6219 replies to this topic

[drg]

Aren't you supposed to give people the 'ill informed' tag and then never admit it.... 

[Hearwhynot]

Aren't you supposed to give people the 'ill informed' tag and then never admit it.... 

 

What do you mean?

 

Also someone has already sent me a private request for the sample. I will be mailing it out to them tomorrow. So nobody needs to request it anymore. Once they have it tested I am sure it may breed some trust.

[drg]

 

What do you mean?

 

Also someone has already sent me a private request for the sample. I will be mailing it out to them tomorrow. So nobody needs to request it anymore. Once they have it tested I am sure it may breed some trust.

 

Never mind, I must have replied to someone a few pages back. My mistake :/

[jefferson]

 

 

Why are my posts ill-informed if I suffer from a severe treatment-resistant condition, take a substance (NSI-189) and I find that it exacerbates my symptoms to the point of them being unbearable? What am I supposed to do? Keep taking it so I can conduct a more "proper" experiment that I can share with the community? There's a member on this forum who got severe paresthesia after taking an initial dose NSI-189 and feared permanent nerve damage until it subsided over a few days. Would you demand that person to continue keep taking the drug at a regular dose for sufficient period of time before sharing their experience? Or would the more likely experience be that after such an experience the person would wash the remaining drug down the toilet?

 

 

 

That was me. And it wasn't a few days, more like a month. Twice. Each time it took about a month to go away, and even now I have very faint, residual sensations. Very scary. It wasn't from going off antidepressants either, because the second trial I did a month after the first time, I had ceased taking all antidepressants two weeks before. The second time I took "NSI-189" (" " are because we're not 100% sure what it is) it caused me the same terrible burning pain less than 24 hours later. There's little doubt in my mind what the culprit is. I don't have a problem believing this drug could work very well in some/most people, but due to individual genetics or biology I suspect there are a lot of people who won't respond or experience bad side-effects. This problem is true of every other antidepressant on the market, and would not be unique to NSI-189. A 100% response/remission rate would be astounding and unheard of. Maybe an analog of NSI-189 would provide better luck for us non-responders, although technically I'm not a non-responder, just couldn't tolerate it. I can't tolerate Amitriptyline but its analog nortriptyline is no problem.

[foreseason]

That was me. And it wasn't a few days, more like a month. Twice. Each time it took about a month to go away, and even now I have very faint, residual sensations. Very scary. It wasn't from going off antidepressants either, because the second trial I did a month after the first time, I had ceased taking all antidepressants two weeks before. The second time I took "NSI-189" (" " are because we're not 100% sure what it is) it caused me the same terrible burning pain less than 24 hours later. There's little doubt in my mind what the culprit is. I don't have a problem believing this drug could work very well in some/most people, but due to individual genetics or biology I suspect there are a lot of people who won't respond or experience bad side-effects. This problem is true of every other antidepressant on the market, and would not be unique to NSI-189. A 100% response/remission rate would be astounding and unheard of. Maybe an analog of NSI-189 would provide better luck for us non-responders, although technically I'm not a non-responder, just couldn't tolerate it. I can't tolerate Amitriptyline but its analog nortriptyline is no problem.

Where did you acquire the NSI?

[Hearwhynot]

I tried the NSI-189 for the first time today, I've heard people take about 40mg and usually twice a day. I've also read a lot of people are taking smaller amounts. I felt motivated when I took it to say the least. No hunger like others have commented. 

 

Does anyone know if mixing NSI-189 and MK-677(Ibutamoren) would be dangerous? I want to take both at the same time if possible.

