6219 replies to this topic

[Mind_Paralysis]

I've been using NSI-189 since 10th September and stopped 5th November because the benefits have plateaued off and I want to move onto my next experiment (which is the lovely memantine and semax armidate).

 

NSI-189 has been really amazing when it comes to levelling out my mood and self talk (can recognise and nip negative thought loops out quickly), not feeling excessively down when things don't turn out the way I expect, and also being more open and social in general. Even went out on 2 dates during this time lol.

 

The anxiety that I had before hand was taken care of really well by 1.5g of MagT (thanks Stinkorninjor!), 12.5mg tianeptine sodium when I get up.

 

When I had exams 50mg modafinil was my bae when it came to helping me lots with my crazy study/work schedule.

 

All in all, I am very pleased with how NSI-189 has helped me and I'll be sure to cycle back onto it in a month or  really when I feel the need to go back on it.

 

As a side note, ut really is true that motivation does surprisingly increase motivation a LOT when NSI-189 is stopped. When there is a task to do instead of debating over this or that I just get on and do it without hesitation. My apartment is like amazingly spotlessly clean haha.

 

Ey way cool that you had some good results LinLin! =)

My NMDA-network must be firing on all cylinders though, because not even 3 (THREE!) GRAMS worth of MagLT was enough for me...! : O I felt only a slight anxiolytic effect from it, and the Tianeptine seemed to exacerbate my sleeping-issues, so I had to quit all of it.
 

Thinking about going back on it soon though, I seem to be slipping into depression again - problems with completing my course because of burnout and SCT is making me rather sad - I'm really tired of all of the failures in my life.

 

Hopefully, soon I'll have Clonidine, and then I'll get improved sleep, so then I should be able to start a regimen of NSI-189 once more! = )

[IP3]

I can get some mementine soon. Did anyone mix it with nsi or tianeptine? Could you describe effects? I am also curious if memantine could supress tolerance for prl 853 as it does for amphetamines.

Edited by IP3, 08 November 2016 - 03:58 PM.

[thebrainstore]

This thread has become a bit too large to read in it's entirety so apologies if this has been asked before but:

​I had a cough and sneeze (expected at this time of year where I live) for about two days before I began my NSI experiment (20mg/day for 12 days).

 

During this experiment I noticed two things:

 

1. My mood lifted to a new baseline, after 72 hours I noticed that for nearly all that time I had the kind of euphoria I would usually get from 45 minutes of cardio (neurogenesis).

 

2. This cough and sneeze turned into a monster of a respiratory infection. I had to take time off work, had insane headaches, lungs were coughing up yellow crap for days.

 

This is very unusual for me to be affected in such a way by environmental pathogens. It was almost a cause for concern considering my diet and supplementation regime but it did not take too long to find the culprit of this. Within 48 hours of cessation of NSI-189 the monster has almost completely gone and tomorrow I expect to feel fine again.

 

Has anyone else notice an immunomodulator effect from NSI-189?

 

 

 

Edited by thebrainstore, 08 November 2016 - 06:45 PM.

[Mind_Paralysis]

This thread has become a bit too large to read in it's entirety so apologies if this has been asked before but:

​I had a cough and sneeze (expected at this time of year where I live) for about two days before I began my NSI experiment (20mg/day for 12 days).

 

During this experiment I noticed two things:

 

1. My mood lifted to a new baseline, after 72 hours I noticed that for nearly all that time I had the kind of euphoria I would usually get from 45 minutes of cardio (neurogenesis).

 

2. This cough and sneeze turned into a monster of a respiratory infection. I had to take time off work, had insane headaches, lungs were coughing up yellow crap for days.

 

This is very unusual for me to be affected in such a way by environmental pathogens. It was almost a cause for concern considering my diet and supplementation regime but it did not take too long to find the culprit of this. Within 48 hours of cessation of NSI-189 the monster has almost completely gone and tomorrow I expect to feel fine again.

 

Has anyone else notice an immunomodulator effect from NSI-189?

