6219 replies to this topic

[Heisenburger]

Coffee does make me superhuman. That's what the big 'C' on my chest stands for.

[pheanix997]

Coffee does make me superhuman. That's what the big 'C' on my chest stands for.

Lol... Coffee puts me to sleep :( 

[pheanix997]

I'm curious as to whether NSI-189 relieves the fatigue associated with depression. I'm still unsure whether my fatigue is psychological, i.e. due to some repressed intrapsychic conflict that causes vacillation, stress, wasted energy, and eventually chronic fatigue (like a mental as opposed to physical, e.g. excess GABA, parking break), or whether my fatigue is biological and perhaps due to some low dopamine/ ADD issues I have.

 

I'm uncertain about this because when i took Concerta for add for a week, it was life-changing, but after that it was making me a bit depressed, awkward, and increasing some anxiety. When I get off the stimulants, though, my energy level plummets once again and I trudge through each day, albeit without anxiety or exasperated sad feelings. Even Wellbutrin proved to be too stimulating for me in the end! 

[jefferson]

 

There isn't. Because it stimulates stem cells, it isn't messing with receptors or reuptake.

It's basically growing a part of your brain to allow it to work better, or reverse the pathology of the depression itself.

Depressed people have a shrunken Hippocampus. SSRI's fight this via increase serotonin transmission, or playing with multiple mechanisms.

 

NSI-189, though, it targets the hippocampus directly, and this causes a reduction of depression symptoms, downstream effects in the limibic system & all neurotransmitters connected to it.

No downregulation or tolerance, that we know of.

 

The mechanism of action seems brilliant. Why work on individual neurotransmitters when you can 1) revamp a region that's directly associated with depression (as opposed to pouring the proverbial gasoline over the entire brain and hoping the right regions get the needed serotonin) and in doing that 2) increase the neurotransmitters associated with that region (and the depression). Seems like a no-brainer to me . I heard a scientist in an interview on Joe Rogan say that the side effects from, say, SSRI's is due to the chemical "locks" binding with identically shaped but the wrong "keys" in the brain. By that logic, it's as if NSI's action overcomes that unwanted extra action.

I've ordered 3 grams, will be starting my trial next week.

I apologize for yet another question that is probably answered somewhere in this long thread, but from my quick search I've found mixed answers: Does the hippocampus maintain its increased size/ improved function after discontinuing NSI? I know nothing about neurology, but if this drug stimulates stem cells, does it not also follow that those newly grown cells will continue to function regardless of whether the drug is still being taken? If the answer is yes, the changes maintain, that's incredible. I can only imagine what the future treatments will be like in 30 years for depressed or brain damaged patients :o.
 

 

 

If I had a dollar for everytime I've thought "nobody knows this" in reference to this thread, I'd have enough money to buy a year's supply of NSI-189. 

 

We don't even know if NSI-189 even increases the size of the hippocampus in humans yet, let alone how much or if the size increase would be sustainable. Yes, there are reasons to be optimistic, but nobody truly knows this yet and anyone implying otherwise is being dishonest. I'm sorry if this is not "politically correct" to say here, but it's the truth! Where is the MRI data? Nowhere. Very likely because NSI-189 produced no volume increase after 30 days in Phase I trials. Now this doesn't really mean much, because 30 days is not a long time. But the point is that unpublished rat studies using ischemic stroke to damage the HC is a long way away from correcting volume reductions from depression-induced atrophy in human MDD people. It might work that way, it might not. There is still no MRI data proving this in humans!

 

That said, I hope NSI-189 works brilliantly for you and addresses all your cognitive problems. If it doesn't, the future still looks bright for small molecule drugs that target the HC directly. But that being said, too much conjecture is being thrown around assumed to be proven fact.

[jaiho]

Yes it's true, alot of this is hypothesis. 

I'm going based on what im experiencing from many months of dosing NSI-189, various doses, and between freebase / phosphate, and the studies on rats, to other people's experiences.

 

Here's more information:

http://smithonstocks...id-subscribers/

 

What we can be pretty sure on, is that NSI-189 is targeting the hippocampus. We understand the brain enough to know the functions of various neurotransmitters, the limbic system, prefrontal cortex etc. and that, Neuralstem have created something based off the hypothesis, that many psychiatric drugs increase neurogenesis in the hippocampus, and found a way to do that directly instead of stimulating the hippocampus via reuptake inhibition.

 

 

SmithOnStocks: How did you discover this small molecule (NSI-189)?

