6219 replies to this topic

[IP3]

I never tried nsi, i wanna order just when Strangelove suspended his businness. Tianeptine gives you motivation and yes happines too because it is opioid. Be careful after month of use i was iritated fortunatelly  this iritation was reversed by (ultra)low dose naltrexone.

Did you noticed that you are more motivated to get the things done when you are on nsi?

Edited by IP3, 09 October 2016 - 04:41 AM.

[bugsbunny]

I never tried nsi, i wanna order just when Strangelove suspended his businness. Tianeptine gives you motivation and yes happines too because it is opioid. Be careful after month of use i was iritated fortunatelly  this iritation was reversed by (ultra)low dose naltrexone.

Did you noticed that you are more motivated to get the things done when you are on nsi?

Do you use the sulphate or the sodium version of tianeptine?

I'm not really more motivated to get things done when using NSI 189 its just easier to finish a task, but that might motivate you. In this circumstance NSI 189 might act paradox, because it makes tasks easier but lets you in a melancholic stadium thinking about things you could have done, because you dont see a good reason to do them. I never had that feeling before, its also not a regular feeling then using NSI 189. The only thing that really boosted my motivation without any other mental sideeffects were soft norepinephrine boosters like ephedrine.

 

Edited by bugsbunny, 09 October 2016 - 03:15 PM.

[DarkSoul]

where can someone obtain nsi-189 

[Satnam Sunner]

Hope everything works out for you StrangeLove !! If anyone has a reliable source of NSI, I am interested. 

[linlin92]

So its been a month since I started NSI-189 and the anxiety is becoming really noticeable. I am just on 20mg BID phosphate but for the past few days have only taken it in the morning because I find the anxiety way too distracting.

 

So I am thinking of having 2g of Mg Threonate at night, and 2g Inositol BID (morning and night). What do you guys think?

[Mind_Paralysis]

So its been a month since I started NSI-189 and the anxiety is becoming really noticeable. I am just on 20mg BID phosphate but for the past few days have only taken it in the morning because I find the anxiety way too distracting.

 

So I am thinking of having 2g of Mg Threonate at night, and 2g Inositol BID (morning and night). What do you guys think?

 

Sounds pretty good to me.

 

Interesting that you TOO seem to get anxiety even from the lower dosages of NSI-189. Do you have a history of anxiety and slight OCD like me?

 

It should be noted that Noopept and Tianeptine seems to help with NSI-189 anxiety as well - definitely worth adding to the stack.

 

Btw, here's my own current stack of NSI-189:

 

 

NSI-189 20 mg

 

Omega-3 2,54 grams (same as before)

 

Magnesium-L-Threonate 3,34 grams (2 caps during day, 3 caps at night)

 

Tianeptine 30 mg (10 x 3 mg throughout the day)

 

 

I feel the MagLT seems to be working decently for anxiety, and perhaps even OCD to an extent, but you do need quite a dose...! Of course, this is individual. I would suggest that if 2 grams of MagLT isn't enough, then you start titrating up to 3 grams as well.

Edited by Stinkorninjor, 11 October 2016 - 12:29 PM.

[Yaguare44]

Be careful with the noopept guys, it does actually increase anxiety for some...

[Mind_Paralysis]

Be careful with the noopept guys, it does actually increase anxiety for some...

 

Ah. Well, Tianeptine and MagLT it is, then.

 

I've never heard of anyone getting anxiety from Tianeptine, so that seems like a sure bet - but out of curiosity, do you know of any such cases?

[jack black]

Stinkor, when I took tianeptine without 5htp and memantine, there was some wired, anxious feeling at times. Some other times it made me tired.

Sorry the NSI not working for you. I'm glad I passed on that.

Edited by jack black, 11 October 2016 - 03:31 PM.

[Mind_Paralysis]

Stinkor, when I took tianeptine without 5htp and memantine, there was some wired, anxious feeling at times. Some other times it made me tired.