 

*Scratches head*

 

To my knowledge, no - I noticed nothing like that. I believe I have slight immuno-suppression from chronic sleeping-issues (which are now at an all-time high, involving non-restful sleep) and I noticed no overt worsening of physical symptoms - no extra infections or anything like that.

 

I think yours is the first I hear about this... this could be related to NSI-189's shifting of energy though - it seems to put a lot of us in a state SIMILAR to feeling sick - we become drowsy and lethargic, like when becoming sick - as if the body is reserving energy for repairs instead of other activities.

 

Could that be the source of your increased vulnerability towards viral agents?

[macropsia]

I imagine this may have been addressed somewhere prior, but has anyone considered or tried pulsatile or semi-pulsatile (pulses over a low constant dose) dosing to increase or retain effectiveness? Continued use seems, so far as reports show, to be most supportive of lasting positive outcomes, but is there any possibility this could be improved upon by 'washout' days or variable dosing?




Also, it is probably simplistic to assume that NSI is broadly immunosuppressive, but it seems likely, based on hypothesized mechanisms, that it is immunomodulatory (I.e., changes the behavior of the immune system in some fashion).

Edited by macropsia, 09 November 2016 - 12:40 AM.

[Convergence]

Interesting you felt that it exacerbated a respiratory infection, because incidentally I've been sick the last couple days and I felt much, much worse today than I usually ever do when I have such an infection. I didn't think my self-experimentation with NSI-189 had anything to do with it, but after reading this, I can't help but wonder if it did. 

Edited by Convergence, 09 November 2016 - 01:37 AM.

[AllAreKosh]

 

 

 

I have been searching for ages for something to reverse, or at least treat, long term effects of a prescription acne medication that has been shown to reduce hippocampal neurogenesis and increase depressive behavior in mice. Bottom line is that I started that medication, and after a few weeks, I suddenly lost the ability to feel strong emotions, along with losing the ability to create vivid scenes in my imagination. This has been totally different than any bout of sadness I experienced before;  it is as if my former notion of the human soul was taken from me.

Welcome to the club. I have the same issues as well, even when I'm not depressed in the typical sense. I've only been taking it a week, so it's a bit early to tell if it's a promising solution in my case.

 

 

Same here. What we have been stricken with feels like something different than the classical description of depression. In fact, he use of "depression" as a catch-all diagnosis for any of a broad range of mood altering afflictions one experiences is total nonsense.

 

NSI-189 is one of a few last-ditch treatments for me. Nothing else has significantly helped me so far and it seems to be one of the few treatments that might directly counter the suspected effects of RoAccutane on the brain. I have so many other symptoms, ridding myself of the constant anhedonic state would at least make life worth living.

Let's keep our hopes up.
 

[Mind_Paralysis]

 

 

 

 

I have been searching for ages for something to reverse, or at least treat, long term effects of a prescription acne medication that has been shown to reduce hippocampal neurogenesis and increase depressive behavior in mice. Bottom line is that I started that medication, and after a few weeks, I suddenly lost the ability to feel strong emotions, along with losing the ability to create vivid scenes in my imagination. This has been totally different than any bout of sadness I experienced before;  it is as if my former notion of the human soul was taken from me.

Welcome to the club. I have the same issues as well, even when I'm not depressed in the typical sense. I've only been taking it a week, so it's a bit early to tell if it's a promising solution in my case.

 

 

Same here. What we have been stricken with feels like something different than the classical description of depression. In fact, he use of "depression" as a catch-all diagnosis for any of a broad range of mood altering afflictions one experiences is total nonsense.

 

NSI-189 is one of a few last-ditch treatments for me. Nothing else has significantly helped me so far and it seems to be one of the few treatments that might directly counter the suspected effects of RoAccutane on the brain. I have so many other symptoms, ridding myself of the constant anhedonic state would at least make life worth living.

Let's keep our hopes up.
 

