6219 replies to this topic

[Area-1255]

From my amateurish knowledge, NSI-189 would help to restore the HPA axis if the Glucocorticoid Receptors (GR) are normal i.e. upregulated.

If not then the effects wouldnt be that pronounced like for anyone else.

 

As said, I´m an amateur, so take this with a grain of salt.

It could also perhaps be the case that by enhancing the Hippocampus, the GR expression would be affected to some extend, but this is just my theory. 

On the other hand, the opposite is validated. So an excess of Glucocorticoids ( chronic stress) do damage the Hippocampus.

Does NSI-189 have effects on glucocorticoid receptor density?

[Blackkzeus]

I received a gram of NSI-189 base from LTR about a week ago. Since then I've been taking about 30 mg sublingually about 1-2 times a day. I  can confidently say the product is a potent anti-depressant, and it's absolutely not placebo because the same effects have manifested everyday I've taken the supplement. Upon taking it sublingually I feel an immediate boost in mood, I become more cheery and positive, less anxious, and more confident  I also notice a slight increase in cognition, it's mildly stimulating mentally. My ability to think more in-depth increases, and I become slightly more verbally fluent, as if I'm able to retrieve more words from the word bank in my mind. All in all it's a fantastic nootropic, absolutely worth the money. 

[Edogawa Rampo]

i don't get  it.

 

tht or tlr? Do they works differently?

 

[Edogawa Rampo]

 

 

So far it seems NSI genuinely works for depression only! Also Neural Stem genuinely seems to be taking time with it, one would be curious as to why a company in need of a hit product hasn't released one yet.

What's the overall consensus on THT's NSI-189?

Well I gave thts nsi 189 a couple of trials now and it's useless. I feel absolutely nothing from it. After 2x 1 month trials of another vendors nsi and responding almost instantly to it through an instant mood boost, memory enhancement, less anxiety in social situations and many other benefits whilst also being able to give up all other supplements and antidepressants I know what to expect from nsi and thts brings no psychoactive effects whatsoever.
I do respond a bit to thts pitolisant with a slight focus boost which is a nice subtle boost instead of modafinil which makes me so wired especially at night!
I'm still not sure nsi 189 as a standalone treatment is enough as I still only do the bare minimum I need to in life. But it's certainly has some unique qualities that other antidepressants don't provide

 

 

excuse me sir. Had been you use weights? Does form of another vendor was freebase?

 

 

[Flex]

 

From my amateurish knowledge, NSI-189 would help to restore the HPA axis if the Glucocorticoid Receptors (GR) are normal i.e. upregulated.

If not then the effects wouldnt be that pronounced like for anyone else.

 

As said, I´m an amateur, so take this with a grain of salt.

It could also perhaps be the case that by enhancing the Hippocampus, the GR expression would be affected to some extend, but this is just my theory. 

On the other hand, the opposite is validated. So an excess of Glucocorticoids ( chronic stress) do damage the Hippocampus.

Does NSI-189 have effects on glucocorticoid receptor density?

 

 

Hmm good point, afaik its unknown. If yes, then some symptoms of either hyper or hypo-cortisolism should appear at higher doses.
 

[Area-1255]

 

 

From my amateurish knowledge, NSI-189 would help to restore the HPA axis if the Glucocorticoid Receptors (GR) are normal i.e. upregulated.

If not then the effects wouldnt be that pronounced like for anyone else.

 

As said, I´m an amateur, so take this with a grain of salt.

It could also perhaps be the case that by enhancing the Hippocampus, the GR expression would be affected to some extend, but this is just my theory. 

On the other hand, the opposite is validated. So an excess of Glucocorticoids ( chronic stress) do damage the Hippocampus.

Does NSI-189 have effects on glucocorticoid receptor density?

 

 

Hmm good point, afaik its unknown. If yes, then some symptoms of either hyper or hypo-cortisolism should appear at higher doses.
 

 

I'd be concerned, maybe..but then, if it was agonistic, we would expect people to experience lethargy and muscle strength decreases - then again, how many of our nootropic experimenters/volunteers here also lift weights?

