Just my thoughts: For those who who don't get a stimulatory reaction from NSI-189, are you on any other supplement, nootropic, or medication that promotes sedation? Because if this drug is going to pass trials and hit the market, it needs to be effective on its own.
SSRI's help anxiety and some depression for a short period of time; stimulants on their own ameliorate ADD symptoms. So NSI-189 needs to be held to the same standards. If this drug is designed to treat depression, then I should be able to take it on its own and get relief. But for me, the anxiety was pretty intense lol. Much more so than 54 mg of Concerta. So if you're getting the benefits ONLY when you're sedating yourself with, say, 50 mg of zoloft of whatever, then this doesn't bode well for the success of NSI-189 as a stand-alone treatment.
It's supposed to be a top-notch drug, not a nootropic to augment with another stack that is already treating what NSI is DESIGNED to be treating on its own. Am I wrong?
I don't doubt that NSI has effects, but yeah there is the question of whether it works by itself or not. I think by itself the effects seem to only come out after 1 week of dosing, so there is a delayed effect there.
A thing to note about NSI is everything I've ever read in detail about NSI was said by Neuralstem, so I think NSI may be their moon shot, however we don't really know what's going behind the scenes, just because NSI does something doesn't mean it will pass the FDA and become a mainstream drug, its possible that NSI has a bad side effect profile that we don't know about.
Remember working antidepressant doesn't mean the person comes out better on the other side, it just means the person no longer exhibits depression symptoms, that could also be a lobotomized zombie. Actually in my experience, it's possible that some people would get more depressed on NSI, because it may magnify what you have already going in your mind.
As for the analogue - I bet they choose 189 over the other ones because the other one had bad potential side effects.
Too much growth is also a bad thing, there is a disoder where the body produces too much HGH and the organs end up getting enlarged and push each other to death. Your brain can only grow so much before it starts pushing against the cranium.
A great deal comounds in a drug screening will have powerful effects that also have large side effects, which is why you don't hear much about ligands these days.
So when they were testing this stuff on stem cells, its likely that a little growth is far better than massive growth. Sudden spikes of cell replication is also likely to increased the chance of cancer.
Edited by Major Legend, 03 August 2015 - 05:47 AM.
