6219 replies to this topic

[jaiho]

could you pm the source for $10 a gram? i wont bother getting pills if thats the case.

I'd prefer Parnate, no drug seems to give me anxiety, since i got depression i am incapable of feeling anxiety anyway.

[Strangelove]

$80 a g for Parnate/tranylcypromine is pretty expensive. It was under $10 a gram when I bought it bulk from a Chinese vendor on Alibaba, good quality too. I don't think the synthesis warrants anywhere near that price, I'd look for a better source.

 

I'd love to see group buys for MAOIs, though, they're incredible antidepressants, one of the few worth using for major depression IMO. The vast majority are garbage and people waste years going through the cycle of being prescribed ineffective drugs because they're believed to be safer and provide less liability.

 

Unfortunately I had to stop using Parnate because I can't use any drug with significant effects on norepinephrine anymore. There was a very distinct effect I could discern and the increase in NE caused horrific anxiety for me. Others with similar experience to drugs that considerably raise NE may experience the same thing.

 

A group buy for Nardil, which seems to be the more popular of the two by far in terms of use and vendor availability, would be my dream. It's really a fascinating drug, many of the experiences on socialanxietysupport are genuinely incredible to read, life changing transformations. Many report that once it kicks in it's like a switch being flicked and they're happy and confident for the first time in their life, they finally feel the way they imagined life should feel like, how they've always wanted to. It's one of the most effective anxiolytics as well, and I think it will generally be more effective for people with endogenous anxiety: https://www.reddit.c...never_heard_of/

I also came cross a study that noted that they found it "dramatically" increased levels of PEA in the brain, or a certain region, something of that nature, which is a pretty interesting effect. You can find all sorts of information about beneficial aspects that have been discovered, really fascinating: https://www.reddit.c...nces_memory_in/

 

What I was referring to is not a new synthesis, its an American lab that also can be founded in Alibaba, its the only source there, and the cheapest I found in general. I am going to send you a PM to see if your vendor still sells it? I am very interested especially at that price!

 

http://www.scbt.com/...lcypromine.html

 

Yes Nardil seem more interesting due to the Gaba T inhibition properties, but it seem to have more side effects, in any case I am interested to try it. 

Parnate its for people that need an activating drug and Nardil can help more with anxiety.

 

Edited by Strangelove, 09 October 2015 - 10:42 AM.

[thomasanderson2]

Shelf Life of NSI-189?

 

I've got a few grams of NSI-189 phosphate left from the group buy at the end of 2013 (or early 2014).

I don't believe it was ever exposed to unusual temperatures or humidity

- and it's mostly remained stored in an inside storage facility at relatively cool room temperatures.

 

Would this still be good to use>

 

 

[thomasanderson2]

 

Although tranylcypromine is not a new drug, is difficult to get a prescription for it, also more importantly we can use the pure chemical and make a nasal spray (or use it sublingually) to effectively eliminate the issue with the "cheese" - tyramine effect. Especially nasal application has double bioavailability and would not go through the stomach to deactivate the MAO enzymes there.

 

 

Excellent ideas:

Are you aware of a standardized way of creating a Nasal Spray using tranylcypromine? 
What materials are required to do this?

Similarly, with sublingual administration, Do you know of a standardized protocol for using tranylcypromine sublingually?

[Shai Hulud]

You guys should ask this in a forum for pharmacology. One specialized on it, where all the pharmacists hang around.
Ime this yielded good results.

Edited by life backwards, 09 October 2015 - 04:02 PM.

[Strangelove]

 

 

Although tranylcypromine is not a new drug, is difficult to get a prescription for it, also more importantly we can use the pure chemical and make a nasal spray (or use it sublingually) to effectively eliminate the issue with the "cheese" - tyramine effect. Especially nasal application has double bioavailability and would not go through the stomach to deactivate the MAO enzymes there.

 

 

Excellent ideas:

Are you aware of a standardized way of creating a Nasal Spray using tranylcypromine? 
What materials are required to do this?

Similarly, with sublingual administration, Do you know of a standardized protocol for using tranylcypromine sublingually?