[Flex]

I meant with hypo, below baseline.

Ok, looked for Dexamethasone(agonist) overdose and Mifepristone(antagonist) overdose.

Muscle weakness and depression occurs by overactivation, dizziness and nausea and fatigue by inhibition.

 

Furthermore, Glucocorticoids are a double edged sword in regards of Neurogenesis.

Simple overactivation inhibits neurogenesis whereas dosed activation increase it and abolition ( inhibition so to say) had only positive effects in the short-term:

 

Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis.

http://www.ncbi.nlm....pubmed/23407954

 

Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels.

http://www.ncbi.nlm....pubmed/15744738

 

So I would say, from my humble opinion, that an inhibition is more the case, if it does affect the GR after all.

Or ..sigh.. via MR activation.. have to look into it..

Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice.

http://www.ncbi.nlm....pubmed/11258486

[Area-1255]

I meant with hypo, below baseline.

Ok, looked for Dexamethasone(agonist) overdose and Mifepristone(antagonist) overdose.

Muscle weakness and depression occurs by overactivation, dizziness and nausea and fatigue by inhibition.

 

Furthermore, Glucocorticoids are a double edged sword in regards of Neurogenesis.

Simple overactivation inhibits neurogenesis whereas dosed activation increase it and abolition ( inhibition so to say) had only positive effects in the short-term:

 

Glucocorticoids orchestrate divergent effects on mood through adult neurogenesis.

http://www.ncbi.nlm....pubmed/23407954

 

Hippocampal neurogenesis is not enhanced by lifelong reduction of glucocorticoid levels.

http://www.ncbi.nlm....pubmed/15744738

 

So I would say, from my humble opinion, that an inhibition is more the case, if it does affect the GR after all.

Or ..sigh.. via MR activation.. have to look into it..

Genetic disruption of mineralocorticoid receptor leads to impaired neurogenesis and granule cell degeneration in the hippocampus of adult mice.

http://www.ncbi.nlm....pubmed/11258486

I've reduced cortisol to nearly nothing and had no ill effects.....

To each their own though, guess it depends on the REASON for low cortisol.

 

The biggest question with any study, is whether we have healthy individuals as set  parameters, and moreover, what defines the overseer's / conductors definition of "healthy" - what guidelines are they using and are they using a universal guideline such as the world health organization or their own and in that particular study, are other factors being taken into account?

 

Of course, no study is perfect, and that's why individuality and one's own experiments are more or less the finishing touch for the holy grail some so avidly seek, at the same time, "placebo" effect is a very real thing and fairly common occurrence, ESPECIALLY with unregulated Internet/Forum reports/anecdotes.

Edited by Area-1255, 14 December 2014 - 02:58 AM.

[Al Capacino]

So far it seems NSI genuinely works for depression only! Also Neural Stem genuinely seems to be taking time with it, one would be curious as to why a company in need of a hit product hasn't released one yet.

What's the overall consensus on THT's NSI-189?

Well I gave thts nsi 189 a couple of trials now and it's useless. I feel absolutely nothing from it. After 2x 1 month trials of another vendors nsi and responding almost instantly to it through an instant mood boost, memory enhancement, less anxiety in social situations and many other benefits whilst also being able to give up all other supplements and antidepressants I know what to expect from nsi and thts brings no psychoactive effects whatsoever.
I do respond a bit to thts pitolisant with a slight focus boost which is a nice subtle boost instead of modafinil which makes me so wired especially at night!
I'm still not sure nsi 189 as a standalone treatment is enough as I still only do the bare minimum I need to in life. But it's certainly has some unique qualities that other antidepressants don't provide

excuse me sir. Had been you use weights? Does form of another vendor was freebase?

