6219 replies to this topic

[brucebanner]

The hippocampus is a small brain structure but increasing its volume by 20% is extreme and possibly dangerous in my opinion.

 

My biggest concern is that extended use of this drug at specific doses could ultimately result in brain hernia, temporal lobe, foramen magnum. May also cause damage to brain structures due to the consistency of the brain and the fixed volume it occupies. Can someone with a degree in this topic allay my fears?

 

Other thoughts:

High doses of NSI result in headaches. Forskolin increases the effectiveness of nerve growth factors. NSI + CILTEP (forskolin) causes debilitating headaches.

Headaches are caused by blood vessels and the meninges. One theorem is friction between structures causes these effects. If we assume that rapid brain growth and micro movements in its structure are causing the headaches, combine this thought with the empirical evidence that headaches subside after a week of supplementing it may validate the idea below.

Neuronal Stem Cells, will depleting their stocks reduce their overall production rate? Reduced long term effectiveness of this drug?

New neurons are more sensitive to GABA, might explain the antidepressant effect.

I'm concerned this drug is receiving false reviews from stockholders. I trade shares and I expect this to be a "pump and dump", the phase 3 trials may be successful but the moment before the news release there will likely be a huge sell-off as people who pumped the stock de-risk. I might be wrong, I'm only raising this point out of loyalty to this forum and general concern.

 

If I were to trial this substance I would get a MRI before and 4 months after. I would also use a dose on the low end and spend my time focused on training my brain so new pathways might be put to good use and not absentmindedness. This is a substance I would cycle.

 

I think it will be beneficial if everyone taking this substance details the superficial details, colour, consistency, taste. This information correlated with effectiveness might be meaningful.

 

I totally agree. I wouldn't dare put this into my system unless I could totally analyse the before and after state. There are lot of brave folks in here! Does anyone in UK, London in particular, know I can get brain scan (MRI or what have you) for reasonable price? Is this covered by the NHS? If not I'll try to get it via the company health plan.

 

We need to make this thread much more scientific. Everyone providing feedback needs to include as much non-sensitive information as possible:

 

1. Age, weight etc.

2. Any relevant history.

 

Then we can begin charting and analysing the data. Having to read through all the thread is very time consuming. Honestly, I can't believe someone hasn't already done this. This is probably asking for a lot but it will help in the long run. I am Software Developer and if anyone wants to undertake such a project, PM and we'll get talking.

[SearchingForAnswers]

The hippocampus is a small brain structure but increasing its volume by 20% is extreme and possibly dangerous in my opinion.

 

My biggest concern is that extended use of this drug at specific doses could ultimately result in brain hernia, temporal lobe, foramen magnum. May also cause damage to brain structures due to the consistency of the brain...

 

I certainly understand what you are saying, but wouldn't they have picked these issues up in Phase 1a of 1b? You'd  think they wouldn't even pursue it if those issues were relevant. Or at least hope they wouldn't...

[BraceWell]

Umm... after reading the negative reviews on this and the pharmacology of it, I'd say that everyone is using it the complete wrong way. If you're pushing your brain to the max every day of course you're going to get negative side effects. It's like taking amphetamines every day and saying at the end "this is horrible, I feel like shit, it's giving me this, this and this and it doesn't work the way I want it to".

Well no shit! Whereas taking it once every few days or once a week will help a lot for focus and generally getting things done.

I think the same can be said for this. I'm going to try using it every 2-3 days at a 10-20mg dosage and will report back in a few weeks and I think I'll see a lot more positive results.

It's the same thing as with anti-depressants. Eg. If I'm feeling particularly low I'll take one and feel the difference almost immediately but after taking them for more than a week, the effects seem to fade out and more adverse effects present themselves. In fact it's the same with /all/ drugs.

Apart from maybe the basics such as choline and a racetam or two, none of these heavy compounds should be taken every day, certainly not THREE times a day! I mean come on, who are we trying to kid ourselves?!

Edited by BraceWell, 29 July 2014 - 04:05 PM.

[Reformed-Redan]

I think nobody knows what they are talking about and most comments are based on pure speculation. I'll just wait for FDA trials to complete.

[foreseason]

Umm... after reading the negative reviews on this and the pharmacology of it, I'd say that everyone is using it the complete wrong way. If you're pushing your brain to the max every day of course you're going to get negative side effects. It's like taking amphetamines every day and saying at the end "this is horrible, I feel like shit, it's giving me this, this and this and it doesn't work the way I want it to".

