6219 replies to this topic

[mamborambo]

thank you very much for all this information. If everything works out I should get my NSI-189 next week. Cant wait to try it.

[themadscientist]

Today is my second day off the NSI, after taking it for about 6 weeks at 80mg a day. I'm feeling kind of weird, like my head is just confused. I'm pretty sure that it's related to stoping the NSI because I rarely ever feel this way. Overall i didn't not experience any benefits at all. The main reason why I started taking NSI or any nootropic for that matter is because my verbal fluency and memory are terrible. This is due to 10 years of heavy marijuana use. And when i say heavy, by that I mean, a 1/2 ounce a day, everyday. I really haven't had any luck with any nootropics just yet, but piracetam w/ alpha gpc did greatly improve my verbal fluency but not for long, it lasted for about a month. I'm going to start taking it again next week, hopefully the effects will come back again.

[Rior]

Those of you who are experiencing negative or non-existent effects, I wanted to ask, how has your diet been? Your pattern of exercise?

[Flex]

Today is my second day off the NSI, after taking it for about 6 weeks at 80mg a day. I'm feeling kind of weird, like my head is just confused. I'm pretty sure that it's related to stoping the NSI because I rarely ever feel this way. Overall i didn't not experience any benefits at all. The main reason why I started taking NSI or any nootropic for that matter is because my verbal fluency and memory are terrible. This is due to 10 years of heavy marijuana use. And when i say heavy, by that I mean, a 1/2 ounce a day, everyday. I really haven't had any luck with any nootropics just yet, but piracetam w/ alpha gpc did greatly improve my verbal fluency but not for long, it lasted for about a month. I'm going to start taking it again next week, hopefully the effects will come back again.

 

I can tell You that, at least for me, Cerebrolysin(10 ml at occasion, uptill now 15 vials) has permanently helped for some cognitive side effects from 10+ Years Cannabis abuse.

Edited by Flex, 12 July 2014 - 12:45 AM.

[themadscientist]

I'm not into needles, otherwise I would have tried it already.

 

 

I workout 6 days a week for about hour each time. My diet is pretty good. It mostly consists of lots of vegetables and meats. No fast food or junk food if that is what your getting at.  

[adarseer]

thank you very much for all this information. If everything works out I should get my NSI-189 next week. Cant wait to try it.

 

Keep us updated
 

[cap3]

After 2 weeks of nsi189 at 80mg per day I feel it's started to make me a little more depressed. I've now lowered my dose to 20mg twice per day and will see how that goes.

I didn't respond well to uridine or cerebrolysin either so am thinking that my issues are more down to imbalances of some sort.

[sk_scientific]

I took nsi-189 (base) from January 1 until the end of March.  I varied my dosage for the first couple of weeks, trying out smaller and larger amounts until I settled upon approximately 30 mgs daily.

 

In the initial couple of weeks I had a couple of acute anxiety or ptsd related episodes, the first of such episodes was significant enough for me to call into work.  Luckily my supervisor was sympathetic.

 

After about the first month, prior stressors and triggers had lesser of an effect on me, and my overall emotional and cognitive states reminded me of my twenties.  Additionally I found my ability to visualize internal maps, even if abstracted or imagined seemed to have improved.  What I perceived to be adhd a decade or more ago seemed to have returned, but this scattered tendency dissipated after I stopped taking NSI.  Some of the clever immaturity of my sense of humor evened back out again, however my emotional stability was enhanced and has continued to be so approximately 4 months after I stopped taking NSI-189 (base).

 

I should mention that for the past many years I have been, pretty much, an alcoholic.  This began as a recreation but became a coping strategy since my college years.  While I was initially taking NSI-189 I made no effort to cut back on my alcohol consumption although I continued, much like an alcoholic would, to tell myself "tomorrow, tomorrow I'll stop."  Some time ago, I'm not certain how many weeks exactly, I just quit, cold turkey.  I've had the occasional inclination to drink but have kept on walking without looking back.  I believe this is largely unrelated to NSI-189, or the correlation is mild.  However, I can say that super acute anxiety attacks have significantly lessened, which may have assisted in my ability to just.stop.drinking.by.choice.  I had the opportunity the past month to spend time around a female who has continued PTSD and another female who has Borderline Personality Disorder with comorbid anxiety, and observe their behavior. One thing that I noticed in the girl with PTSD, aside from drug and alcohol abuse, was the seemingly irrational fits of anxiety which would cause her to cordon off people in her life, and frequent inexplicable fits of deep breathing and chest grabbing.  The deep breathing and chest grabbing were two features that I personally demonstrated since I had previously left Northern Virginia after working for a Department of Defense contracting company.  I noticed at this time that I wasn't enacting these same anxiety-mitigating behaviors hardly at all, and much was failing to affect me as significantly as before.