[jefferson]

 

 

That was me. And it wasn't a few days, more like a month. Twice. Each time it took about a month to go away, and even now I have very faint, residual sensations. Very scary. It wasn't from going off antidepressants either, because the second trial I did a month after the first time, I had ceased taking all antidepressants two weeks before. The second time I took "NSI-189" (" " are because we're not 100% sure what it is) it caused me the same terrible burning pain less than 24 hours later. There's little doubt in my mind what the culprit is. I don't have a problem believing this drug could work very well in some/most people, but due to individual genetics or biology I suspect there are a lot of people who won't respond or experience bad side-effects. This problem is true of every other antidepressant on the market, and would not be unique to NSI-189. A 100% response/remission rate would be astounding and unheard of. Maybe an analog of NSI-189 would provide better luck for us non-responders, although technically I'm not a non-responder, just couldn't tolerate it. I can't tolerate Amitriptyline but its analog nortriptyline is no problem.

Where did you acquire the NSI?

 

 

I was a part of the VLK groupbuy.

 

 

I tried the NSI-189 for the first time today, I've heard people take about 40mg and usually twice a day. I've also read a lot of people are taking smaller amounts. I felt motivated when I took it to say the least. No hunger like others have commented. 

 

Does anyone know if mixing NSI-189 and MK-677(Ibutamoren) would be dangerous? I want to take both at the same time if possible.

 

Nobody even knows if taking NSI alone is truly safe yet (especially longterm), how in the world would anyone know if combining it with another research chemical would be safe? There was someone asking last week if NSI-189 could be safely combined with MXE... Methoxetamine!!! Not to be mean, but the best answer you or anyone is going to get in these cases is someone else here who took the combo and lived to post about it, which still tells you very little since the sample size is n=1.

[sk_scientific]

As I stated previously in this thread, I am undertaking a 2nd go round with NSI-189.

 

My first experience was a 3 month endeavor beginning January and ending about three months later, and this was with NSI-189 Base.  My experiences after the fact implied that the benefits persisted many months after cessation.

 

At the present, I am taking NSI-189 Phosphate and I am almost a week in.  I have none of the negative anxiety related side effects that I had in the first two weeks of the prior endeavor, although the mild stimulatory effect is present.

 

I feel SHARPER one week in this time around.  Appetite isn't voracious as before.  People in my family have tried to play their usual head games with me and it's had little impact.  I also find myself bouncing back from being aggravated a bit more swiftly than usual.

 

Little to no depressive anything, overall sense of well-being is good.  The buzzing inside of the head has returned and it's not invasive, might even be described as pleasant.  I'm writing with better clarity and thoughtfulness.

 

Haven't had a drop of alcohol.

[Rior]

 

 

 

Why are my posts ill-informed if I suffer from a severe treatment-resistant condition, take a substance (NSI-189) and I find that it exacerbates my symptoms to the point of them being unbearable? What am I supposed to do? Keep taking it so I can conduct a more "proper" experiment that I can share with the community? There's a member on this forum who got severe paresthesia after taking an initial dose NSI-189 and feared permanent nerve damage until it subsided over a few days. Would you demand that person to continue keep taking the drug at a regular dose for sufficient period of time before sharing their experience? Or would the more likely experience be that after such an experience the person would wash the remaining drug down the toilet?

 

 

 

That was me. And it wasn't a few days, more like a month. Twice. Each time it took about a month to go away, and even now I have very faint, residual sensations. Very scary. It wasn't from going off antidepressants either, because the second trial I did a month after the first time, I had ceased taking all antidepressants two weeks before. The second time I took "NSI-189" (" " are because we're not 100% sure what it is) it caused me the same terrible burning pain less than 24 hours later. There's little doubt in my mind what the culprit is. I don't have a problem believing this drug could work very well in some/most people, but due to individual genetics or biology I suspect there are a lot of people who won't respond or experience bad side-effects. This problem is true of every other antidepressant on the market, and would not be unique to NSI-189. A 100% response/remission rate would be astounding and unheard of. Maybe an analog of NSI-189 would provide better luck for us non-responders, although technically I'm not a non-responder, just couldn't tolerate it. I can't tolerate Amitriptyline but its analog nortriptyline is no problem.