 

 

I have not looked into it, but would not be difficult to make, for sublingual use I have tried crushing a tablet and put it under my tongue and it works, but its a hassle crashing three and hold them under your tongue, using the pure powder would be very easy to do.

 

I have sent inquiries for a new synthesis for NSI-189 phosphate.

Edited by Strangelove, 09 October 2015 - 04:22 PM.

[Strangelove]

Anyone interested placing the order for tranylcypromine? You are going to need a VAT# but they are not particularly concerned about the company buying it (if its any kind of research institution). I ll buy 2.5 grams out of 5.

 

Anyone buying it and do not like the effects, I ll buy it myself soon, after I put together the funds for it.

[thomasanderson2]

I'm actually interested in it - as I've seen many people reporting it's effectiveness.

 

For me personally some questions:

(Requiring homework on my part before pulling the trigger) 

 

First is understanding how it can be used without risk of hypertension (i.e., as we are "researching" without supervision - I would have a hard time explaining this to my doctors);

and also, whether this can remain both safe and effective long-term.

In other words, would this eventually lose it's efficacy?

Or would there be any adverse effects over times on other body system?

 

[Strangelove]

The risk of hypertension depends on the deactivation of MAO (that breaks down tyramine) when the tranylcypromine reach the stomach. Eating high tyramine foods, brings tyramine to the brain that releases and takes the place of norepinephrine giving a sudden shock. This is why they made high doses selegiline (generalized MAOI only at higher doses) transdermal through a patch.

 

Yes, the good part is that there are many people using tranylcypromine for decades without loosing its effectiveness, in the very rare case it does, you can take a break and use it again as couple reports indicate. The main problem can be insomnia, this is why I use lower doses only in the morning.

[bthom04]

Long time sufferer of anhedonia. Looking to get a small order of NSI 189 of say 1 gram. Looking for it in phosphate. I have tried almost everything to get out of this condition and have yet to find a treatment. Please help.

[Strangelove]

Long time sufferer of anhedonia. Looking to get a small order of NSI 189 of say 1 gram. Looking for it in phosphate. I have tried almost everything to get out of this condition and have yet to find a treatment. Please help.

 

PM sent, specifically for anhedonia you can also check my thread for tranylcypromine group buy, personally I find it very effective!

[jaiho]

We should keep this thread to NSI discussion :P

I've made a few parnate threads and isnt much interest in it, probably because of the interaction risks, which are generally overstated in the medical community.

It's my last resort option if all else fails for Anhedonia, mainly because of the amount of dosing required daily, lots of pills.. A powder would be nice but dosing accuracy would be an issue, considering a 10mg difference is dramatic.

 

NSI-189 was amazing when it was working. I've built up a tolerance, which is really shitty considering it had zero side effects.

[Strangelove]

We should keep this thread to NSI discussion :P

I've made a few parnate threads and isnt much interest in it, probably because of the interaction risks, which are generally overstated in the medical community.

It's my last resort option if all else fails for Anhedonia, mainly because of the amount of dosing required daily, lots of pills.. A powder would be nice but dosing accuracy would be an issue, considering a 10mg difference is dramatic.

 

NSI-189 was amazing when it was working. I've built up a tolerance, which is really shitty considering it had zero side effects.

 

You are right, I started a new thread for a tranylcypromine group buy.

 

http://www.longecity...ntal-endurance/

 

I am interested for a pure tranylcypromine powder because I think some of the side effects related to tranylcypromine is the MAO inhibition in the stomach even if you do not have a full blown crisis, I have changed ROA (way more difficult with the pills) and feels better, no side effects at all these days, and feeling very good! Double bioavailability makes it more cost effective and we could use a 10mg scoop for easy dosing... 

Edited by Strangelove, 11 October 2015 - 11:34 AM.

[Shai Hulud]

I really don't think scoops are adequate for measuring dosage sensitive substances.
Even if you had one made especially for this substance, you'd still have differences in grain size in different batches, resulting in a changed volume of the same weight.
So please invest in a decent scale.