 

I forced myself to revisit many of the sites and locations and states of prior traumatic events and found them to have a significantly reduced impact on my physiological and emotional systems.  I am a bit more impervious to the toxic people in my life, however not completely so.  All of this is an important indication of the efficacy of drug to me if even just conjecture, largely qualitative.

 

Longitidunally, I can not comment on persistent benefits aside from a short term evaluation: 4 months after stopping my dosing schedule, emotional hardiness, stamina and stability are present.  Will this be so in 1 year, 5 years, 10 years?  I can not say.  Something to keep in mind is that nature (genetics) set the stage and playing field for your life, environment, decisions and circumstance (nurture) to have their way with you.  If you have a genetic predisposition for depression, and that depression is the result of neurology being impacted by irregular neurochemistry, allophathic solutions may still be a necessity even if a jolt of rewiring from activation of neurological stemcells gives you enhanced cognition for a duration of time.  Whatever the case, that we have a drug that causes structural change that we perceive as harmless is truly exciting news.  This is the wild west in Cognitive Science and Pharmacology in my opinion.

 

Anyhow...

 

Now that I am not drinking, I am preparing to embark upon a 3 month trial of NSI-189 Phosphate.  This will effectively put me at about 6x the length of administration of that done in the studies, however cycled.  I have a suspicion that the benefits may be more pronounced when my frontal lobe isn't frequently saturated in alcohol, and may give me SOME perception of the difference between NSI-189 (base) and NSI-189 Phosphate.   I surmise that this might not necessarily be the case as I am unaware of how production of stemcells works in the brain - if there is a relatively fixed number of such, or if the hippocampus continues to produce them after activation and consolidation.  Whatever the case, I will report my findings and do my utmost not to confound my own personal case study this time around with alcohol or cocktails of other nootropics.

 

Family members, some few friends, and a couple of researchers that I spoke with about my endeavor into DARPA's mysterious wonderdrug strongly discouraged the activity.  Some of these individuals had legitimate arguments that were scientifically based, and I'm sure most of you are aware of those risks.  However some certain others in my life likened this activity to drug abuse, to which I could only smirk through the irritation.  Whatever the case, I think my personal, adult, decision to undergo this activity was one of the very best that I ever made, perhaps second only to studying Psychology and Cognitive Science at I.U.

 

Anyway, here we go once more.  Cheers, my friends!

Edited by sk_scientific, 12 July 2014 - 04:01 PM.

[cap3]

I took nsi-189 (base) from January 1 until the end of March.  I varied my dosage for the first couple of weeks, trying out smaller and larger amounts until I settled upon approximately 30 mgs daily.
 
In the initial couple of weeks I had a couple of acute anxiety or ptsd related episodes, the first of such episodes was significant enough for me to call into work.  Luckily my supervisor was sympathetic.
 
After about the first month, prior stressors and triggers had lesser of an effect on me, and my overall emotional and cognitive states reminded me of my twenties.  Additionally I found my ability to visualize internal maps, even if abstracted or imagined seemed to have improved.  What I perceived to be adhd a decade or more ago seemed to have returned, but this scattered tendency dissipated after I stopped taking NSI.  Some of the clever immaturity of my sense of humor evened back out again, however my emotional stability was enhanced and has continued to be so approximately 4 months after I stopped taking NSI-189 (base).
 
I should mention that for the past many years I have been, pretty much, an alcoholic.  This began as a recreation but became a coping strategy since my college years.  While I was initially taking NSI-189 I made no effort to cut back on my alcohol consumption although I continued, much like an alcoholic would, to tell myself "tomorrow, tomorrow I'll stop."  Some time ago, I'm not certain how many weeks exactly, I just quit, cold turkey.  I've had the occasional inclination to drink but have kept on walking without looking back.  I believe this is largely unrelated to NSI-189, or the correlation is mild.  However, I can say that super acute anxiety attacks have significantly lessened, which may have assisted in my ability to just.stop.drinking.by.choice.  I had the opportunity the past month to spend time around a female who has continued PTSD and another female who has Borderline Personality Disorder with comorbid anxiety, and observe their behavior. One thing that I noticed in the girl with PTSD, aside from drug and alcohol abuse, was the seemingly irrational fits of anxiety which would cause her to cordon off people in her life, and frequent inexplicable fits of deep breathing and chest grabbing.  The deep breathing and chest grabbing were two features that I personally demonstrated since I had previously left Northern Virginia after working for a Department of Defense contracting company.  I noticed at this time that I wasn't enacting these same anxiety-mitigating behaviors hardly at all, and much was failing to affect me as significantly as before.
 