Richard: Well, we were actually looking for it.  Because of our unique window on the brain, we were awarded a contract from DARPA to screen for and discover a new class of drugs to specifically protect and enhance hippocampal neural stem cells in something called The Warfighter of the Future program. The “super solider” of the future was to be enhanced both physically and mentally.

One of Neuralstem’s stem cell lines produces hippocampal neurons that can differentiate in cell cultures. These cells have been used to screen for new drug candidates that might protect and repair the hippocampus.

Traditional drug development must decide on a molecular target in the brain and develop a drug that will interact with the target, which may or may not have a therapeutic effect. Neuralstem can take a different approach by screening drugs against hippocampal cells in a culture dish. We can be agnostic about the precise target and just look for a molecule that can cause neurogenesis.

We are able to test compounds against the cells with all manner of toxic insults applied, which you can think of as models of various diseases like stroke for instance; and we can also test compounds against the various stages of neurogenesis.  We have found that there are distinct phases in fact, and we can influence the process of neurogenesis with different compounds at different points in the process.

So this was the world’s first (and only) thorough search for a new class of neurogenic drugs, specifically neurogenic in the human hippocampus, based on screening against actual human hippocampal neural stem cells. It was only after we had begun this process, when evidence began to accumulate showing a very high correlation between hippocampal atrophy and depression, that we began looking in that direction with our research.

 

 

I can almost say with certainty, that this drug is growing my hippocampus. Perhaps, not physically increasing in size, but it's certainly stimulating it.

A popular psychiatrist by the name of Dr Gillman would say that, if you're not getting side effects, chances are, you aren't going to get an anti depressant response. I would say with this substance, that no longer applies.

 

 

 

[ceridwen]

Maybe what we need is to find something that blocks caffeine tolerance then.

[ceridwen]

I wonder if it is worth taking while my hippocampus is diseased I doubt it would cure it

[Strangelove]

I take NSI-189 with moclobemide, an MAOI. no interaction.

 

For the "brain lighting up" kind of reports from SSRIs, these are usually temporary. SSRI's artificially increase serotonin in the synapse, and this good feeling rapidly disappears as receptors downregulate.

You then end up in a nice level mood, harder to experience lows & highs.

 

NSI-189 for me, doesn't provide a brain lighting up feeling. It's a more consistent decrease in depression that feels natural. Emotions aren't blocked, sex doesn't feel pointless. Things just feel more normal.

 

Reading the moclobemide wiki, seems like a three page of antidepressant advertisement! Pretty cool if thats objective information.

 

I am wondering if this is why you seem to have so great results, is it this combo?

 

I am selling from my private stack from a trusted lab at a good price, but still few that first try it return for more. It works good for me, but I believe (as another member asked before) that we maybe overhyping it because of the hippocampus neurogenesis? I started realizing that 80% of the posts are from the same few members?

[jaiho]

I think it largely depends on the kind of depression you have. There's so many types, and nsi 189 will probably be similar to SSRIs in that regard. I think it's really useful for Anhedonia depressives, rather than people who feel too much anxiety or dread / sadness type depression.
I tried moclobemide with it as an experiment. Before nsi, a combination of tianeptine, moclobemide and occasionally modafinil sorted me out.

[Skypp]

 

 

 

 

I am selling from my private stack from a trusted lab at a good price, but still few that first try it return for more. It works good for me, but I believe (as another member asked before) that we maybe overhyping it because of the hippocampus neurogenesis? I started realizing that 80% of the posts are from the same few members?

 

 

I received my batach from you SL (THANKS!) Have not started it yet as I have an opened bottle still going from International Peptide (which by the way seems to be good stuff). LOTS of people on Reddit are asking where to find it.

 

Why would hyping the neurogenesis be a problem? That's what it does and it's a good thing. People are consuming all sorts of less effective products. I would wager that a very substantial portion of the adult population has hippocampal function reduction. If not from depression then from stress and prescription drugs (and non-prescription). Flouride as well as mercury in vaccines also kill hippocampal cells. (TRUE) . Flouride alone will shrink and calcify that area of the brain. (Don't use toothpaste that has it.)

 

I have been giving NSI-189 to someone who is a high achieving, type A person who would not have been classified as typically depressed. However, high stress levels manifested through chronic joint pain, insomnia, teeth-grinding, and angst. In his forties, both his hips had to be resurfaced (not a full replacement). Since I have been administering this product, it's like a cloud has lifted. He is not in physical pain anymore. No more insomnia, no teeth-grinding. Almost no angst. This is a miracle as I finally assumed many of these issues were just part of a personality type. No, they were part of a depression pattern. I will see if this lasts, but so far, amazing.
 