Well no shit! Whereas taking it once every few days or once a week will help a lot for focus and generally getting things done.

I think the same can be said for this. I'm going to try using it every 2-3 days at a 10-20mg dosage and will report back in a few weeks and i think I'll see a lot more positive results.

It's the same thing as with anti-depressants. Eg. If I'm feeling particularly low I'll take one and feel the difference almost immediately but after taking them for more than a week, the effects seem to fade out and more adverse effects present themselves. In fact it's the same with /all/ drugs.

Apart from maybe the basics such as choline and a racetam or two, none of these heavy compounds should be taken every day, certainly not THREE times a day! I mean come on, who are we trying to kid ourselves?!

 

Everyone is using it the completely wrong way??

 

It seems to be that most people are using it exactly how it was used in the studies.  You read about the pharmacology of NSI-189 and are now some kind of expert?   I think I'll listen to the people who spent years researching and developing the compound when it comes to dosing.

 

Comparing NSI-189 to amphetamines??

 

Seriously??  You're comparing two completely different substances with totally different MOA's.  These drugs are are not the slightest bit similar. 

 

"I'm going to try using it every 2-3 days at a 10-20mg dosage and will report back"

 

So you're preaching about the proper way to take NSI-189 yet you haven't even tried it yet. 

 

If you're getting such a strong reaction from single doses of anti-depressants it's more likely they are just putting you into some manic or hypo-manic state.  Based on your know it all attitude in this post, I wouldn't be surprised if you're in that state currently. 

Edited by foreseason, 29 July 2014 - 04:24 PM.

[BraceWell]

Well it's obviously not working for a lot of people here.

 

You gonna keep telling people to do it every day and watch them fuck up? I'm simply suggesting an alternative method and you blast me for it? I can see just how 'forward thinking' this place is. Well what if it works better this way? Scientists are always going to give the mice it every day to see results but never go for the long game because their funding wouldn't cover them to be sitting on their ass waiting for the next day they can dose the mice/people.

 

Also, maybe I was in a hypomanic state, because I'd just taken my first dose of NSI....and you're telling me to take it every day. Yeah mate. Sure.

 

 

[foreseason]

Well it's obviously not working for a lot of people here.

You gonna keep telling people to do it every day and watch them fuck up? I'm simply suggesting an alternative method and you blast me for it? I can see just how 'forward thinking' this place is. Well what if it works better this way? Scientists are always going to give the mice it every day to see results but never go for the long game because their funding wouldn't cover them to be sitting on their ass waiting for the next day they can dose the mice/people.

Also, maybe I was in a hypomanic state, because I'd just taken my first dose of NSI....and you're telling me to take it every day. Yeah mate. Sure.

I'm not telling people to do anything. Where did you get that? I shared how I dosed it and my reasoning behind it. If anyone is telling people what to do it's you. You weren't "simply suggesting" anything. You were telling everyone they are taking it wrong based on some nonsensical logic. It's humorous that you have taken one dose and felt that was enough to come on here and start preaching about how we're all doing it wrong.

There are countless medications which are prescribed as needed. So you're claims that scientists will always say dose everyday doesn't make sense.

If you read through this thread you would know that a lot of people, including myself, had a strong hypo-manic type reaction to the first dose. It's pretty common and doesn't last.

[fourohfournotfound]

If it's true that nsi 189 is causing neurogenesis then I don't agree with an intermittent dosing schedule. The structure of the brain changes in relation to long term stress in many areas and in particular the hippocampus. It begins to have decreased receptor densities which in turn creates a new baseline mood for the individual experiencing this. This in my opinion is alot of the reason that once clinical depression starts it is very likely to return. The body/brain does not change it's point of homeostasis easily. In order change the homeostasis point long term changes must be made. While intermittent dosing may help if tolerances are developed to this drug I haven't heard anyone complain about a tolerance forming. In fact most have stated that the full effects build over time.

 

Also the brain growing in size is somewhat of a misnomer. Neurogenesis is a natural process that more increases the receptor densities in an area of your brain. These receptors add up to very little of the total mass of the brain. The headaches only indicate that there is more/less bloodflow to your brain. Headaches could pretty much mean anything and on their own indicate very little. An mri/cat scan would really be the only way to see what's truly happening to the structures of the brain. If they were actually a problem caused by the brain growing too much I doubt they would go away after time. Almost every person that has taken this for the full 30 days that I've read has had a reduction or complete disappearance of the headaches after a period of time.