Sorry the NSI not working for you. I'm glad I passed on that.

 

I wouldn't say NSI isn't working - it's actually improved my depression substantially, the fatigue however, is another thing altogether.

 

I guess NSI can rebuild your brain, but if your body is in a state of energy-save-mode to prevent viral infection, which is apparently what happens when you get CFS, then it's not really the thing to treat that.

 

I'll keep going with the NSI-189 though, because it does work as a good antidepressant, and being tired is rather depressing.

[IP3]

Bugsbunny: I am using Tianeptine sodium (prescription, from pharmacy).

Your description of NSI effects ar quite interesting as i  need something that gives me energy to finish my tasks rather than to start them.

 

 Big question: i should take NSI at the morning or at evening before bed?

[thebrainstore]

Interesting thread. Lots of talk of different reactions to the same substance. I'm no biochemist but I know a little about brain function. If this NSI compound is increasing growth of the hippocampus, then is it fair to assume that it is also increasing the rate of neurogenesis?

 

If that were the case and some of your brains are already functioning badly, would this new 'allowance' of brain cells not just go straight to improving the efficacy of this bad function? I don't see how it could be selective, and if you already have too much activity in one area, a load of new brain cells isn't necessarily going to adjust that activity downward but more likely send it up.

 

Apologies if you feel that this is a poorly thought out question, I'm just trying to work out why the results are so hit-and-miss as I don't want to waste my money or create new problems.

 

From what I have gleaned through reading parts of the thread it seems that the experiential results of NSI use are that it is acting as a catalyst for pre-existing brain function patterns.

 

If your car is covered in dents and mud, would you wash off the mud and polish what remains of the paint in the hope that would restore it, or would you go and get the panels seen to first?

 

[Ark]

Is anyone buying Nuerostem Stock? I noticed they are at 32 cents a share. If Nuerostem comes to market with NSI-189their stock price could go as high $18 a share.


Thoughts,comments and, or questions?

Cheers!

Edited by Ark, 12 October 2016 - 11:29 AM.

[bugsbunny]

Interesting thread. Lots of talk of different reactions to the same substance. I'm no biochemist but I know a little about brain function. If this NSI compound is increasing growth of the hippocampus, then is it fair to assume that it is also increasing the rate of neurogenesis?

 

If that were the case and some of your brains are already functioning badly, would this new 'allowance' of brain cells not just go straight to improving the efficacy of this bad function? I don't see how it could be selective, and if you already have too much activity in one area, a load of new brain cells isn't necessarily going to adjust that activity downward but more likely send it up.

 

Apologies if you feel that this is a poorly thought out question, I'm just trying to work out why the results are so hit-and-miss as I don't want to waste my money or create new problems.

 

From what I have gleaned through reading parts of the thread it seems that the experiential results of NSI use are that it is acting as a catalyst for pre-existing brain function patterns.

 

If your car is covered in dents and mud, would you wash off the mud and polish what remains of the paint in the hope that would restore it, or would you go and get the panels seen to first?

It depends on what problem you have. If youre using meds on your own you take the risk of a doctor, so you need to find out what your problem could be. For example it is a good thing if a depressed person starts to feel something again, thats the goal of anti depressants. Nootropics should improve the mental abilitys, it might be that NSI 189 has too much impact on feelings to be a safe nootropic. So if your emotions are ok all in all you might screw it up with the wrong medication.

mental abilities

 

[focus83]

Is anyone buying Nuerostem Stock? I noticed they are at 32 cents a share. If Nuerostem comes to market with NSI-189their stock price could go as high $18 a share.


Thoughts,comments and, or questions?

Cheers!

 

I invested about $12.000 in Neuralstem, now holding 13.000 shares since 2 years. It's a high risk, high reward investment just like with pretty much any biotech stock. If the currently running NSI-189 phase 2 trial yields good or even great results and should NSI-189 even make it to the market maybe becoming the next blockbuster antidepressant, then the sky is the limit. If in addition to NSI-189 they manage to commercialize stem cell therapies for ALS, chronic spinal cord injury, stroke, alzheimers and so forth (or just for some of the indications) then we are more likely talking about a share price of somewhere between $20 and $60.

