6219 replies to this topic

[bugsbunny]

I think i had Sluggish Cognitive Tempo all my life. I was introvert and a little bit slow. It turned into ADHD and extroversion after a psychosis with strong dopamine inhibator called Ethylphenidate and was permanent. Maybe you can get a little bit information about the disease, because that acually happened to me.

[IP3]

Dryness in mouth on esci is noticable, but much less pronounced than during my very short paroxetine trial. Escitalopram brain fog resembles C60 side effects that i am prone for. I not even mention about sexual side effects, i known about anorgasmia and lack of libido but this frighten me most: https://www.ncbi.nlm...pubmed/24242893 and it is true... Erection is very hard to achieve.

Edited by IP3, 11 November 2016 - 01:37 PM.

[jack black]

Yeah memantine worsened my dyslexia slightly. But I ramped up the dose very slowly and only did max 10mg per day.

[jack black]

In case someone is wandering why the CUR stock has been moving in the last 2 days, I'm buying and this is extremely thinly trading stock. I'm done, so it will probably bounce down.

Happy speculating!

[Mind_Paralysis]

In case someone is wandering why the CUR stock has been moving in the last 2 days, I'm buying and this is extremely thinly trading stock. I'm done, so it will probably bounce down.

Happy speculating!

 

Good times! I'm thinking about investing myself, actually. = ) When I finally have some more money, I'm going to buy a few shares! There's definite potential here...

[dmmbbs]

Does NSI-189 have any enantiomers?

[tautomeric]

Does NSI-189 have any enantiomers?

 

Obviously no, no chirality center, no substitued biaryls, allenes, 8 structure..

 

Edited by tautomeric, 15 November 2016 - 11:36 AM.

[dmmbbs]

@tautomeric - Thanks. Since I had no effects on my depression after 29 days of administration, I was starting to worry whether my supplier had sent the wrong stereoisomer. Now it seems either my supplier has sent totally different something or I am unresponsive to the drug. Anyhow, I'll continue and increase the dose from 40 mg qd to 40 mg bid.

[f099y]

Hi I've read much here and elsewhere and I know most of this is covered to some extent between all the posts, but I just want to clarify for which of the following I could expect NSI to help with:

 

Memory impairment

Brain fog/blank mind

Anhedonia

Blunted affect

Fatigue

Alogia

Dizziness

Social anxiety/extreme social awkwardness

etc.

 

If NSI can potentially cover enough of these than I would rather use it than a combination of other things. I want to try it anyway, but just looking for some encouragement. What really hinders me from just starting it though is the many difficulties with actually receiving it-authenticity of product, delivery of product, etc.

 

Anyway any insight on the above would be appreciated!

[dmmbbs]

Hi I've read much here and elsewhere and I know most of this is covered to some extent between all the posts, but I just want to clarify for which of the following I could expect NSI to help with:

 

Memory impairment

Brain fog/blank mind

Anhedonia

Blunted affect

Fatigue

Alogia

Dizziness

Social anxiety/extreme social awkwardness

etc.

 

If NSI can potentially cover enough of these than I would rather use it than a combination of other things. I want to try it anyway, but just looking for some encouragement. What really hinders me from just starting it though is the many difficulties with actually receiving it-authenticity of product, delivery of product, etc.

 

Anyway any insight on the above would be appreciated!

 

First get a diagnosis. If you do have one, let us know. If it's prodromal phase of schizophrenia, it's not possible to confirm now until positive symptoms set in. All depends on how old you are, for how long you are experiencing the symptoms, and much more.

 

[f099y]

 

Hi I've read much here and elsewhere and I know most of this is covered to some extent between all the posts, but I just want to clarify for which of the following I could expect NSI to help with:

 

Memory impairment

Brain fog/blank mind

Anhedonia

Blunted affect

Fatigue

Alogia

Dizziness

Social anxiety/extreme social awkwardness

etc.

 

If NSI can potentially cover enough of these than I would rather use it than a combination of other things. I want to try it anyway, but just looking for some encouragement. What really hinders me from just starting it though is the many difficulties with actually receiving it-authenticity of product, delivery of product, etc.

 

Anyway any insight on the above would be appreciated!

 

First get a diagnosis. If you do have one, let us know. If it's prodromal phase of schizophrenia, it's not possible to confirm now until positive symptoms set in. All depends on how old you are, for how long you are experiencing the symptoms, and much more.

