1725 replies to this topic

[Breezey]

Got the first hard data on PRL-8-53 improving long term memory. I felt like the clinical trial was poorly designed to assess gains in higher performing individuals. I came up with a modified version of it.

Had a friend generate two lists of 100 pseudorandom 6 letter words, with a 50-word sublist for each. Made two pills, one with 5mg PRL-8-53 mixed with baking soda, the other only baking soda.

On the first day, I took pill A and waited an hour. Then was studied 50 word sublist A for 5 minutes. At 24h after, I tried to pick out the 50 words on the sublist out of 100 item wordlist A. I correctly identified 21 of them.

After waiting another day, I repeated the procedure with pill B and sublist+wordlist B, again trying to pick out the words at t=24h. This time I scored 48.

I'll let you guess which one was placebo

Protip: Placebo does not result in 228% of baseline performance on memory retention

I'll have to repeat this study with larger doses, and larger wordlists/different datasets.

Edit: Should add this was still on 5mg Selegiline daily. This may be effecting results to some degree.
Should also add I ran tests on short term memory for digit retention. Scored 11 on placebo and 12 on PRL. Clearly I'm a high preformer, and clearly PRL isn't doing much if anything there. Had much better results with Sunifiram on improving digit retention.

Hey 3AlarmLampscooter, try picking out the words from list A and B again and see what results you get. And tell us how old you are if you don't mind. Are you prescribed selegiline? Why do you take it?

Edited by Breezey, 17 November 2013 - 02:59 PM.

[3AlarmLampscooter]

Got the first hard data on PRL-8-53 improving long term memory. I felt like the clinical trial was poorly designed to assess gains in higher performing individuals. I came up with a modified version of it.

Had a friend generate two lists of 100 pseudorandom 6 letter words, with a 50-word sublist for each. Made two pills, one with 5mg PRL-8-53 mixed with baking soda, the other only baking soda.

On the first day, I took pill A and waited an hour. Then was studied 50 word sublist A for 5 minutes. At 24h after, I tried to pick out the 50 words on the sublist out of 100 item wordlist A. I correctly identified 21 of them.

After waiting another day, I repeated the procedure with pill B and sublist+wordlist B, again trying to pick out the words at t=24h. This time I scored 48.

I'll let you guess which one was placebo

Protip: Placebo does not result in 228% of baseline performance on memory retention

I'll have to repeat this study with larger doses, and larger wordlists/different datasets.

Edit: Should add this was still on 5mg Selegiline daily. This may be effecting results to some degree.
Should also add I ran tests on short term memory for digit retention. Scored 11 on placebo and 12 on PRL. Clearly I'm a high preformer, and clearly PRL isn't doing much if anything there. Had much better results with Sunifiram on improving digit retention.

Hey 3AlarmLampscooter, try picking out the words from list A and B again and see what results you get. And tell us how old you are if you don't mind. Are you prescribed selegiline? Why do you take it?

Interesting idea! I got 17 on A and 39 on B. Scary how much useless information my brain is in fact holding onto

I had not looked at the lists in between the tests and now.

I'm in my early 20s, and take selegiline for neurprotection/life extension plus to potentiate stimulants.

[tiger858]

Does anyone get a numb tongue after taking this sublingually? how are you guys taking yours ?

[deadkenny64]

Does anyone get a numb tongue after taking this sublingually? how are you guys taking yours ?

Yes, it seems to last for about 15 minutes. I tried both oral and sublingual and the oral dose didn't seem to have much effect where the sublingual was noticable. I am currently taking 5 mg once a day for only 3 days a week until there is more info on long term effects and tolerance.

I have to say that for me, this is the best nootropic I have tried. It gives me a level of focus and clarity not experienced before. Also taking 1 mg of Hydergine daily. So far I have tried piracetam, oxiracetam, noopept, sunifiram, unifiram and coluracetam. This seems to be in a different league.

[mf6lol5]

Has anyone experienced the 21 item short term memory?

Has anyone experienced the 21 item short term memory?

