6219 replies to this topic

[neuroatypicow]

no interactions so far with Klonopin and Brintellix.

[Joe chiavarini]

From what I have read people wont post suppliers on this board because Nuralstem will go after the suppliers.Maybe those requesting product on this site will get a pm from a supplier?

[JASOG888]

Does anybody know if NSI-189 would possibly interact with Prozac, Wellbutrin, Zyprexa or Klonopin?

 

I coudn't detect any interaction with Wellbutrin or Zoloft.
 

[sk_scientific]

The action of this compound is very different from drugs that agonize and antagonize neurotransmitter receptor sites or those that block reuptake.  Likelihood of interaction as you would see in the case of traditional psychoactive drugs appears to be very, very low.

Edited by sk_scientific, 15 July 2014 - 03:38 AM.

[ZHMike]

As far as interactions go, we need to know how this drug is metabolized.  If it is metabolized in the liver we need to know which specific CYP 450 enzyme metabolizes it.. 3a4?  2d6?  The CYP 450 system is what determines most interaction potential.

[cap3]

Has anyone else felt really tired on NSi189?

I'm struggling to get out of bed even though I am sleeping a good 8 hours. Normally I am ok with less sleep. Feel lethargic and tired all day too and can't even find the energy or motivation to exercise.

I noticed the same thing with cerebrolysin in the last week too. I do suffer from adrenal fatigue/low cortisol from time to time so I'm going to support my adrenals and see if that helps. I wonder whether your body needs to maintain a certain energy level for these drugs to be effective.

I have also lowered my dose to 40mg per day

[mamborambo]

Has anyone else felt really tired on NSi189?

I'm struggling to get out of bed even though I am sleeping a good 8 hours. Normally I am ok with less sleep. Feel lethargic and tired all day too and can't even find the energy or motivation to exercise.

I noticed the same thing with cerebrolysin in the last week too. I do suffer from adrenal fatigue/low cortisol from time to time so I'm going to support my adrenals and see if that helps. I wonder whether your body needs to maintain a certain energy level for these drugs to be effective.

I have also lowered my dose to 40mg per day

 

The brain needs most of the energy in our body. If NSI-189 really promotes neurogenesis it means that the energy demand of the brain could be higher. If you suffer from adrenal fatigue it means that your energy supply in your body is disturbed. 80% of your bodys energy is created in your thyroid. Maybe you should fix your thyroid as well....  http://www.stoptheth...m/adrenal-info/

[brucebanner]

How do I get hold of some?

Anyone in London or the UK interested?

[tolerant]

Does anybody know if NSI-189 would possibly interact with Prozac, Wellbutrin, Zyprexa or Klonopin?

 

No interaction with Zoloft, Lyrica or Clonazepam, but as I have mentioned a number of times in this thread, taking NSI-189 actually made my MDD/anxiety symptoms worse.

[mamborambo]

 

Does anybody know if NSI-189 would possibly interact with Prozac, Wellbutrin, Zyprexa or Klonopin?

 

No interaction with Zoloft, Lyrica or Clonazepam, but as I have mentioned a number of times in this thread, taking NSI-189 actually made my MDD/anxiety symptoms worse.

 

how long did u take it? how much did u take? were u trying to get off srri/antidepresants at the same time?

Edited by mamborambo, 15 July 2014 - 08:14 AM.

[tolerant]

@mamborambo

 

I took various doses, from about a minimum of 5-10mg orally to a maximum of 40mg sublingually, I tried once daily and twice daily. I did it over the course of about two weeks, but there weren't that may doses because every time I took it, it made me feel worse for a few days, during which time I didn't take any. And no, I wasn't trying to get off any other drugs during that time.

Edited by tolerant, 15 July 2014 - 09:19 AM.

[Kyle McGill]

Just received my 3 grams of freebase today, and excited to get started! Does anybody know if it is safe to combine this with a low dose of lorazepam that that I plan to be taking just for the next week due to work related stress?

Edited by Kyle McGill, 15 July 2014 - 06:54 PM.