[jefferson]

Overhyping a drug that hasn't been proven to work beyond one small trial is irresponsible at best and dangerous at worst. You do realize that this thread is sort of like a filter, where only the most positive responders come back and post again and again? People who it didn't work for just drop out and you never hear from them again. I think I'm the only exception. We've had people on here who talk about Neuralstem like it's their church and NSI is the messiah. It may actually be for them, but it's still something of a red flag that you're only getting part of the story.

 

Not to say it doesn't really work, but for many reasons, not least of which is its well publicized purported method of action, the placebo is likely to be gigantic. It would actually be quite incredible if there were no significant placebo effect, in addition to a possible real effect of the drug, considering the strength of the placebo in every other clinical trial done today.

 

 

[drg]

Generally people are on this site to look at unproven drugs/supplements because they are willing to take the risk for a potential improvement in quality of life. This forum is one big overhyping of drugs in general but for some people drugs are the only answer.

 

Anecdotal evidence is all we have for novel/ research chemicals like NSI189 and it is a good thing.

 

You also have evidence by the sheer size of this thread there is more interest in NSI189 than most of the other commonly suggested drugs on this forum. I doubt this interest would be sustained if it is ineffective. When people buy something they want it to be worth the money.  More people will learn about it by word of mouth if it is successful for someone they know and more likely to try it. Anyways I doubt some big giant placebo effect would attract all this attention.

 

 

Overhyping a drug that hasn't been proven to work beyond one small trial is irresponsible at best and dangerous at worst. You do realize that this thread is sort of like a filter, where only the most positive responders come back and post again and again? People who it didn't work for just drop out and you never hear from them again. I think I'm the only exception. We've had people on here who talk about Neuralstem like it's their church and NSI is the messiah. It may actually be for them, but it's still something of a red flag that you're only getting part of the story.

 

Not to say it doesn't really work, but for many reasons, not least of which is its well publicized purported method of action, the placebo is likely to be gigantic. It would actually be quite incredible if there were no significant placebo effect, in addition to a possible real effect of the drug, considering the strength of the placebo in every other clinical trial done today.

 

[jefferson]

I'm not saying it's all placebo, but it's naive to think there is none. The normally very powerful anti-depressant placebo would be even more powerful since we're priming people with lines like "20% bigger hippocampus".

[stillwater]

Conversely there are those that get better and never bother to look back or log on again.

 

I'm on roughly day 23 of around sublingual 15 mg a day, I've only had about a 15-20% improvement in depressive symptoms, which I guess is better than baseline for me. I have had a dramatic increase in my ability to smell in the last week, which when sitting on a bus or walking down back alleys isn't necessarily a good thing.  I do plan on continuing to a max of maybe 40 days before stopping. No radical side effects other than the occasional mild headache so far.

 

 

[tintinet]

Conversely there are those that get better and never bother to look back or log on again.

I'm on roughly day 23 of around sublingual 15 mg a day, I've only had about a 15-20% improvement in depressive symptoms, which I guess is better than baseline for me. I have had a dramatic increase in my ability to smell in the last week, which when sitting on a bus or walking down back alleys isn't necessarily a good thing. I do plan on continuing to a max of maybe 40 days before stopping. No radical side effects other than the occasional mild headache so far.

I've been taking 10-20 mg SL for a bit over a week and my results are similar so far. Nothing I could not yet attribute to placebo effect.

[Adaptogen]

i trialed 20mg b.i.d., for close to a month and noticed no changes in depressive symptoms or cognition.

[jaiho]

there's a poll on reddit if you're skeptical. It worked for more people than it didn't.

If it was placebo, we would notice an effect rapidly after dosing. Personally i get nothing until the month mark, and it's consistent when it kicks in.

[Skypp]

I'm not saying it's all placebo, but it's naive to think there is none. The normally very powerful anti-depressant placebo would be even more powerful since we're priming people with lines like "20% bigger hippocampus".

 

When some people take penicillin, they have a near lethal allergic reaction to it, some are healed instantly, and some take much longer. No two people react to a drug exactly the same way. Some people smoke pot and feel good, some get paranoid.

