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NSI-189

nsi-189

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#3241 Major Legend

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Posted 23 July 2015 - 04:15 AM

Oh and on the whole "intellectual peak talk". I can't believe somebody used the daily mail as a reference here. 

 

Besides humans would surely either destroy themselves or reach singularity by the time the decline is to be of any significance. Bearing in mind we are talking

generational IQ change here when technology is talking about doubling exponentially every year. So if there was a decline - so what? Somebody born today will enter the adult world 20 years later . 20 years ago was 1995, and as far as i'm aware half of this amazing technology we are using wasn't even imagined yet.

 

 


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#3242 jonnyD

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Posted 23 July 2015 - 12:38 PM

I got my NSI-189 (freebase) and took ~25mg sublingual today in the morning and 25mg again at lunchtime. 

 

The first 45-60 minutes feels exactly like a low dose acid.  Strange body feeling, increased color and 3d perception and the feeling like everything is "breathing" a little... i do not know how to describe it better. 

 

Does this stuff act on 5-HT receptors?


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#3243 Zhivili

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Posted 24 July 2015 - 03:51 AM

Don't understand the "dislikes" on my previous posts, somebody asked a question and I answered it based on personal experience, not good enough? Not sure if I like it here.

 

 

I got my NSI-189 (freebase) and took ~25mg sublingual today in the morning and 25mg again at lunchtime. 

 

The first 45-60 minutes feels exactly like a low dose acid.  Strange body feeling, increased color and 3d perception and the feeling like everything is "breathing" a little... i do not know how to describe it better. 

 

Does this stuff act on 5-HT receptors?

It is not known if NSI-189 acts on 5-HT receptors, however it is worth noting that some drugs such as coluracetam and noopept have been reported to induce the psychedelic-esque effects that you have described. 

 

---------------------

 

 

 

I am on day 4 of NSI-189. I am taking it to help combat crippling depression that I have dealt with since I was a child. Have bumped my dosage up to 30mg Freebase sublingually yesterday, experienced no ill effects so far. A post in the previous page reported a negative reaction with selank and NSI-189 - I am on day 2 of combining it with NA-Selank with good results. I have read that NSI commonly causes anxiety, I have yet to experience any. Perhaps the selank is helping, perhaps I am flat out not experiencing it. Worth noting I also take 500-1000mg of Ashwagandha nightly as well.

 

My next report shall be posted further along my regimen and be more in depth.


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#3244 fourohfournotfound

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Posted 24 July 2015 - 04:18 AM

I determined that the negative reaction that I though was selank and nsi combo was actually a very bad fever and sickness. I haven't had a fever that bad in about 10 years so I had forgotten what it felt like. I know it was just being sick because other people in my office seemed to get the same thing. Selank in general doesn't work very well for me as it seems to increase stress and anxiety rather than reducing it. Semax seems to reduce anxiety and stress for me so added to the reduction I get from nsi it works out great. I also believe the the bdnf boosting properties of semax that it could help to create a fertile environment for the new hippocampus cells to grow in. Personally I think that the anxiety that nsi can give is dose related as well as it seeming to go away with time. At this point nsi seems to reduce my anxiety even though it seemed to increase it for the first few weeks.


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#3245 jefferson

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Posted 25 July 2015 - 05:08 AM

I want to share my NSI-189 experience as a friendly warning to those considering trying it. I have done two cycles and recently attempted a third one but had to stop because of some pretty serious nerve/neuropathy type side effects.

A little background:

I tried my first cycle about a year ago and had what I thought was a physical injury during the same time period. I spend a good amount of time in the gym so when I started having neck/back pains reminiscent of a pinched nerve I figured I had hurt myself in the gym. I didn't even think to connect it to the NSI because it really felt like an injury. I did a 4 week cycle and it probably took 4 months for this "injury" to resolve itself.

A few months later I tried another NSI cycle and within a few days I began to experience similar pains. I had pain when turning or bending my neck, shooting pains down my arm, and Numbing/cramping in my hands. Again I assumed I has re injured myself but was definitely suspicious of the timing. I cut my cycle short because I was concerned the NSI was, if nothing else, aggravating the injury. Again, after some time, the pains slowly disappeared.

Fast forward to now, about a year later. I decide to try NSI one more time. Not even 12 hours after my first dose I started getting pains/cramping in my hands and a familiar tightness in my neck. It's now very obvious to me that these are direct side effects of the NSI-189. I only took two doses this time and 48 hours since the last one the symptoms are starting to resolve themselves.

Side effects like this seem to be pretty rare. I only remember one or two other people on here reporting anything like this. It seems to be transient and resolves itself after cessation of the NSI-189. Although it's hard to say for sure that I haven't done any permanent damage

Anyways, I just wanted to share that so people are aware. Good luck to you all

Note: The only other medication I'm on is gabapentin which I take for anxiety. Whether there is a possible interaction there I don't know.