[boythatssomebreath]

The first time I took PRL at 5 mg, it blew me away - only for a couple hours - but, it was great. I have been taking three day breaks between each dose, and am to the point now that it really does nothing for me, even at 10 - 15mg doses twice a day . Per the recommendation of 3Alarm, I am going to mix with Coluracetam (whenever NSN has it back in stock). I have not seen an increase in memory as many have reported. Has anyone tried with CILTEP yet?

[Isochroma]

Tolerance, as I expected.

It's an H3 Histamine inverse agonist so I expect upregulation of endogenous H3 agonist(s).

[stponky]

The first time I took PRL at 5 mg, it blew me away - only for a couple hours - but, it was great. I have been taking three day breaks between each dose, and am to the point now that it really does nothing for me, even at 10 - 15mg doses twice a day . Per the recommendation of 3Alarm, I am going to mix with Coluracetam (whenever NSN has it back in stock). I have not seen an increase in memory as many have reported. Has anyone tried with CILTEP yet?

I have been taking it during the week days for about a week now. 5-10mg in the morning. First day was ok. When I was going to sleep I remembered a guy's name I hadn't thought of in over 10 years. However, now, I have no reaction. Hopefully, I don't crash when I stop taking it.

Edit: I am not taking it with anything else. Just vitamins (B6, B12, Folic Acid, CoQ10, Omega3, Phosphatidyl Choline).

I find it hard to believe this is the most powerful memory enhancer.

Edit 2: I was taking it orally mixed in water. Maybe this is where I am going wrong. However, today I did try sublingual. I will keep trying it that way.

Edited by stponky, 22 November 2013 - 05:21 AM.

[blood]

The first time I took PRL at 5 mg, it blew me away - only for a couple hours - but, it was great.

When you say it "blew you away" do you mean you got a stimulant effect, like a good cup of coffee?

Or do you mean there was a sudden increase in feelings of wellbeing?

Or a sudden increase in the performance of your memory?

[mf6lol5]

So far it seems the PRL 8-147 isn't holding up to our expectations.

[Nattzor]

Tolerance, as I expected.

It's an H3 Histamine inverse agonist so I expect upregulation of endogenous H3 agonist(s).

[Citation needed]

So far it seems the PRL 8-147 isn't holding up to our expectations.

1. It's PRL-8-53, not PRL-8-147.
2. Only ONE person have done any serious testing with it and he got great results. That the rest of the people want to "feel" it like a stimulant is quite irrelevant. Would be good if more people actuall quanitifed it.

[mf6lol5]

Tolerance, as I expected.

It's an H3 Histamine inverse agonist so I expect upregulation of endogenous H3 agonist(s).

[Citation needed]

So far it seems the PRL 8-147 isn't holding up to our expectations.

1. It's PRL-8-53, not PRL-8-147.
2. Only ONE person have done any serious testing with it and he got great results. That the rest of the people want to "feel" it like a stimulant is quite irrelevant. Would be good if more people actuall quanitifed it.

Great Results as in an extremely powerful memory? or just slightly noticable effects on memory?

[Nattzor]

Great Results as in an extremely powerful memory? or just slightly noticable effects on memory?

As in 128% over baseline.

[mf6lol5]

Sounds like it's living up to it's 1970's study

[mait]

Got my PRL-8-53 from NSN. 10mg subliminally and: no increase in digit span (7), monkey ladder (8) or spacial span (7). Slight increase in grammatical reasoning 18 -> 21. I by and large had reached my ceiling in those Cambridge Brain Sciences site's tests. Confounding factor is lack of sleep today that usually decreases my mental performance quite a bit - PRL-8-53 seems to be working well to counteract this effect. Subjective feeling is increased clear headiness and ability to concentrate.

Edited by mait, 22 November 2013 - 03:23 PM.

[Ragin87]

Got my PRL-8-53 from NSN. 10mg subliminally and: no increase in digit span (7), monkey ladder (8) or spacial span (7). Slight increase in grammatical reasoning 18 -> 21. I by and large had reached my ceiling in those Cambridge Brain Sciences site's tests. Confounding factor is lack of sleep today that usually decreases my mental performance quite a bit - PRL-8-53 seems to be working well to counteract this effect. Subjective feeling is increased clear headiness and ability to concentrate.