 

If you stick with intermittent dosing I'm sure you will be fine. I just don't personally believe that it will as effectively cause neurogenesis. If you are very sensitive to this substance a lower dose than the one used in the study may be useful. While it is true all of us are taking some risk those that took this substance a year ago haven't spoke of any long term problems. Many have spoke of long term remission of depression which is something that no other drug can offer. That's why for many it's worth it.

 

edit: Let's have a real debate. Attacking each other won't help any of us out.

Edited by fourohfournotfound, 29 July 2014 - 11:35 PM.

[tjcbs]

Has anyone else ordered the NSI from tht.co? It has a very different taste and odor compared to what I got from nyles7. This stuff smells like amaretto, and is very bitter, whereas the nyles7 stuff was odorless and tasteless. A bit worried I got ripped off... just not sure by whom. 

 

Edited by tjcbs, 30 July 2014 - 05:09 AM.

[foreseason]

Has anyone else ordered the NSI from tht.co? It has a very different taste and odor compared to what I got from nyles7. This stuff smells like amaretto, and is very bitter, whereas the nyles7 stuff was odorless and tasteless. A bit worried I got ripped off... just not sure by whom. 

 

When did you get your NSI from Nyles?  I believe his first batch was freebase form and his more recent batch was phosphate. 

 

The phosphate form I received from Nyles was bitter tasting and very similar to what I got from THT. 

[Hearwhynot]

 

Just a heads up:

Transhuman Technologies site is back online, and they carry NSI-189.

Not sure if it's legit, just wanted to let you guys know

 

I can't say for sure if it's legit or not. However, I will say it looked and tasted awfully similar to what I got from Nyles7. 

 

 

I have a bit of the phosphate for myself and I'd say it is a little bitter also. I don't know about transhuman technologies, but I used the other persons also.

[nat]

PSA

 

Everyone needs to stop speculating on physical mechanisms unless they have significant neuroscientific education. (That includes myself.) Indulging in simplifications/inaccuracies like "neurogenesis is an increase in receptor density" is less productive than just waiting for Neuralstem to release information based on careful, longterm, objective study. It regresses understanding while giving the appearance of progressing it.

 

That's not to say that there's no place for speculation. A useful kind of speculation is mapping the relationship between substance intake (route, dosage, timing, cycling, chemical variant), subjective effects and environmental factors. That kind of speculation doesn't require broscience and in fact loses its utility when broscience is accepted as legitimate conversation.

 

It's been about a week since ending my first 3g cycle. I did 2x40mg daily. The changes have been overwhelmingly positive.

 

Notable effects are:

• Improved piano skill
• Regulated sleep cycle
• Better response to caffeine
• No situational anxiety anymore
• Daily realizations about human nature that are quite simple and obvious in hindsight but which have always eluded me
• Ability to turn off internal monologue at will
• Headache (while on cycle)
• Easier goal mapping
• Much easier meditation
• More enjoyment of music
• Hyperemotionality (while on cycle, approaching the end) but overall emotions are less urgent than they used to be and they're simpler to work through
• Much better word recall in common conversation

In essence, I would describe my whole experience as one of being forced by NSI-189 to come to terms with a lot of things about myself that I'd buried with platitudes and inappropriate abstractions. This has led to some amount of existential pain, but ultimately there was no way of getting around that. I took this substance because I saw it as a chance to heal myself, not looking for it to heal me, and I suspect that that mindset is crucial in speeding up its alleviation depressive/traumatic issues.

 

You've been sitting in a pile of nails and wood and don't know why it isn't spontaneously assembling into a beautiful house. NSI-189 might be the hammer that allows you to attach pieces of wood together quickly and without personal injury, but it's just the hammer. You still have to draw up the blueprints and learn to strike nails accurately and powerfully.

 

It's for this reason that I regret my use of tianeptine throughout most of the cycle. (Or rather, I would if the word 'regret' held much use for me anymore.) Its recently discovered µ-opioid agonism likely started to inhibit my subjective progress around the second week of NSI-189 use. The most important parts of the cycle, I feel, are those moments in which I experienced pain and came out on top of it. The memory of that kind success is powerful and starts bleeding into one's expectation of future analogous successes.