 

 

I would certainly agree that a genetic component may cause dramatic differences in response to NSI-189. We know NSI is a neurogenic compound, and while it seems most of its effects are isolated to the hippocampus, I wouldn't exactly be surprised if it caused some sort of effects on other areas of the nervous system. Thus, it definitely doesn't seem ridiculous that peripheral neuropathy would be a possibility. Sorry you seem to be a responder with adverse effects.

[faultybrain]

Hi all;

 

I suffer from MDD with associated anxiety and have been through a slew of medications from different classes, as well as non pharmacological treatments such as the new-ish rTMS treatment, all to no avail. I hear some pretty promising data regarding NSI-189 but do not wish to wait and risk my condition deteriorating for the next 5+ years until Neuralstem gets to market. I'm hoping that someone here can help me.

At the moment, it seems there's so much talk about Wuhan Hengheda Pharm Co, and looking back through the thread the closest speculation as to the authenticity of their product is the absorbency graph posted a few pages back - it shows it isn't similar to the 2 group buy products, but the peaks look at least a little similar. Could this be due to the similarity of bonds all organic compounds share? Is there anything more than pure speculation as to the authenticity of this product?

Also, I've noticed apart from these chinese manufacturers, and the rather expensive Australian product on eBay atm, there isn't anywhere else to buy this. Does anyone have any idea of potential leads, or even if someone has a couple of grams left over from a group buy they may have been in that they no longer want, please reply!

Any information that isn't pure speculation is welcome. 

[burtsl]

Hi All,

 

I've been taking NSI-189 that I bought from teamtlr (http://teamtlr.com/) for about 1 week (arrived on 7/14/2014). 

 

It has literally changed my life. I am no longer depressed, and I used to be depressed on a daily basis. I feel happier in general and more sociable. The other day I started making conversation with the bus driver for no reason and I never do that. 

 

I am also diagnosed with ADD (inattentive primary). I do notice a significant spike in my motivation to get things done. Most days I simply sit around at home watching netflix, but in the last week I started planning out what I wanted to get done, a week in advance, and I crammed in a bunch of personal and social events, that I find hard to believe that I accomplished.

 

I started taking 10mg BID orally for a few days, then I learned to take it sublingually since then. For the last day or two I've started taking about 20mg BID.

[neuralis]

Thanks for this post, I was wondering if they are legit or not. Going to put down a order later today.

[Amorphous]

burtsl, 

 

Please see the following link: 

http://www.longecity...es/#entry675726

 

 

[faultybrain]

Thank you burtsl, I will without doubt check them out, but yeah, if possible would you be able to edit your post to avoid them being shut down? Regardless, thank you for the help!

[neuralis]

Put down an order with them for some NSI and fasoracetam.

Don't know if I really want the Faso, it was more of a impulse buy. But I'm excited to finally have a chance to get my hands on some NSI.. It's fascinating substance to say the least.

[faultybrain]

Can I ask how much you purchased? I was considering 3g to start with but it's quite a lot to shell out if it doesn't work. Will I be able to tell after 1g if it works or not, do you think?

[Hearwhynot]

Sigh, to be honest being a source is a lot of work. People make a large investment on their own part, hoping to see something come out of it. I am a reseller of a lot of products, and because I can't sell some of them anymore on e-bay though they are not illegal to sell. I am stuck with 1,000's of grams of all sorts of things.

 

I'll give an example. These are not illegal the last time I checked, but I have difficulty selling them online unless I open my own online store.

 

Niclosamide, Metformin and Moclobemide. These are investments we've made and we can't sell them on e-bay anymore, maybe amazon not even sure I have to read their rules and regulations before I can. This also has to do greatly with NSI and other things. Truth is you can sell nsi-189 on ebay right now. But If you try you'll learn the difficulty that comes with it.