[Strangelove]

Yes, but even the dosage is not the same for everyone, from PMs I discuss NSI-189 dosing varies. 

The scoop is good to find your own personal dosage and stay there, its much easier than using a scale, and I generaly prefer it.

[Shai Hulud]

You are right about NSI-189.
But in general I don't think it's a good idea. NSI-189 seems to be very benign in acute side effects, maybe that's even true for the mentioned MAOIs by your ROA.
However, people reading here shouldn't get the impression scoops should be used with all substances.

[Strangelove]

Yes I agree, you certainly cannot do this with etizolam for example... There are reports people sleeping and being in a haze for days by not calculating dosage exactly.

 

But you are right for tranylcypromine, people report dosing from 10mg to 160mg like the experience I posted before.

 

Although I calculate average nasal dose at 15mg/25mg a day.

[Heisenburger]

Anybody who gets their hands on pure eti powder and doesn’t immediately make a PG solution out of it has a fool for a pharmacist.

 

[Forty Six & 2]

Indeed PG makes for a very viable research solution with Etizolam. ;-)

 

We have Etizolam >99% coming in late this week, so if anyone still wants to catch the pre-order special it will remain just a bit longer.

 

As well, we will have Pyrazolam >99%.

 

Both are limited initial batches, particularly the Pyrazolam is very limited, which is not on the site, but if one has interest just inquire.

 

Upon request with any order of the above, we will as well throw in some free HEBM-OX 2mg aliquots, which some may actually find most favorable results within research of all that are within this class.

 

[Heisenburger]

Indeed PG makes for a very viable research solution with Etizolam. ;-)

 

Especially if there are children and/or pets in the house. Or even ignorant adults who take one look at any unidentified white powder they stumble across and immediately assume it’s an all-day pass to Disneyland.

 

Again, I want to reiterate my request for a five-milligram sample of your etizolam. I don’t think that’s an unreasonable request. I will pay postage, and if it turns out to be pure eti I’ll toot your whistle over at Pharmacy Reviewer, as that place is crammed to the rafters with eti-heads. Most of us are buying pressed tablets at a cost of at least $400/gram. If I try it and vouch that it’s the real deal, they will sit up and take notice.

 

Now, back to your regularly-scheduled NSI-189 thread…

[Bukujutsu]

Indeed PG makes for a very viable research solution with Etizolam. ;-)

 

We have Etizolam >99% coming in late this week, so if anyone still wants to catch the pre-order special it will remain just a bit longer.

 

As well, we will have Pyrazolam >99%.

 

Both are limited initial batches, particularly the Pyrazolam is very limited, which is not on the site, but if one has interest just inquire.

 

Upon request with any order of the above, we will as well throw in some free HEBM-OX 2mg aliquots, which some may actually find most favorable results within research of all that are within this class.

 

I'd love a good source for pyrazolam. I've sent this to two people and am planning to make a thread on it:

 

http://www.hindawi.c...ps/2012/416864/

The main points is that tolerance to the anxiolytic effect specifically doesn't seem to develop, and that the anti-cognitive effects can be avoided with drugs selective for the A2 subreceptor, which is why I chose pyrazolam. If you read reports on it it's consistently described as being non-recreational and lacking side effects, it just removes/prevents general/social anxiety and that's it. This may also be why there's much lower availability, because it's not fun.

 

I was planning to purchase it from tic-research/till.i.come@riseup.net along with something else, he was selling it for $190 a gram, but he ran out before I could and didn't know when it would be in stock since someone would have to place an order for a custom synthesis. Then within the last few months a vendor scammed him for 10K and he said he was going to stop vending at least until he refunded everyone. I think he had been in the hospital before that and had a very big backlog of messages and orders to deal with. I'm not sure if he's going to vend again.

 

It also seems to be water soluble, a property benzos generally lack (I think), making sublingual and intranasal administration more effective, which is great because it allows a very rapid onset of anxiolysis.

 

What is the price estimated to be? This could be a lifesaver for many people.

