6219 replies to this topic

[rjfm]

*backs away slowly*

[Hyperflux]

I am starting to see some of NSI-189's benefits after one week of consistent dosing of 10mg sublingual. Notably, bombardment of long-term memory recall (which sometimes leads to daydreaming), feeling of serenity and contentment with just being, and a general mood lift. I am showing a lot of pro-social behavior and I am less robotic when talking to people, I would say I have generally reduced social apathy. Music also sounds very emotional, certain passages can paint a picture that is extremely vivid to me.

 

The dissociation side effect completely went away but I am still lethargic sometimes, hopefully that goes away. My phone (Sleep as Android sonar mode) shows that it slightly reduces the quality of my sleep even if taken first thing in the morning, but I do have a sluggish thyroid (waiting on endo to increase my T3 dose). I tried 20mg sublingual to see what it would be like. I noticed very sharp vision, reminds me of ETH-LAD's HD vision if anyone is familiar with that. It also made me more tired and my eyebrows kept twitching oddly enough. 

Edited by Hyperflux, 28 February 2017 - 09:19 PM.

[Twindaddy37]

*backs away slowly*

 lol

[Twindaddy37]

I am starting to see some of NSI-189's benefits after one week of consistent dosing of 10mg sublingual. Notably, bombardment of long-term memory recall (which sometimes leads to daydreaming), feeling of serenity and contentment with just being, and a general mood lift. I am showing a lot of pro-social behavior and I am less robotic when talking to people, I would say I have generally reduced social apathy. Music also sounds very emotional, certain passages can paint a picture that is extremely vivid to me.

 

The dissociation side effect completely went away but I am still lethargic sometimes, hopefully that goes away. My phone (Sleep as Android sonar mode) shows that it slightly reduces the quality of my sleep even if taken first thing in the morning, but I do have a sluggish thyroid (waiting on endo to increase my T3 dose). I tried 20mg sublingual to see what it would be like. I noticed very sharp vision, reminds me of ETH-LAD's HD vision if anyone is familiar with that. It also made me more tired and my eyebrows kept twitching oddly enough. 

I experienced all of these things, except the lethargy. And my twitch was in my L eyelid, but that went away. When i first started taking NSI i loved the increase color depth and HD vision and how elegant music sounded- i don't think this fades, but i do think that you get used to it to the point where it no longer stands out and becomes the norm, so its not as apparent. I do not look at things anymore and say "wow thats vibrant" as i did in the beginning, because i have adjusted to it. I have no doubt in my mind this substance will continue to have cumulative positive effects- looking forward to a full year on it or so. 

[TRUGAN]

Where is the best place to get this stuff (NSI-189)

[Tryptamine]

Hello, 

 

Does anyone have experience with making solutions from NSI-189 for oral/sublingual dosing both from the freebase and phosphate form. What are good candidates for solvents, which would keep it stable for up to a month? 

[Mind_Paralysis]

Where is the best place to get this stuff (NSI-189)

 

Right here on this forum! = )

 

Send a PM to the user Strangelove - he'll hook you up with the good stuff.

[Hyperflux]

Has anyone gotten constipation from NSI out of curiosity? 

[muntjac]

NSI-189, a Small Molecule with Neurogenic Properties, Exerts Behavioral and Neurostructural Benefits in Stroke Rats

 

Enhancing neurogenesis may be a powerful stroke therapy. Here, we tested in a rat model of ischemic stroke the beneficial effects of NSI-189, an orally active, new molecular entity (mol. wt. 366) with enhanced neurogenic activity, and indicated as an anti-depressant drug in a clinical trial (Fava et al., 2015) and being tested in a Phase 2 efficacy trial (ClinicalTrials.gov, 2016) for treatment of major depression. Oral administration of NSI-189 in adult Sprague-Dawley rats starting at 6 hours after middle cerebral artery occlusion, and daily thereafter over the next 12 weeks resulted in significant amelioration of stroke-induced motor and neurological deficits, which was maintained up to 24 weeks post-stroke. Histopathological assessment of stroke brains from NSI-189-treated animals revealed significant increments in neurite outgrowth as evidenced by MAP2 immunoreactivity that was prominently detected in the hippocampus and partially in the cortex. These results suggest NSI-189 actively stimulated remodeling of the stroke brain. Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF. These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hour time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke.