 

 

Most intriguing - going over the effects of Isotretinonin (accutane) I find myself somewhat baffled - certainly it covers areas waay beyond my expertise.

 

I must say though, that it looks to be a, well, a NUCLEAR option - targetting all of the four big pathways of acne pathology. It would appear to work as a form of... well... CHEMOTHERAPY!
 

Inducing cellular death and all sorts of things - even used for some forms of cancer, it is.

 

 

Going over your symptoms though, they do look similar to my own... what I have is called "burnout" - it's a state wherein constant stress triggers cortisol-release in the hippocampus for a prolonged period of time - high cortisol also triggers extreme insomnia, which causes issues for all of the systems in the body. All of this leads to sensitivity to depression - because it majorly inhibits BDNF-release and neurogenesis - eventually, the high cortisol reaches a level where it induces BRAIN-DAMAGE.

 

In essence, I now have (had, actually) the brain of a major alcoholic.

 

Cortisol is an endogenous glucocorticoid, and I started digging into Isotretinoin, to see if there was a connection, and there are some signs of glucocorticoid modulating activity...

 

However, it actually seems like it may LOWER cortisol?? I was expecting it to do the opposite, but there are signs towards this. But there are also signs that in some tissues it actually functions similar to a glucocorticoid.

 

There is ONE similarity in our potential diseases though... an imbalance of the pituitary axis - my own brain-damage is induced because of ultra-high levels of cortisol, your own, may actually be caused by super-low levels of cortisol.

 

I suppose there is some logic to it - since Cortisol is actually involved in repairing systems such as the skin, during normal levels.

 

 

Anyways, I had some GOOD results from NSI-189, and I am about to go on a second cycle soon, because of that - since our symptoms are similar, and shrinking of the hippocampus have been observed in both of our diseases, then I think it's definitely possible that NSI-189 could have some effect on your condition as well.

 

 

References:

-------------------

Isotretinoin and mental health in adolescents: Australian consensus.

https://www.ncbi.nlm...pubmed/24283385

 

The effect of perinatal hormonal imprinting with 13-cis-retinoic acid (isotretinoin) on the thymic glucocorticoid receptors of female and testosterone level of male adult rats.

https://www.ncbi.nlm...pubmed/10569251

 

Isotretinoin influences pituitary hormone levels in acne patients.

https://www.ncbi.nlm...pubmed/21103844

 

 

The effect of different doses of isotretinoin on pituitary hormones.

https://www.ncbi.nlm...pubmed/25721216

[jack black]

As a side note, ut really is true that motivation does surprisingly increase motivation a LOT when NSI-189 is stopped. When there is a task to do instead of debating over this or that I just get on and do it without hesitation. My apartment is like amazingly spotlessly clean haha.

Could you please clarify for me NSI189 vs motivation? Did it increase during taking in or only after stopping it?
Thanks!

[jack black]

I can get some mementine soon. Did anyone mix it with nsi or tianeptine? Could you describe effects? I am also curious if memantine could supress tolerance for prl 853 as it does for amphetamines.

I took them together. Initially I was on low dose memantine, 5mg and started tianeptine, about 10mg. That felt sedating for a few days. Then I increased memantine to 10mg and immediately felt better. I was on that combo (+5htp) for a couple of weeks and felt fairly motivated and productive until I stopped memantine for the sake of experimentation. Much worse now and thinking about restarting memantine or trying something else.

[jack black]

Tianeptine seemed to exacerbate my sleeping-issues, so I had to quit all of it.

Have you considered adding some 5htp in PM? It works for faberware and myself.

[bugsbunny]

This thread has become a bit too large to read in it's entirety so apologies if this has been asked before but:

​I had a cough and sneeze (expected at this time of year where I live) for about two days before I began my NSI experiment (20mg/day for 12 days).

 

During this experiment I noticed two things:

 

1. My mood lifted to a new baseline, after 72 hours I noticed that for nearly all that time I had the kind of euphoria I would usually get from 45 minutes of cardio (neurogenesis).