Relatively similar experience for me as well at 10 mg, although my digit span did have an increase from 8->10 and I do believe that is statistically significant. However, much like 3Alarm, I am on a host of other nootropics/medications that are very similar to his with the exception of colouracetam. Thus, in the pursuit of isolating the effects(quantitative, subjective, and hopefully a mechanism of action) of PRL-8-53 I believe my data should only be relied upon if necessary as I am not exactly standardizing and controlling for error. My experiences may lend some credibility to 3Alarms theory on the synergy between colouracetam, PRL-8-53, and amphetamine derivatives(as I am on D-amphetamine), but I would need to get a hold of some colouracetam to acquire adequate data for that.

side note: I did experience significant numbing on the tongue and sublingual areas of my mouth when dosing sublingually, but this seems to be quite common.

Edited by Ragin87, 22 November 2013 - 08:45 PM.

[boythatssomebreath]

Tolerance, as I expected.

It's an H3 Histamine inverse agonist so I expect upregulation of endogenous H3 agonist(s).

[Citation needed]

So far it seems the PRL 8-147 isn't holding up to our expectations.

1. It's PRL-8-53, not PRL-8-147.
2. Only ONE person have done any serious testing with it and he got great results. That the rest of the people want to "feel" it like a stimulant is quite irrelevant. Would be good if more people actuall quanitifed it.

Excuse me there, sir. Why are you making assumptions that I have not quantified my results of PRL-8-53? I, like Mait, have found no gains of any kind WHILE TAKING PRL BY ITSELF. Have taken 5, 10, and 15 mg (capped) and have seen no increase in digit span, monkey ladder, or spacial span. 3Alarm is experiencing gains, but is also on a substantial amount of other substances. As I have noted above, I am going to test as a stack with Coluracetam. I am just not seeing the gains that were reported in the 1970's study - some may experience these gains (lucky bastards), but I have not.

[boythatssomebreath]

The first time I took PRL at 5 mg, it blew me away - only for a couple hours - but, it was great.

When you say it "blew you away" do you mean you got a stimulant effect, like a good cup of coffee?

Or do you mean there was a sudden increase in feelings of wellbeing?

Or a sudden increase in the performance of your memory?

The first time I took it (@5 mg, with no other noots of any kind), I did not perform any official testing, but actually "felt" more than I experience of my typical stack (the "Ten months of Research Stack") which consists of about seven different substances totaling many thousands of milligrams. I had an earlier post noting my experiences that morning which you can read. Yes, kind of like a nice very clean caffeine feel to it. Large gain in verbal fluency, an overall since of great confidence, and an ability to solve complicated problems with ease (I'm an engineer in the defense / space industry). Lasted about three hours, and has never been felt again...sigh...

[mf6lol5]

So, for the majority, this Prl 8153 isn't living up to expectations. If it does nothing without stacking it with something then why take it? I am also curious to how some people experience fantastic results while others feel moderate to low even no results.

[Nattzor]

Excuse me there, sir. Why are you making assumptions that I have not quantified my results of PRL-8-53? I, like Mait, have found no gains of any kind WHILE TAKING PRL BY ITSELF. Have taken 5, 10, and 15 mg (capped) and have seen no increase in digit span, monkey ladder, or spacial span. 3Alarm is experiencing gains, but is also on a substantial amount of other substances. As I have noted above, I am going to test as a stack with Coluracetam. I am just not seeing the gains that were reported in the 1970's study - some may experience these gains (lucky bastards), but I have not.

Your quantifying the wrong things. PRL was not studied, at all, for digit span memory, it was studied for long term memory. 3Alarm didn't use a super big stack when he tried the long-term memory thing, only PRL + Selengile (iirc) and some basics.

No one has noticed digit span increase from just PRL (or well, maybe 2), but the drug was not designed for that. If those were the effects you wanted I can agree that it didn't work, for that.