 

 

Hi thanks for the reply! Interesting that you would think of schizophrenia-I do fit nearly all of the negative symptoms, but have never had any positive symptoms(except maybe for paranoia in social situations.) I've been diagnosed with Major Depression 7 years ago, I'm now 27. I've been to 3 psychiatrists, I don't know if the current one has changed my diagnosis at some point, from our discussions I would think he considers me to be treatment resistant/atypical with possible co-morbidities.

 

The brain fog/memory problems started roughly 1 and a half years ago. The dizziness started with Serdep withdrawals at the start of the year and has remained since then, though at a less intense level.

 

I'm quite sure that no single med will help me, I'm not even sure if drugs are the correct approach at this point. But blood tests haven't picked up anything till now, so if I have some condition I don't know what it is currently.

Edited by f099y, 15 November 2016 - 05:26 PM.

[jaiho]

Those symptoms also suit a severe depression, especially the blank mind/ Anhedonia symptoms.

NSI-189 can help, though i found it wasn't enough alone. Same with Strangelove, he had to add an MAOI to it.

My experience is that Moclobemide + NSI-189 was a very good combination. If that doesn't cut it, you could try Parnate + NSI-189.

But first, obviously try the NSI-189 by itself first, for a solid month.

[f099y]

Yes I didn't previously realise how insidious depression can really be, so I suppose it could be the correct diagnosis. I am however still seeing a neurologist in January as I'm desperate and any insights are appreciated. Your comment about a MAOI is slightly disheartening as I've just recently tried Moclobemide for 6 weeks at 600mg/day with barely any success. Is Parnate much more potent? If NSI by itself isn't powerful enough then I'm not sure what else to do. Selegiline is one other substance that sounds promising and which I could still try.

 

 

 

 

[jaiho]

Parnate is very potent, far more so than Moclobemide or SSRIs.

NSI-189 is good because it can be combined with anything. I find it works better with MAOIs.

 

[Mind_Paralysis]

Parnate is very potent, far more so than Moclobemide or SSRIs.

NSI-189 is good because it can be combined with anything. I find it works better with MAOIs.

 

Hmm, really? What would you say about my current combo, which I started today?

 

50 mg Duloxetine

20 mg Atomoxetine (I'm already a slow metabolizer, so adding dulo doesn't mean sh*t for me, CYP2D6-wise)

NSI-189 20 mg

 

Would an SNRI play well with NSI as well? I'm thinking since it's a dual uptake agent, although not a tripple - like an MAOI. (yes, I know it's not the same mode of effect, mainly thinking in that more than one neurotransmitter is affected)

 

I'm titrating the Duloxetine out though, trying to discontinue it safely, but it seems like I'm going to be cutting it fairly short, however... Damn. Hope it's enough to not get brain-zaps.

[jaiho]

MAOIs, i think, are more likely to be a potentiator of NSI-189 due to it possibly being a selective SRI in the hippocampus.

Personally i dont enjoy the feeling of SSRIs or SNRIs in monotherapy. There is a certain feeling of disconnect from one's environment, or humanity, i suppose.

 

I'm a fan of MAOIs due to them feeling "clean". Best way i can describe it. Before i ever tried them, i thought they would be dirty powerful drugs. I was gobsmacked when i first tried Parnate. It felt like i wasn't on a drug at all. The depression just floated away.

 

Atomexetine is an NRI so you could combine that with an MAOI and that would eliminate the need for the tyramine diet. Since NRIs block the pressor response. 

 

Edited by jaiho, 15 November 2016 - 11:24 PM.

[macropsia]

I have a few brief thoughts on NSI polytherapy:

1. It is possible, in some cases, particularly those in which an autoimmune condition may be present, that an anti-inflammatory/glial cell modulator of some stripe may be necessary to keep gains. Possible options would include: longer-acting NMDA antagonists, ibudilast, galantamine and possibly montelukast.
Some combo of the above would probably be better than any one.

2. While I'm not familiar enough (and don't have the time on hand to further research the matter, i can try to do so tomorrow) with different isoforms of the serotonin transporter and their differential distribution, it seems likely that MAOIs would help for some of the same reasons that gabaergics would. Given that the largest problem with NSI as a monotherapy seems to be anxiety, this would seem to make sense.

3. This ventures into more experimental territory, but it would be very interesting to see what would happen alongside something that causes suppression of cortisol, i.e., dexamethasone. To get a useful read one might test cortisol levels after administering NSI after a small dose of dex. Just an odd thought.

