Posted 17 December 2016 - 05:56 PM
In case someone is wandering why the CUR stock has been moving in the last 2 days, I'm buying and this is extremely thinly trading stock. I'm done, so it will probably bounce down.
Happy speculating!
in case anyone cares, i liquidated the position for next to no gain (measly couple of hundreds at the most). this stock may take off in the future, but it's about dead right now. i'm concerned when the next stock crash comes (long overdue) i don't want to hold the bag.
Posted 20 December 2016 - 04:40 AM
Can anyone confirm that this reports are proof that this is NSI?
https://allchemy.pl/...d_attachment=87
https://allchemy.pl/...d_attachment=88
https://allchemy.pl/...d_attachment=91
Posted 20 December 2016 - 04:58 AM
In case someone is wandering why the CUR stock has been moving in the last 2 days, I'm buying and this is extremely thinly trading stock. I'm done, so it will probably bounce down.
Happy speculating!
in case anyone cares, i liquidated the position for next to no gain (measly couple of hundreds at the most). this stock may take off in the future, but it's about dead right now. i'm concerned when the next stock crash comes (long overdue) i don't want to hold the bag.
Posted 21 December 2016 - 10:35 AM
Oh I am really enjoying my second cycle of NSI-189 so far :')
Every day its 22mg NSI-189 taken straight in the morning with breakfast, with a spray of 100mcg Acetyl-Selank up each nose and 12.5mg Tianeptine sodium.
Every week I would choose 3-4 days where I stack PRL-8-53 with it as well. This combo works amazing with NSI-189 because I find myself constantly wanting to learn new things and I remember most of it. I am doing some pre-study for uni next year, flicking through anatomy books, and learning a new language as well. I don't find it tedious, but fun!
Anxiety is not an issue unless (like strangelove said in the last page) its a problem you can't fix immediately (like if you're at work and something is bothering you but you can't think of how to deal with it straight away). Besides, the Selank and tianeptine both make me chill as anything I forget what anxiety even is.. My car broke down today and I wan't even fazed one bit. I sat quietly and waited for the roadside assistance service to arrive. Normally I would be petrified like hell, thinking of the worst and madly calling everyone in hysterics. No more!
One thing I have learnt is that you will need as much sleep as possible for the best results. Don't be afraid of going to bed an hour earlier than normal (or as soon as you feel tired) so you wake up next day feeling better than the day before. Oh and drink lots of water (3L a day) and take fish oil because the brain loves water and omega-3. 
Edited by linlin92, 21 December 2016 - 10:36 AM.
Posted 21 December 2016 - 09:30 PM
I am not quite sure why it would be dangerous on irresponsible for someone who has weighed it out, to "approximately" divulge how many milligrams is in a MICROSCOOP.
I suppose whoever gave you the rating thinks this:
it's a dangerous way of measuring substances, because the amount present changes all the time - because of how densely the powder is packed, it can dipher significantly, between dosings.
I'll try to give my two shakes on it though:
I'd say, around 5-10 mg's.
As I recall, around 4-5 scoops was the amount necessary to obtain 20 mg.
When it comes to Tianeptine however, the dosing is different - one scoop is around 5-6 mg, and about two scoops makes for one 10-13 mg dose. It will always vary, however.
When it comes to NSI-189, the dosing isn't THAT finicky - it can dipher a bit - but if we're talking something like Memantine... well, if you dipher 5 mg, you'll get brain-fog like all h*ll, and your entire day will be wrecked.
Posted 21 December 2016 - 09:41 PM
I am not quite sure why it would be dangerous on irresponsible for someone who has weighed it out, to "approximately" divulge how many milligrams is in a MICROSCOOP.
I suppose whoever gave you the rating thinks this:
it's a dangerous way of measuring substances, because the amount present changes all the time - because of how densely the powder is packed, it can dipher significantly, between dosings.
I'll try to give my two shakes on it though:
I'd say, around 5-10 mg's.
As I recall, around 4-5 scoops was the amount necessary to obtain 20 mg.
When it comes to Tianeptine however, the dosing is different - one scoop is around 5-6 mg, and about two scoops makes for one 10-13 mg dose. It will always vary, however.
When it comes to NSI-189, the dosing isn't THAT finicky - it can dipher a bit - but if we're talking something like Memantine... well, if you dipher 5 mg, you'll get brain-fog like all h*ll, and your entire day will be wrecked.
perfect, thanks for this information.
Posted 22 December 2016 - 08:20 AM
Im curious, people who have been on SSRIs, and then found themselves on NSI-189.