 

Risks:

 

- They have paused they stem cells clinical trials in favor for NSI-189, because their finances have been very weak for quite some time now. However, a couple of weeks ago they received a $20 mio strategic investment from Tianjin pharmaceuticals. That will give them enough cash to last for another 1,5 - 2 years and finish phase 2 trial without worrying about bankruptcy.

 

- Should phase 2 data be negative, then Neuralstem could indeed go bankrupt unless their stem cell therapies have advanced to the point where they have a realisitic chance to commercialize them.

 

- We will see some major dilution within the next months due to the investment from Tianjin. Neurastem also faces delisting from NASDAQ CM as they share price has dropped below $1. They might be forced to do a reverse split in order to remain listed. That decision will be made within the next 10 months. Even though a reverse split is not decreasing the value of your investment per se, it is generally considered a bad sign and usually results in a significant drop in share price.

 

The price per share has been a bargain for many months now. It used to be $0.19 just some weeks ago! I suggest you just go ahead and buy some shares with money you can afford to loose.

 

If we are lucky, then this company could turn into a multi-billion dollar company sometime in the next 5 - 10 years. You need to be very patient though. This is not the kind of investment that is going to make you rich or affluent over night.

 

Good luck!

Edited by focus83, 12 October 2016 - 04:56 PM.

[bugsbunny]

 

Is anyone buying Nuerostem Stock? I noticed they are at 32 cents a share. If Nuerostem comes to market with NSI-189their stock price could go as high $18 a share.


Thoughts,comments and, or questions?

Cheers!

 

I invested about $12.000 in Neuralstem, now holding 13.000 shares since 2 years. It's a high risk, high reward investment just like with pretty much any biotech stock. If the currently running NSI-189 phase 2 trial yields good or even great results and should NSI-189 even make it to the market maybe becoming the next blockbuster antidepressant, then the sky is the limit. If in addition to NSI-189 they manage to commercialize stem cell therapies for ALS, chronic spinal cord injury, stroke, alzheimers and so forth (or just for some of the indications) then we are more likely talking about a share price of somewhere between $20 and $60.

 

Risks:

 

- They have paused they stem cells clinical trials in favor for NSI-189, because their finances have been very weak for quite some time now. However, a couple of weeks ago they received a $20 mio strategic investment from Tianjin pharmaceuticals. That will give them enough cash to last for another 1,5 - 2 years and finish phase 2 trial without worrying about bankruptcy.

 

- Should phase 2 data be negative, then Neuralstem could indeed go bankrupt unless their stem cell therapies have advanced to the point where they have a realisitic chance to commercialize them.

 

- We will see some major dilution within the next months due to the investment from Tianjin. Neurastem also faces delisting from NASDAQ CM as they share price has dropped below $1. They might be forced to do a reverse split in order to remain listed. That decision will be made within the next 10 months. Even though a reverse split is not decreasing the value of your investment per se, it is generally considered a bad sign and usually results in a significant drop in share price.

 

The price per share has been a bargain for many months now. It used to be $0.19 just some weeks ago! I suggest you just go ahead and buy some shares with money you can afford to loose.

 

If we are lucky, then this company could turn into a multi-billion dollar company sometime in the next 5 - 10 years. You need to be very patient though. This is not the kind of investment that is going to make you rich or affluent over night.

 

Good luck!

 

antidepressants are a mulibillion dollar industry. I would be surprised if they authorize a med that actually works permanent.

I would be surprised

 

[focus83]

 

 

Is anyone buying Nuerostem Stock? I noticed they are at 32 cents a share. If Nuerostem comes to market with NSI-189their stock price could go as high $18 a share.


Thoughts,comments and, or questions?

Cheers!