Weights to measure? Yes a cheap 10-20 quid set.
It's only phosphate I've used from two separate vendors

I received a gram of NSI-189 base from LTR about a week ago. Since then I've been taking about 30 mg sublingually about 1-2 times a day. I can confidently say the product is a potent anti-depressant, and it's absolutely not placebo because the same effects have manifested everyday I've taken the supplement. Upon taking it sublingually I feel an immediate boost in mood, I become more cheery and positive, less anxious, and more confident I also notice a slight increase in cognition, it's mildly stimulating mentally. My ability to think more in-depth increases, and I become slightly more verbally fluent, as if I'm able to retrieve more words from the word bank in my mind. All in all it's a fantastic nootropic, absolutely worth the money.

I second that entirely with their phosphate.

[Milkyway]

Has anyone tried getting it from a Chinese supplier?  Do you think the suppliers on alibaba are trustworthy?  I am getting quoted 130 dollars for 10 grams plus 40 s and h.  That is a pretty good deal.

[themadscientist]

Yes I have. The supplier was HHD Pharma, and I dealt with Nancy Chaung. I received my order roughly 5 days after ordering it. I paid via Western Union but only ordered a 1 gram sample. It was in free base form and I'm pretty confident it was legit. I have also tried THT's NSI and it did not net the same results as the batch from HHD Pharma.

[Adaptogen]

Yes I have. The supplier was HHD Pharma, and I dealt with Nancy Chaung. I received my order roughly 5 days after ordering it. I paid via Western Union but only ordered a 1 gram sample. It was in free base form and I'm pretty confident it was legit. I have also tried THT's NSI and it did not net the same results as the batch from HHD Pharma.

 

How can you make the assumption that it was legitimate NSI-189 without any certificate of analysis?
I would be extremely hesitant to judge it as authentic based on subjective effects alone

[Area-1255]

 

Yes I have. The supplier was HHD Pharma, and I dealt with Nancy Chaung. I received my order roughly 5 days after ordering it. I paid via Western Union but only ordered a 1 gram sample. It was in free base form and I'm pretty confident it was legit. I have also tried THT's NSI and it did not net the same results as the batch from HHD Pharma.

 

How can you make the assumption that it was legitimate NSI-189 without any certificate of analysis?
I would be extremely hesitant to judge it as authentic based on subjective effects alone

 

THT provides COA's correct?

[Milkyway]

In reference to the Mad Scientist's post #2812 did you get a significantly less expensive price with HHD pharma?  That is what I am getting and I just want to know why, even though I don't want to look a gift horse in the mouth.  How could it be so much cheaper?  I am also wondering if there could be problems with customs or at least a delay in getting 10 grams imported from China.

[Edogawa Rampo]

THT.co  nsi-189 not real?

Does tht.co  nsi 189 differs from all other's nsi-189 effects?

[DaneV]

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

 

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

[Area-1255]

THT.co  nsi-189 not real?

Does tht.co  nsi 189 differs from all other's nsi-189 effects?

Where did you find that load of bologne? I believe the consensus was it might* be slightly reduced in potency in comparison to others, but this was just by a couple users - many others have noted favorable effects by their brand.

Edited by Area-1255, 21 December 2014 - 12:34 AM.

[Flex]

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

 

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

 

Aphex reported it allready as green and that its working.

http://www.longecity...-11#entry670281

http://www.longecity...e-2#entry667708

 

Why do You doubt it,

Does it not work ?

[Al Capacino]

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

I may try 7,8 dhf from team tlr in that case. I bought tht's back in May and found very slight anxiolytic effects at 60mg intranasally which lasted an hour at most. I just wrote it off. But if you're noticing better effects from another vendor I may reconsider. Could you explain a bit further on your experience with it?

I think tht is bogus tbh. I've tried about a quarter of their products and noticed very little from anything. Their products physical appearance, taste and smell all differ to other vendors. Obviously I don't judge completely on that but when there are little to no effects from products you have tried from other vendors and not only respond but respond strongly to its pretty obvious. And I'm someone quite sensitive to medication!

[Edogawa Rampo]

tht.co bogus?

 

 

What says about it in closed forum?

 

[Area-1255]

tht.co bogus?

 

 

What says about it in closed forum?