 

Well, well, well, another NSI user with nerve pain finally emerges. Since this proves my reaction wasn't a freak, one-in-a-million side effect, it will be very, very interesting to see if this shows up in larger clinical trials, and at what rate and severity. 

 

Not to make light of your situation, but this actually reassures me that I didn't get bunk NSI, nor that I'm insane or stirring up trouble here for no reason. A year ago I had a far worse, but similar reaction: sharp shooting pains in my arms and chest, paresthesia in my legs and neck. 

 

Gabapentin worked very well to block the pain while I was on it. After 3 months, I stopped the Gabapentin and by then symptoms were about 2/3 gone. A little over a year later, my nerves are maybe 95% better. I only get mild burning sensations when I'm very stressed or dwelling on it, and only late at night when it does occur. Anyway, the good news is that over enough time it does seem to get a lot better, even with the more severe reaction I had to it.

 

Your body seems to have become more sensitive to the NSI-linked nerve damage with each dose-- precisely what happened with me. 20 mg the first day was fine, 50 mg the next day knocked me on my ass for a month. After another month of giving my nerves time to heal, a mere 10mg orally gives me sharp shooting pains lasting for a week along with bad paresthesia lasting for months.

 

Moral of the story: If you have this reaction, STOP IMMEDIATELY. DO NOT attempt to try a "safer" lower dose. It could be even worse the second time around even at a far lower dose.


Edited by jefferson, 25 July 2015 - 05:10 AM.

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#3246 Limitless life

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Posted 25 July 2015 - 11:42 AM

Hi there. I have nsi-189 for sale at moment for 125 a gram. Willing to send small sample. I just did 30 day check. Bought a gulf order and its been great for me. Now that I know it's good product I'm willing to sell some at great rate so others can benefit.
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#3247 Limitless life

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Posted 25 July 2015 - 11:49 AM

Spell check kills me on my mobile. Supposed to say cycle. And bulk not gulf. Been following thread for awhile and putting up site soon as I'm so fascinated with these compounds and had so much success with many such as semax, phenyl-piracetam, etc. I have purchased bulk of high quality in many products. Now I'm at phase where I need to get advertising money so I can advertise on this site. Nootropics have become my passion and hobby and I hope to be able to continue learning more and help people to acquire products as prices cheaper than most us companies. Happy to be here
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#3248 drg

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Posted 25 July 2015 - 03:20 PM

125$/g is ridiculous price


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#3249 jonnyD

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Posted 25 July 2015 - 05:49 PM

125$/g is ridiculous price

 

Definatly. Paid 1/5 ... 


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#3250 MetaMind

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Posted 25 July 2015 - 06:58 PM

After multiple cycles of NSI for the past 2 years I finally want to share my experience I had with this compound.

Neuralstem this is for you!

 

 

Case Study:

 

 

gender: male

age: 28

hair: lightly curly, black

weight: 71 kg (156lb)

height: 179 cm

genetic makeup:

        father-wise: italian(Huguenots)

      mother-wise: blonde-nordic (german)

 

 

 

Background:

I was raised in a above-middleclass family (both parents are academics) living in a single-family house with garden.

I ve one brother (blonde-nordic) who stems from my mothers old marriage.

In school I was a constant underperformer crippled with cognitive deficits, attention problems and subtle feelings of agression. I m linking this behaviour to the fact that my mothers parents died 1986(father) and 1989(mother). I was born in 1987 so I can only can guess that my mother back then was severely depressed and missed crucial developmental caregiving. In addition my mother was suffering from her fathers agressive tensions, beating her up I cannot prove...she rarely speaks about her past. She is also a very socially isolated kind of person, only few friendships made back in her elementary school years. Although she is a taugh women (possibly mild autistic behaviour) I never really developed a loving child-mother relationship to her.

My father has a very calm personality, he rarely has agressive outbursts like my mother or is in any way mean to others.

He was also raised under troubled conditions... his father was incarciated in a russian goulag during the nazi era... when he came home he was a broken man and was supposedly not a good father. So my father was raised by a surrogate family although I m not 100% clear if that was the case... he too speaks very rarely abouth his childhood/past.

My father was more the person I could releate with...allthough in my early years (6-12) I called him viscious names and kind of enjoyed humiliating him coz he was so passive, calm speaking and warm hearthed which stand in absolute opposition to what I experienced/learned in school (academic & social meritocracy hell)

My brother was my prime charackter-evolving influence where he showed me many qualitative sophisticated music and movies even when I wasnt able to conceive them at this very young age.