 

I invested about $12.000 in Neuralstem, now holding 13.000 shares since 2 years. It's a high risk, high reward investment just like with pretty much any biotech stock. If the currently running NSI-189 phase 2 trial yields good or even great results and should NSI-189 even make it to the market maybe becoming the next blockbuster antidepressant, then the sky is the limit. If in addition to NSI-189 they manage to commercialize stem cell therapies for ALS, chronic spinal cord injury, stroke, alzheimers and so forth (or just for some of the indications) then we are more likely talking about a share price of somewhere between $20 and $60.

 

Risks:

 

- They have paused they stem cells clinical trials in favor for NSI-189, because their finances have been very weak for quite some time now. However, a couple of weeks ago they received a $20 mio strategic investment from Tianjin pharmaceuticals. That will give them enough cash to last for another 1,5 - 2 years and finish phase 2 trial without worrying about bankruptcy.

 

- Should phase 2 data be negative, then Neuralstem could indeed go bankrupt unless their stem cell therapies have advanced to the point where they have a realisitic chance to commercialize them.

 

- We will see some major dilution within the next months due to the investment from Tianjin. Neurastem also faces delisting from NASDAQ CM as they share price has dropped below $1. They might be forced to do a reverse split in order to remain listed. That decision will be made within the next 10 months. Even though a reverse split is not decreasing the value of your investment per se, it is generally considered a bad sign and usually results in a significant drop in share price.

 

The price per share has been a bargain for many months now. It used to be $0.19 just some weeks ago! I suggest you just go ahead and buy some shares with money you can afford to loose.

 

If we are lucky, then this company could turn into a multi-billion dollar company sometime in the next 5 - 10 years. You need to be very patient though. This is not the kind of investment that is going to make you rich or affluent over night.

 

Good luck!

 

antidepressants are a mulibillion dollar industry. I would be surprised if they authorize a med that actually works permanent.

I would be surprised

 

 

 

Oh please, not that same old FDA/big pharma conspiracy theory thing again. This is getting really old. If the randomized, double-blind, placebo controlled NSI-189 trials yield hard data proving its efficacy in treating depression and potentially other conditions without serious, life threatening side effects then this will get approved. Besides, NSI-189 will likely not reverse depression permanently, but only for much longer than current ADs.
 

[IP3]

The problem is that i cannot focus on my daily duties, i am constantly mind wandering. I find hard to swich attention and focus on my work.Will nsi provide any benefits for me?

Or do you know any other drugs that can help constant wanderer? Prl 853 seems to do a lot but tolerance builds up in three to four days.

Edited by IP3, 13 October 2016 - 11:42 AM.

[bugsbunny]

Well, I think we all are interessted in a cheap good working antidepressant from the perspective of a suffering patient, but reality has shown something else. You have a money interest, neuralstem has it and the big pharma has it too and in the end psychatrists and neurologists are in it too. The healthcare system is rotten. Nevertheless, good luck! Might be youre a very rich man soon     

[bugsbunny]

The problem is that i cannot focus on my daily duties, i am constantly mind wandering. I find hard to swich attention and focus on my work.Will nsi provide any benefits for me?

Or do you know any other drugs that can help constant wanderer? Prl 853 seems to do a lot but tolerance builds up in three to four days.

That can be a problem while taking NSI-189. It reduces focus with constant taking, so i wouldnt advice to drive a car while beeing on high doses. Spontaneous daydreams might occure. I had the same problem with mind wandering and dexamphetamine helped me with that on longterm but also induced fear.

[Mind_Paralysis]

The problem is that i cannot focus on my daily duties, i am constantly mind wandering. I find hard to swich attention and focus on my work.Will nsi provide any benefits for me?

Or do you know any other drugs that can help constant wanderer? Prl 853 seems to do a lot but tolerance builds up in three to four days.

 

"Pathological mind-wandering"... "pathological rumination"...

 

What you're describing isn't depression - it's SCT, also known as CDD - Concentration Deficit Disorder.

