6219 replies to this topic

[sunshinefrost]

*** participants***

Hadorra
Science guy*********************** UK
Sunshinefrost**********************Canada
Izan82****************************Netherlands
Rior
Peakplasma************************Canada
Zeroskater6979
Spookytooth***********************Germany
OpaqueMind***********************UK
Redan ****************************USA
Daouda ***************************France
Golden1***************************KimJung USA
Mait
Colli******************************UK
Metagene *************************USA
Hebbeh***************************USA
Rikelme***************************USA
Sparkk51 **************************USA
Megatrone*************************Norway
Mastermind 57 *********************USA
Nero.
Brand22
Q did it***************************USA
Telight ***************************USA
Vtsimple**************************USA
Artificiality
Lostfalco
Psionic****************************Czech Republic
Lourdaud**************************Sweden
Meatsauce ************************ USA
Crusader.
Major legend***********************Hong Kong
Metamind *************************Germany
Baronjpetor 1***********************Mexico
Psychopath*************************Slovakia
Damnedowl ************************Germany
Z85*******************************USA
Trophic *************************** USA
Sub-Rx
Therein****************************USA--------------à 40th
Werper****************************USA
Neurogenesis factor *****************Canada
Kyle Mcgill************************ Canada

[Xenix]

what is this NSI-189? i wish i could see molecular structure.


Im confused, it is a SSRI?

It is not a SSRI

.

Hey, I'm just curious where you found that molecular structure of NSI-189? I can't find it anywhere else except on this thread.

If you're not full, or have some people drop out from the group buy, consider me in. I live in Australia.

Edited by Xenix, 18 April 2013 - 08:23 PM.

[brand2]

USA

[mait]

Estonia

[zeroskater6979]

Guys please forgive me, but I've recently run into financial troubles that will preclude me from participating, (which really pisses me off). Perhaps once I regain my footing, I can buy some NSI from Science Guy's surplus purchase, however I don't want to set a precedent or presume that I can get away with taking advantage of S.G.'s generosity that a lot of us so far have experienced.

[Rior]

This thread moves so damn quickly. USA here, looking forward to this going through

[Artificiality]

USA

[Nero]

USA

Edited by Nero, 19 April 2013 - 02:39 AM.

[sunshinefrost]

Alright the account is created on payitsquare. You can now create an account and find my page. The page is called: "enhance your memory".
I had hoped for friday, and here we are

i'll update the list soon with the payments i see as they come in.

Edited by sunshinefrost, 19 April 2013 - 03:43 AM.

[daouda]

So what are we supposed to send? 136.25 USD? No little extra for the cost of shipping the bulk order to scienceguy?
When I get to the page it says "the amount is still to be determined" and "amount due per person : 25 dollars/choose qtty" . I think some things are still missing

Edited by daouda, 19 April 2013 - 03:54 AM.

[crusader]

United States

[sunshinefrost]

Hold on. I still need to set something on the page. The payments should start tomorow. Sorry about that...

[z85]

I'm not able to find the page called "enhance your memory" on payitsquare, sunshinefrost have you temporarily removed the page while you finish setting it up?

[Q did it!]

Just sing in and go to the search tab and post the tittle in the search bar that will come up.

Attached Files

•  Capture.PNG   128.51KB   44 downloads

[sunshinefrost]

The page isnt ready. It will be tomorow morning. I have a minor bug.

[ScienceGuy]

Hi Everyone,

Sorry for pulling a brief vanishing act... I just finished a 41-HOUR DAY

In case there are any issues regards everyone paying via PAYITSQUARE, just to let everyone know that we do have a PLAN B to fall back on, in that I already have a VERIFIED PAYPAL account and it would most certainly be possible for everyone to pay the US$136.25 for their 2.5 GRAMS NSI-189 directly to me via PAYPAL

Please kindly note that my PAYPAL ACCOUNT has been active for a very long time period and is well used; and so none of the issues that occur with attempting to gather together monies for a GROUP BUY using a NEW PAYPAL ACCOUNT (which has all sorts of restrictions until it has been frequently used for a while) should occur

I should point out that this has a COST IMPLICATION since payment via PAYPAL incurs a higher TRANSACTION FEE than PAY-IT-SQUARE

ScienceGuy do you ve a verified paypal account?

YES

what is this NSI-189? i wish i could see molecular structure.


Im confused, it is a SSRI?

It is not a SSRI

.

Hey, I'm just curious where you found that molecular structure of NSI-189?

The PATENT DOCUMENTATION... I attached it as a DOWNLOADABLE FILE in one of my earlier posts in this thread

[hadora]

Hi Everyone,

Sorry for pulling a brief vanishing act... I just finished a 41-HOUR DAY

In case there are any issues regards everyone paying via PAYITSQUARE, just to let everyone know that we do have a PLAN B to fall back on, in that I already have a VERIFIED PAYPAL account and it would most certainly be possible for everyone to pay the US$136.25 for their 2.5 GRAMS NSI-189 directly to me via PAYPAL

Please kindly note that my PAYPAL ACCOUNT has been active for a very long time period and is well used; and so none of the issues that occur with attempting to gather together monies for a GROUP BUY using a NEW PAYPAL ACCOUNT (which has all sorts of restrictions until it has been frequently used for a while) should occur

I should point out that this has a COST IMPLICATION since payment via PAYPAL incurs a higher TRANSACTION FEE than PAY-IT-SQUARE

ScienceGuy do you ve a verified paypal account?