Edited by muntjac, 01 March 2017 - 08:55 PM.

[bugsbunny]

@muntjac

Your link isnt working. The human brain is more complex anyways.

 

"Where is the best place to get this stuff (NSI-189)"

There is no serious NSI-189 source, because its not allowed to synthesize NSI. You have to trust privat persons that buy their stuff in china.

 

 

"Has anyone gotten constipation from NSI out of curiosity? "

No

 

"Does anyone have experience with making solutions from NSI-189 for oral/sublingual dosing both from the freebase and phosphate form. What are good candidates for solvents, which would keep it stable for up to a month? "

Isnt NSI-189 stable more then a month itself? You could try DMSO. Dunno if its smart to play with potency of NSI-189.

 

 

[muntjac]

They expire the PDF links to full text for some reason, here's the abstract. The PDF link is on the left.

[Tryptamine]

 

"Does anyone have experience with making solutions from NSI-189 for oral/sublingual dosing both from the freebase and phosphate form. What are good candidates for solvents, which would keep it stable for up to a month? "

Isnt NSI-189 stable more then a month itself? You could try DMSO. Dunno if its smart to play with potency of NSI-189.

 

Do you think that 50/50 ethanol/water solution would also do the trick? 

[Mind_Paralysis]

NSI-189, a Small Molecule with Neurogenic Properties, Exerts Behavioral and Neurostructural Benefits in Stroke Rats

 

Enhancing neurogenesis may be a powerful stroke therapy. Here, we tested in a rat model of ischemic stroke the beneficial effects of NSI-189, an orally active, new molecular entity (mol. wt. 366) with enhanced neurogenic activity, and indicated as an anti-depressant drug in a clinical trial (Fava et al., 2015) and being tested in a Phase 2 efficacy trial (ClinicalTrials.gov, 2016) for treatment of major depression. Oral administration of NSI-189 in adult Sprague-Dawley rats starting at 6 hours after middle cerebral artery occlusion, and daily thereafter over the next 12 weeks resulted in significant amelioration of stroke-induced motor and neurological deficits, which was maintained up to 24 weeks post-stroke. Histopathological assessment of stroke brains from NSI-189-treated animals revealed significant increments in neurite outgrowth as evidenced by MAP2 immunoreactivity that was prominently detected in the hippocampus and partially in the cortex. These results suggest NSI-189 actively stimulated remodeling of the stroke brain. Parallel in vitro studies further probed this remodeling process and demonstrated that oxygen glucose deprivation and reperfusion (OGD/R) initiated typical cell death processes, which were reversed by NSI-189 treatment characterized by significant attenuation of OGD/R-mediated hippocampal cell death and increased Ki67 and MAP2 expression, coupled with upregulation of neurogenic factors such as BDNF and SCF. These findings support the use of oral NSI-189 as a therapeutic agent well beyond the initial 6-hour time window to accelerate and enhance the overall functional improvement in the initial 6 months post stroke.

 

YES!! ^^

This is some EXCELLENT news...! : D Because I have a friend who suffers from persistent fatigue from a stroke, as well as some cognitive deficits from the ordeal as well. With this, there's definitely indication that he should try NSI-189! = )

Only problem is he also suffers from neuropathic pain as well, from the surgery when they went in to decrease pressure from the build-up of blood in his brain - but, if I ever get an AM-404 group buy going, then that should take care of any neuropathy as well. (he currently uses medical cannabis with good results when it comes to the neuropathy - but AM-404 should be better, less cognitive deficits.)
 

