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NSI-189

nsi-189

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#2281 SearchingForAnswers

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Posted 08 July 2014 - 02:45 PM

Very crappy day today. Quite depressed; however I'm about certain it's because I took melatonin last night to get to sleep (3mg). I'm very sensitive to the stuff and should have known better - there's a reason for the warning on the label about taking it if you suffer from depression.

 

Bound to be quite unproductive today, but hey, it happens. Nothing to do with the NSI as far as I can tell.

 

By the way, does anybody know if NSI-189 will pop hot for some metabolite or something on a urinalysis? For that matter, Tianeptine? I very much doubt it for the NSI, but the Tianeptine seems possible...



#2282 SearchingForAnswers

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Posted 08 July 2014 - 04:42 PM

I found this quote about the hippocampus on the internet; the last section is quite prescient as it relates to NSI-189:

 

Several parts of the brain are key actors in a highly dynamic interplay that gives rise to fear and anxiety. Using brain imaging technologies and neurochemical techniques, scientists are finding that a network of interacting structures is responsible for these emotions. Much research centers on the amygdala, an almond-shaped structure deep within the brain. The amygdala is believed to serve as a communications hub between the parts of the brain that process incoming sensory signals and the parts that interpret them. It can signal that a threat is present, and trigger a fear response or anxiety. It appears that emotional memories stored in the central part of the amygdala may play a role in disorders involving very distinct fears, like phobias, while different parts may be involved in other forms of anxiety.

Other research focuses on the hippocampus, another brain structure that is responsible for processing threatening or traumatic stimuli. The hippocampus plays a key role in the brain by helping to encode information into memories. Studies have shown that the hippocampus appears to be smaller in people who have undergone severe stress because of child abuse or military combat. This reduced size could help explain why individuals with PTSD have flashbacks, deficits in explicit memory, and fragmented memory for details of the traumatic event.

Also, research indicates that other brain parts called the basal ganglia and striatum are involved in obsessive-compulsive disorder.

By learning more about brain circuitry involved in fear and anxiety, scientists may be able to devise new and more specific treatments for anxiety disorders. For example, it someday may be possible to increase the influence of the thinking parts of the brain on the amygdala, thus placing the fear and anxiety response under conscious control. In addition, with new findings about neurogenesis (birth of new brain cells) throughout life, perhaps a method will be found to stimulate growth of new neurons in the hippocampus in people with PTSD.


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#2283 BigPapaChakra

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Posted 08 July 2014 - 09:17 PM

Just found something that can (1) help people with neuro-psychiatric illnesses, and/or (2) help quantify the effects of awesome compounds such as NSI and Cerebrolysin. It's called NeuroQuant. You can purchase it and it basically assess MRIs in a quantitative manner and displays in depth results as to brain volume, function, and damage in specific areas of the brain, including the hippocampus. Here is a facility that utilizes NeuroQuant to diagnose and develop treatments for TBI's, Alzheimer's, mold exposure, and more. I'm thinking about getting an MRI and then using NeuroQuant, then progressing from there to treat myself.


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#2284 tolerant

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Posted 09 July 2014 - 12:05 AM

Just found something that can (1) help people with neuro-psychiatric illnesses, and/or (2) help quantify the effects of awesome compounds such as NSI and Cerebrolysin. It's called NeuroQuant. You can purchase it and it basically assess MRIs in a quantitative manner and displays in depth results as to brain volume, function, and damage in specific areas of the brain, including the hippocampus. Here is a facility that utilizes NeuroQuant to diagnose and develop treatments for TBI's, Alzheimer's, mold exposure, and more. I'm thinking about getting an MRI and then using NeuroQuant, then progressing from there to treat myself.

 

I strongly encourage everyone who has not done so already to view my thread regarding the discussion of NSI-189 vendors. In it, I suggest a secure way to discuss these vendors in an effort for people to confer about product quality concerns without fear of repercussion from Neuralstem.