 

 

Psychopathology:

As mentioned above I was struggeling with school in early age (C's and some D's all over the place in school reports)

Coming from a kind of high archiving family it was very painful seeing me not be able to grasp and comprehend the subject material I had to learn for school. A form of ADS was diagnosed later in life at age 25.

After elementary school I visited my brothers Gymnasium (which is a kind of upper-level education high school) I failed miserably and had to leave after just one year.

Then made my way through normal high school and thats the time where I firstly got in contact of my drug of choice: Cannabis. (age 13)

Over the years I was getting depressed more and more... my social surroundings just didnt fit to my personality which was shaped so much by my brothers alternative taste of music and art. At age 16 I used cannabis almost on a daily basis. The anxiety level was on many occasions unbarable...but as beeing a male I wasnt able to talk in any form to anyone about this...I just would not be able to get my point across I guess. I didnt even counciously noticed that I had severe mental problems...some kind of strange deulsion. I constantly felt totally unsecure in my peer group so after long trial and error/failing I just gave up and left them (age 20).

Anything that comes after isn't  really worth mentioning... tried to study 2 times (economics: 2 semesters / bioinformatics: 3 Semester) but I was too mentally unstable and non-capacitive to pursue it any timelonger. I also have never experienced a relationship with a women... I just cannot attract or ve even tried to find a woman with this psychological state of mind.

Now I m sitting in my room all day... crippled with anxiety and depression...basicly no future!

 

 

NSI-189 treatment:

In the past I tried some medications to alleviated my symptoms of depression,ADS and social anxiety:

Elontril, Edronax, Cipralex, Cymbalata, Ritalin, Modafinil

All SSRIs had mild to no response to me, except Cymbalta which unfortunetly lost its efficacy after just 2 month.

Modafinil helped me out of my catatonic depression-related states but wasnt able to sustain it.

I also used many nootropics...where I only found 5-HTP - L-Tyrosin useful for mild mood uplifiting and noopept-alpha gpc against brainfog.

In desprate pursue of new treatments I stumbled upon NSI-189 in late 2012. Then I was in the first NSI-groupbuy from "ScienceGuy"(mid 2013) which is known as the most respected and high quality NSI synthesis + testing yet.

I took 40mg once a day sublingually for little over 1 month. In paralel I stopped using cannabis 2 weeks before and stayed abstinent for 1 year!

To my very despair it never  showed up substantial mood alterings or cognitive betterment of any kind!

The only clear effect I ve noticed over time is that my timeawareness changed dramaticly... the 1 year back felt like 5 years before...really strange coz in past attempts of abstination I never experienced this effect before.

Fast Forward 2015 I recieved a 5g sample from a very kind member of this forum. I m absolutely certain that his sample was 100% legit coz it had the same structural appearance and taste, tounge numbing effect like ScienceGuy's NSI.

This time I took 40mg twice a day in combination with weight lifting/workout and blueberrys supplementation to harness the maximum hippocampal neurogenesis effect.

I took it for 2,5 months but still it wasnt able to relieve me of my loss of motivation, cloudy depressive thoughts and despair. I just dont know whats wrong with me...why it is not working?

All in all it was a worthwile attempt but with no happy end for me.


Edited by MetaMind, 25 July 2015 - 07:03 PM.

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#3251 Shai Hulud

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Posted 25 July 2015 - 07:16 PM

After multiple cycles of NSI for the past 2 years I finally want to share my experience I had with this compound.

Neuralstem this is for you!

 

 

Case Study:

 

 

gender: male

age: 28

hair: lightly curly, black

weight: 71 kg (156lb)

height: 179 cm

genetic makeup:

        father-wise: italian(Huguenots)

      mother-wise: blonde-nordic (german)

 

 

 

Background:

I was raised in a above-middleclass family (both parents are academics) living in a single-family house with garden.

I ve one brother (blonde-nordic) who stems from my mothers old marriage.

In school I was a constant underperformer crippled with cognitive deficits, attention problems and subtle feelings of agression. I m linking this behaviour to the fact that my mothers parents died 1986(father) and 1989(mother). I was born in 1987 so I can only can guess that my mother back then was severely depressed and missed crucial developmental caregiving. In addition my mother was suffering from her fathers agressive tensions, beating her up I cannot prove...she rarely speaks about her past. She is also a very socially isolated kind of person, only few friendships made back in her elementary school years. Although she is a taugh women (possibly mild autistic behaviour) I never really developed a loving child-mother relationship to her.

My father has a very calm personality, he rarely has agressive outbursts like my mother or is in any way mean to others.

He was also raised under troubled conditions... his father was incarciated in a russian goulag during the nazi era... when he came home he was a broken man and was supposedly not a good father. So my father was raised by a surrogate family although I m not 100% clear if that was the case... he too speaks very rarely abouth his childhood/past.