[NG_F]

So, for the majority, this Prl 8153 isn't living up to expectations. If it does nothing without stacking it with something then why take it? I am also curious to how some people experience fantastic results while others feel moderate to low even no results.

It's simple some of those people which are a Minority probably have some sort of affiliation with this nootropic.They have an agenda to promote. One of the popular Noot suppliers are the rare few that are carrying this item..NSN..Need I say more??
Yet they've been taking Too long IMO to get some Ani and colu back. I mean Ani? Really? I can see colu as even NM is on back order. I got my 3gms just in time though. I hope they get some more in faster then NSN ever could, so I experience no down/lag time

[3AlarmLampscooter]

Yes, I've definitely noticed PRL-1-853 has helped my memory. In fact, before I started the PRL-47-8, I couldn't even remember the name of what drugs I took. Since I started on the RLP-47-53-1, I've been able to memorize entire textbooks in a few minutes, like the autistic savant Daniel Peek... or was it Kim Tammet?

EDIT: That was a joke! Please don't downvote for a bit of lighthearted humor poking fun at all the people who can't seem to figure out the name of the drug we're discussing!

In all seriousness though, I should again remind everyone that my trails were conducted while on Selegiline. And also that PRL-8-53+selegiline failed improve my digit span (although it did improve long term retention 128%), although adding in coluracetam did, and tianeptine+armodafinil+coluracetam+2-fma+clonidine even more (despite none of them except coluracetam having their own significant increases).

Edited by 3AlarmLampscooter, 23 November 2013 - 07:33 PM.

[Isochroma]

PRL-47-8?
RLP-47-53-1?

Apparently your memory ain't what you claim it is.
It seems the two nonexistent molecules in your post above are not helping you which itself is quite reasonable.

[3AlarmLampscooter]

PRL-47-8?
RLP-47-53-1?

Apparently your memory ain't what you claim it is.
It seems the two nonexistent molecules in your post above are not helping you which itself is quite reasonable.

But that's the joke... *facepalm*

[chemicalambrosia]

What is the half-life of this stuff, and are there active metabolites? 3alarm, it could have been downstream effects or a buildup effect instead of a bunch of synergistic compounds together. I don't know too much about this and I'm just throwing that out there, for what its worth. I bought a little of this RLP-47-53-1 and I've got memory problems of my own, but want to wait a while before I try it out of caution.

[stponky]

What is the half-life of this stuff, and are there active metabolites? 3alarm, it could have been downstream effects or a buildup effect instead of a bunch of synergistic compounds together. I don't know too much about this and I'm just throwing that out there, for what its worth. I bought a little of this RLP-47-53-1 and I've got memory problems of my own, but want to wait a while before I try it out of caution.

Yeah, it would be interesting to know as well. For some pre-workouts they use vitamin C (?not sure?) to draw out the metabolism time. I think something like that for PRL would be useful.

Also, there are a lot of variables for noots. The same person on the same dose might behave very differently if they had a good night's sleep vs. poor sleep.

I also find that stimulants don't have as much effect on me when I take magnesium (Magceutics).

Edited by stponky, 23 November 2013 - 10:00 PM.

[xsiv1]

Edit: watching thread closely

Edited by xsiv1, 23 November 2013 - 10:19 PM.

[Guacamolium]

So far it seems the PRL 8-147 isn't holding up to our expectations.

Wow. that's surprising.

/s

[3AlarmLampscooter]

What is the half-life of this stuff, and are there active metabolites? 3alarm, it could have been downstream effects or a buildup effect instead of a bunch of synergistic compounds together. I don't know too much about this and I'm just throwing that out there, for what its worth. I bought a little of this RLP-47-53-1 and I've got memory problems of my own, but want to wait a while before I try it out of caution.

Interesting thought actually. I'm not sure exactly. Hansl's paper did indeed mention active metabolites, I believe one of them was hydroxylated.

[m0sy]

Just received 500mg of PRL-8-53. My first test will be in determining the best mode of administration (oral vs. sublingual) at 10mg doses. As well, I will post any other notable observations while taking PRL-8-53.