 

http://www.longecity...si-189-sources/

 

It is a lengthy post and copy and pasting a quoted version of it here would heavily steer this current thread off topic. Please visit the actual link above. If you have any comments, concerns, or ideas about this concept, please be sure to make a post in the linked thread.

 

 

 

 

It's good that this kind of new stuff is coming out. Soon this little device (http://www.consumerphysics.com/myscio/) may make all discussion of vendors absolete.


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#2285 SearchingForAnswers

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Posted 09 July 2014 - 02:35 AM

BigPapa, Would an MRI I have from about 8 years ago still be a valid comparison? I'm now in my early 50's. Digitizing it would the the hard part...

Does anybody think about how strange it will be if this stuff actually works in the long term? I mean, my life (the bad parts at least) has been defined by the depression, anxiety, moodiness, and inattentiveness for as long as I can remember it.

I'm already becoming more tolerant, that much is for sure. But how would it change my personality, otherwise - this part of my brain possibly getting "fixed". Will I miss the old me? Naahhhhhhh.....
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#2286 MizTen

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Posted 09 July 2014 - 03:28 AM

...................................
Does anybody think about how strange it will be if this stuff actually works in the long term? I mean, my life (the bad parts at least) has been defined by the depression, anxiety, moodiness, and inattentiveness for as long as I can remember it.

I'm already becoming more tolerant, that much is for sure. But how would it change my personality, otherwise - this part of my brain possibly getting "fixed". Will I miss the old me? Naahhhhhhh.....

 

 

I too, have been wondering a lot how my refurbished upgraded brain is going to work in the long term. Although it hasn't exactly changed my personality, the better aspects of who I am are stronger and more active now, following my NSI-189 trials. But over time, I suspect it will change my personality quite a bit. My brain works significantly better, my stress responses are pretty much transformed, and the fusion of emotion, memory, and cognition is very nearly perfect most of the time.

 

Which means that I now have to actually do some pretty difficult things to improve certain parts of my life. Running on empty before (NSI-189) left me with little ability to even see what changes needed to happen, much less the energy and drive to do something. Even though I am more tolerant of other people's issues and the trivial annoyances of daily life, the experience of healing so easily also shows me that I've got some work to do. When your brain and nervous system are working normally, the external aspects of life that are causing problems become much more apparent and call out for some adjustments. It reminds me of what it feels like to take a vow, or make some major commitment to a lifestyle or belief system that you know has a lot of power for positive change.

 

Or being given a gift of great value, with the requirement of taking exceptionally good care of it, a little like some mythic quest story. There's a lot of the Hero's Journey in all this for me.

 

There's no going back. 


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#2287 SearchingForAnswers

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Posted 09 July 2014 - 03:32 AM

Mizten,
How many trials,
Duration on / off,
Dosage,
Did you conduct?

#2288 MizTen

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Posted 09 July 2014 - 03:36 AM

Mizten,
How many trials,
Duration on / off,
Dosage,
Did you conduct?

 

 

Approximately 3 trials.

4-8 weeks on and off.

25-50 mg once a day to TID

 

Not sure what the last question means....



#2289 SearchingForAnswers

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Posted 09 July 2014 - 03:44 AM

Ah, as in "how many trials did you conduct", you answered it. Thanks!

#2290 HenryHH

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Posted 09 July 2014 - 05:42 AM

Has anyone taken NSI-189 for at least 1-2 weeks and then performed any sort of memory-testing activity, such as studying for and then taking a university exam? I don't suffer from depression, but I am taking classes that involve LOTS of memorization (e.g., A&P, microbiology, etc.), so I would be very interested in taking NSI-189 if it specifically improves memory function. So in general, are you able to take it and then memorize the same amount of information (or more information) with a lesser amount of studying?

 

Thanks in advance for your input....


Edited by HenryHH, 09 July 2014 - 05:42 AM.


#2291 jefferson

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Posted 09 July 2014 - 07:15 AM

I assume if it hasn't been revealed by now then that means Neuralstem saw negligible or even no hippocampal volume increase in any of the groups. It'll be very interesting to see if it just takes more time, or if the supposed antidepressant effects are due to something else.