 

2. This cough and sneeze turned into a monster of a respiratory infection. I had to take time off work, had insane headaches, lungs were coughing up yellow crap for days.

 

This is very unusual for me to be affected in such a way by environmental pathogens. It was almost a cause for concern considering my diet and supplementation regime but it did not take too long to find the culprit of this. Within 48 hours of cessation of NSI-189 the monster has almost completely gone and tomorrow I expect to feel fine again.

 

Has anyone else notice an immunomodulator effect from NSI-189?

I had the same thing. My theory is, that the heating supply of the body is reduced, which expresses in cold and sticky bodyparts. So if the body wants to heat up to fight bacteria its not that effective. It might be that sleeping under NSI-189 influence isnt as effective because of REM-reduction. Together it might make you susceptible for infections. It might be because of to much reduction of cortisol which is important for the immune system.

heating supply

 

 

Edited by bugsbunny, 09 November 2016 - 03:43 PM.

[Mind_Paralysis]

 

Tianeptine seemed to exacerbate my sleeping-issues, so I had to quit all of it.
 

Have you considered adding some 5htp in PM? It works for faberware and myself.

 

I haven't, no.

I don't think it would do much difference for me though, as you know, I have a severe, severe form of sleep-disturbance - I'm going to be trying Clonidine soon - have a deal for it going as we speak - so hopefully I'll have it in my hands in a few days.

 

The combo of NSI-189 and Tianeptine was especially sleep-disturbing btw - so NSI-189 in itself disturbs my sleep - although not to any great extent.

 

I'm thinking Tianeptine and Clonidine could be an interesting combo - Alpha-2-agonism should shut my mind down enough to sleep through even NSI-189 + Tianeptine combo.
 

[Mind_Paralysis]

 

As a side note, ut really is true that motivation does surprisingly increase motivation a LOT when NSI-189 is stopped. When there is a task to do instead of debating over this or that I just get on and do it without hesitation. My apartment is like amazingly spotlessly clean haha.

Could you please clarify for me NSI189 vs motivation? Did it increase during taking in or only after stopping it?
Thanks!

 

 

NSI-189 was initially very motivating - the first week or so - especially when combined with Modafinil! Holy hannah! It was almost like being well again...

 

After the first week and running out of Modafinil, I felt a definitive lessening of the motivating feeling - instead I started getting those waves of sleepiness and fogginess.

 

So, IMHO, yes, NSI-189 is motivating, buuut... it varies quite a lot - don't bet on it performing all the time for you.
 

[thebrainstore]

It's method of action is to increase neurogenesis and enlarge the Hippocampus. I don't see how that directly correlates to motivation in the short term. If the brain is putting on a growth spurt one might expect some downtime, not unlike the soreness after training at the gym.

 

I have not been disappointed with the action of NSI-189 because I don't think I had any unrealistic expectations of what it might do. I seem to be a candidate who might get the best out of the substance given that I suffered early years trauma and long term exposure to cortisol as I was growing up. If this isn't you, then you might not have an undersized hippocampus and therefore experimenting with largely untested research chemicals might not be the best idea.

​I don't take anything in the hope that it will cure something, I assess method of action and check that against the problem being presented. As such everything that I have taken has been a success, although I decided that some things (like Tianeptine Sulfate) were not suitable for long term use despite having positive short term effects.

[jack black]

​I decided that some things (like Tianeptine Sulfate) were not suitable for long term use despite having positive short term effects.

 

why if i may ask?

[jack black]

It might be because of to much reduction of cortisol which is important for the immune system.

heating supply

 

 

 

it's the opposite, cortisol suppresses immunity, ask anyone who takes steroids for autoimmune diseases and such.
 

Edited by jack black, 09 November 2016 - 04:44 PM.

[thebrainstore]

 

​I decided that some things (like Tianeptine Sulfate) were not suitable for long term use despite having positive short term effects.

 

why if i may ask?