[Forty Six & 2]

TeamTLR is based on honor, integrity, and standards of excellence, which we feel confident holds for all we do.  Though such has been 'challenged', this has been born out, as we knew it would be.

 

We as well within this believe in fostering 'good faith' and 'good will'.

 

@Heisenburger:

As such, we would gladly for your sincere research interest for pure powder form of Etizolam even be willing to front you 1 gram if desired, wherein you can remit upon your approval of quality. 

 

Our Etizolam 99% is being re-packed in the lab and should be to us within a week.  The pre-order special pricing, as per on the site currently, likely will be removed any day and revert to the normal retail pricing.

https://teamtlr.com/...anxiolytic.html

 

Pyrazolam 99%min is in production.  We have successfully prior in the past produced at >99% and can offer true, highest quality here as well.  Pricing will be ~$260/g, however, we will do $230/g for pre-orders.  

 

Kindly send all requests for such to TLR@TeamTLR.com

 

Further, anyone who believes NSI-189 is a worthwhile agent, as within the scope of research into promisingly superior 'neurogenic/nootropic antidepressants', would do themselves well to check out our offerings of NRX-1074 and GLYX-OX, two vastly superior agents within this class.

 

OK...

Now,... back to your regularly-scheduled NSI-189 thread…which of late is not all that much on point or interesting otherwise,...

Edited by Forty Six & 2, 13 October 2015 - 03:03 PM.

[stillwater]

 

 

Further, anyone who believes NSI-189 is a worthwhile agent, as within the scope of research into promisingly superior 'neurogenic/nootropic antidepressants', would do themselves well to check out our offerings of NRX-1074 and GLYX-OX, two vastly superior agents within this class.

 

OK...

Now,... back to your regularly-scheduled NSI-189 thread…which of late is not all that much on point or interesting otherwise,...

 

 

 

 

What are some of the effects you've experienced  with NRX-1074?

[Forty Six & 2]

Within in vivo research both NRX-1074 and GLYX-OX demonstrate profound effects within neurogenic/synaptogenic facilitated cognitive enhancement and mood enhancement (antidepressant and related).  These are looked at as the most promising for rapid-onset antidepressant effects for MDD and TRD.

 

For more:

https://teamtlr.com/...neurogenic.html

https://teamtlr.com/...ocognitive.html

 

Both act via the glutamatergic system as functional antagonists of the Glycine-binding site of the NMDAr complex, thought to be perhaps the most superior pathway to elicit effects as so markedly demonstrated upon depression, akin to the rapid and potent efficacy of ketamine, but without any of the adverse effects.

[Heisenburger]

I can’t talk about it too much because the person I’m referring to wants to maintain privacy, but I’ve been in extensive contact with somebody in the Pacific Northwest who has purchased TLR’s NRX-1074 and believes that his TRD is lifting for the first time in decades. He has tried SSRIs, NSI-189, and tianeptine to no avail. But he says the NRX-1074 is working for him.

[Al Capacino]

Seriously, can we stay on subject. Stick to pm's or create another thread for all this marketing of products that aren't even nsi.

[chrisp2]

Getting back on topic...  What's the latest on safety of NSI-189?

 

A number of people seem to be taking a drug that is not yet (near) approval...

[Heisenburger]

A number of people seem to be taking a drug that is not yet (near) approval...

 

That's what makes us pirates.
 

[jaiho]

Getting back on topic...  What's the latest on safety of NSI-189?

 

A number of people seem to be taking a drug that is not yet (near) approval...

 

Well, it has passed safety trials, and is now onto efficiency trials.

Though, no drug is deemed safe until it's been in widespread use for decades. So, any newly released drug is a risk, even if it passes FDA trials.

[thedarkbobo]

Yarr...well I'm still taking it. still alive, although my brain expanded outside of the skull a bit and now I need a need a new pirate hat (joke hehe).

 

Short term (1-3 days) affects my mood and learning (mm best effect is when I take it in the evening for the next day...).

There are some long term changes that I cannot describe now - don't remember how I was before lol.

 

Not much to report besides that.