I forced myself to revisit many of the sites and locations and states of prior traumatic events and found them to have a significantly reduced impact on my physiological and emotional systems.  I am a bit more impervious to the toxic people in my life, however not completely so.  All of this is an important indication of the efficacy of drug to me if even just conjecture, largely qualitative.
 
Longitidunally, I can not comment on persistent benefits aside from a short term evaluation: 4 months after stopping my dosing schedule, emotional hardiness, stamina and stability are present.  Will this be so in 1 year, 5 years, 10 years?  I can not say.  Something to keep in mind is that nature (genetics) set the stage and playing field for your life, environment, decisions and circumstance (nurture) to have their way with you.  If you have a genetic predisposition for depression, and that depression is the result of neurology being impacted by irregular neurochemistry, allophathic solutions may still be a necessity even if a jolt of rewiring from activation of neurological stemcells gives you enhanced cognition for a duration of time.  Whatever the case, that we have a drug that causes structural change that we perceive as harmless is truly exciting news.  This is the wild west in Cognitive Science and Pharmacology in my opinion.
 
Anyhow...
 
Now that I am not drinking, I am preparing to embark upon a 3 month trial of NSI-189 Phosphate.  This will effectively put me at about 6x the length of administration of that done in the studies, however cycled.  I have a suspicion that the benefits may be more pronounced when my frontal lobe isn't frequently saturated in alcohol, and may give me SOME perception of the difference between NSI-189 (base) and NSI-189 Phosphate.   I surmise that this might not necessarily be the case as I am unaware of how production of stemcells works in the brain - if there is a relatively fixed number of such, or if the hippocampus continues to produce them after activation and consolidation.  Whatever the case, I will report my findings and do my utmost not to confound my own personal case study this time around with alcohol or cocktails of other nootropics.
 
Family members, some few friends, and a couple of researchers that I spoke with about my endeavor into DARPA's mysterious wonderdrug strongly discouraged the activity.  Some of these individuals had legitimate arguments that were scientifically based, and I'm sure most of you are aware of those risks.  However some certain others in my life likened this activity to drug abuse, to which I could only smirk through the irritation.  Whatever the case, I think my personal, adult, decision to undergo this activity was one of the very best that I ever made, perhaps second only to studying Psychology and Cognitive Science at I.U.
 
Anyway, here we go once more.  Cheers, my friends!

Great post!

Can I ask if you noticed any positive effects in the first month or did all the improvements occur from a month onwards?

[themadscientist]

I forgot to mention one thing. Do not take NSI with the Ciltep stack. I experienced a terrible migraine which lasted for 3 days.

[sk_scientific]

=============================

Great post!

Can I ask if you noticed any positive effects in the first month or did all the improvements occur from a month onwards?

=============================

 

As you might know, memories of this nature do tend to get a bit audited by virtue of the way our encoding and retrieval systems work, but I think that the positive effects were progressive and started to be detected around week two and continued onward.  One odd side effect that I noticed around the 3rd or 4th week that continued for a couple of months but later subsided was my sense of balance and equillibrium being a bit off.  I remember bumping into stuff with my hands as I walked by and feeling a little wobbly or clumsy.  Though I do remember feeling sharper by around week two, and my ability to construct images in my brain being enhanced around that time and progressing onward.  I began to notice mild memory benefits somewhere along the way.  The more stimulatory effects that some people describe of NSI wore off toward the end of the first month but the psychological hardiness continued to improve, even after I stopped taking NSI.

 

If I were to take a stab at what was going on, it's that initially there is some pharmacological effect that can be felt from drug action, as the substance may metabolize into other things or interact with the brain in more ways than just structural.  However the quieted anxiety, depression or PTSD symptoms were more noticeable when I found myself in situations that would normally have provoked me.  It was kind of like navigating through life, coming upon a stimulus and having a realization, "oh shit, that would have totally sent me on a spin 8 months ago, weird."