 

 

Personal reasons, off topic, irrelevant to this discussion and different substances have different reasons but generally I am against shortcuts to health and anything which can produce emotional dependency i.e. I can't function right without using X pharmaceutical.

Edited by thebrainstore, 09 November 2016 - 05:41 PM.

[macropsia]

To clarify my above post, continued use referred to the 'long-pulse' (1-2 months) that I've seen most commonly. I was wondering if anyone had considered varying the dose within that window for optimal effect? Without knowing the mechanism by which 'tolerance' accrues this would be difficult to know, but others may have considered this.

[linlin92]

 

As a side note, ut really is true that motivation does surprisingly increase motivation a LOT when NSI-189 is stopped. When there is a task to do instead of debating over this or that I just get on and do it without hesitation. My apartment is like amazingly spotlessly clean haha.

Could you please clarify for me NSI189 vs motivation? Did it increase during taking in or only after stopping it?
Thanks!

 

 

Hi jack, I wouldn't say that NSI-189 directly gave me any motivation while I was on it. For the first week I felt more tired and had to take naps in the car between classes. Looking back though I definitely got more things done on it, maybe this was due to a) NSI-189 improving my mood so I am spending less time stressing out and feeling sorry for myself, b) I slept more so my focus/concentration was on point and I didn't tend to get distracted as much, and c) the days when I was super busy I added 50mg modafinil and 20mg fascoracetam to the mix really perked me up.

 

Since I stopped taking NSI-189 and all noots to give my brain a bit of a break I just wake up and really feel like getting things done! like cleaning, going to the gym, planning social events. Its a bit weird because I expected the opposite to be honest. Not that I am complaining!

 

I am starting memantine today :')
 

[Alexiel]

Hello everybody, i'm a new user, i can't read hundreds of pages about NSI 189, but i'd like to know, from who has tested it, if it's useful for concentration, memory and focus. And where can i find a legit vendor in Europe? Thanks very much

Edited by Le Nebbie Di Avalon, 10 November 2016 - 10:24 PM.

[Mind_Paralysis]

Hello everybody, i'm a new user, i can't read hundreds of pages about NSI 189, but i'd like to know, from who has tested it, if it's useful for concentration, memory and focus. And where can i find a legit vendor in Europe? Thanks very much

 

It's useful for some aspects of memory - but concentration and focus? No.

 

Somewhat the opposite, I would even say!

 

If you read a few of the posts on the prior page you will soon figure out who the legit vendor in Europe is - he's a member of this forum, actually.

Edited by Stinkorninjor, 10 November 2016 - 10:46 PM.

[Alexiel]

 

Hello everybody, i'm a new user, i can't read hundreds of pages about NSI 189, but i'd like to know, from who has tested it, if it's useful for concentration, memory and focus. And where can i find a legit vendor in Europe? Thanks very much

 

It's useful for some aspects of memory - but concentration and focus? No.

 

Somewhat the opposite, I would even say!

 

If you read a few of the posts on the prior page you will soon figure out who the legit vendor in Europe is - he's a member of this forum, actually.

 

 

Oh thanks very much, i think your are talking about Strangelove, don't you?

I've just sent him a private message.

 

It's difficult to me to remane focused for much time, i'm ADD, i've have moments in what i'm a sort of genius, but can't stay too much time on a book, or focused on only one thing, or work, and so on... Distraction is always with me!

I'm taking Ritalin for about 4 years, but its effect  is very little now.
Now i'm taking citicholine and uridine ( to re-calibrate my dopamine receptors, maybe!), but i'm looking for somewhat like Ritalin ( in the first months of use), that can give me attention and focus.

Modafinil isn't legal to order here in Europe without a prescription, but i could test maybe flmodafinl or similar, that aren't registered yet.

 

I've also read that taking memantine for some days can erase the tolerance for Ritalin, but i don't know if it's true or bullshits.