 

My business has expanded recently. So I am going to have to put a lot more work myself. But there isn't as much profit as some would think since we take a lot of the risk as resellers. Nobody ever makes a request for 250g-500g of a product, then we have to try to get it then get it through customs, then test it to make sure it's proper. Then we have to build trust with people to make sure word spreads that we are a good source of whatever it is. Afterall the best advertisement is and has been for the last 1000's of years is word of mouth.

 

Since I'm a reseller I understand that side of it very much. I see a lot of questions and I feel I can't answer them directly. I don't mind answering some of those questions in private as it won't be seen in a post. But we have to always be cautious.

 

Yours Truly

-G The lifelong reseller.

 

On a side note I do sell dinosaur teeth! That's easy to do!

[faultybrain]

Thanks for your reply, I pm'd you.

Does anyone have an estimate on how long it takes to see an effect? I've ordered 1g to test the waters but do not wish to be disappointed just because I did not order enough
Thanks for your reply, I pm'd you.

Does anyone have an estimate on how long it takes to see an effect? I've ordered 1g to test the waters but do not wish to be disappointed just because I did not order enough

[Hearwhynot]

I saw an effect on day 1 and pretty fast. Not sure on the anti-depressant side since I don't have issues on that side already. But it did help make me proactive in daily activities.

[neuralis]

Faulty, I ordered 1 gram for starters as well. Mostly because I'm a bit wary of Australian customs seizing the stuff. If it so happens that it gets through and I get positive response from it, I'll order more for sure. Most of the people trying out nsi notice effects in the first week, so 1 gram should be enough for first trials.

Though I'm not sure how much I can benefit from NSI for my condition, it's definitely interesting alley to explore. All my hopes are tied to the Dihexa group buy delivering one day.

[SearchingForAnswers]

My update;
Several days of some pretty bad anxiety, not a smidgen of depression. I've had less coffee today, and I'm just wondering if all those new virgin neurons are just hypersensitive to it!
I'll try a caffeine free day tomorrow and hopefully that'll tell me something.

[noot_in_the_sky]

Hey, guys I don't know if your all aware of this, but it was publish in an article information about this forum's group buys & NSI-189. I'm letting you know so you all can take some extra precautions when disclosing your location and personal information, specially since the company behind NSI has been try to stop its sell on line.

 

Forum link to thread:

http://www.longecity...ihexa-and-more/

Edited by noot_in_the_sky, 22 July 2014 - 02:43 PM.

[FW900]

Coinciding with the previous post, I'm pleased to announce the NSI-189 source discussion group is now live. Any information discussed within it will be private and unviewable to nongroup-members.

 

If you wish to join this group, please post in the linked thread. Please reply to this post in the linked thread as well.

 

http://www.longecity...es/#entry676330

[foreseason]

 

Update/Warning about Nutraction:
 
A few weeks ago I purchased NSI-189 from Nutraction.com
 
After receiving it, and being concerned about it's authenticity, I contacted Jason from Nutraction.  He told me I could return the product for a refund. 
 
I returned the NSI-189 and according to the USPS tracking it arrived last wednesday (7/9/14).  It has been 8 days since then with no refund.  I attempted to contact them a few days ago and my email has not been replied to. 
 
I will be sending another email today. 

I wouldn't bother it seems their website is down and they are not responding to my emails either.

I ordered nsi 189 from them a month ago but never received anything

 

 

This morning I sent an email to Jason telling him I was filing a complaint with IC3 (internet crime complaint center), my local law enforcement, and GoDaddy (hosts nutraction.com) 

 

About an hour later I received my refund.  Isn't that interesting...
 

[faultybrain]

(Sorry, please ignore, accidental double post in wrong thread)

Edited by faultybrain, 23 July 2014 - 09:39 AM.

[SearchingForAnswers]

Well, I have roughly 8 days of NSI therapy left.