Which did you find more effective?
Personally for me, i found SSRIs had a more, obvious effect, feeling more artificial.
NSI-189 feels far more subtle, but the mood lift feels more natural with no downsides i can notice.
Posted 22 December 2016 - 10:24 AM
Im curious, people who have been on SSRIs, and then found themselves on NSI-189.
Which did you find more effective?
Personally for me, i found SSRIs had a more, obvious effect, feeling more artificial.
NSI-189 feels far more subtle, but the mood lift feels more natural with no downsides i can notice.
I agree that the mood-lifts from both are different - however, I don't quite agree with NSI-189 being more subtle - just different.
In the long-term, the artificial feeling of SSRI's are more noticeable to me - I feel kind of boxed in emotionally, almost sedated.
However, the short-term effects of NSI-189 is something else! The first few days on it, the acute effects are definitely noticeable! The unusual happiness is quite quick in the come-on, and then there's the enhanced emotionality - everything is dialled up to 11! It's almost like being on several drugs at once.
The enhanced emotionality goes away after a while though, but then the anxiety comes in to replace it.
So no, I wouldn't exactly call it more natural - but more discreet when it comes to long-term treatment, sure.
Posted 24 December 2016 - 04:47 AM
I'm off NSI for arround 3 months and have to say that I have some permanent effects, good and bad ones. Negative ones first: Hypersensitivity especially in stress situations worsened, that comes along with Tourette like syndromes, but i can fix that with tianeptine. Might be a rebound and I will observe it for another 3 months and tell you guys. The good one is my memory is still enhanced but im memorizing to much junk that would be filtered by my former self. Its a great compound, but keep in mind its a chemical that can alter your brain structure permanently. So it might make you more functional but it comes with a price possibly. I wish happy holidays and stay healthy.
Edited by bugsbunny, 24 December 2016 - 04:48 AM.
Posted 24 December 2016 - 06:55 AM
I dont want to be putting any drug up on a pedestal as its different for everyone but for me personally NSI-189 is nothing short of incredible. Im 26, I have been depressed since my early school life and suicidal for the past 9 years. The first time taking NSI-189 it felt like the despair was immediately banished. Now this was absolutely bizarre going from one state to another and im pretty terrible at introspection to begin with, i figured it wouldnt last or was a placebo. After a month and a half or so I stopped for 2 weeks and the depression slowly came back until it was at its crippling full force again and i was thinking suicidal thoughts again. Resume NSI-189 and those thoughts are again immediately abolished. Also a note to the friendly thoughts aspect is i use to need some kind of music or tv playing when going to sleep to distract my mind from negative thoughts. Now its simply peaceful being alone with my thoughts.
Now this has not magically made me happy. There are still many parts of my life im unhappy with but i feel like this gives me the tools to cope with them and one day change them.
Posted 24 December 2016 - 09:53 AM
I dont want to be putting any drug up on a pedestal as its different for everyone but for me personally NSI-189 is nothing short of incredible. Im 26, I have been depressed since my early school life and suicidal for the past 9 years. The first time taking NSI-189 it felt like the despair was immediately banished. Now this was absolutely bizarre going from one state to another and im pretty terrible at introspection to begin with, i figured it wouldnt last or was a placebo. After a month and a half or so I stopped for 2 weeks and the depression slowly came back until it was at its crippling full force again and i was thinking suicidal thoughts again. Resume NSI-189 and those thoughts are again immediately abolished. Also a note to the friendly thoughts aspect is i use to need some kind of music or tv playing when going to sleep to distract my mind from negative thoughts. Now its simply peaceful being alone with my thoughts.
Now this has not magically made me happy. There are still many parts of my life im unhappy with but i feel like this gives me the tools to cope with them and one day change them.
If you never tried tianeptine you could try that too because it is a very good anti depressant if you dont overdose. A classic SNRI or rhodalia rosea, st. john wort works wonders in some persons. Ofcourse its good that NSI helps you, but since its an untested research chemical right now it shouldnt be your only option. Depressions could have many reasons like toxins in your body, to be sure i would do a detox with sauna, vitamins and spirulina. If toxins or parasites, fungus are the cause you will get long term benefits if you get rid of them. Thats not easy and will take months. Next thing is the hormonal balance check, enough sleep, good food etc.
Edited by bugsbunny, 24 December 2016 - 09:57 AM.
Posted 25 December 2016 - 05:44 PM
I wanna share with you my "success story" with coctail of tianeptine buspirione and melatonin. For two months i use buspirione 3x5 mg daily, for two weeks i increased dose to 3x10 mg daily. I take last dose with melatonin 30min-1 hour before sleep.