 

Are you by chance easily fatigued, and somewhat brainfogged as well? I should note that this is a special interest of mine - since I have the disease myself.

 

You might want to read up on this disorder, because you do seem to fit the bill to a certain extent.

 

Here:

 

https://en.wikipedia...cognitive_tempo
 

 

This disorder is caused by genetically malformed brain-circuitry - in the Superior Parietal Lobe (back of the head, close to the top) - it's not curable, only treatable.

 

The drugs which work are all Norepinephrinergic - because it's related to alertness and wakeness as well as attention - in stark contrast to ADHD which is treated with dopaminergic drugs.

 

I recommend Atomoxetine, possibly Reboxetine as well.

Edited by Stinkorninjor, 13 October 2016 - 05:12 PM.

[Mind_Paralysis]

 

The problem is that i cannot focus on my daily duties, i am constantly mind wandering. I find hard to swich attention and focus on my work.Will nsi provide any benefits for me?

Or do you know any other drugs that can help constant wanderer? Prl 853 seems to do a lot but tolerance builds up in three to four days.

That can be a problem while taking NSI-189. It reduces focus with constant taking, so i wouldnt advice to drive a car while beeing on high doses. Spontaneous daydreams might occure. I had the same problem with mind wandering and dexamphetamine helped me with that on longterm but also induced fear.

 

 

Fascinating.

I've experienced such increased difficulties myself - HOWever... I actually have some symptoms of ADHD, and severe symptoms of CDD - Concentration Deficit Disorder, as well.

 

Curious... I've seen other CDD-ers mention how they feel NSI-189 actually helps with the symptoms of CDD - I personally can't quite agree with that... what it helps with is the shyness, inactivity and such, but it actually WORSENS focus, it would seem.

 

Perhaps the other CDD-ers are mistaking increased energy as increased focus?

 

The motivation and energy-part is ephemeral with NSI-189 though - seems to be mainly a specific period of the treatment, then you either get tired, or neutral.

[bugsbunny]

 

 

The problem is that i cannot focus on my daily duties, i am constantly mind wandering. I find hard to swich attention and focus on my work.Will nsi provide any benefits for me?

Or do you know any other drugs that can help constant wanderer? Prl 853 seems to do a lot but tolerance builds up in three to four days.

That can be a problem while taking NSI-189. It reduces focus with constant taking, so i wouldnt advice to drive a car while beeing on high doses. Spontaneous daydreams might occure. I had the same problem with mind wandering and dexamphetamine helped me with that on longterm but also induced fear.

 

 

Fascinating.

I've experienced such increased difficulties myself - HOWever... I actually have some symptoms of ADHD, and severe symptoms of CDD - Concentration Deficit Disorder, as well.

 

Curious... I've seen other CDD-ers mention how they feel NSI-189 actually helps with the symptoms of CDD - I personally can't quite agree with that... what it helps with is the shyness, inactivity and such, but it actually WORSENS focus, it would seem.

 

Perhaps the other CDD-ers are mistaking increased energy as increased focus?

 

The motivation and energy-part is ephemeral with NSI-189 though - seems to be mainly a specific period of the treatment, then you either get tired, or neutral.

 

I wouldnt even say it reduces the focus... its something different. I would rather say it reduces a whole part of awareness. So you can do the task, like driving a car, but you do it with reduced apperception, which makes you think the focus is reduced but actually your subconscious is still the boss. Some people say NSI-189 real effect kicks in after quiting it, so these effects might be just temporary.

[Mind_Paralysis]

 

 

 

The problem is that i cannot focus on my daily duties, i am constantly mind wandering. I find hard to swich attention and focus on my work.Will nsi provide any benefits for me?

Or do you know any other drugs that can help constant wanderer? Prl 853 seems to do a lot but tolerance builds up in three to four days.