I'm Add, hyperactive only in my mind, but  my body is always aweary, so for me a substance that calms my mind down and gives energy to my body would be perfect for me
 

[thebrainstore]

NSI-189 appears to prompt growth of the hippocampus and an increase in neurogensis. It is suitable for people who have suffered years of cortisol exposure, the main symptom of which is stunted hippocampal growth resulting in major depressive disorder (treatment resistant).

 

This method of action and effect does not seem suitable for your symptoms, so I think NSI-189 may not be what you are looking for.

[IP3]

Stinjornir:

 

Yes clonidine will put you down, if you take it at night but you can develop depression fairly quickly (as me) watch yourself). Clonidine was also only drug that supressed nsi-induced anxiety.

 

Jack Black: You have no memory problems on tianeptine? Many pepole reports short term memory loss.

 

For something completly different. I have problems with mild ocd and depression. Two weeks ago i started escitalopram 5mg, intrusive thoughts weakened, but my verbal inteligence is shattered. I find writing in english extremely hard. Anyone of you have the same problem?

To what ssri should i eventually swich? Or memantine would be better choice?

 

https://www.ncbi.nlm...pubmed/17545748

 

[jack black]

Jack Black: You have no memory problems on tianeptine? Many pepole reports short term memory loss.

Funny that you mentioned that. I had a few embarrassing brain farts yesterday. But probably not related to tianeptine, as I've been taking it for a while. I'm thinking the US election results are sinking in and I'm getting depressed again. I need to get some of that NSI189.

Keep also in mind I'm not taking it alone as it was too sedating. I initially combined it with memantine, later with 5htp, and now with amantadine.

Furthermore, if you see the studies in depressed patients, there is improvement in cognition, of course, as depression causes pseudodementia. The reports you talk about are anegnotes from various people who may have taken it for recreational reason and not depressed in the first place.

Edited by jack black, 11 November 2016 - 12:22 PM.

[bugsbunny]

Strange, what dosages of Tianeptine are you guys using? Its a little bit sedating but i had no memory los or problems to remember things at 40mg per day. The biggest problem for me was the headache at start of my treatment, but it faded away after 3 days.

Edited by bugsbunny, 11 November 2016 - 12:33 PM.

[bugsbunny]

It might be psychological. Your mind doesnt see a need to remember something because learning/remembering was connected to fear in the past, like the students that learn for exams at the last day afternoon.

Edited by bugsbunny, 11 November 2016 - 12:39 PM.

[IP3]

I ment MEMANTINE, not tianeptine, sorry. Tianeptine improves m memory. This is brain mess with escitalopram...

[Mind_Paralysis]

Yes, it's him. I figure we shouldn't say it out loud, since so many sources of NSI have been closed down, and they might be about to swing out another round of Cease and Desist -letters as well.

 

Cool that you mention how Clonidine could work on NSI-189 -induced anxiety btw! = ) That would be an awesome plus in my book! I don't figure I'll get depressed if I take it with NSI btw - and should I feel any such tendencies, I could just smack on Tianeptine as well, and just be sailing smoooth!

 

 

 

Hello everybody, i'm a new user, i can't read hundreds of pages about NSI 189, but i'd like to know, from who has tested it, if it's useful for concentration, memory and focus. And where can i find a legit vendor in Europe? Thanks very much

 

It's useful for some aspects of memory - but concentration and focus? No.

 

Somewhat the opposite, I would even say!

 

If you read a few of the posts on the prior page you will soon figure out who the legit vendor in Europe is - he's a member of this forum, actually.

 

 

Oh thanks very much, i think your are talking about Strangelove, don't you?

I've just sent him a private message.

 

It's difficult to me to remane focused for much time, i'm ADD, i've have moments in what i'm a sort of genius, but can't stay too much time on a book, or focused on only one thing, or work, and so on... Distraction is always with me!

I'm taking Ritalin for about 4 years, but its effect  is very little now.
Now i'm taking citicholine and uridine ( to re-calibrate my dopamine receptors, maybe!), but i'm looking for somewhat like Ritalin ( in the first months of use), that can give me attention and focus.