YES

what is this NSI-189? i wish i could see molecular structure.


Im confused, it is a SSRI?

It is not a SSRI

.

Hey, I'm just curious where you found that molecular structure of NSI-189?

The PATENT DOCUMENTATION... I attached it as a DOWNLOADABLE FILE in one of my earlier posts in this thread

hey ScienceGuy, can your company give you the synthesis route they use ?

[shields_05]

If there's still room or anyone has to bow out, I'll gladly take a spot.

I'm from Australia. I'd be happy to help out with the distribution in this part of the world too.

[Xenix]

From what I've read, the key to our intelligence is not the number or size of neurons but the connections between them.

It seems that people planning on using NSI purely for cognitive enhancement may be a little disappointed. Sure, NSI has amazing potential if the 20% hippocampus increase of size claim is true - permanent enhancement sounds great - but that sounds like it's involved mostly with the potential to stimulate neurogenesis - not neuronal connections/synapse formation.

I'm aware that the brain has MANY billions of neurons, and some (potential) hundred of thousands of potential neurons are killed off by the brain everyday... so neurogenesis could hopefully save those neurons from 'suicide' produced by the hippocampus (or elswhere).

So what I'm wondering is if NSI could help produce enough neurogenesis to make a noticeable difference (saving several hundreds of thousands of potentially new neurons a day from dying) in everyday cognitive functioning; it sounds like a lot of neuronal growth/preservation, but, relatively speaking, it's pretty small.

But this is where it gets interesting - if NSI lives up to the hype and is combined with a compound like Dihexa (which MAY significantly increase synapse formation), something *AMAZING* may be waiting around the corner for us - neurogenesis AND synaptogenesis - wowza.

[meatsauce]

But this is where it gets interesting - if NSI lives up to the hype and is combined with a compound like Dihexa (which MAY significantly increase synapse formation), something *AMAZING* may be waiting around the corner for us - neurogenesis AND synaptogenesis - wowza.

We should work on getting a group buy for Dihexa going.

I think it is very important to combine these substances with meditation and activities that push the limits of what your are capable of. Learn an instrument, talk about a subject out loud in detail coherently without saying umm. Interact with people. Learn to juggle. Become ambidextrous. Develope visual imagination and concentration with meditation. The great geniuses of time have all had a great amount of concentration and the ability to visualize. Nikolai Tesla could imagine his inventions in complete detail without writing them down. I could go on but I have to get going.

[Xenix]

Hi Everyone,

Sorry for pulling a brief vanishing act... I just finished a 41-HOUR DAY

In case there are any issues regards everyone paying via PAYITSQUARE, just to let everyone know that we do have a PLAN B to fall back on, in that I already have a VERIFIED PAYPAL account and it would most certainly be possible for everyone to pay the US$136.25 for their 2.5 GRAMS NSI-189 directly to me via PAYPAL

Please kindly note that my PAYPAL ACCOUNT has been active for a very long time period and is well used; and so none of the issues that occur with attempting to gather together monies for a GROUP BUY using a NEW PAYPAL ACCOUNT (which has all sorts of restrictions until it has been frequently used for a while) should occur

I should point out that this has a COST IMPLICATION since payment via PAYPAL incurs a higher TRANSACTION FEE than PAY-IT-SQUARE

ScienceGuy do you ve a verified paypal account?

YES

what is this NSI-189? i wish i could see molecular structure.


Im confused, it is a SSRI?

Hey, I'm just curious where you found that molecular structure of NSI-189?

The PATENT DOCUMENTATION... I attached it as a DOWNLOADABLE FILE in one of my earlier posts in this thread

hey ScienceGuy, can your company give you the synthesis route they use ?

Seconded. Any more information/literature about how it is synthesised would be greatly appreciated

[sunshinefrost]

neurogenesis AND synaptogenesis - wowza.

NZT-48

[daouda]

But this is where it gets interesting - if NSI lives up to the hype and is combined with a compound like Dihexa (which MAY significantly increase synapse formation), something *AMAZING* may be waiting around the corner for us - neurogenesis AND synaptogenesis - wowza.

We should work on getting a group buy for Dihexa going.

I think it is very important to combine these substances with meditation and activities that push the limits of what your are capable of. Learn an instrument, talk about a subject out loud in detail coherently without saying umm. Interact with people. Learn to juggle. Become ambidextrous. Develope visual imagination and concentration with meditation. The great geniuses of time have all had a great amount of concentration and the ability to visualize. Nikolai Tesla could imagine his inventions in complete detail without writing them down. I could go on but I have to get going.