Where do you newbies get this stuff from? It's not bogus....it's been remarked as possibly* a little less potent, but we do need more reports...personally, I'm satisfied with their products, though I haven't tried their NSI-189 yet, when I do , I will write a log, but I can attest to the potency of their pitolisant, 9-me-bc and tianeptine (past).

[Gorthaur]

 

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

I may try 7,8 dhf from team tlr in that case. I bought tht's back in May and found very slight anxiolytic effects at 60mg intranasally which lasted an hour at most. I just wrote it off. But if you're noticing better effects from another vendor I may reconsider. Could you explain a bit further on your experience with it?

I think tht is bogus tbh. I've tried about a quarter of their products and noticed very little from anything. Their products physical appearance, taste and smell all differ to other vendors. Obviously I don't judge completely on that but when there are little to no effects from products you have tried from other vendors and not only respond but respond strongly to its pretty obvious. And I'm someone quite sensitive to medication!

 

 

I think that THT's business model is to offer a wide variety of obscure compounds, most of which you can't get anywhere else. These compounds aren't supposed to have an in-your-face effect for anyone and everyone who takes them. They're supposed to have a subtle but positive effect for people with specific needs/health problems. 

[Area-1255]

 

 

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

I may try 7,8 dhf from team tlr in that case. I bought tht's back in May and found very slight anxiolytic effects at 60mg intranasally which lasted an hour at most. I just wrote it off. But if you're noticing better effects from another vendor I may reconsider. Could you explain a bit further on your experience with it?

I think tht is bogus tbh. I've tried about a quarter of their products and noticed very little from anything. Their products physical appearance, taste and smell all differ to other vendors. Obviously I don't judge completely on that but when there are little to no effects from products you have tried from other vendors and not only respond but respond strongly to its pretty obvious. And I'm someone quite sensitive to medication!

 

 

I think that THT's business model is to offer a wide variety of obscure compounds, most of which you can't get anywhere else. These compounds aren't supposed to have an in-your-face effect for anyone and everyone who takes them. They're supposed to have a subtle but positive effect for people with specific needs/health problems. 

 

Definitely, and I have a feeling they are going to be innovator's again very soon....  

[DaneV]

 

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

 

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

 

Aphex reported it allready as green and that its working.

http://www.longecity...-11#entry670281

http://www.longecity...e-2#entry667708

 

Why do You doubt it,

Does it not work ?

 

 

I can`t say anything about it`s effects, but I recall having red from different sources that pure 7,8 is a dense, beige powder. Not fluffy and green like the one that is found in THT`s container. For this reason, I haven`t even tried the one I got from them yet. I have no time to look it up right now, but if I find these sources i`ll publish them if you want.

 

That saying, i`m not saying there is no 7,8 DHF in tht`s shipped product, but if the (independant, non-vendor) sources i`ve red are right, something is just "off" about THT`s 7,8 DHF. Also, they haven`t been able to provide any solid proof about the legitamacy about their products (unfortunately my current vendor, teamtlr isn`t either).

[Area-1255]

 

 

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

 

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

 

Aphex reported it allready as green and that its working.

http://www.longecity...-11#entry670281

http://www.longecity...e-2#entry667708

 

Why do You doubt it,

Does it not work ?

 

 

I can`t say anything about it`s effects, but I recall having red from different sources that pure 7,8 is a dense, beige powder. Not fluffy and green like the one that is found in THT`s container. For this reason, I haven`t even tried the one I got from them yet. I have no time to look it up right now, but if I find these sources i`ll publish them if you want.

 

That saying, i`m not saying there is no 7,8 DHF in tht`s shipped product, but if the (independant, non-vendor) sources i`ve red are right, something is just "off" about THT`s 7,8 DHF. Also, they haven`t been able to provide any solid proof about the legitamacy about their products (unfortunately my current vendor, teamtlr isn`t either).

 

They provide chemical analysis pages on each product page, and I don't think transhuman would take the risk of having purity issues being that they are based or at least ship from within the USA, plus if the products are unique and exclusive, they are not going to want to mess something up for everybody once found out....