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#2292 themadscientist

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Posted 09 July 2014 - 08:28 AM

So here is my final conclusion after taking both the base and phosphate versions for a little over a month now. Actually before I say this, please don't criticize me. This is just simply my opinion, you don't have to believe it.

I can honestly say I have experienced no benefits from the NSI at all. This could be one of two things, it doesn't work or I don't have real NSI.
Now, like I said in earlier posts the base from alibaba is definitely questionable. But the phosphate from THT I'm 90% sure is legit. Now given the lack of MRIs by Nurealstem and my personal experience with the drug , I think NSI might just be bullshit. I don't think they will admit this because this is the onyl drug cur has on its roster.
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#2293 Nattzor

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Posted 09 July 2014 - 09:09 AM

 

 

It's good that this kind of new stuff is coming out. Soon this little device (http://www.consumerphysics.com/myscio/) may make all discussion of vendors absolete.

 

 

http://www.reddit.co...ter_could_make/

http://www.reddit.co...at_will_enable/

 

Most likely not, no.

 

 

I assume if it hasn't been revealed by now then that means Neuralstem saw negligible or even no hippocampal volume increase in any of the groups. It'll be very interesting to see if it just takes more time, or if the supposed antidepressant effects are due to something else.

 

It could mean they're saving that data for when they publish the full study (lets hope so atleast).

 

 

So here is my final conclusion after taking both the base and phosphate versions for a little over a month now. Actually before I say this, please don't criticize me. This is just simply my opinion, you don't have to believe it.

I can honestly say I have experienced no benefits from the NSI at all. This could be one of two things, it doesn't work or I don't have real NSI.
Now, like I said in earlier posts the base from alibaba is definitely questionable. But the phosphate from THT I'm 90% sure is legit. Now given the lack of MRIs by Nurealstem and my personal experience with the drug , I think NSI might just be bullshit. I don't think they will admit this because this is the onyl drug cur has on its roster.

 

No, it's not their only drug. Heck, they're not really focusing on it as much as the other drug. If they run into any money problems, NSI-189 will be the first one to go for sure.

 

Saying it's "bullshit" because an anti-depressant did not work on a healthy person is silly as fuck.


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#2294 world33

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Posted 09 July 2014 - 10:32 AM

So here is my final conclusion after taking both the base and phosphate versions for a little over a month now. Actually before I say this, please don't criticize me. This is just simply my opinion, you don't have to believe it.

I can honestly say I have experienced no benefits from the NSI at all. This could be one of two things, it doesn't work or I don't have real NSI.
Now, like I said in earlier posts the base from alibaba is definitely questionable. But the phosphate from THT I'm 90% sure is legit. Now given the lack of MRIs by Nurealstem and my personal experience with the drug , I think NSI might just be bullshit. I don't think they will admit this because this is the onyl drug cur has on its roster.


Are you taking NSI-189 for any particular condition or just as a nootropic? I tried both Nyles7 phosphate and alibaba.com freebase and still experiencing positive effects every time I take any of them. Maybe those that do not experience any positive effect in the short or long term do not need NSI-189 in the first place.

Edited by world33, 09 July 2014 - 10:35 AM.


#2295 SearchingForAnswers

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Posted 09 July 2014 - 03:08 PM

Well...

I'm taking it for MDD, Anxiety, ADD, and a bit of OCD... I guess I just got lucky.

 

If every day were like today, I would die quite happy. However, only the long term will tell. I will tell you this, I had a job interview today (I'm employed but looking), and I was able to recall things I haven't done for two years. For me, that's quite significant.

 

And there's this strange feeling I'm getting today, I've only felt it on and off throughout my life, regardless of circumstances. I think it's called "Happiness".