4. I've yet to try it, but bromantane might also be a good adjunct and stimulant replacement, esp. because of its NMDA properties. It's basically an amphetaminized adamantane-looking moiety.

5. This will look like a bit of a puzzle, but I think there's something to be sorted out here and I haven't had the occasion to try the full range of possibilities, but: Tramadol enhances the antidepressant properties of NMDA antagonism, 5ht2a agonism is also neurogenic.

I wouldn't go combining 2a agonists with tram. all willy-nilly-like (seizure incitation much? though i imagine this is probably preventable via suppression of what feels like tramadol's glutamatergic properties, I've seen at least one anecdote to support). It seems like you can reset response to both NMDA receptor antagonism and some kinds of painkillers with 5ht2a agonists.

It would not surprise me if a cycle that included occasionally happier days of bolus-antidepressant dose arylcyclohexylamine (with low dose pregabalin to suppress rebound) and tramadol would reset some of NSI's effect. Just a hunch. A judiciously chosen 'hexylamine-tryptamine bolus administration, with a later addition of a glutamate suppressor (say, t+2:00h if we assume a faster route of admin. with a ahorter acting ) may well do similarly.

These are merely airmchair ponderings and are largely outside of practiced medicine, but some combination of means to 1) keep gains between cycles (now I sound like an 'effing body builder with all the baseless broscience and talk of keeping gains..) so as to be able to space cycles more considerably, and 2) a means to kick off the cycle with a freshened NMDA system (through a combo of sigma agonism and NMDA blockage; this part is at least theoretically probable) could very well be useful in some possible universe.

Also, low dose tramadol might be an acceptable adjunct, though obviously anathema or just less than preferrable due to its being an opiate. Though if NSI works how we think it does, this may not be as much of an issue as some might suppose.

Edited by macropsia, 16 November 2016 - 03:10 AM.

[macropsia]

This isn't, by any means, to speak ill of any more minimalist approaches which may well work, but I can't help but to speculate as to how these things might (in a distant future) integrate with psychedlically-aided psychotherapy, which itself may well have a bit to do neuroinflammation, neurogenesis and NMDA receptors.

[HardstyleShuffler]

Parnate is very potent, far more so than Moclobemide or SSRIs.

NSI-189 is good because it can be combined with anything. I find it works better with MAOIs.

When you say can be combined with anything? To what extent? Does that mean that nsi isnt an ssri, I was under the impression that ssri+maoi=no bueno.

 

 

Its been about a month and a half and I would say the nsi is helping. This week the effects have been much more prominent and I saw how quickly I would dismiss other people's ideas. I changed my acceptance of ideas in general and found that I could imagine more myself (coming from having lost my inner monologue and any mental space manipulation). Today I felt a smile trying to break free and a rather strong level on contentness. 

 

Edited by HardstyleShuffler, 16 November 2016 - 09:37 AM.

[macropsia]

Another brief afterthought on NSI polytherapy: in those with a putative glutamate/GABA imbalance (it's hard to do in vivo studies on such things; perhaps autopsy data might be helpful?) it may be absolutely crucial to deal with tachycardia so as to preserve the patient's ability to sleep.

It is possible that some health problems might lead to a compensatory dysregulation of steroid pathways, thereby increasing likelihood of adverse cardio effects.

This isn't related per se, but when I was younger there was a period of time when I could barely sleep at all. This went untreated, but my state continued to decline thereafter and I don't think I recovered. Bodies will almost always adjust, but it is hard to predict how, and exactly what functions will be preserved/prioritized by a somatic system.

This isn't, by any means, to speak ill of any more minimalist approaches which may well work, but I can't help but to speculate as to how these things might (in a distant future) integrate with psychedlically-aided psychotherapy, which itself may well have a bit to do neuroinflammation, neurogenesis and NMDA receptors.

Edited by macropsia, 16 November 2016 - 12:43 PM.

[jack black]

If anxiety is the only issue with NSI189, combo with tianeptine should cover it all. NMDA antagonist would be well taken care of. Anyone took that combo?

[macropsia]

Some of the same physiological proccesses may alternately present as sleeplesness.

I have not tried tia. therewith. Hath tried anyone tried memantine therewith? If it did help with sleep this would tell us something about its MOA as well.

[Mind_Paralysis]

If anxiety is the only issue with NSI189, combo with tianeptine should cover it all. NMDA antagonist would be well taken care of. Anyone took that combo?

 

I tried it with Tianeptine - it actually seemed to make the sleeping-issues I have worse.