My father was more the person I could releate with...allthough in my early years (6-12) I called him viscious names and kind of enjoyed humiliating him coz he was so passive, calm speaking and warm hearthed which stand in absolute opposition to what I experienced/learned in school (academic & social meritocracy hell)

My brother was my prime charackter-evolving influence where he showed me many qualitative sophisticated music and movies even when I wasnt able to conceive them at this very young age.

 

 

Psychopathology:

As mentioned above I was struggeling with school in early age (C's and some D's all over the place in school reports)

Coming from a kind of high archiving family it was very painful seeing me not be able to grasp and comprehend the subject material I had to learn for school. A form of ADS was diagnosed later in life at age 25.

After elementary school I visited my brothers Gymnasium (which is a kind of upper-level education high school) I failed miserably and had to leave after just one year.

Then made my way through normal high school and thats the time where I firstly got in contact of my drug of choice: Cannabis. (age 13)

Over the years I was getting depressed more and more... my social surroundings just didnt fit to my personality which was shaped so much by my brothers alternative taste of music and art. At age 16 I used cannabis almost on a daily basis. The anxiety level was on many occasions unbarable...but as beeing a male I wasnt able to talk in any form to anyone about this...I just would not be able to get my point across I guess. I didnt even counciously noticed that I had severe mental problems...some kind of strange deulsion. I constantly felt totally unsecure in my peer group so after long trial and error/failing I just gave up and left them (age 20).

Anything that comes after isn't  really worth mentioning... tried to study 2 times (economics: 2 semesters / bioinformatics: 3 Semester) but I was too mentally unstable and non-capacitive to pursue it any timelonger. I also have never experienced a relationship with a women... I just cannot attract or ve even tried to find a woman with this psychological state of mind.

Now I m sitting in my room all day... crippled with anxiety and depression...basicly no future!

 

 

NSI-189 treatment:

In the past I tried some medications to alleviated my symptoms of depression,ADS and social anxiety:

Elontril, Edronax, Cipralex, Cymbalata, Ritalin, Modafinil

All SSRIs had mild to no response to me, except Cymbalta which unfortunetly lost its efficacy after just 2 month.

Modafinil helped me out of my catatonic depression-related states but wasnt able to sustain it.

I also used many nootropics...where I only found 5-HTP - L-Tyrosin useful for mild mood uplifiting and noopept-alpha gpc against brainfog.

In desprate pursue of new treatments I stumbled upon NSI-189 in late 2012. Then I was in the first NSI-groupbuy from "ScienceGuy"(mid 2013) which is known as the most respected and high quality NSI synthesis + testing yet.

I took 40mg once a day sublingually for little over 1 month. In paralel I stopped using cannabis 2 weeks before and stayed abstinent for 1 year!

To my very despair it never  showed up substantial mood alterings or cognitive betterment of any kind!

The only clear effect I ve noticed over time is that my timeawareness changed dramaticly... the 1 year back felt like 5 years before...really strange coz in past attempts of abstination I never experienced this effect before.

Fast Forward 2015 I recieved a 5g sample from a very kind member of this forum. I m absolutely certain that his sample was 100% legit coz it had the same structural appearance and taste, tounge numbing effect like ScienceGuy's NSI.

This time I took 40mg twice a day in combination with weight lifting/workout and blueberrys supplementation to harness the maximum hippocampal neurogenesis effect.

I took it for 2,5 months but still it wasnt able to relieve me of my loss of motivation, cloudy depressive thoughts and despair. I just dont know whats wrong with me...why it is not working?

All in all it was a worthwile attempt but with no happy end for me.

 

Hi. Sorry to hear it didn't work out for you. As there are some similarities in our background I'd like to give you some advice as to what try next. Hope this can help you.

1) Did you ever try psychotherapy? If not, you should.

2) Do you have a job? Again, if not, get one. You will be forced to learn and interact, even if it's a very simple task. In my experience this helps with brain fog and memory, but only after some time. If you can find sth. with some social interaction, that would be better.

I started carrying and delivering blood samples at a local clinic, it's a boring and dumb job, but my memory really got better after some weeks/months.

3) Get tianeptine. Helped my cognition. It's available as a prescription medicine in Germany

4) Vortioxetine could also be worth a try, as antidepressant with pro-cognitive properties. I Just started it today, so I can't yet say if it helps.


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#3252 MetaMind

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Posted 25 July 2015 - 07:50 PM

Thank you for your input.

1.: I tried psychotherapy in combination with NSI,workout etc.  I noticed some thought altering behaviour when I talk and reflect about it but I m just to desprate right now...so that my psychotherapist decided to intermit the therapy so that I can join a day hospital... after that I will continue with the therapy but to be honest I dont think it will make any substantial difference to me.