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#2296 HenryHH

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Posted 09 July 2014 - 06:08 PM

Has anyone taken NSI-189 for at least 1-2 weeks and then performed any sort of memory-testing activity, such as studying for and then taking a university exam? I don't suffer from depression, but I am taking classes that involve LOTS of memorization (e.g., A&P, microbiology, etc.), so I would be very interested in taking NSI-189 if it specifically improves memory function. So in general, are you able to take it and then memorize the same amount of information (or more information) with a lesser amount of studying?

 

Thanks in advance for your input....

 

Just wanted to give this a bump...



#2297 cap3

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Posted 09 July 2014 - 07:11 PM

I have been taking NSI189 for 12 days now at 40mg twice daily, still no benefits but really hoping it kicks in soon.

 

 

 

 

 



#2298 Kyle McGill

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Posted 09 July 2014 - 08:28 PM

Could someone please PM me with a legitimate source for this compound? Could really benefit me, thanks :-)

#2299 tolerant

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Posted 09 July 2014 - 08:52 PM

It's good that this kind of new stuff is coming out. Soon this little device (http://www.consumerphysics.com/myscio/) may make all discussion of vendors absolete.

 
http://www.reddit.co...ter_could_make/
http://www.reddit.co...at_will_enable/
 
Most likely not, no.
 


I read the discussions on reddit. Without wanting to steer this discussion off-topic, I would reply as follows. I would say that the opinion on reddit is divided. I don't have the knowledge to comment on whether this device can work as claimed, but I would tend to think that massive use of the device would result in the creation of databases of spectra which are well beyond those that are currently available to chemists. Maybe these databases will eventually be able to distinguish between minute differences in spectra. Also, what nobody has mentioned I don't think is that this device will work together not only with the crowd-sourced databases but with apps that are yet to be developed. If you click here then go to "Applications" > "I have an idea for a SCiO application, how feasible is it?" you'll see that the developers are themselves not sure of what can be achieved. It's also interesting to note that they put an app that would determine the THC content of marijuana as "highly feasible". So they are not averse to uses of questionable legality, so to speak. When I recently tried to submit some ketamine for analysis by a lab, I was told that I would need a license to handle scheduled substances in order to do that. This device would eliminate such hurdles.
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#2300 ceridwen

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Posted 09 July 2014 - 09:37 PM

With Scio could I or my Cryonics vendor be able to rebuild my caudate nucleus in other words rebuild me? I'm desperate as you can understand. Would I or my carer be able  to get a scan that eventually might be used to help rebuild my brain back to a normal or even enhanced level? Could I give myself a brain scan and show what creates my consciousness with a term long term view to enhancing it back to where it used to be or even enhance it? My consciousness is fading fast. I need help. Could scio be the beginning of what the world has been waiting for in order to defeat all types of dementia? Could it be the beginning of the end of dementia?



#2301 Rior

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Posted 09 July 2014 - 09:50 PM

I wanted to mention two things of interest in this thread:

 

First and foremost, I have created an "NSI-189 BENEFITS/DETRIMENTS Poll that can be found here.  It would be great if those who have experienced NSI here would help by posting there. As of now, I'm trying to have the thread moved to the "Brain Health" section of this forum, as it would be more appropriate here.

 

Second,

I will be commencing my trial of NSI-189.  It is ScienceGuy's original group buy NSI.  I've been holding onto it for a little over a year now, not using it, waiting to see further results before I put my head into the trial myself.  That said: It's worth regarding the molecule's stability (has it degraded over the last year?).  

 

My plans are this so far:

 

30mg NSI-189 BID, in the morning and at night, ORALLY (not sublingual), on an empty stomach.

25mg Zoloft (A very small, dose, but very helpful for me)

Fish oil at night (purposes of helping produce myelin while sleeping for any new neurons)

Creatine at 5-10g/day

Heavy exercise regimen (I've been on a heavy regimen for about 2-3 months now)

ZMA supplement (Zinc, Magnesium and B vitamins) at night

Occasional GHB use for aiding in sleep (perhaps 3 nights a week.  Muscle recovery, as well as generally higher quality sleep as I tend to have poor sleep quality)

 

 

Yes, I know I have many confounding variables in my NSI experiment. I acknowledge that. I'm doing it primarily for myself though, obviously, and plan on sharing my experiences solely for the purposes of others who may find interest in it. 