 

I think the greatest benefits are noticed after the fact, and for people who are used to taking a drug and feeling an effect, like say that of a benzodiazepine, this might be a bit hard to swallow and might be cause for them discarding the treatment.  

 

Some people may have it right about neurological consolidation or crystallization occuring once treatment has stopped (I'm sure there's a better term for the cementing and subsequent pruning of newly formed neurological pathways in this context).  I have a suspicion that it takes some amount of time for newly born neurological pathways to be sufficiently reinfoced with cognitive activation, synaptic action potentail, etc in order for those pathways to functionally diversify and make more complex your neural networks.

 

To address your question a different way, for me:

The first week was unpleasant.

The second week was more interesting (I feel like I'm younger in my brain and enhanced).

By the end of month 1, some effects were no longer detectable (mostly side effects).

Onward, effects were subtle, progressive and occasionally imperceptible.

Upon succession of dosing, I became used to how I was feeling, equilibrium and balance stabilized and it wasn't until I encountered stressors and situations that would have normally impacted me to a greater degree that I realized that changes had been made and persisted.

 

Additionally, I think that it takes time for behaviors to drop away from your person because although you've given yourself some new wiring, you still tend to employ scripts and strategies that you have always used.  Perhaps it's by virtue of a more stabilized emotional and cognitive reality that some behaviors lessen in severity, you begin to get new feedback from the external environment owing to this, and new behavioral strategies emerge.  I think it will be interesting to see if the second dosing supports this notion.

Edited by sk_scientific, 12 July 2014 - 05:16 PM.

[nat]

I forgot to mention one thing. Do not take NSI with the Ciltep stack. I experienced a terrible migraine which lasted for 3 days.

I also experienced this.

[Flex]

I´ve made a little thread for Vlk to gater some ideas to recover his money (arround 20,000 Pounds ! ) from a NSI Group buy.

There is also the narration which explains what happened

 

http://www.longecity...lk/#entry674351

 

I know this could be a bit off topic, but its for Vlk who contributed that people get their NSI.

So hopefully I´m in a gray zone with this ;-)

 

Edited by Flex, 13 July 2014 - 05:06 PM.

[jefferson]

To new people who have responded recently, I'm curious: have you been taking NSI-189 sublingually or orally? When you say orally, does that mean you're putting it in an empty pill? on a sandwich? For sublingually, are you leaving it on your tongue or gumline, and for how long?

 

Thanks

[neuroatypicow]

 on a sandwich?

Thanks

 

that made me laugh, thanks

i take it sublingually, which means to put it right under your tongue, in the little trough on either side of the webbing that divides the lower palate. the tissue there will absorb substances. try to keep it there, try to keep your mouth still so you don't stimulate the undertongue saliva glands. keep it there for 15 minutes or more. then swallow the remainder and chase with a tasty beverage. it's bitter stuff.

[Dosteov]

I need to try this. Can anyone recommend a source? I see one vendor selling it on Ebay. They have over 1K positive reviews but I have no idea if they are legit.  Thanks!

[Babychris]

Can it repair some Serotoninergic neurons destroyed by mdma use ? 

 

Furthermore can we use it in conjuction of a MXE therapeutic dose ?

[ken_shiro]

what should i buy for human consumption, freebase (cas 1270138-40-3) or phospahte (cas 1270138-41-4)?

 

is nsi-189 good for learning?

[mamborambo]

Here is the nmr from the alibaba source which is Wuhan HengHeDa Pharm Co



Here is the packaging from tht.co

 

i dont understand the nmr...what does it mean?

[Babychris]

Someone could help me with my questions ?

[Nattzor]

Someone could help me with my questions ?

 

No one knows. You're asking question about a drug with few published studies where the MoA is not known or atleast not published.

[cATsE]

I need to try this. Can anyone recommend a source? I see one vendor selling it on Ebay. They have over 1K positive reviews but I have no idea if they are legit.  Thanks!

I see two vendors on Ebay, both from Australia. But yeah, has anyone tried some from either of them? 