Somebody made a great point that no toxicology study has even been conducted with dihexa yet...
About the stuff you wrote below, I agree 100%, and would add "learn a (or several) foreign languages" which is a fun, useful endeavour that challenges the brain in almost every way possible (like learning an instrument and pushing it far enough to be able to improvise within a grid etc)... I dont thing I could bother with dual n-back or other computerized "brain workouts" which don't really do much to enrich you

[lostfalco]

usa

[Xenix]

After being exposed to Carbon Monoxide, patients almost always suffer great damage to their hippocampus.

...One of the more isolating problems suffered by patients with CO poisoning is a significant personality change. Patients, formerly even-tempered are prone to anxiety and quick to anger. This is likely related to the damage to the hippocampus, which is highly affected after deprivation of oxygen. The hippocampus is connected to the hypothalamus which is involved in the regulation of emotions.

...the patient can suffer hippocampal atrophy. This atrophy may not develop for weeks or longer after the exposure.

http://ontheobservat...oss-affect.html


Sounds like I may have a chance to return to my former self here if NSI can live up to its claims of a 20% increase in hippocampus size.

What interested me was the hippocampus' indirect influence over emotions - would people taking NSI experience a greater range/enhancement of emotions? I thought antidepressants (I know this isn't exactly one, but somewhat shares a similar mechanism of action) usually blunt emotions?

Failing this, I really don't know where to go from here. If it doesn't work for me I think I'll look into getting potassium cyanide synthesised.

Edited by Xenix, 20 April 2013 - 09:56 AM.

[Major Legend]

I think the fact that dihexa has to be kept in cold storage will be a problem for a group buy.

[MetaMind]

has the payment procedure allready started coz I cant find the payitsquare groupbuy profile ("enhance your memory")

[Xenix]

I think the fact that dihexa has to be kept in cold storage will be a problem for a group buy.

You're correct. Peptides *ideally* need to be stored at -20 Celsius at all times or else they rapidly degrade (I think it's about a week before they do so, or else they can last many months in proper storage) also, the freeze-thaw cycle is known to degrade them, so a consistently cold temperature is required - this is where aliquoting (splitting the order into several vials) comes in handy.

But I'm digressing on Dihexa - back to NSI.

Incidentally I have contacted a Biotech company here in my country and they are able to synthesize NSI-189 for me (roughly $200/gram). Thus, I'll be going solo on purchasing it as the group buy is currently full.

My (NSI) manufacturer is asking me if I would like NSI-189 in free amine salt or phosphate salt format - I have enquired about the possibility of getting it in acetate salt form, but I don't know which format would be best suited - in terms of efficacy, safety and oral bioavailability - to choose. I can't seem to find any helpful information on Google (after a substantial amount of time searching)... could someone please point me in the right direction?

Thanks

Edited by Xenix, 20 April 2013 - 01:07 PM.

[hadora]

I think the fact that dihexa has to be kept in cold storage will be a problem for a group buy.

You're correct. Peptides *ideally* need to be stored at -20 Celsius at all times or else they rapidly degrade (I think it's about a week before they do so, or else they can last many months in proper storage) also, the freeze-thaw cycle is known to degrade them, so a consistently cold temperature is required - this is where aliquoting (splitting the order into several vials) comes in handy.

But I'm digressing on Dihexa - back to NSI.

Incidentally I have contacted a Biotech company here in my country and they are able to synthesize NSI-189 for me (roughly $200/gram). Thus, I'll be going solo on purchasing it as the group buy is currently full.

My (NSI) manufacturer is asking me if I would like NSI-189 in free amine salt or phosphate salt format - I have enquired about the possibility of getting it in acetate salt form, but I don't know which format would be best suited - in terms of efficacy, safety and oral bioavailability - to choose. I can't seem to find any helpful information on Google (after a substantial amount of time searching)... could someone please point me in the right direction?

Thanks

phosphate salt is what they use in the clinical trial

can you send me the name of your biotech company by pm just to see their website ?

Edited by hadora, 20 April 2013 - 02:03 PM.

[Xenix]

I think the fact that dihexa has to be kept in cold storage will be a problem for a group buy.

You're correct. Peptides *ideally* need to be stored at -20 Celsius at all times or else they rapidly degrade (I think it's about a week before they do so, or else they can last many months in proper storage) also, the freeze-thaw cycle is known to degrade them, so a consistently cold temperature is required - this is where aliquoting (splitting the order into several vials) comes in handy.

But I'm digressing on Dihexa - back to NSI.

Incidentally I have contacted a Biotech company here in my country and they are able to synthesize NSI-189 for me (roughly $200/gram). Thus, I'll be going solo on purchasing it as the group buy is currently full.

My (NSI) manufacturer is asking me if I would like NSI-189 in free amine salt or phosphate salt format - I have enquired about the possibility of getting it in acetate salt form, but I don't know which format would be best suited - in terms of efficacy, safety and oral bioavailability - to choose. I can't seem to find any helpful information on Google (after a substantial amount of time searching)... could someone please point me in the right direction?

Thanks

phosphate salt is what they use in the clinical trial

can you send me the name of your biotech company by pm just to see their website ?

Thanks. PM sent. That solves the issue of NSI. Now to find out if phosphate salt can be used when synthesising peptides like Dihexa... Don't know if phosphate salt would alter the pH/can be solubilised properly. Don't know if it would be preferable to use phosphate over acetate salt.