[mamborambo]

@mamborambo

 

I took various doses, from about a minimum of 5-10mg orally to a maximum of 40mg sublingually, I tried once daily and twice daily. I did it over the course of about two weeks, but there weren't that may doses because every time I took it, it made me feel worse for a few days, during which time I didn't take any. And no, I wasn't trying to get off any other drugs during that time.

so you took it for two weeks...within those two weeks you didnt take it for a few days because you felt bad...

[Dosteov]

What's the best way to mix 1G? Is 1ML of water sufficient?  Does the water have to be refrigerated and mixed?

 

I was planning on running it for 25 days at 40MG a day.

 

I plan on starting within the week.

 

[sk_scientific]

What's the best way to mix 1G? Is 1ML of water sufficient?  Does the water have to be refrigerated and mixed?

 

I was planning on running it for 25 days at 40MG a day.

 

I plan on starting within the week.

 

 

The BASE is largely insoluable in water, and to a similar degree the same is true of the phosphorylated variant as well, atleast in my experience.  I would not recommend mixing it anyhow.  Weighing,  and using sublingually is the best methodology.  You will see much will remain granulated in your saliva.

Edited by sk_scientific, 16 July 2014 - 02:46 AM.

[mamborambo]

strange thing happened to me after I took it for two days. the night after I took my second dose I got terrible night sweats. I woke up in the middle of the night and the whole bed was soaked. It was hot last night but we had hotter days here and it didnt happen, so I think it is probabbly caused by the NSI-189. The same thing happened to me when I stopped my cannabis addiction. Back then it stopped after less than two weeks and then I would feel great again.

 

I have to add onething: I dont have a clue how much I took  My scale is due to arrive today. I couldnt wait so I just took the tip of a knife.

[Dosteov]

I guess I need to get a scale. Is accuracy to .01 G sufficient. I think that means it is accurate up to 10MG.  So .04 G is 40 MG.

 

What protocol are most people following? 40MG or 80MG a day?

 

@mamborambo how do you feel after two days?

 

How soon do people feel a positive effect?

 

[eno]

I guess I need to get a scale. Is accuracy to .01 G sufficient. I think that means it is accurate up to 10MG.  So .04 G is 40 MG.

 

Better use a scale with a display up to .001g.

Search for GEM20 digital scale. This is what I would recommend. It's less than 20 bucks.

 

Any cheap scale like this will be more inaccurate around the zero point (to hide an inevitable drift). So put a piece of paper on it, look at the weight, then add the desired amount of the compound.

[mamborambo]

I guess I need to get a scale. Is accuracy to .01 G sufficient. I think that means it is accurate up to 10MG.  So .04 G is 40 MG.

 

What protocol are most people following? 40MG or 80MG a day?

 

@mamborambo how do you feel after two days?

 

How soon do people feel a positive effect?

 

Well, today is the third day, I took my third dose a couple hours ago and will take a another dose later this day. 

 

I feel good. I am under a lot of stress. Not sure if the NSI-189 is doing anything already, but I feel more calm...and strangely I guess I feel more confident. This is probably just a placebo at this stage. But I am glad about it. One more thing: I wanted to bring out the trash last night and ended up cleaning the whole kitchen...Usually I dont have the energy to do anything...but again, THIS IS PROBABLY JUST A PLACEBO AT THIS STAGE..   

Edited by mamborambo, 16 July 2014 - 06:35 PM.

[tolerant]

@mamborambo

 

I took various doses, from about a minimum of 5-10mg orally to a maximum of 40mg sublingually, I tried once daily and twice daily. I did it over the course of about two weeks, but there weren't that may doses because every time I took it, it made me feel worse for a few days, during which time I didn't take any. And no, I wasn't trying to get off any other drugs during that time.

 

I find it absolutely unbelievable, that every time I share my experience with NSI-189, my posts get marked down as "ill-informed" by a host of members. I'm not making any claims, I'm not telling people not to take it, I'm just sharing my experience. And I continue to do it by publicly answering anew every post which asks me about my experience, although all the information is available to anyone who refers to my previous posts. Even though it's somewhat painful for me to keep sharing a negative experience I had with a drug I put a lot of hope into and which quite a few of other members found truly helpful.