[typ3z3r0]

Theoretically, it may help increase the number of serotonergic neurons in the hippocampus, so it may repair some damage from MDMA use, however serotonergic neurotoxicity induced by MDMA is not restricted to the hippocampus. It also affects the occipital lobe, parietal cortex, and prefrontal cortex. If you'd like to learn more, try reading through some of the studies or reviews in this document I've compiled. You may also wish to read through this: http://www.reddit.co..._1_metabolites/

[Puppeteer]

Theoretically, it may help increase the number of serotonergic neurons in the hippocampus, so it may repair some damage from MDMA use, however serotonergic neurotoxicity induced by MDMA is not restricted to the hippocampus. It also affects the occipital lobe, parietal cortex, and prefrontal cortex. If you'd like to learn more, try reading through some of the studies or reviews in this document I've compiled. You may also wish to read through this: http://www.reddit.co..._1_metabolites/

Can you suggest any other supplements or nootropics that may aid in recovering from MDMA neurotoxicity at all?

[sk_scientific]

 

Theoretically, it may help increase the number of serotonergic neurons in the hippocampus, so it may repair some damage from MDMA use, however serotonergic neurotoxicity induced by MDMA is not restricted to the hippocampus. It also affects the occipital lobe, parietal cortex, and prefrontal cortex. If you'd like to learn more, try reading through some of the studies or reviews in this document I've compiled. You may also wish to read through this: http://www.reddit.co..._1_metabolites/

Can you suggest any other supplements or nootropics that may aid in recovering from MDMA neurotoxicity at all?

 

 

Given what is available that I am aware of at this time, Dihexa, NSI-189, J147 and to a significantly lower degree, GVS-111 are all candidates for some amount of neurological repair in this context.  Understand that as was previously stated MDMA abuse has consequences throughout the brain and the degree of damage depends on many factors thus what is possible in terms of neurological repair will vary by individual.

Edited by sk_scientific, 14 July 2014 - 07:18 PM.

[Rior]

If we're being realistic, it's likely that NSI-189 promotes structural growth in other areas of the brain, in addition to the hippocampus. The hippocampus was the initial point of study for growth with NSI, as it's the area of the brain targeted as having desire for growth to counteract things like PTSD or depression, but I would certainly not be surprised if additional studies undertaken at later dates show it causes growth in other areas as well (parietal lobe, prefrontal cortex, etc).

[sk_scientific]

If we're being realistic, it's likely that NSI-189 promotes structural growth in other areas of the brain, in addition to the hippocampus. The hippocampus was the initial point of study for growth with NSI, as it's the area of the brain targeted as having desire for growth to counteract things like PTSD or depression, but I would certainly not be surprised if additional studies undertaken at later dates show it causes growth in other areas as well (parietal lobe, prefrontal cortex, etc).

 

Probably, but it's not necessarily that the hippocampus was targeted per se.  It's that this is the location where neurogenesis and NSCs happen most frequently.  We now know that NSI-189 patients on active therapy showed increased high-frequency brain wave activity in the left temporal region, which contains the hippocampus, and there is suspicion that it is also having an neurogenerative effect in the left mesial temporal lobe somewhere outside of the hippocampus.  It has yet to be demonstrated that NSI-189 provokes neurogenesis in the prefrontal cortex.

 

This is why, I hypothesize that following treatment of NSI-189, after a consolidation period, with a drug like Dihexa may prove beneficial - Dihexa stimulates dendritic spinogenesis, and from these finger-like dendritic spines are created, new functional synapses.

 

I speculate NSI-189 and Dihexa impact similar areas most significantly (with Dihexa's operational areas being more diverse), but that NSI-189 has an action on neural stem cells (there is room for this to be refuted) and that Dihexa has a different action on those already existing synapses, perhaps all over the brain.

 

One-two punch of drugs, not taken to together but in responsible sequence.

 

I'm still trying to get my head around J147.

Edited by sk_scientific, 14 July 2014 - 10:59 PM.

[SearchingForAnswers]

Well, I'm in the ER waiting to be seen. I'm probably just having a panic
Attack but I'm being extra careful, given that I've let myself get out of
Physical condition.
Feel like it's tuff to breathe, lightheaded, no pain but I have been getting
Some chest pain in the recent past, though I've had that before (diagnosed
As idiopathic).
Likely not related to NSI or c60, but I thought it prudent to post.

[SearchingForAnswers]

Yeah, panic attack. It's subsided and I'm going home before being seen; starting a new job and I think it's just stress.

[Justice]

Does anybody know if NSI-189 would possibly interact with Prozac, Wellbutrin, Zyprexa or Klonopin?