Modafinil isn't legal to order here in Europe without a prescription, but i could test maybe flmodafinl or similar, that aren't registered yet.

 

I've also read that taking memantine for some days can erase the tolerance for Ritalin, but i don't know if it's true or bullshits.

I'm Add, hyperactive only in my mind, but  my body is always aweary, so for me a substance that calms my mind down and gives energy to my body would be perfect for me
 

 

 

Hmm... have you considered that perhaps you don't have ADHD, but also SCT? Or perhaps no ADHD at all, only SCT?

 

SCT = Sluggish Cognitive Tempo.

 

I have a combo of low-level ADHD and high-level SCT and I have somewhat similar symptoms. About 30% of everybody with SCT has ADHD to some extent as well.

 

The fact that Ritalin doesn't work too well on you fits the profile - in general, stimulants doesn't work as treatment of SCT-symptoms - because stimulants are mainly dopaminergic, and SCT is actually a disorder of Norepinephrinergic systems.

 

 

Read more about it here:

 

https://en.wikipedia...cognitive_tempo

 

And if you want in-depth advanced info on it, but told in a simple way, then check out these slides:

http://drkevintblake.../2016-SCT-1.pdf

 

If that's the disease you have... then I recommend Atomoxetine (strattera) or Reboxetine - Norepinephrine Reuptake Inhibitors.

 

 

Stinjornir:

 

Yes clonidine will put you down, if you take it at night but you can develop depression fairly quickly (as me) watch yourself). Clonidine was also only drug that supressed nsi-induced anxiety.

 

Jack Black: You have no memory problems on tianeptine? Many pepole reports short term memory loss.

 

For something completly different. I have problems with mild ocd and depression. Two weeks ago i started escitalopram 5mg, intrusive thoughts weakened, but my verbal inteligence is shattered. I find writing in english extremely hard. Anyone of you have the same problem?

To what ssri should i eventually swich? Or memantine would be better choice?

 

https://www.ncbi.nlm...pubmed/17545748

 

I did not have short-term memory loss on Tianeptine either.

You have to take into account that me and Jack_Black have several abnormalities in our brains though, I myself have this diagnosis:

ADHD-PI-SCT-DCD-DC

 

Meaning a combination of ADHD, SCT and Developmental Coordination Disorder (difficulties juggling) and Dyscalculia (difficulties counting).

 

Jack probably has a combo of ASD-SCT, at the very least - meaning Autism Spectrum Disorder and Sluggish Cognitive Tempo.

 

Our response to Tianeptine need NOT be the same as the neurotypical majority - in fact, it seems to be different, even from the two of us, our response differs - as well as in comparison to the majority.

 

 

For a quick comparison, I can mention that I have tried both Sertraline and Fluoxetine (SSRI's) and Duloxetine (SNRI) and I did not experience verbal intelligence -loss on those either.

HOWever... On Bupropion (NDRI + nAch antagonist), I experienced it BIG-time! I kept forgetting words all the time, to the point of my spoken sentences coming out cracked and incomprehensible. (at 600 mg I was a complete dope!)

 

 

EDIT:

D'oh! Now I see you mention Memantine...

 

An interesting side-note about Memantine - it's one of a very select few drugs which act as ALPHA-7-NICOTINIC ANTAGONISTS! A property it SHARES with Bupropion - both have the effect at a rather low level though, having much greater activity at other receptors.

 

It's possible the verbal memory mess they can both induce, are in fact related to this property... Ach-antagonism generally induces problems with memory, as a fact - that's the reason why the dreaded TCA's and Deliriants both cause memory-issues to varying degrees. (in the case of Deliriants, like scopolamine, the effect is actually so great that it causes amnesia!)

 

As far as I know, Escitalopram has no anticholinergic activity whatsoever... in fact, it's the most selective, PURE SSRI's there is.

 

Curious that it would cause memory-issues...

Edited by Stinkorninjor, 11 November 2016 - 01:12 PM.