 

Why are my posts ill-informed if I suffer from a severe treatment-resistant condition, take a substance (NSI-189) and I find that it exacerbates my symptoms to the point of them being unbearable? What am I supposed to do? Keep taking it so I can conduct a more "proper" experiment that I can share with the community? There's a member on this forum who got severe paresthesia after taking an initial dose NSI-189 and feared permanent nerve damage until it subsided over a few days. Would you demand that person to continue keep taking the drug at a regular dose for sufficient period of time before sharing their experience? Or would the more likely experience be that after such an experience the person would wash the remaining drug down the toilet?

 

If you go over to the NSI-189 poll, you'll find that 25% of people found the drug "ineffective" or "very harmful". And if the poll was not made public, I'm sure there would be more people reporting similar experiences. The organiser of the biggest group buy of this drug told me that the feedback he got from some people who had a level of anxiety before taking the drug was that it increased their anxiety. But this entire line of discussion is peripheral and is not my point. Even if I was the only person who didn't have a positive experience with the drug, why would that be a reason for continually marking my posts as "ill-informed"? Are you going to do this with this post as well?

Edited by tolerant, 17 July 2014 - 05:26 AM.

[typ3z3r0]

I personally did not find my one month or so trial of NSI-189 unbearable, however I do feel that when I used it, I would feel more lazy, and perhaps sometimes a bit anxious. I'm not sure how much it contributed to my more positive state now, as I used multiple things within close proximity to it, however I don't feel that it significantly positively impacted my life as it has for some people. :P

[mamborambo]

 

@mamborambo

 

I took various doses, from about a minimum of 5-10mg orally to a maximum of 40mg sublingually, I tried once daily and twice daily. I did it over the course of about two weeks, but there weren't that may doses because every time I took it, it made me feel worse for a few days, during which time I didn't take any. And no, I wasn't trying to get off any other drugs during that time.

 

I find it absolutely unbelievable, that every time I share my experience with NSI-189, my posts get marked down as "ill-informed" by a host of members. I'm not making any claims, I'm not telling people not to take it, I'm just sharing my experience. And I continue to do it by publicly answering anew every post which asks me about my experience, although all the information is available to anyone who refers to my previous posts. Even though it's somewhat painful for me to keep sharing a negative experience I had with a drug I put a lot of hope into and which quite a few of other members found truly helpful.

 

Why are my posts ill-informed if I suffer from a severe treatment-resistant condition, take a substance (NSI-189) and I find that it exacerbates my symptoms to the point of them being unbearable? What am I supposed to do? Keep taking it so I can conduct a more "proper" experiment that I can share with the community? There's a member on this forum who got severe paresthesia after taking an initial dose NSI-189 and feared permanent nerve damage until it subsided over a few days. Would you demand that person to continue keep taking the drug at a regular dose for sufficient period of time before sharing their experience? Or would the more likely experience be that after such an experience the person would wash the remaining drug down the toilet?

 

If you go over to the NSI-189 poll, you'll find that 25% of people found the drug "ineffective" or "very harmful". And if the poll was not made public, I'm sure there would be more people reporting similar experiences. The organiser of the biggest group buy of this drug told me that the feedback he got from some people who had a level of anxiety before taking the drug was that it increased their anxiety. But this entire line of discussion is peripheral and is not my point. Even if I was the only person who didn't have a positive experience with the drug, why would that be a reason for continually marking my posts as "ill-informed"? Are you going to do this with this post as well?

 

@tolerant

I think it is good what you are doing and you are making valid points here. I understand your decision to stop taking NSI-189  if the drug had unbearable side effects for you. Nobody can tell you that these side effects will stop after x-weeks as the drug has only passed phase 1 trials. It seems from the anecdotal evidence here on the forum that these side-effects stop after a while...however, this anecdotal evidence is unreliable. 

 

About the member who had parasthesia: I think he was trying to get off antidepressants at the same time and that can cause strange symptoms...including shock like sensations. http://www.medscape....rticle/455760_3

 

Anyway, I apologize for marking your post as ill-informed    I somehow thought that you didnt know that the anecdotal evidence exists that says that the side effects will probably go away.

[tolerant]

mamborambo, thank you for understanding. I think I will return to NSI at some point. 