 

With NSI-189, some people can't sleep, some get anxious and some get lethargic. The worst reaction I've had is it makes me sleepy, so I take it at night. There is also a dull headache that seems to come and go. Why are we willing to take something that is not yet approved by the FDA? The same reason people go to uncharted places, or try bungy jumping, we are brave, curious, or desperate.

 

Perhaps everything has some degree of "placebo effect". Our imaginations are more powerful than any drug. It won't help to grow your hippocampus if your attitude remains bad.

[Heisenburger]

Why are we willing to take something that is not yet approved by the FDA? The same reason people go to uncharted places, or try bungy jumping, we are brave, curious, or desperate.

 

Not to mention the fact that we do our homework first, and investigate these compounds before ingesting them to make sure they have a high potential benefits/potential risk ratio. Feeeeedback, bitches—that’s the name of the game. It’s this place’s single greatest asset.

[swashbucklinpirates]

Overhyping a drug that hasn't been proven to work beyond one small trial is irresponsible at best and dangerous at worst. You do realize that this thread is sort of like a filter, where only the most positive responders come back and post again and again? People who it didn't work for just drop out and you never hear from them again. I think I'm the only exception. We've had people on here who talk about Neuralstem like it's their church and NSI is the messiah. It may actually be for them, but it's still something of a red flag that you're only getting part of the story.

 

Not to say it doesn't really work, but for many reasons, not least of which is its well publicized purported method of action, the placebo is likely to be gigantic. It would actually be quite incredible if there were no significant placebo effect, in addition to a possible real effect of the drug, considering the strength of the placebo in every other clinical trial done today.

 

Not just you! Did you know this interview someone quoted about the hippocampal growth, with Neuralstem's CEO, was with a stock broker? The guy is CEO, he is a stock holder who has a vested financial interest in having investors buy neuralstem stock.

 

Of course he's going to say "This drug may actually structurally rebuild the hippocampus, inducing up to a 20% increase in hippocampal volume if results in animal models are replicated in humans.". That's a BIG if, and combined with the vagueness of NSI-189's mechanism of action, who knows if they'll ever put out on the huge sum of taxpayer money they happened into.

 

I realize phase 1 trials are probably just a safety screening to find out about any huge risks or side effects in humans - but why weren't they sticking their group into MRIs and looking for hippocampal growth right then?

 

Anyway, I had a moment today where I found myself able to remember a couple people's names who I just had met. I almost, in that moment, wanted to believe I was experiencing inflated hippocampus volume, but no - I think I was just paying attention a little more than usual.

 

Other than that, NSI-189 to me to *only* be some bitter liquid I for some reason continue to ingest after breakfast.

[jaiho]

What are your depression symptoms? Nsi 189 has been the only one to relieve my Anhedonia to some degree. The kind where music is just white noise, women are not interesting, the outside world colourless.
Nsi 189 brings me back into the world.

[jefferson]

For reasons I've already gone into earlier in this thread, any poll on Longecity or Reddit is going to be biased and unreliable in terms of showing us the rate of response. Selection bias is impossible to get around-- people will self select themselves to do the poll, leaving less motivated people out. These less motivated might have had more neutral reactions. Perhaps I'm wrong in the direction, but it's a source of bias which would not be inherent in a real clinical trial. The best polls and anecdotal evidence can really do for us is not to tell us the percentage of people NSI helps, but the possible side-effects people may experience from the drug (and again not even the rate of side-effects).

 

Like everything else, there could be a subset of people NSI helps very much, a subset it helps some, and a subset it doesn't help at all or even hurts. We have no idea what the numbers for those groups are based on responses in this thread alone. That's my main point. It's most useful to discover possible side-effects of the drug, although we don't know if these side-effects (like paresthesia) are 1/10, 1/100, or 1/1000.

[pheanix997]

For reasons I've already gone into earlier in this thread, any poll on Longecity or Reddit is going to be biased and unreliable in terms of showing us the rate of response. Selection bias is impossible to get around-- people will self select themselves to do the poll, leaving less motivated people out. These less motivated might have had more neutral reactions. Perhaps I'm wrong in the direction, but it's a source of bias which would not be inherent in a real clinical trial. The best polls and anecdotal evidence can really do for us is not to tell us the percentage of people NSI helps, but the possible side-effects people may experience from the drug (and again not even the rate of side-effects).

 

Like everything else, there could be a subset of people NSI helps very much, a subset it helps some, and a subset it doesn't help at all or even hurts. We have no idea what the numbers for those groups are based on responses in this thread alone. That's my main point. It's most useful to discover possible side-effects of the drug, although we don't know if these side-effects (like paresthesia) are 1/10, 1/100, or 1/1000.