That can be a problem while taking NSI-189. It reduces focus with constant taking, so i wouldnt advice to drive a car while beeing on high doses. Spontaneous daydreams might occure. I had the same problem with mind wandering and dexamphetamine helped me with that on longterm but also induced fear.

 

 

Fascinating.

I've experienced such increased difficulties myself - HOWever... I actually have some symptoms of ADHD, and severe symptoms of CDD - Concentration Deficit Disorder, as well.

 

Curious... I've seen other CDD-ers mention how they feel NSI-189 actually helps with the symptoms of CDD - I personally can't quite agree with that... what it helps with is the shyness, inactivity and such, but it actually WORSENS focus, it would seem.

 

Perhaps the other CDD-ers are mistaking increased energy as increased focus?

 

The motivation and energy-part is ephemeral with NSI-189 though - seems to be mainly a specific period of the treatment, then you either get tired, or neutral.

 

I wouldnt even say it reduces the focus... its something different. I would rather say it reduces a whole part of awareness. So you can do the task, like driving a car, but you do it with reduced apperception, which makes you think the focus is reduced but actually your subconscious is still the boss. Some people say NSI-189 real effect kicks in after quiting it, so these effects might be just temporary.

 

 

Oh yeah, I forgot to mention it, since I've got friggen' brain-fog... (did both my business-course and some slight forest-hunting today, which is causing fatigue) But I would recommend MODAFINIL instead of Dexamphetamine - I've had both on prescription, and I can tell ya' that the Modafinil helps a LOT more with clarity and alertness - your energy-levels seem more stabile while on Modafinil, while taking NSI-189.

 

Out of curiosity, what sorts of substances have everyone tried while taking NSI-189? And what would you say the results are?

 

Tianeptine - helps with anxiety, improves mood - the drop-off when it stops working is clear though.

 

Modafinil - EXCEPTIONAL results...! Improves mood, clarity, damn-near everything with NSI! Nothing but good to say about the combo.

 

Magnesium-L-Threonate - helps with anxiety, worsens brain-fog. Does not seem to affect the fluctuating energy-levels curiously enough.

[IP3]

I live in europe so i have only methylphenidate avaiable.

Stinkonijnor : i read some time ago about SCT and i agree that i have it rather than adhd. It totally describes what i have in head. I am extreme prone for faigue.

We have atomoxetine in Poland but price is horrendous.

If i good know prl act as antagonist on some brain histamine receptors as modafinil. I tried it 5 years ago and it was good however i felt a little (key word: a little) bit anxious.

 

[Mind_Paralysis]

I live in europe so i have only methylphenidate avaiable.

Stinkonijnor : i read some time ago about SCT and i agree that i have it rather than adhd. It totally describes what i have in head. I am extreme prone for faigue.

We have atomoxetine in Poland but price is horrendous.

If i good know prl act as antagonist on some brain histamine receptors as modafinil. I tried it 5 years ago and it was good however i felt a little (key word: a little) bit anxious.

 

I take it you mean PRL is an AGONIST of Histamine-receptors, right? Antagonists actually make you very, very tired - it's one of the reasons why Mirtazapine can actually be used as a highly potent sleeping-pill as well as an antidepressant.

 

I've never tried the stuff you mention, but I can tell you that Methylphenidate definitely gives me a LOT of anxiety, and Amphetamine a liiittle bit of anxiety - Modafinil however, is actually anxiolytic to me.

 

So, it might not necessarily by anxiogenic. The fact that it worked anxiolytically on me while under the influence of NSI-189, which is a highly anxiogenic compound to me, implies that at least in my own case, Modafinil is less prone to anxiey-induction than other stimulating compounds.
 

[IP3]

Yes, i ment agonist ;-)

[bugsbunny]

 

I live in europe so i have only methylphenidate avaiable.

Stinkonijnor : i read some time ago about SCT and i agree that i have it rather than adhd. It totally describes what i have in head. I am extreme prone for faigue.

We have atomoxetine in Poland but price is horrendous.

