did make recalling memories formed on it quite easily.

As for your headache, I have never had a headache with this substance and I was using it at 10mg BID for 3 days now. I would be curious to know if you continue to get headaches after every time you dose.

Edited by telight, 09 November 2013 - 12:47 AM.

[3AlarmLampscooter]

Interesting stuff. I don't know if PRL-8-147 is specifically described in either of those patents, but I would be extremely interested in finding out the properties of a lot of the example pyrrolidine compounds, and wouldn't be shocked if one of them were in fact PRL-8-147.

[Godof Smallthings]

So, a hypothetical test for somebody who really wants to try this out would be to read 10 pages of text before taking the compound, then try to write that text down from memory as accurately as possible 1 week later.

After that, take another similar 10 page text when on PRL-8-53 and try writing it down 1 week later. Compare number of errors.

If you pick a subject you are really interested in and want to learn more about, this should be a useful test as well.

[xks201]

Okay so one dose was used on humans that they based all these positive effects on, correct? Imagine if someone took this daily for like a month or more. Lol. Im on selegine too and I think it may be potentiating it.

[Amorphous]

Did anyone get any improvement in their n-back game? or any improvement of working memory?

Did anyone get any improvement in their n-back game? or any improvement of working memory?

[phil8462643]

Did anyone get any improvement in their n-back game? or any improvement of working memory?

Did anyone get any improvement in their n-back game? or any improvement of working memory?

did anybody try?

[mait]

Did anyone get any improvement in their n-back game? or any improvement of working memory?

Did anyone get any improvement in their n-back game? or any improvement of working memory?

did anybody try?

I know my monkey ladder peak score (1 month testing and - plateau reached), digit span peak score (1 month testing -plateau reached) and dual n-back peak score (weekly testing / training for 1 year - plateau reached).

Here are my results: monkey ladder 7
Digit span: 7
Dual n-back: 70% right at dual-3-back (Brainworkshop program gives n-back level at 3.5-3.8).

As You can see I am pretty retarded, when it comes to WM and I feel my constraints in situations when I have to do mental rotations or calculus. I am in for 2.53g of this stuff from SG and also ordered 0,25g form NSN. I am certain that I would pick up the effects of PRL-8-53 on WM if they exist.

Edited by mait, 09 November 2013 - 02:08 PM.

[Nattzor]

Did anyone get any improvement in their n-back game? or any improvement of working memory?

Did anyone get any improvement in their n-back game? or any improvement of working memory?

Check the 3-4 latest pages, 2 or 3 have tried digit span memory with no improvement.

Edited by Nattzor, 09 November 2013 - 02:02 PM.

[Introspecta]

Why didn't you guys make a new thread for PLR 8 143. I hadn't been following this thread and now realize people are posting experiences with PLR 8 in here. Just a suggestion so if new people come around and want to seek info.

Edited by joelski28, 09 November 2013 - 02:20 PM.

[jly1986]

Why didn't you guys make a new thread for PLR 8 143. I hadn't been following this thread and now realize people are posting experiences with PLR 8 in here. Just a suggestion so if new people come around and want to seek info.

I think "147" is basically synonymous with "53" in referring to the PRL 8-53 substance. Search for either and you get the same results. The only actual nootropic is 53. The 147 was a mistaken reference somewhere online. You can actually trace the origin of the misnumbering by searching for "PRL 8-147."

[Nattzor]

Why didn't you guys make a new thread for PLR 8 143. I hadn't been following this thread and now realize people are posting experiences with PLR 8 in here. Just a suggestion so if new people come around and want to seek info.

I think "147" is basically synonymous with "53" in referring to the PRL 8-53 substance. Search for either and you get the same results. The only actual nootropic is 53. The 147 was a mistaken reference somewhere online. You can actually trace the origin of the misnumbering by searching for "PRL 8-147."

Again, 147 exists, we just don't know the structure and the studies lack. Maybe not under that exact name (though I think it is that name), but it's a "more powerful" PRL-8-53.

Edited by Nattzor, 09 November 2013 - 06:38 PM.

[MizTen]

Why didn't you guys make a new thread for PLR 8 143. I hadn't been following this thread and now realize people are posting experiences with PLR 8 in here. Just a suggestion so if new people come around and want to seek info.

If you mean PRL-8-53, rather than PLR 8 143, that thread is here:

http://www.longecity...-53-Experiences

[Nattzor]

Why didn't you guys make a new thread for PLR 8 143. I hadn't been following this thread and now realize people are posting experiences with PLR 8 in here. Just a suggestion so if new people come around and want to seek info.

If you mean PRL-8-53, rather than PLR 8 143, that thread is here:

http://www.longecity...-53-Experiences

This thread has been about PRL-8-53 since the first page or so, we could just change the title.

[MizTen]

Why didn't you guys make a new thread for PLR 8 143. I hadn't been following this thread and now realize people are posting experiences with PLR 8 in here. Just a suggestion so if new people come around and want to seek info.

If you mean PRL-8-53, rather than PLR 8 143, that thread is here:

http://www.longecity...-53-Experiences

Yeah, that might be helpful...

[Wu Hang]

if 8-147 can be made from the existing document we had, then great I wouldn't hesistate to test it to my newly bought rat. I have doubted the possibilities before, because it has never been patented, however I might be wrong

[Introspecta]

Oh thanks Mizten. I never really go in the section listed supplements. I always go in Brain Health. Seems kinda pointless to have all these different subforums with pretty much all similiar topics but thats just my opinion. I was gonna start a plr 8-53 in this subforum so everyone can see it but now that there is one in the supplements I don't know. Yeah if the OP can change the headline that would be good if thats even possible if not oh well.

[MizTen]

Oh thanks Mizten. I never really go in the section listed supplements. I always go in Brain Health. Seems kinda pointless to have all these different subforums with pretty much all similiar topics but thats just my opinion. I was gonna start a plr 8-53 in this subforum so everyone can see it but now that there is one in the supplements I don't know. Yeah if the OP can change the headline that would be good if thats even possible if not oh well.

Yes, I saw after the fact that it was in the Supplement section. So sorry if my post was misleading.

I'm fine with however the posted info on Longecity's boards plays out in terms of actually finding some guidance and correlations. It is what it is...