[tjcbs]

 

Has anyone else ordered the NSI from tht.co? It has a very different taste and odor compared to what I got from nyles7. This stuff smells like amaretto, and is very bitter, whereas the nyles7 stuff was odorless and tasteless. A bit worried I got ripped off... just not sure by whom. 

 

When did you get your NSI from Nyles?  I believe his first batch was freebase form and his more recent batch was phosphate. 

 

The phosphate form I received from Nyles was bitter tasting and very similar to what I got from THT. 

 

 

I got the NSI from Nyles after he had stopped selling it. I e-mailed him, and he said sure, I have a few grams left. Very sketchy, in retrospect I should never have accepted. 

 

I have stopped reporting immediate effects here. They are usually unsustainable or placebo, and just add smoke and hype to the board. Only sustained effects have any meaning. But, I will say that this stuff, from THT, is *active*. Whereas Nyles' NSI was totally inert. Maybe it was old freebase that had degraded? Isn't freebase supposed to taste bitter as well? 

[foreseason]

Has anyone else ordered the NSI from tht.co? It has a very different taste and odor compared to what I got from nyles7. This stuff smells like amaretto, and is very bitter, whereas the nyles7 stuff was odorless and tasteless. A bit worried I got ripped off... just not sure by whom.

When did you get your NSI from Nyles? I believe his first batch was freebase form and his more recent batch was phosphate.

The phosphate form I received from Nyles was bitter tasting and very similar to what I got from THT.

I got the NSI from Nyles after he had stopped selling it. I e-mailed him, and he said sure, I have a few grams left. Very sketchy, in retrospect I should never have accepted.

I have stopped reporting immediate effects here. They are usually unsustainable or placebo, and just add smoke and hype to the board. Only sustained effects have any meaning. But, I will say that this stuff, from THT, is *active*. Whereas Nyles' NSI was totally inert. Maybe it was old freebase that had degraded? Isn't freebase supposed to taste bitter as well?

Nyles is generally regarded around here to be reputable and trustworthy. Have you tried emailing him with your questions? He always provides me with long detailed responses

I purchased my NSI from nyles pretty recently and it is bitter and similar to what I received from tht. That's all I can say really.

Edited by foreseason, 30 July 2014 - 06:51 PM.

[fourohfournotfound]

PSA

 

Everyone needs to stop speculating on physical mechanisms unless they have significant neuroscientific education. (That includes myself.) Indulging in simplifications/inaccuracies like "neurogenesis is an increase in receptor density" is less productive than just waiting for Neuralstem to release information based on careful, longterm, objective study. It regresses understanding while giving the appearance of progressing it.

 

That's not to say that there's no place for speculation. A useful kind of speculation is mapping the relationship between substance intake (route, dosage, timing, cycling, chemical variant), subjective effects and environmental factors. That kind of speculation doesn't require broscience and in fact loses its utility when broscience is accepted as legitimate conversation.

 

It's been about a week since ending my first 3g cycle. I did 2x40mg daily. The changes have been overwhelmingly positive.

 

Notable effects are:

• Improved piano skill
• Regulated sleep cycle
• Better response to caffeine
• No situational anxiety anymore
• Daily realizations about human nature that are quite simple and obvious in hindsight but which have always eluded me
• Ability to turn off internal monologue at will
• Headache (while on cycle)
• Easier goal mapping
• Much easier meditation
• More enjoyment of music
• Hyperemotionality (while on cycle, approaching the end) but overall emotions are less urgent than they used to be and they're simpler to work through
• Much better word recall in common conversation

In essence, I would describe my whole experience as one of being forced by NSI-189 to come to terms with a lot of things about myself that I'd buried with platitudes and inappropriate abstractions. This has led to some amount of existential pain, but ultimately there was no way of getting around that. I took this substance because I saw it as a chance to heal myself, not looking for it to heal me, and I suspect that that mindset is crucial in speeding up its alleviation depressive/traumatic issues.

 

You've been sitting in a pile of nails and wood and don't know why it isn't spontaneously assembling into a beautiful house. NSI-189 might be the hammer that allows you to attach pieces of wood together quickly and without personal injury, but it's just the hammer. You still have to draw up the blueprints and learn to strike nails accurately and powerfully.