 

It didn't help too much with the anxiety either... which made me rather disappointed. I never tried more than 10x3 mg per day though, and sometimes only 2x10 mg per day. Perhaps a higher dose would have worked?

 

I'm going on NSI-189 again as we speak, stacking it with Atomoxetine and Duloxetine. (discontinuing Dulox though)

[TheCipher]

Okay,

 

My experience with NSI so far is approximately what I expected; nothing. But this is because I first tested if I react allergic by taking rather small doses. Today I took 10mg which is far from the effective dose, but I think it's better to build-up rather than decrease the dose. I have taken it orally so far, but some people have suggested sub lingual, so I'd like to ask of there is a difference for NSI?

[jack black]

If anxiety is the only issue with NSI189, combo with tianeptine should cover it all. NMDA antagonist would be well taken care of. Anyone took that combo?

I tried it with Tianeptine - it actually seemed to make the sleeping-issues I have worse.

It didn't help too much with the anxiety either... which made me rather disappointed. I never tried more than 10x3 mg per day though, and sometimes only 2x10 mg per day. Perhaps a higher dose would have worked?

Did you take it with caffeine? It blocks some of the tianeptine's actions.

[TheCipher]

Hey guys,

I got brain damage when I was 16 from long term use of abusing the inhalant hair spray. My vision is very impaired like being very drunk, my short and long term memory is very poor, thought barely enter my mind and I can't think (Brain fog), I have depression, anxiety, and mood swings which are torture to live with every day. Anti depressants never helped me. I haven't touched the inhalant in 13 years but the damage has remained and continues to worsen for some reason. If I drink alcohol or smell strong fumes like paint I get further brain damage. I can't live like this anymore and I desperately need something that can reverse the brain damage and bring me back to myself. I tried driving lessons a few years ago but couldn't drive safely. I want to go on with my life. I've looked into Cerebrolysin, HBOT (Hyperbaric Oxygen Chamber but haven't tried it yet. I just found out about NSI-189.

Thanks

 

Hey there,

 

I'm rather new here too, but I would like to ask you if you make sure that you have a proper sleep-hygiene and if you do cardio every day? Regarding the substances I am not qualified to give you advice, another member might be able to. But you should definitely look into language learning or learning maths, as both grow the brain ( https://www.scientif...e-bra-13-02-28/ , I don't have the link for the math abstract anymore though ).

 

Don't worry you'll be healthy again!

[Mind_Paralysis]

 

 

If anxiety is the only issue with NSI189, combo with tianeptine should cover it all. NMDA antagonist would be well taken care of. Anyone took that combo?

I tried it with Tianeptine - it actually seemed to make the sleeping-issues I have worse.

It didn't help too much with the anxiety either... which made me rather disappointed. I never tried more than 10x3 mg per day though, and sometimes only 2x10 mg per day. Perhaps a higher dose would have worked?

Did you take it with caffeine? It blocks some of the tianeptine's actions.

 

 

Nope. No caffeine - I'm a tee-totaller. Other than the compounds I take medicinally, I never use anything.

 

The very best results I had was actually when I combined it with Modafinil - NSI-189 made me feel HAPPY then! It was even slightly anxiolytic - I could definitely feel a lot of stimulation, but for some reason it didn't bother me the way it usually does.

 

Interestingly enough, I'm having some good results now as well - stacking it with Atomoxetine. Not quite as good though - with Modafinil it was almost like euphoria! : )

 

Interestingly enough, I definitely did NOT experience any euphoria when combining it with Vyvanse - not pleasurable at all! Just felt like a heavier load, and amphetamine doesn't seem to 'euphoriate' me to any greater extent.

[sharpC]

any guys who had success with sublingual use? What's the best method, since saliva ruins everything

[macropsia]

Some seem to have liked it, others have found it too intense. My suspicion is that its effect is partially peripheral (for some this is possibly the preferred effect), thus it is probably good to experiment but either oral or a combination of the two is probably best.

Edited by macropsia, 19 November 2016 - 01:21 PM.

[linlin92]

Back onto NSI-189 again and this time I am going for 2 months at least. I forgot how tired it makes you feel at first! I am trying to only use Modalert or caffeine as a last resort but I do have n acetyl semax to help with wakefulness.

20mg once a day, might go up to 15mg B.I.D once I settle into it again.

 

I am combining it with PRL-8-53 this time and hope to be impressed with the results. I love the feel of resilience and being in a realistic positive mood no matter what life tries to throw at me :')