2.: dealing with severe social anxiety and discomfort makes any attempt to hold a job on  a longer term impossible... it feels like torture to me wandering around and do pointless mundane things over and over again. I worked at multiple call centers and tried some back office stuff but it was unbearble. Negative thought patterns kicked in almost imediatley!

3.:I read about it... intresting allthough it supposedly ve some addictive properties to it...where I wanna stay away from. But I will talk to my doctor about it.

4.: this one is new to me...maybe you can elaborate your expirience later when you took it for a sufficient amount of time.

 

Again thank you for suggestions


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#3253 Shai Hulud

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Posted 25 July 2015 - 08:01 PM

Thank you for your input.

1.: I tried psychotherapy in combination with NSI,workout etc.  I noticed some thought altering behaviour when I talk and reflect about it but I m just to desprate right now...so that my psychotherapist decided to intermit the therapy so that I can join a day hospital... after that I will continue with the therapy but to be honest I dont think it will make any substantial difference to me.

2.: dealing with severe social anxiety and discomfort makes any attempt to hold a job on  a longer term impossible... it feels like torture to me wandering around and do pointless mundane things over and over again. I worked at multiple call centers and tried some back office stuff but it was unbearble. Negative thought patterns kicked in almost imediatley!

3.:I read about it... intresting allthough it supposedly ve some addictive properties to it...where I wanna stay away from. But I will talk to my doctor about it.

4.: this one is new to me...maybe you can elaborate your expirience later when you took it for a sufficient amount of time.

 

Again thank you for suggestions

 

You're welcome. 

As long as you get your presciption for tianeptine from one physician, I don't think there's any way you'll get addicted to it.

The standard dose is 12,5 mg thrice a day. People who abuse it take way higher doses and addictive properties are probably from opioid receptor agonism. As tianeptine is a weak agonist, that's the reason people have to take such high dosages for a buzz. If you'll be after that, your presciption will run out in no time. Most people on this forum live in countries where it's not an approved medication, so they just dose powder, which makes higher doses more probable, as most people don't even have a scale working reliable with so small amounts.

So I'm pretty confident you won't have to fear addiction.

And one more addition: Pregabalin could help you with your anxiety, but will probable mess with memory and attention span in higher dosages. Still, it's worth a shot in your situation.

Edit:

And also group therapy can be very helpful in my experience.


Edited by life backwards, 25 July 2015 - 08:04 PM.

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#3254 thedarkbobo

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Posted 25 July 2015 - 09:04 PM

Wall of text.

 

Mmmm I see life was hard for you, but that's the past and what you have is the future.

If you need to change anything - make it quick, not some few months lenght therapies. I have a quiet good family, but when I was a teenager I was very shy. At one night I was very sad with this and have decided that It doesn't work for me and since tomorrow I will be more open. It took one thought process to see how people that attrat people behave and execute this decision. To start talking more, SMILE and to not care too much what they think.

So I say to you: forget about anxiety, make new version of yourself, talk to yourself that what does not work is not for you. You can do better. Start observing what best performers do, how they think. Can also google some in this area. Challange yourself with whatever is your fear IF you really want to change. I know I don't like some things like heights but I don't feel need to climb a mountain (again) to show anything. You current state though is disfunctional so you rather should take the challange. Maybe go to church, join some club, join dancing lessons etc...

 

Maybe cannabies ruined your brain a bit, so I can only tell you from my experience what worked that I can learn quite fast and am in really good shape at 27:

diet...eating a lot of anything, not much trash food...alcohol not often (btw you loose precious time when partying or doing drugs..not only money/health)

experiences - trying many things like traveling to some places with family when I was young, trying different sports, do not limit myself to math but trying to grasp other disciplines

solving riddles since I was young

playing pc games hmm not sure if that helped much besides quick writing and pc skills and maybe as a way to reduce anxiety after school

saying "I can do this" even if I had no idea how to do many things and then using all my resources to do such thing (competitions, new jobs)

spending houuurssss and hooourssss learing stuff....literally years...trying things that I don't even do now like 3d graphics, painting, programming...I don't think there is any shourtcut for this. I could spend 12h learning and listening to music/doing other stuff in the meanwhile + eating during exam sessions. So in this area, as in any pursuit in life you have to grind. Thats easy solution.

 

Relax..life is long.

 

 


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#3255 MetaMind

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Posted 25 July 2015 - 10:11 PM

@life backwards

I will get in contact with my physician ask himabout this...if he refuses there are still UK suppliers who are shipping to europe. I also ve a mg scale so measuring it should be no problem. The group therapy thing I tried once but I felt very uncomfortable laying out my delusional nerdy loner life to others... when youre in a group with more then 3 participants  primitve group behaviour kicks in and you are not allowed to speak  the daring truth about society, myself etc....it will be supressed and disfigured!

