I'm increasingly skeptical that VLK's batch is NSI-189. I'm not accusing him of being a scammer, as I think in that scenario it's possible he was scammed by this unknown lab he got it from, or they just really messed up. As has been noted, there's been no independent testing done on this stuff. You guys are all just taking a guy on the internet at his word who is taking some guys he knows at their word and staking your health on it. The chemical anecdotally being similar in color, density, taste means little, as it has very generic qualities. I'm also very skeptical of reports claiming significant improvement in mood or cognitive ability a couple days or weeks after taking "NSI-189". That sounds more like a strong placebo effect. I mean, it takes neurons 4-6 weeks just to migrate and mature in the hippocampus.
I will post what happened when I took VLK's "NSI" here. I originally posted it in the "Participants" thread May 9th.
My experience with NSI-189, assuming that's what this is, has been a nightmare. I first took 20 mg orally on April 28th. The next day I took 50 mg on April 29th. 90 minutes after taking it I experienced sharp pains in my groin that continued for several hours and returned later that night. The sharp pains went away but over the next week I experienced burning pains in my pelvis. The sensation has now spread to my legs and arms. It's a mild burning sensation, not really painful as much as annoying.
This is almost certainly some type of nerve damage, and due to the sharp pains I experienced so soon after taking the drug, I highly highly suspect it was NSI that caused this. I don't blame VLK or anyone for this. Perhaps I'm just unlikely and this is a rare side-effect. After all, NSI-189 has not undergone significant testing in clinically controlled trials. I had just stopped taking lithium a couple days prior to NSI-189, but because of it's half-life I'm sure it was still in my blood, so the chance for a bad reaction between those two cannot be discounted.
The good news is that the pain is not that severe, maybe 1/10 at the worst, but psychologically it's very unnerving and disquieting. I have no idea what the prognosis of these pain/sensations are, or if they will ever go away, nor does anyone. Nerve pain is poorly understood. At least it was caused by a drug, which can be stopped, and not some disease like diabetes where the damage is ongoing. I saw my psychiatrist yesterday and he basically shrugged and said the damage may be permanent. I just started taking nortriptyline and gabapentin for the neuropathic pain. Hopefully they will work and give my body a chance to heal.
It's notable I didn't have any side-effects at all after taking 20 mg, but of course I'm not going to test it again. I advise anyone still intent on taking this stuff to be very cautious and start on a very low dose for a few months to see if that alone can help you before moving up to a higher one because it seems there is a risk here.
I think my experience just adds to the need for independent testing to done on this batch to truly confirm this is NSI-189.
NSI-189 is a small molecule and is supposed to have few interactions with major transmitters and thus few side-effects. It was safely tested on 60 people in 1a and 1b studies without anything remotely like this happening. Word is, this next study with even more people and at higher doses is going well too. Obviously the full range of side-effects, both rare and very rare, when taking this drug won't be known until thousands of people have taken it. Maybe I'm just very very unlucky, and peripheral neuropathy is a very rare side-effect in someone with my genetic/biological makeup. Or maybe not. Maybe this isn't NSI-189 but something very nasty.
If you guys want to continue playing with fire, go ahead. I'm not working on my PhD in Chemistry so excuse me if I can't test it myself, or am unwilling to ship it overseas to pay thousands to have it done there, but if anyone like Joeyo has the capabilities to do that, then I will gladly send my 6g to them so they can tell me exactly what it is I have poisoned myself with.