Some time ago i realized that i feel.... normal... just like 5 years ago. I realized that i wanna play video games... It may sounds silly but i lost pleasure in such activities long, long time ago.
My thoughts became more fluent and plastic.
I am also taking baclofen few times daily as needed ang gynostemma (Jinagoulan) infusion at night.
References:
https://www.ncbi.nlm...pubmed/26025562
https://www.ncbi.nlm...pubmed/25156283
https://www.ncbi.nlm...pubmed/22998742
Posted 25 December 2016 - 07:55 PM
Reading the "success stories" to me screams placebo and trying hard to connect irrelevant experiences with the use of it. 5-htp or sjw does a thousand things more than this does when it comes to effects.
I had no "cognitive enhancement" whatsoever and I am almost certain nobody else did
Posted 26 December 2016 - 12:35 AM
Reading the "success stories" to me screams placebo and trying hard to connect irrelevant experiences with the use of it. 5-htp or sjw does a thousand things more than this does when it comes to effects.
I had no "cognitive enhancement" whatsoever and I am almost certain nobody else did
All SJW did for me is turn me into a sleeping zombie. 5htp does nothing.
NSI-189 has far more pronounced effects after 4 weeks.
I think people who notice immediate effects are getting some sort of placebo response. The studies only show results starting after a week, maximum benefits beyond 4-6 weeks.
Posted 26 December 2016 - 12:49 AM
Reading the "success stories" to me screams placebo and trying hard to connect irrelevant experiences with the use of it. 5-htp or sjw does a thousand things more than this does when it comes to effects.
I had no "cognitive enhancement" whatsoever and I am almost certain nobody else did
Absolute nonsense. People give way WAY too much credit to placebo. Placebo effects are extremely mild at best. The placebo effects you read about in studies are not just patients taking sugar pills - they are patients taking sugar pills from doctors and nurses who are sympathetic, giving them attention and supportive therapy in order to keep them in the trial to avoid drop-outs. Why do pharmaceutical companies want to avoid drop-outs? Because you can't use their results in the analysis. For example, if very depressed patients don't respond to the placebo pill, after a few weeks they will sense they are not getting better and drop out. The healthier patients in the placebo group will respond to the placebo because, well, they are healthier to begin with. This will result in an inaccurate over-inflation of positive placebo reports which doesn't bode well to the company's anti-depressant being tested. To combat this, pharmaceutical companies provide minimally supportive therapy - not too much to artificially raise scores - but enough to retain the severely depressed patients who get the shit-end of the stick by getting put into the placebo arm.
If placebo effects were as real as uninformed people seem to say, we'd all be taking vitamin D for depression. Or exercise. NSI-189's effects are very real.... here's what I noticed aside from the memory experience I posted a few weeks ago (which I haven't experienced since)
-Much more endurance in Cardio workouts. I don't get winded as easily and I just seem to tolerate the pain remarkably better.
-Visual perception, e.g. colours, lights, texture, are all very enhanced leading to a brighter perception of the world.
-Able to instantly turn off anxiety when it comes on. I've read about this one a couple years ago and didn't believe it until I started noticing myself doing it when trialing the drug. It honestly feels like I can hit a switch in my brain that allows me to step back and not get anxious. Like there's more grip or control of my brain.
Edit: I will add that a probable reason many don't feel the effects of NSI is because they are on other drugs/ anti-depressants. I can't feel my adderall as well when I'm on cipralex either.... or maybe it just doesn't work for you. But don't just assume everyone is a placebo responder. Those anti-psychiatry books that pump up the placebo effect have gotten way too much press in recent decades.
Another way to determine if someone is a placebo responder is to see if the effects maintain or drop off. If NSI-189 stops working for someone, I'd say there's a good chance the effects were placebo. Patients who respond to sugar pills in drug trials usually relapse if their depression is worse. That's what sick people do. Those with lighter depression are more likely to continue to experience placebo effects. That's what healthy people do.
After two years of on-off again use of NSI-189, i get the EXACT same physiological response. Just like any other potent pharmaceutical.
Edited by pheanix997, 26 December 2016 - 01:00 AM.
Posted 26 December 2016 - 04:05 AM
Edited by Ark, 26 December 2016 - 04:07 AM.
Posted 26 December 2016 - 04:36 AM
Buspirione/melatonin combo reversed my depression-induced cognitive imparment, but didnt give me any additional benefits, beyond that what i have before.