 

 

@thedarkbobo

Thank you for informative response!

 

Mmmm I see life was hard for you...

 

Dont get me wrong... I was raised under very good conditions as I stated in my case report... big house...big garden... I had lots of friends back in elementary school etc.

Also I traveled a lot with my parents and visited many exotic countrys and people back then....gosh it feels like centurys before.

Still I evolved into such a strange loner guy.

Regarding your "just observe and execute" hint... I tried this tactic for years and years in the past (age 22-27) but what I noticed is that I run reletavely easy into a wall of anxiety and absolute thought-emptiness where it just overwhelmed me. Call me weak, not trying hard enough etc but when you endured these mental symptoms for a sufficient  amount of time you lose hope very quickly and I also linking my state heavily on genetic / developmental issues... thats why the NIMH (National Institute of Mental Health) reclassified Depression and Anxiety to a "Brain Disease"  not a Behaviour Disease.

I also not taking exotic drugs or alcohol in the past...only cannabis which I m off now for 4 month now. 

Im also more the alternative type of guy...beeing very suspicious of opportunistc archiever alpha male behavioral patterns that are so demanded in our society.

Look I ve attended an art group for political awreness lets say :P where I m participating for 2,5 years now... but I just cannot build up a warm and near relationship with others...sometimes I feel I m mildy autistic like maybe my mother.

The only thing I can show to the world is my totally kickass mod for the game:Natural Selection 2 called: Last Resistance(Survivor) where I m preparing a trailer right now.

It took me months and months of painful backtracking and learning how to program etc but now I m finished....thats the good thing.

As for just lern new stuff and get over with...I just noticed if you dont ve the outer trigger elements that give you meaning in life motivation will fade farely quickly and your in an non-capacitive state.

Also my heavy cannabis consume potentially damaged my Hippocampus even more... I dont know.

Maybe I will make another NSI cycle in a few month or so.

Again thank you for your point of view...its appreciated!


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#3256 h2o

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Posted 26 July 2015 - 04:41 AM

Hi MetaMind,

Thank you for sharing your story and 2 year experience with NSI. Your experiences and personality is actually quite similar to mine.

I too was one of the first people (lab rats) to take ScienceGuy’s NSI back in August 2013. Yes, it really has been that long. I had cycled NSI-189 for a total of 1.5 years.

The difference is that I have no history of recreational drug use, but experienced crippling social isolation and lack of achievements compared to my other members of my family. (My father was an engineer while my younger brothers are pharmacy and computer science majors.) I too, am now almost 27 and have never been in a romantic relationship.

 

But unlike you, I did have some improvements taking NSI-189. I got a positive reaction right away and it continued for a while. However, I was never “cured.” Lifelong depression and isolation wreaks havoc on the white and gray matter of the brain. The DSM characterizes major depressive disorder as depression that lasts two weeks or more – yes only two weeks - while I compare that duration to the depression I experienced for over a decade.  I see that you have been suffering that same decade I have been suffering. Same condition, suffered during the same point in time, just different country and different families.

 

Thanks to NSI-189, I learned to know what neurogenesis or improved brain function feels like. This was especially true when I was out with friends or did novel activities. Later on, I was able to detect what I would call “the NSI effect” on a few other supplements such as TA-65 and Semax. But it still was not enough…

The problem is this: you must be willing to make full 360 life changes which unfortunately I failed to do. I knew that this would be the challenge 30 days into taking NSI in 2013. I really tried to learn a new language for instance which was one of the things I referred to back in an update, but without enough support the whole thing came crashing down.

 

 Also, one of the problems I have is issues with spatial navigation. I don’t think NSI-189 has noticeably helped with this even though the hippocampus has been associated with rapid creating of spatial maps etc. This may be due to not knowing how to specifically train and measure this, but I figured that if I did improve spatial navigation, I would notice it simply driving day to day.

 

I still would like to restart another cycle of NSI in the future. But it’s so much easier to take a drug then to change old life habits. I totally agree with life backwards from Germany when he says that taking on new tasks at work improves the brain. I also agree with thedarkbobo in that trying as much new activities as possible the best for keeping the brain fit. And one final thing I would mention is…. STAY AWAY FROM THE COMPUTER especially when you could be having face to face interactions.  Social isolation and excessive computer use have been linked to disintegrity and loss of white brain matter. This leads to slower processing speed and aloofness.