 

My background: Multiple concussions from soccer. Multiple. Reduced capacity for working memory, reduced capacity for storage of long-term memory, reduced verbal fluency, reduced creativity, almost -zero- sense of smell anymore, mild, occasional depersonalization.  Essentially, I could use some brain growth IMO.

 

So far: 2 days in I can at least note the immediate effects I experience, which mimic those I experienced over the 4 day trial I gave NSI a year ago. The first thing I notice is mental and physical stimulation. It is dramatic in comparison to my usually-lethargic self. It comes on within 45 minutes to an hour after dosing, and almost feels like a mild amphetamine high.  (I'll be driving and music feels enhanced, my eyes are darting around everywhere heavily analyzing everything.)  I would so far state that it is certainly not placebo, as it is a dramatic change in headspace. I could be mentally enhancing the effects due to excitement after noticing a difference, however there is certainly a difference in headspace nonetheless.  So far my verbal fluency has already picked up a little bit, and my racing thoughts have slowed down a little as well. This is too soon for this to be a result of new neurons/neurogenesis, so I'm naturally assuming that there is some other pharmacological mechanism happening that has enhanced my thoughts so far. 

 

I guess that's all so far, will update as I go along.  I'll note that a year ago I did try combining NSI with a 5mL dose of cerebrolysin, and it was a terrible, head-foggy combination.

 

Edit: Just need to edit this once more to say HOLY SHIT does NSI give me a massive spike in energy. I had forgotten I had taken it, then here I am about an hour later flying with energy wondering why. Then I remembered the NSI. Jesus. It's damned euphoric honestly.  I know this is a very atypical response to the NSI, and I don't expect the effect to last longer than 4-6 days....but it's nice while it's here.


Edited by Rior, 09 July 2014 - 10:41 PM.

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#2302 FW900

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Posted 09 July 2014 - 10:32 PM

 

 

It's good that this kind of new stuff is coming out. Soon this little device (http://www.consumerphysics.com/myscio/) may make all discussion of vendors absolete.

 
http://www.reddit.co...ter_could_make/
http://www.reddit.co...at_will_enable/
 
Most likely not, no.
 

 


I read the discussions on reddit. Without wanting to steer this discussion off-topic, I would reply as follows. I would say that the opinion on reddit is divided. I don't have the knowledge to comment on whether this device can work as claimed, but I would tend to think that massive use of the device would result in the creation of databases of spectra which are well beyond those that are currently available to chemists. Maybe these databases will eventually be able to distinguish between minute differences in spectra. Also, what nobody has mentioned I don't think is that this device will work together not only with the crowd-sourced databases but with apps that are yet to be developed. If you click here then go to "Applications" > "I have an idea for a SCiO application, how feasible is it?" you'll see that the developers are themselves not sure of what can be achieved. It's also interesting to note that they put an app that would determine the THC content of marijuana as "highly feasible". So they are not averse to uses of questionable legality, so to speak. When I recently tried to submit some ketamine for analysis by a lab, I was told that I would need a license to handle scheduled substances in order to do that. This device would eliminate such hurdles.

 

 

There would not be a massive use of this device. Most people cannot interpret spectra let alone operate a spectrometer. It takes some training and even if this hypothetical device was out there, the cost would be absurd. In the $100,000 range at the very least. The cheapest benchtop NMR spectrometer that I know of has a price tag of $30,000 (+ occasional cartridge replacement costs). There would not be a massive use of this device under any circumstances. If such a small spectrometer was created and it was "affordable", it would have shitty resolution which would make interpreting it extremely difficult and therefore render the device useless for any purpose.

 

This thing was probably made by a couple scammers on Kickstarter who were (and seemingly still are) planning on taking your money and making a run for it. I cannot understate the impracticability and uselessness of this device. You would need to be a lunatic to have any hope that this thing would work reasonably well.