All very true but the people NSI helps are free to come here and post their positive responses - in fact I'm sure most posters here appreciate the feedback. This thread generates awareness and may (or may not) help people with a very debilitating illness, where other methods posed problems. 

I don't think the posters who are saying it's going to work for everyone. Maybe, like neurotransmitter-enhancing drugs, it'll only create a great enough response to warrant continued use in people with the actual deficits NSI aims to treat, i.e. hippocampal atrophy. 

 

I think the marketing of these drugs causes the problems - SSRI's are marketing to treat depression, but this outrages  some people with depression whom it doesn't help. Probably because they're not low on serotonin. So SSRI's should really be marketed toward people with low serotonin, which may manifest differently to different people - some it may come up as depression, others as anger issues, etc. If you're not low on serotonin, you're not going to get a good response. If you are, you'll feel the effects within a day or two, and you feel it almost on a bodily level, which can't be denied or chalked up to placebo effect. 

Edited by pheanix997, 16 July 2015 - 02:03 PM.

[jefferson]

All very true but the people NSI helps are free to come here and post their positive responses - in fact I'm sure most posters here appreciate the feedback. This thread generates awareness and may (or may not) help people with a very debilitating illness, where other methods posed problems. 

 

I agree. I am only here as a counterbalance.

[Skypp]

What truly amazes me is that when you try to share something you think might help someone, and you've said NOTHING OFFENSIVE, you get a "dislike" click. As a female person, it usually happens when people figure out I'm not male. Wow, really? What was there to "dislike" in an honest discussion of how I believe NSI-189 might have helped someone? You really have to be angry and depressed to find fault with that comment.

 

[Major Legend]

What truly amazes me is that when you try to share something you think might help someone, and you've said NOTHING OFFENSIVE, you get a "dislike" click. As a female person, it usually happens when people figure out I'm not male. Wow, really? What was there to "dislike" in an honest discussion of how I believe NSI-189 might have helped someone? You really have to be angry and depressed to find fault with that comment.

 

Yeah just ignore those idiots..females bring a much needed balance to thought and opinion. A lot of men just have these crappy preconceptions once they figure out you are female, rendering your comments less relevant in their eyes, which is of course completely stupid.

 

Besides all male environments suck lol. I don't get those weight lifting, ufc types that just hang out with other men and compare muscles, any all male environment is a little creepy, even though if thats the sad reality of a lot of technology based companies.

[sparkk51]

^ are you a white knight ><?

[neuroatypicow]

i lol'd at that. ^

 

i'm a few days into a jar of NSI, way too early to report anything other than acute side effects. almost immediately upon administration of 20mg., SL, i get an uncomfortable pressure feeling in my temples. just one side at a time, which side apparently decided by the NSI. that fades halfway into the 15 minutes during which i hold the substance against my mucosa. no other side effects so far to report.

 

using NSI for depression and the cognitive impairment and anxiety that came with it. am on conventional psych meds. will give 'reports from the pasture' as they come in.

~moo

-bringing much needed balance to thought and opinion since 1994

Edited by neuroatypicow, 17 July 2015 - 08:59 AM.

[idontknow]

I received my batach from you SL (THANKS!) Have not started it yet as I have an opened bottle still going from International Peptide (which by the way seems to be good stuff). LOTS of people on Reddit are asking where to find it.

 

Why would hyping the neurogenesis be a problem? That's what it does and it's a good thing. People are consuming all sorts of less effective products. I would wager that a very substantial portion of the adult population has hippocampal function reduction. If not from depression then from stress and prescription drugs (and non-prescription). Flouride as well as mercury in vaccines also kill hippocampal cells. (TRUE) . Flouride alone will shrink and calcify that area of the brain. (Don't use toothpaste that has it.)

 

I have been giving NSI-189 to someone who is a high achieving, type A person who would not have been classified as typically depressed. However, high stress levels manifested through chronic joint pain, insomnia, teeth-grinding, and angst. In his forties, both his hips had to be resurfaced (not a full replacement). Since I have been administering this product, it's like a cloud has lifted. He is not in physical pain anymore. No more insomnia, no teeth-grinding. Almost no angst. This is a miracle as I finally assumed many of these issues were just part of a personality type. No, they were part of a depression pattern. I will see if this lasts, but so far, amazing.