 

Additionally, from my NSI-189 experience taking 40mg sublingually twice a day is better than taking 40mg three times a day orally. At first I only took it orally because that’s how it was taken in the official trials and it’s much more convenient than having to wait for it to dissolve under the tongue. Once I realized how much better and fast acting it was to take NSI sublingually, I rarely took it orally again.


Edited by h2o, 26 July 2015 - 04:46 AM.

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#3257 Major Legend

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Posted 27 July 2015 - 09:00 AM

Hi, i just figured out and wanted to added that the NSI only works with Noopept in conjunction, so my previous experiences were the two of them together, and do not reflect upon NSI alone, or NSI

at all.

 

So either Noopept is basically what is doing the trick instead of NSI, its highly plausible as NSI by its own seemed to have very mild numb like effects. I had mistakenly thought that the effects were due to NSI building up, but nope it was just because I added Noopept, under the tongue by the way.

 

It's also plausible that I don't actually have any NSI, but in fact just have noopept, as they taste almost identical to me.


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#3258 h2o

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Posted 28 July 2015 - 01:05 AM

And one final thing I would mention is…. STAY AWAY FROM THE COMPUTER especially when you could be having face to face interactions.  Social isolation and excessive computer use have been linked to disintegrity and loss of white brain matter. This leads to slower processing speed and aloofness.

 

 

 

I received a PM asking me to cite specific studies supporting this claim so here you go

 

A few studies that relate specifically to the negative effects of excessive computer use:

 

Gray Matters: Too Much Screen Time Damages the Brain

 

Abnormal White Matter Integrity in Adolescents with Internet Addiction Disorder: A Tract-Based Spatial Statistics Study

 

I wonder if it's the excessive computer use per se that causes these problems or rather the social isolation.

 

Social Isolation Disrupts Brain's 'White Matter' Formation – Key to Brain 'Plasticity', MS and Mood Disorders

 

Mystery of How Social Isolation Messes with Brain Solved

 

Myelin vital for learning new practical skills

 


Edited by h2o, 28 July 2015 - 01:08 AM.

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#3259 mindpatch

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Posted 28 July 2015 - 03:33 AM

First of all, you'd have to be ten years old, or eighty-five not to know that Pharma companies and others with an agenda, regularly write Wikipedia pages. They are often wrong, or very misleading. If you believe fluoride is okay, or mercury, go right ahead and consume all you want. I have done a ton of research as well, with experts, and have come to a very different conclusion. Just because someone doesn't mirror your consensus-reality world view, does not mean they are wrong. Reality itself is completely mailable and is created by how we all collapse the wave into solid particles with our thoughts and beliefs. You are no more in possession of the truth than I am just because you read a Wikipedia page and some Pharma sponsored "papers". Sorry, but the ones who read and believe the mainstream propaganda are often less intelligent and informed. It takes some guts these days to speak out, especially if you are a woman. I really feel for the (former) Reddit CEO, like her or not, the abuse she suffered on the internet makes me think humankind is sinking to a new level of low. (Probably all that mercury and fluoride we've been forced to ingest. LOL) There used to be more geniuses per every 1000 born in the USA. The rate has been slipping. WHY? Environmental toxins and all the crap they shoot into near newborns.  Okay, go ahead and only believe your "facts", based on research like that done by Dong-Pyou Han (falsified AIDS research for grant money). Do you think that is an isolated case? No, it's happening all the time. PLEASE~ if you want to sound smart, (or actually be smart) don't quote a pharma page on Wikipedia.

 

 

Dear Skypp

 

I had this client that I worked with who was adept at making this unreasonable requests, talking endlessly about how the root cause of all dysfunction was related to a lack of balance of minerals and her holistic health practice.  She would leave these long rambling phone messages about how the world didn't understand the special needs of being a woman and how there was this huge conspiracy, literally breaking down and sobbing during the message.  I saved them because they were so unhinged, and it became a running joke among my colleagues and I.  She lived in Long Beach so, who knows, maybe there's a connection. 

 

My point is, I've seen your type before.  You're unbalanced, which ordinarily wouldn't be that big a deal if you were harmless, but the in brief time I've skimmed through your hyperbolic posts, you've claimed numerous conspiracies by entities that are trying the silence the truth; a truth that only you really seem to know.  When challenged by the rational here, you then claim victimhood for being woman while simultaneously calling everyone who doesn't completely accept your spurious arguments stupid.  You then wonder why the community here is not very receptive to your already silly conspiracy peddling.  

 

I don't want to needlessly me harsh here, but I just don't have patience for people like you.  It's just selfishness.  Can you please not troll the board or this thread with your nonsense. It's already long enough. 


 

 

 


Edited by mindpatch, 28 July 2015 - 03:38 AM.