[Babychris]

It seems that there is more negative than positive report ? Or maybe I just let my attention more on the negatives one. But really I don't remember reading an experience about someone getting from a terrible drama to the paradise

[SearchingForAnswers]

Well, thought I'd post an update on my experience with NSI-189.

I've been taking it TID x40mg for about 19 -20 days now; the fatigue that people report is very real, it can definitely make you tired. But I think some people are truly missing the point when they discuss quitting it due to MODEST side effects; this isn't something you take for it's immediate effect, you take it for it's long term effect.

 

Summary:

1. Right now, I haven't had a depressed day for about 5 days.

2. I had a sort of panic attack about 2 days ago - it occurred after dinner, after consuming some c60oo (though it started mildly before that). I have a history of these panic attacks and thinking my heart is having a problem, because they are typically accompanied / start with chest pain (diagnosed as idiopathic, as I've had a complete cardiac work up). The only thing different this time is that there was no pain. My blood pressure peaked at about 150 / 95, then came down. In fact, it's now almost normal at 117/84 last night.

3. I've been fairly emotional, but much of this, and probably the panic attack is due to the fact that I applied for an overseas job and found out that I'm going, so I will have to leave my family for awhile.

4. My memory seems better, it doesn't seem to be as much of a struggle to recall routine things.

5. I'm taking this for MDD/Anxiety, not as a nootropic. So I have not objective test, just anecdotal evidence.

6. I had the initial very positive reaction for the first couple of days, possibly placebo, but it seemed very, very real. After that, the fatigue set in.

7. The fatigue appears to be subsiding.

8. I have small children, and I am able to connect with them better; I don't have to feign interest in my son's minecraft so much, for example. There is less tumult in the household, and that's very good. (My wife is also taking it BID).

 

Hope that helps....

[stillwater]

Good report, I have panic /anxiety disorder and worry about any increase, possibly even permanent from this.

[SearchingForAnswers]

Stillwater, it may happen, but it should be transient and well worth it when done. Mine was up for several days, but it's melted away. However I have lots going on now. I am hoping beyond hope that this is my ticket out of permanent depression, panic attacks, anxiety and other effed up symptoms, and the bad judgements it has helped me make in the past.

 

I believe if not for the MDD and other ailments, my career and savings would be much farther along. It can get really cripping... just right now, and for the last 5 days straight, I feel so damned good.

 

One other thing I forgot to mention earlier is that my libido keeps getting crazy crazy high.

Edited by SearchingForAnswers, 17 July 2014 - 05:47 PM.

[foreseason]

Update/Warning about Nutraction:

 

A few weeks ago I purchased NSI-189 from Nutraction.com

 

After receiving it, and being concerned about it's authenticity, I contacted Jason from Nutraction.  He told me I could return the product for a refund. 

 

I returned the NSI-189 and according to the USPS tracking it arrived last wednesday (7/9/14).  It has been 8 days since then with no refund.  I attempted to contact them a few days ago and my email has not been replied to. 

 

I will be sending another email today. 

[cap3]

Update/Warning about Nutraction:
 
A few weeks ago I purchased NSI-189 from Nutraction.com
 
After receiving it, and being concerned about it's authenticity, I contacted Jason from Nutraction.  He told me I could return the product for a refund. 
 
I returned the NSI-189 and according to the USPS tracking it arrived last wednesday (7/9/14).  It has been 8 days since then with no refund.  I attempted to contact them a few days ago and my email has not been replied to. 
 
I will be sending another email today. 

I wouldn't bother it seems their website is down and they are not responding to my emails either.

I ordered nsi 189 from them a month ago but never received anything

[Hearwhynot]

I joined today because I saw this post, if someone would like I have a chart of nsi and am more than willing to send a sample to someone of it if they would like to check the authenticity. I'd prefer someone in the US though so I may use tracking.

 

I want to be clear though when I say someone, I'd prefer someone who is a trusted member of the forum since I don't have a reputation of any sort myself. I'd gladly trade a sample to gain some trust. I have already been dealing in it and maybe someone recognizes this name here already.

 

I hope to hear from someone interested in this small exchange.

 

If you'd like to know more about me I'd be more than willing to give more information.

 

I can also post the chart here if it allows me to. I think after 10 posts I can?