 

The side effects have gotten severe enough that I'm reducing my dosage from 40mg TID to 20mg 2 - 3x. So far, at 20mg this morning it seems tolerable. The following side effects have been observed, quite severe lately:

1. An extremely narrow focus of attention, almost like what I image autism to be like

2. Pressure in the head that is really very uncomfortable.

3. Generally, it's been a bit of a roller coaster, sometimes feeling incredibly well and other times.

4. A decent run of at least a mile will wipe out the side effects, for about 3 - 4 hours. But I can only do that about once a day, given that I'm at work and such.

5. The pressure in the head is accompanied by a sort of vague anxiety, which on a couple of occasions resulted in a panic attack until I reasoned out that it was indeed just a temporary side effect.

 

I think I'll probably do another 30 day cycle if I need it in the future, albeit probably at 40mg OD.

 

I can tell I'm going to feel great, because as I skipped the normal 3rd dose yesterday and didn't take the reduced dose until a couple of hours ago, I felt progressively better (than normal).

Edited by SearchingForAnswers, 23 July 2014 - 02:02 PM.

[tolerant]

It is interesting that as the NSI-189 thread unfolds, there are more and more incidences of non-response/adverse effects being shared. I now realise that I got enticed into NSI-189 by two or three fairytale stories of people "feeling like teenagers again", "feeling that everything is OK" and other feelings which matched exactly what I craved. But I had a bit of a revelation of sorts about this drug. In reality, the success ratio of NSI-189 doesn't appear to be greater than that of any other anti-depressant. What it's got going for it is that it has no withdrawal syndrome and that its benefits last even after it's discontinued. But the actual revelation I had was that the few people who had fairytale life-changing experiences from taking NSI-189 probably just needed an anti-depressant, any anti-depressant. They didn't come to NSI-189 as psychiatric patients having exhausted all conventional therapies. They came to NSI-189 feeling that they needed some sort of a lift or boost, but have probably never tried a single anti-depressant in their life. Now I more than welcome these people to come forward and correct me if I'm wrong. But my guess is that they would have achieved the same fairytale response from a conventional anti-depressant, just as was the case with me when I first tried a conventional anti-depressant.

Edited by tolerant, 23 July 2014 - 03:28 PM.

[Babychris]

Maybe not maybe yes,but for sure NSI-189 is like any drug, far from a miracle substance.

 

And that's easy to understand since roots of depression could be so multiple and no AD treat them. I think that AD are really effective if you have a "simple cause " depression I mean like If you have broken up with someone, or if a relative up to the sky.

 

Then for others I think that it's much harder.

[JASOG888]

I have been experiencing uneven results from the NSI-189 which I blame on my not using a scale. My scale isn't accurate down to the level I need for this, so I have been using a "micro" scoop. When the dose is too large, I become very unemotional. It can get pretty strange not feeling any emotions, but it's still better than being depressed. I had been taking zoloft and wellbutrin for years and have wanted to get off them for a while now. Between NSI-189 and cerebrolysin, I feel like I will be able to function well ithout the AD meds.  I guess it's time to invest some money in a micro balance. Small doses of NSI-189 about 3 times a day are working pretty good for me. I have never felt any pressure in my head. I have recently started working out again, so I expect to get an even better effect from the NSI-189.

[fourohfournotfound]

I've found dosages can vary about 20% when using a microscoop sometimes I don't measure it on the scale. I honestly haven't found much difference either way. The effects of nsi feel somewhat similiar to caffeine wearing off after 6 hours or so and having a very slight effect on me. I have also noticed that within an hour after taking it I am more emotional. I was on the verge of tears while watching transformers. It wasn't even sad just any time it became emotionally intense I felt a sudden sadness. I also don't feel much at all if I don't take it for a few days and seem to regress to a semi depressed state. I almost feel like I have some fake nsi, but I got it from Nyles so I would think it would be legit.

 

I wish I could find different vendor, but I don't qualify for the source group.

Edited by fourohfournotfound, 24 July 2014 - 01:42 AM.