 

The language used in the video isn't even geared toward someone with the slightest inkling of an understanding of chemistry. It has a "molecular sensor" and that shows a "molecular fingerprint". :laugh:  The video is contradictory in and of itself as they say you can have instant results yet your spectra is interpreted with some kind of cloud interfaced.

 

And do you even know what is on the surface of everything in that video? Look all around you, almost every single thing scanned in that video is a surface with dozens to thousands of different compounds. Even if this shared database of different spectra existed, what would it be exactly of? It would be a grossly distorted and extremely inaccurate picture of anything contained within the database.

 

That app you mentioned that they mentioned would not be "highly feasible". You cannot tell the chemical makeup of a plant, specifically alkaloid content as a percentage, simply by scanning it with a spectrometer. The fact that they said this is highly feasible reiterates that they are hucksters selling a piece of crap.


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#2303 VP.

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Posted 09 July 2014 - 10:35 PM

I assume if it hasn't been revealed by now then that means Neuralstem saw negligible or even no hippocampal volume increase in any of the groups. It'll be very interesting to see if it just takes more time, or if the supposed antidepressant effects are due to something else.

 

Neuralstem has not released any data about hippocampus growth or lack of growth. Garr was interviewed about 8 months ago saying they did not expect hippo growth in 28 days but they would be happy if they found growth. Garr also has told some that the MRI data needs more analysis. My guess is that they want to get the phase 1b results published in a tier 1 journal and are saving hippo numbers for later publication.



#2304 SearchingForAnswers

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Posted 10 July 2014 - 02:39 PM

Mitzen,

 

May I ask how long before you noticed fairly consistent, day to day alleviation of depression? Did you get much out of your first cycle, and how long after that before you consistently felt better?

 

Thanks in advance.



#2305 MizTen

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Posted 11 July 2014 - 01:24 AM

Mitzen,

 

May I ask how long before you noticed fairly consistent, day to day alleviation of depression? Did you get much out of your first cycle, and how long after that before you consistently felt better?

 

Thanks in advance.

 

 

From looking through my notes and posts, it only took 4 days. Life events kinda slowed down the effect for a while, though didn't stop it. Then when I stopped the strong effect kicked in again. Definitely indicates that it's an excellent candidate for cycling, at least for me.

 

So I got lots out of my first cycle and was consistently feeling better within a week of starting. I just had trouble believing that it wasn't a placebo effect at first, so I didn't initially want to attribute the changes to NSI-189. I also was trying to tone down my reports so I didn't sound like some sort of drug evangelist.


Edited by MizTen, 11 July 2014 - 01:25 AM.

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#2306 MizTen

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Posted 11 July 2014 - 01:30 AM

is it actually necessary to cycle this stuff or can you take it for three, four months straight? 

 

 

From my own experience and reading through others' positive and negative reports, it seems like cycling it will provide more benefits. I still don't know exactly how those cycles might work, but for sure your brain is experiencing big changes from the drug and also has it's own innate cycles and changes, plus responses to external stimuli, so I'd give my head a break. Also, by cycling it, you'll get a better idea of how it works for you.



#2307 MizTen

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Posted 11 July 2014 - 01:52 AM

Has anyone taken NSI-189 for at least 1-2 weeks and then performed any sort of memory-testing activity, such as studying for and then taking a university exam? I don't suffer from depression, but I am taking classes that involve LOTS of memorization (e.g., A&P, microbiology, etc.), so I would be very interested in taking NSI-189 if it specifically improves memory function. So in general, are you able to take it and then memorize the same amount of information (or more information) with a lesser amount of studying?

 

Thanks in advance for your input....

 

 

I did do some brain training games for a while and got a very large improvement after a couple of weeks. But those results were a bit confounded in terms of NSI-189's effect on memory because I used PRL-8-53 sometimes. I also had significant improvement in other areas of memory, and possibly that was an effect of the combo.