 

It's for this reason that I regret my use of tianeptine throughout most of the cycle. (Or rather, I would if the word 'regret' held much use for me anymore.) Its recently discovered µ-opioid agonism likely started to inhibit my subjective progress around the second week of NSI-189 use. The most important parts of the cycle, I feel, are those moments in which I experienced pain and came out on top of it. The memory of that kind success is powerful and starts bleeding into one's expectation of future analogous successes.

 

Personally I would love to see those mri studies they have been referring to. Neuralstem said they were going to release them a long time ago.

 

My nsi 189 from Nyles is labeled nsi 189 phosphate. It is a fine white powder on the top of the bag and a few chunks on the bottom. The color is pure white. The taste is somewhat bitter and chemical like. It doesn't seem to have much of a smell to it. It numbs my mouth wherever it touches and is quite hydrophobic. Is the powder from tht hydrophobic? I will say I'm not sure how much the first bag of nsi has done. I feel slightly better, but generally even just exercise provides about the same amount of relief.
 

Edited by fourohfournotfound, 30 July 2014 - 08:14 PM.

[explr9]

Nat- your description is very similar to my experience. From the first day, it felt like i was being given an opportunity.

 

I am reading a lot about hippocampal function, it seems to be the main brain structure for converting implicit memory into explicit memory, thereby claiming authorship in one's life. Dan Siegal, in his book mindsight, refers to the hippocampus as the master assembler of one's personal narrative. 

 

 

[uralsky]

From what I hear and from my experience: the phosphate form tastes only slightly bitter but numbing, while the base form is very bitter and not numbing. Also, the base is more fluffy than the phosphate. Is that what others see?

[protoject]

was anyone able to reverse the acute effects of pregabalin with NSI-189 by any chance?
Considering that as an option for the daytime since it supposedly restores some function that pregabalin does the opposite?

[stillwater]

I'm only 3 days into it, but didn't get the initial euphoria that some seemed to. It's definitely doing something though, but nothing outwardly positive quite yet. It has made my already crappy sleep crappier, but not a big deal, I'm decades used to that. 

 

I'll make another post when I'm further along with more precise details and effects and will discuss the nsi itself when the other forum starts up.

 

[ModusOperandi]

Is there any theoretical conflict taking Mr.Happy Stack (uridine UMP, Alpha-GPC) while taking NSI-189, or is it better to take Uridine after NSI cycle? Better yet- has anyone tried it? Bless!

[tolerant]

An update on my previous post. The lab has contacted me saying that the impurities alluded to earlier were arising out of their own solvent. Therefore they said that "it appears your sample is pure". We still don't have a final verdict on whether its is NSI-189 or not. The lab has requested a few hundred mg (instead of the original 5 mg I sent them) to run another 13C scan, which they will do free of any additional charge. After that we should have our final results.

[brucebanner]

Just got my NSI-189 Phosphate.

 

I will dosing orally, as per study. I'll start with 20mg B.I.D. first thing in the morning then I'll increase to the 40mg if I don't experience any adverse effects. I've left it to the weekend just in case anything happens. I am somewhat hesitant to take it because, I can experience superb well-being, hardly any anxiety and clear thoughts by using my current stack:

 

8am:

• 250-500mg CDP Choline - Had 250mg this morning and it was fine

8am and 1pm

• 10-20mg Coluracetam - Sublingual solution so it varies between 10-20mg
• 10-20mg Noopept

3pm or so

• 5-10mg Sunifiram

Sometimes I will also add the below at 8am and 1pm:

 

• 12.5mg Tianeptine - Sublingual solution
  This is very synergistic with Coluracetam and maybe to a lesser extent Noopept. If NSI-189 doesn't provide similar benefits, I won't hesitate to drop it. Not worth the hassle since I am very productive on this stack, but there is also a part of me that is asking "what if". For sure I'll stop taking this on NSI-189.

 

Questions:

1. Should I carry on taking Noopept and Coluracetam?
2. Is taking Armodafinil safe whilst on NSI-189? I am taking 37.5mg with the above and it's simply superb.
3. Shall I stop taking my adaptogenics? Bacopa etc?

Thanks,

Edited by brucebanner, 01 August 2014 - 10:35 PM.