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#3260 mindpatch

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Posted 28 July 2015 - 05:03 PM

Hi there. I have nsi-189 for sale at moment for 125 a gram. Willing to send small sample. I just did 30 day check. Bought a gulf order and its been great for me. Now that I know it's good product I'm willing to sell some at great rate so others can benefit.

I'd definitely be interested if, and only if, you will send a sample for independent purity testing.  


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#3261 Heisenburger

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Posted 28 July 2015 - 05:42 PM

I'd definitely be interested if, and only if, you will send a sample for independent purity testing.  

 

If you’re willing to pay that kind of price, I have six grams from a verified source that I’ll sell you for $500, overnight shipping included.

 


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#3262 Heisenburger

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Posted 28 July 2015 - 07:23 PM

125$/g is ridiculous price

 

I’ll betcha that’s about how much it’s going to cost if and when it finally clears FDA hurdles and becomes available to the public. Basically $5.00 for a 40-milligram tablet or capsule. :wacko:

 


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#3263 Heisenburger

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Posted 28 July 2015 - 07:48 PM

 

Hi there. I have nsi-189 for sale at moment for 125 a gram. Willing to send small sample. I just did 30 day check. Bought a gulf order and its been great for me. Now that I know it's good product I'm willing to sell some at great rate so others can benefit.

I'd definitely be interested if, and only if, you will send a sample for independent purity testing.  

 

 

Surely you jest. Just for shits and giggles, I just listed my six grams on eBay for $550 as a joke. If somebody is actually stupid enough to come along and buy it, I’ll just turn around and buy 100 grams from HHD and give you some.


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#3264 flux923

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Posted 28 July 2015 - 09:46 PM

First time trying out NSI-189 and it makes me feel almost unable to feel a negative emotion of any sort so far. Overall I feel great, optimistic and energized, with zero anxiety and only bad thing is I feel slightly intellectually slow and not as nimble as before but I hope that is transitory as I might have taken a slightly bigger dose. Great experience so far overall.


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#3265 mindpatch

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Posted 29 July 2015 - 02:53 AM

 

I'd definitely be interested if, and only if, you will send a sample for independent purity testing.  

 

If you’re willing to pay that kind of price, I have six grams from a verified source that I’ll sell you for $500, overnight shipping included.

 

I honestly didn't notice the price he was asking.  ....Naw, I'll pass on that.  In all seriousness, we do as a community need to be watching out for scam artists selling God-Knows-What.  NSI is already an experimental drug that has not been subject to long term safety tests.  Now there are random people materializing here soliciting.  When people are desperate to fix themselves and get relief from depression and misery and are willing to pay for new and novel chemicals to help, the abuse potential is very high.  


Edited by mindpatch, 29 July 2015 - 02:55 AM.

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#3266 jaiho

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Posted 29 July 2015 - 02:57 AM

That's why people need to provide independent chemical certificates with their product. We know where they're buying it, most likely hhdpharm, but we need to be sure.
There's another vendor that popped up on nootropics subreddit that is using TOR and btc to avoid neuralstem.
I say to hell with patents when it comes to debilitating disease.
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#3267 Heisenburger

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Posted 29 July 2015 - 03:17 AM

Naw, I'll pass on that. 

 

Not so fast—if you act now I’ll throw in a half-empty tub of phenibut and a $25 Olive Garden gift card.

 


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#3268 Zhivili

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Posted 29 July 2015 - 03:59 PM

A few little tidbits:

 

1. I tried to see if NSI-189 would react to a Marquis reagent. No reaction. Figured this would be helpful information if people wanted to test what they got, but alas. Guess if you test your NSI and you get a reaction then something is wrong!

 

2. I am a regular user of recreational drugs, including psychedelics and cannabinoids (only marijuana and AB-FUBINACA). So far NSI has not really had any reactions with them, however the incidence of headaches seems to increase.


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#3269 mindpatch

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Posted 29 July 2015 - 05:02 PM

 

Naw, I'll pass on that. 

 

Not so fast—if you act now I’ll throw in a half-empty tub of phenibut and a $25 Olive Garden gift card.

 

Throw in the slightly used set of Ginzu steak knives and the ShamWow and it's a deal. 


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#3270 Major Legend

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Posted 29 July 2015 - 05:10 PM

 

 

Naw, I'll pass on that. 

 

Not so fast—if you act now I’ll throw in a half-empty tub of phenibut and a $25 Olive Garden gift card.

 

Throw in the slightly used set of Ginzu steak knives and the ShamWow and it's a deal. 

 

 

Remember you are not selling them things, you are selling them a transformational dream. "Buying 

the Heisenburger Ultraman Tool Kit , is the first step to voluntarily take action to change your life for the better."


Edited by Major Legend, 29 July 2015 - 05:12 PM.

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