 

But I don't think that you will get a strong memory retention and retrieval effect in the first few weeks with new information. I think one of the reasons for some of the initial introspective lethargy that occurred for me and some other people is that your brain is busy processing old stuff that needs emotional recycling (though you might not be conscious of the memories). This takes a lot of energy.

 

At the same time if, in the short term, your sole intention with taking it is to do learning and retrieval that you need at the present time for exams, it might work well. But I don't think that's such a good idea. A lot of people got uncomfortable with some of the initial effects. There's a lot of new processing going on in your brain and it takes a whole lot of energy, I think. There's also the issue of memory consolidation, which seemed to stretch out quite a bit for me. 

 

To me, it makes a lot of sense that Neuralstem is calling it a synaptogen. 



#2308 mamborambo

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Posted 11 July 2014 - 05:15 AM

 

is it actually necessary to cycle this stuff or can you take it for three, four months straight? 

 

 

From my own experience and reading through others' positive and negative reports, it seems like cycling it will provide more benefits. I still don't know exactly how those cycles might work, but for sure your brain is experiencing big changes from the drug and also has it's own innate cycles and changes, plus responses to external stimuli, so I'd give my head a break. Also, by cycling it, you'll get a better idea of how it works for you.

 

 

can you tell me how you cycled it? 



#2309 HenryHH

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Posted 11 July 2014 - 05:30 AM

 

Has anyone taken NSI-189 for at least 1-2 weeks and then performed any sort of memory-testing activity, such as studying for and then taking a university exam? I don't suffer from depression, but I am taking classes that involve LOTS of memorization (e.g., A&P, microbiology, etc.), so I would be very interested in taking NSI-189 if it specifically improves memory function. So in general, are you able to take it and then memorize the same amount of information (or more information) with a lesser amount of studying?

 

Thanks in advance for your input....

 

 

I did do some brain training games for a while and got a very large improvement after a couple of weeks. But those results were a bit confounded in terms of NSI-189's effect on memory because I used PRL-8-53 sometimes. I also had significant improvement in other areas of memory, and possibly that was an effect of the combo.

 

But I don't think that you will get a strong memory retention and retrieval effect in the first few weeks with new information. I think one of the reasons for some of the initial introspective lethargy that occurred for me and some other people is that your brain is busy processing old stuff that needs emotional recycling (though you might not be conscious of the memories). This takes a lot of energy.

 

At the same time if, in the short term, your sole intention with taking it is to do learning and retrieval that you need at the present time for exams, it might work well. But I don't think that's such a good idea. A lot of people got uncomfortable with some of the initial effects. There's a lot of new processing going on in your brain and it takes a whole lot of energy, I think. There's also the issue of memory consolidation, which seemed to stretch out quite a bit for me. 

 

To me, it makes a lot of sense that Neuralstem is calling it a synaptogen. 

 

 

Thanks for the synopsis! Actually, the bolded portion of your post is exactly why I want to take NSI-189 (I don't suffer from depression, AFAIK). I really can't wait to try it...



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#2310 MizTen

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Posted 11 July 2014 - 04:31 PM


 


is it actually necessary to cycle this stuff or can you take it for three, four months straight? 

 
 
From my own experience and reading through others' positive and negative reports, it seems like cycling it will provide more benefits. I still don't know exactly how those cycles might work, but for sure your brain is experiencing big changes from the drug and also has it's own innate cycles and changes, plus responses to external stimuli, so I'd give my head a break. Also, by cycling it, you'll get a better idea of how it works for you.
 
 
can you tell me how you cycled it? 

It was somewhat random, due to travel, work, and unexpected crises. But there were 3 weeks on, 5 days off, two weeks on, 3 weeks off, 6 weeks on, 1 week off, etc.

This may actually have worked pretty well. Also, when I had negative effects that a number of other people reported, I sometimes would stop for a day or two, or use a very reduced dose.

Titration, along with cycling, could possibly ameliorate some of the discomfort that can arise.

Edited by MizTen, 11 July 2014 - 04:38 PM.

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