If i good know prl act as antagonist on some brain histamine receptors as modafinil. I tried it 5 years ago and it was good however i felt a little (key word: a little) bit anxious.

 

I take it you mean PRL is an AGONIST of Histamine-receptors, right? Antagonists actually make you very, very tired - it's one of the reasons why Mirtazapine can actually be used as a highly potent sleeping-pill as well as an antidepressant.

 

I've never tried the stuff you mention, but I can tell you that Methylphenidate definitely gives me a LOT of anxiety, and Amphetamine a liiittle bit of anxiety - Modafinil however, is actually anxiolytic to me.

 

So, it might not necessarily by anxiogenic. The fact that it worked anxiolytically on me while under the influence of NSI-189, which is a highly anxiogenic compound to me, implies that at least in my own case, Modafinil is less prone to anxiey-induction than other stimulating compounds.
 

 

What is the reason for mixing tianeptine and NSI-189 together? I understand that it reduces fear, but isnt Tianeptine working solo?

[Mental_Divergence]

Where can I buy this stuff?
Have tianeptine, will get Modafinil, but where can I get NSI?

[Mind_Paralysis]

 

 

I live in europe so i have only methylphenidate avaiable.

Stinkonijnor : i read some time ago about SCT and i agree that i have it rather than adhd. It totally describes what i have in head. I am extreme prone for faigue.

We have atomoxetine in Poland but price is horrendous.

If i good know prl act as antagonist on some brain histamine receptors as modafinil. I tried it 5 years ago and it was good however i felt a little (key word: a little) bit anxious.

 

I take it you mean PRL is an AGONIST of Histamine-receptors, right? Antagonists actually make you very, very tired - it's one of the reasons why Mirtazapine can actually be used as a highly potent sleeping-pill as well as an antidepressant.

 

I've never tried the stuff you mention, but I can tell you that Methylphenidate definitely gives me a LOT of anxiety, and Amphetamine a liiittle bit of anxiety - Modafinil however, is actually anxiolytic to me.

 

So, it might not necessarily by anxiogenic. The fact that it worked anxiolytically on me while under the influence of NSI-189, which is a highly anxiogenic compound to me, implies that at least in my own case, Modafinil is less prone to anxiey-induction than other stimulating compounds.
 

 

What is the reason for mixing tianeptine and NSI-189 together? I understand that it reduces fear, but isnt Tianeptine working solo?

 

 

Tianeptine reduces fear, reduces anxiety - and NSI-189 causes anxiety, in some predisposed individuals.

 

Tianpetine actually seems to alter your entire stress-response...! 0_o Modulating NMDA-receptors negatively and decreasing serotonin, which does cause anxiety.

 

That's why I'm taking it - to smooth out the bumps which NSI-189 causes. Tianeptine is also slightly, slightly energizing as well.
 

 

Tianeptine is especially useful for me, who's got both upregulated Kappa-receptors and an exagerated stress-response because of burnout - check it out, man! = )

 

Prevention of stress-induced morphological and cognitive consequences.

https://www.ncbi.nlm.../pubmed/9405958

 

Beneficial Effects of Tianeptine on Hippocampus-Dependent Long-Term Memory and Stress-Induced Alterations of Brain Structure and Function

https://www.ncbi.nlm...les/PMC4034085/

 

Tianeptine reverses stress-induced asymmetrical hippocampal volume and N-acetylaspartate loss in rats: an in vivo study.

https://www.ncbi.nlm...pubmed/22047727

 

 

It helps to guide the neurogenesis NSI-189 does, into a more peaceful and calm mind.

 

 

Most peeps might NOT need it as adjunctive to NSI-189 though... only take it if you're actually feeling anxious or angry on NSI-189.

 

 

On another note - my anxiety and S-OCD has actually been decreased significantly the last few days! = ) Tianeptine actually seems to be the real deal... Well, it could of course be NSI-189 or the MASSIVE friggin' doses of MagLT I'm doing.