I always got good effects from the products I've tried from them.

[Al Capacino]

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

Aphex reported it allready as green and that its working.
http://www.longecity...-11#entry670281
http://www.longecity...e-2#entry667708

Why do You doubt it,
Does it not work ?

I can`t say anything about it`s effects, but I recall having red from different sources that pure 7,8 is a dense, beige powder. Not fluffy and green like the one that is found in THT`s container. For this reason, I haven`t even tried the one I got from them yet. I have no time to look it up right now, but if I find these sources i`ll publish them if you want.

That saying, i`m not saying there is no 7,8 DHF in tht`s shipped product, but if the (independant, non-vendor) sources i`ve red are right, something is just "off" about THT`s 7,8 DHF. Also, they haven`t been able to provide any solid proof about the legitamacy about their products (unfortunately my current vendor, teamtlr isn`t either).

They provide chemical analysis pages on each product page, and I don't think transhuman would take the risk of having purity issues being that they are based or at least ship from within the USA, plus if the products are unique and exclusive, they are not going to want to mess something up for everybody once found out....
I always got good effects from the products I've tried from them.

You can't mock other people's experiences with their products just because you claim to have had positive experiences with their products! I'm starting to think you are affiliated with them.
I'm curious about your statement that they are based and ship from USA because the 2 packages I've ordered from them, one in May and the other a few weeks ago was shipped from Hong Kong...

[Area-1255]

 

 

 

 

I`m getting decent results from a combination of NSI-189 + 7,8 DHF after 4 days of usage. I`m using 2x25mg NSI orally and 30mg 7,8 DHF intranasally. A week ago, when I decided this untested combination I stuggled with pretty severe suicidal thoughts and other depression symptoms which now seem to be partly gone (allthough I can never rule out the natural fluctations in my mental state).

About tht; I`m not to sure about their legitimacy the 7,8DHF I got from them was yellow/green while the one from teamtlr (which i`m using now) was beige like expected.

Aphex reported it allready as green and that its working.
http://www.longecity...-11#entry670281
http://www.longecity...e-2#entry667708

Why do You doubt it,
Does it not work ?

I can`t say anything about it`s effects, but I recall having red from different sources that pure 7,8 is a dense, beige powder. Not fluffy and green like the one that is found in THT`s container. For this reason, I haven`t even tried the one I got from them yet. I have no time to look it up right now, but if I find these sources i`ll publish them if you want.

That saying, i`m not saying there is no 7,8 DHF in tht`s shipped product, but if the (independant, non-vendor) sources i`ve red are right, something is just "off" about THT`s 7,8 DHF. Also, they haven`t been able to provide any solid proof about the legitamacy about their products (unfortunately my current vendor, teamtlr isn`t either).

They provide chemical analysis pages on each product page, and I don't think transhuman would take the risk of having purity issues being that they are based or at least ship from within the USA, plus if the products are unique and exclusive, they are not going to want to mess something up for everybody once found out....
I always got good effects from the products I've tried from them.

You can't mock other people's experiences with their products just because you claim to have had positive experiences with their products! I'm starting to think you are affiliated with them.
I'm curious about your statement that they are based and ship from USA because the 2 packages I've ordered from them, one in May and the other a few weeks ago was shipped from Hong Kong...

 

Where do you live? What products did you order? I live in the USA, maybe the products I've ordered were shipped from local warehouses...

[Milkyway]

Has anyone thought about buying it from a Chinese manufacturer and requesting a certificate of analysis?  They seem to have better prices.  Or is the fear that it will be poor quality?

[explr9]

I have found NSI + 78DHF combo to be effective. NSI@25mg, 78DHF @ 30..The combo can offset the lethargy that comes from NSI alone, especially at the start of an NSI cycle. 

 

 After 10 days or so, it gets intense, and I stop the 78d for a week or so. 

[Christin]

Anyone doubt nsi-189 from HHD PHARM can contact with me directly. Our products can stand all kinds of test!