Hyping neurogenesis is problematic, because it is not proven in humans. In fact the NSI-189 phase 1b trial didn't mention any neurogenesis even though they did neuroimaging on their subjects, so they should have been able to detect it. Either there was no neurogenesis in vivo, or they particularly chose to not lose a single word on it in their phase 1b presentation. You could find arguments for both, but as of yet we do not know if the apparently statistically significant antidepressive effects of NSI really do come from neurogenesis.

 

What truly amazes me is that when you try to share something you think might help someone, and you've said NOTHING OFFENSIVE, you get a "dislike" click. As a female person, it usually happens when people figure out I'm not male. Wow, really? What was there to "dislike" in an honest discussion of how I believe NSI-189 might have helped someone? You really have to be angry and depressed to find fault with that comment.

 

I do not believe that people dislike your opinions because you are a women, but because comments like 'Flouride as well as mercury in vaccines also kill hippocampal cells. (TRUE)' is a damaging conspiracy theory statement that has little to no scientific evidence:

 

https://en.wikipedia...sal_controversy

The thiomersal controversy describes claims that vaccines containing the mercury-based preservative thiomersal contribute to the development of autism and other brain development disorders.^[1] The current scientific consensus is that no convincing scientific evidence supports these claims,^[2][3] and a 2011 journal article described the vaccine-autism connection as "the most damaging medical hoax of the last 100 years".^[4]

 

Poorly researched statements like that also make the rest of your post sound non-credible.

 

Negative feedback is meant to help you question the validity and reasoning behind your answer. This is a scientific community and not a popularity contest, so you shouldn't feel insulted over it.

[pheanix997]

 

I received my batach from you SL (THANKS!) Have not started it yet as I have an opened bottle still going from International Peptide (which by the way seems to be good stuff). LOTS of people on Reddit are asking where to find it.

 

Why would hyping the neurogenesis be a problem? That's what it does and it's a good thing. People are consuming all sorts of less effective products. I would wager that a very substantial portion of the adult population has hippocampal function reduction. If not from depression then from stress and prescription drugs (and non-prescription). Flouride as well as mercury in vaccines also kill hippocampal cells. (TRUE) . Flouride alone will shrink and calcify that area of the brain. (Don't use toothpaste that has it.)

 

I have been giving NSI-189 to someone who is a high achieving, type A person who would not have been classified as typically depressed. However, high stress levels manifested through chronic joint pain, insomnia, teeth-grinding, and angst. In his forties, both his hips had to be resurfaced (not a full replacement). Since I have been administering this product, it's like a cloud has lifted. He is not in physical pain anymore. No more insomnia, no teeth-grinding. Almost no angst. This is a miracle as I finally assumed many of these issues were just part of a personality type. No, they were part of a depression pattern. I will see if this lasts, but so far, amazing.

Hyping neurogenesis is problematic, because it is not proven in humans. In fact the NSI-189 phase 1b trial didn't mention any neurogenesis even though they did neuroimaging on their subjects, so they should have been able to detect it. Either there was no neurogenesis in vivo, or they particularly chose to not lose a single word on it in their phase 1b presentation. You could find arguments for both, but as of yet we do not know if the apparently statistically significant antidepressive effects of NSI really do come from neurogenesis.

 

What truly amazes me is that when you try to share something you think might help someone, and you've said NOTHING OFFENSIVE, you get a "dislike" click. As a female person, it usually happens when people figure out I'm not male. Wow, really? What was there to "dislike" in an honest discussion of how I believe NSI-189 might have helped someone? You really have to be angry and depressed to find fault with that comment.

 

I do not believe that people dislike your opinions because you are a women, but because comments like 'Flouride as well as mercury in vaccines also kill hippocampal cells. (TRUE)' is a damaging conspiracy theory statement that has little to no scientific evidence:

 

https://en.wikipedia...sal_controversy

The thiomersal controversy describes claims that vaccines containing the mercury-based preservative thiomersal contribute to the development of autism and other brain development disorders.^[1] The current scientific consensus is that no convincing scientific evidence supports these claims,^[2][3] and a 2011 journal article described the vaccine-autism connection as "the most damaging medical hoax of the last 100 years".^[4]

 

Poorly researched statements like that also make the rest of your post sound non-credible.

 

Negative feedback is meant to help you question the validity and reasoning behind your answer. This is a scientific community and not a popularity contest, so you shouldn't feel insulted over it.

 

Disagreeing with a female is sexist, you should know that!