Ark, I thing 98% (it is just my rude estimation) of depressions are to go with hippocampal athrpohy due to chronic stress, causes may be different but physiological effect is the same.
Those other depressions like from heavy metal poisioning are extremely rare imho.
Edited by IP3, 26 December 2016 - 04:37 AM.
Posted 26 December 2016 - 05:40 AM
I think your estimate is incorrect, My research indicates only 60-80% of depression is the direct result of hippocampal athrpohy.Buspirione/melatonin combo reversed my depression-induced cognitive imparment, but didnt give me any additional benefits, beyond that what i have before.
Ark, I thing 98% (it is just my rude estimation) of depressions are to go with hippocampal athrpohy due to chronic stress, causes may be different but physiological effect is the same.
Those other depressions like from heavy metal poisioning are extremely rare imho.
Edited by Ark, 26 December 2016 - 05:53 AM.
Posted 26 December 2016 - 05:50 AM
Edited by Ark, 26 December 2016 - 05:56 AM.
Posted 26 December 2016 - 08:36 AM
Agreed but fixing the hippocampus without fixing the cuasing coefactor is the equivalent of bailing water from a sinking ship, if you can't stop the source the NSI-189 is nothing more then a stop gap messure.Maybe not directly, but i thought they will sonner or later shrink your hippocampus.
Edited by Ark, 26 December 2016 - 08:42 AM.
Posted 26 December 2016 - 10:17 AM
Right, I'm back on NSI-189, just trialled two days worth of 20 mg per day, and today is the first day of trialling 20 mg x2 per day = 40 mg per day.
It'll be a short trial though, because I only have Modafinil worth of 4 days, and without it, I'll definitely go really tired or more anxious.
Stack:
NSI-189 - 40 mg
Modafinil - 150 mg
Omega-3 EPA - 930 mg
Omega-3 DHA - 660 mg
Zink-Citrate - 30 mg (elemental)
Magnesium Citrate - 60 mg
Magnesium Lactate - 3000 mg
(360 mg elemental in total)
Agreed but fixing the hippocampus without fixing the cuasing coefactor is the equivalent of bailing water from a sinking ship, if you can't stop the source the NSI-189 is nothing more then a stop gap messure.Maybe not directly, but i thought they will sonner or later shrink your hippocampus.
Just my opinion, but one must address the cause and repair the damage simultaneously, in order to fix resistant cases of depression almost more times then not. If long lasting postive results are to be expected in the outcome of the patient's own treatment,then people must stop thinking so one dimensional about depression.
You forgot one of THE biggest reasons for getting depression:
Neuropsychiatric disorder.
You can get depressed in the modern world, EASILY, if you have alterations to your basic neural circuitry, altering your environmental response. Society is built to fit the majority, so if you deviate from the expected behavioural norm, you're going to get into trouble.
Depending on your environment, and the severity of your disorder, then ALL of these disorders will make you depressed in the long run:
Autism
ADHD
SCT
Borderline (yes, BPD is such a disorder - read up on the newest data)
Dyscalculia
Dyslexia
Schizoid Personality Disorder (WHY is this called a PD?? We KNOW it's a form of Schizo! Jesus...)
Schizotypal Personality Disorder (AGAIN... WHY hold on to the old PD-label?? IDIOTIC!!)
Idiopathic Hypersomnia (narcolepsy 'lite')
Let's say at least 25% of those people will eventually be struck by some form of depression as a result of extreme environmental pressure - then, my friend, you will end up with a significant proportion of all people seeking help for depressive symptoms, and being put on antidepressants.
Coming back to what you said about treating the underlying causes, ADHD is a great example here - As you're probably aware, traditional stimulants have FAILED to meet the end-point results in many, many AD-trials - BUT...! Not so when it comes to ADHD-ers - all of a sudden, compounds which usually cause depressive symptoms in the long run, and SIGNIFICANT anxiogenic symptoms, are all of a sudden anti-depressive and anxiolytic! The improvement to an ADHD-ers mood is often dramatic, following the start of treatment with Stimulant-therapy.
So yes, I definitely agree with treating the underlying causes - however, there's another aspect to this - sometimes a depressed patient is so badly ravaged, so far gone, that for him or the Dr's to try and find the underlying cause is simply not feasible - one MUST begin by draining all of that water from the ship, or it'll sink in a matter of minutes!
Hence, one goes on an antidepressant, which gives the patient the ability to start pondering exactly why the patient is actually so ill.
Edited by Stinkorninjor, 26 December 2016 - 10:44 AM.
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