[fourohfournotfound]

No one really knows what will happen when you combine nsi 189 with other substances. It's method of action hasn't been released so it's anyone's guess. From what I've read there have been at least a few people who have had problems when taking it with coluracetam. I took oxiracetam at the same time and didn't have any problems, but everyone's brain is a bit different, so be very cautious until more information is released.

[Al Capacino]

I've finally succumbed to the nsi hysteria.
My 3g product arrived on Friday. This is nearing the end of day 2 of 20mg twice a day and I have a couple of observations so far.

Most noticeable effect is a very uncomfortable anxiety feeling in my chest and stomach. It's uncontrollable and intolerable for me until I took pregabalin to calm myself down. I also took venlafaxine which had no effect on the anxiety when it normally does with my usual general anxiety.

Mood increase seemed subtle if at all. Venlafaxine easily took care of that.
Obviously the benefits will come over time and I'm willing to bear out the negative anxiety for the cause.

I simply thought I'd share the initial experience and for people who especially already have an anxiety problem to be wary and ready to counteract it!

[crazepharmacist]

Does anyone else get a numbing sensation from NSI 189 phosphate sub-lingual ROA? Reminds me of PRL-853, though maybe not quite as extreme. 

 

Edit: by numbing I mean physically on the inside of mouth/tongue, not some kind of mental effect. 

Edited by crazepharmacist, 03 August 2014 - 10:10 PM.

[crazepharmacist]

Double post, sorry. 

Edited by crazepharmacist, 03 August 2014 - 09:23 PM.

[datrat]

I've finally succumbed to the nsi hysteria.
My 3g product arrived on Friday. This is nearing the end of day 2 of 20mg twice a day and I have a couple of observations so far.

Most noticeable effect is a very uncomfortable anxiety feeling in my chest and stomach. It's uncontrollable and intolerable for me until I took pregabalin to calm myself down. I also took venlafaxine which had no effect on the anxiety when it normally does with my usual general anxiety.

Mood increase seemed subtle if at all. Venlafaxine easily took care of that.
Obviously the benefits will come over time and I'm willing to bear out the negative anxiety for the cause.

I simply thought I'd share the initial experience and for people who especially already have an anxiety problem to be wary and ready to counteract it!

 

Just curious, are you dosing sublingually or orally? There's another thread questioning the sublingual method and if you are dosing sublingually your anxiety experiences are pertinent to that discussion.
 

[Al Capacino]

Yes datrat I was sublingually until my second dose last night I decided to take it orally and things have settled down since then. I'm now experiencing some very positive feelings...emotions! I've been dulled for so long on regular antidepressants that it's like I feel how I used to as a kid! Will see how long this lasts but since I've started taking it orally I'm amazed by the effects already! I'm simply happy and worry free! Wow lol

[chris106]

Don't flame world33, the parrot whispered it into his ear

EDIT: What the f... - ah, nevermind :(

Edited by chris106, 04 August 2014 - 07:02 AM.

[arcticjoe]

Just got my NSI-189 Phosphate.

 

I will dosing orally, as per study. I'll start with 20mg B.I.D. first thing in the morning then I'll increase to the 40mg if I don't experience any adverse effects. I've left it to the weekend just in case anything happens. I am somewhat hesitant to take it because, I can experience superb well-being, hardly any anxiety and clear thoughts by using my current stack:

 

8am:

• 250-500mg CDP Choline - Had 250mg this morning and it was fine

8am and 1pm

• 10-20mg Coluracetam - Sublingual solution so it varies between 10-20mg
• 10-20mg Noopept

3pm or so

• 5-10mg Sunifiram

Sometimes I will also add the below at 8am and 1pm:

 

• 12.5mg Tianeptine - Sublingual solution
  This is very synergistic with Coluracetam and maybe to a lesser extent Noopept. If NSI-189 doesn't provide similar benefits, I won't hesitate to drop it. Not worth the hassle since I am very productive on this stack, but there is also a part of me that is asking "what if". For sure I'll stop taking this on NSI-189.

 

Questions:

1. Should I carry on taking Noopept and Coluracetam?
2. Is taking Armodafinil safe whilst on NSI-189? I am taking 37.5mg with the above and it's simply superb.
3. Shall I stop taking my adaptogenics? Bacopa etc?

Thanks,

 

for me modafinil + nsi = seriously heavy migrane. Also I have found that NSI does not play nice with gingo either, so maybe best to try it on its own.