[Bukujutsu]

A warning about stopping NSI-189. I traded 25g from Strangelove. Which lasted me...10 months if I'm making a silly mistake on the basic math. I had a very significant reduction in depression and particularly anhedonia, could enjoy some things again, and it even prevented my seasonal affective disorder, which had consistently set in every year once the weather dropped and lowered my already low mood, with a particularly bad effect on energy levels/motivation. Based on the proposed mechanism of action I wanted to see what changes I would occur. I believe I may recall multiple members mentioning that the real improvements were noticeable when they stopped.

 

It's a major mistake not to leave enough of a substance you depend on set aside just in case you ever need it. You do not want to experience that, don't wait too long before reordering.

 

I'm rapidly sliding back in the higher ranges of severe depression. I'm neurologically abnormal and am most likely going to need to be on the strongest antidepressants available for the rest of my life. I've tried an enormous amount of substances, close to what Redan has, and nothing has ever made me feel "happy" and all the associated emotions of a healthy mindset, they've just made life tolerable.
 

Shame the US healthcare system is such a disgrace and you'll have a damn hard time finding a doctor willing to consistently prescribe you high doses of Nardil. Apparently endless years of suffering, stagnation, incredible damage to your health and well being, and an even higher rate of suicide than you're already predisposed to (Fun fact, people with Asperger's live on average 12 years longer than general, mostly because of suicide. Suicidal ideation, 10x, higher than even psychosis. Some of the highest comorbidities for severe general and social anxiety, depression, and OCD; not to mention some of the poorest life outcomes.)

 

I just want something that works, I've suffered my entire life and I can't imagine continuing like this for decades.

Edited by Bukujutsu, 04 March 2017 - 12:40 AM.

[jaiho]

Did you find NSI-189 more effective than Nardil, bukujutsu?

 

I'm similar to you i'd say. Last time i was on NSI, as soon as i ran out it was an immediate fall into severe depression, almost as soon as the drug leaves my system. So it's fairly biologically based for some of us.

 

 

[Bukujutsu]

Unfortunately the idiotic psychiatrist took me off because I went hiking in a regional park for the first time in years due to my depression and anxiety already greatly receding, and I slid down a slope and ended up with systemic poison ivy (not life threatening, but I was pretty red and swollen).  She didn't even taper me off, she thought that due to the half-life it would be fine, but takes a few days at least and is utterly idiotic to do to someone that is severely depressed. I was having brain zaps, suddenly feelings of shock while moving.

 

I didn't have enough time on it to really gauge it, I was only receiving 45mg and there tends to be a threshold effect. I'm taking matters into my own hand. Came across an odd source for phenelzine sulfate by luck and at a fair price. Will have it tested if it goes through. If it doesn't work out, I want to set up a group buy and would value any recommendations for a lab that could synthesize it or help from someone that has done this before. It's terrible to be in a constant state of suffering for years on end without change in sight.

 

[Fletch]

Did you find NSI-189 more effective than Nardil, bukujutsu?

 

I'm similar to you i'd say. Last time i was on NSI, as soon as i ran out it was an immediate fall into severe depression, almost as soon as the drug leaves my system. So it's fairly biologically based for some of us.

 

I feel for you Bukujutsu, hang in there. I'm waiting to hear back from Strangelove and asked him how he thought Nardil and NSI-189 might feel together since I'm on Nardil (75mg).

 

Have you tried Ketamine? TMS is really expensive but that may help you too. I happen to live near UCSD in San Diego and will be hopefully starting TMS and possibly ketamine there soon. NSI-189 seems to act similarly to TMS via left-hippocampal activity/nuerogenesis. NSI-189 might be a much cheaper alternative to TMS. Hopefully Strangelove can help me. Nardil/TMS/ketamine/NSI-189 seems like ultimate combo for depression but maybe too much?

[Bukujutsu]

I actually tried (es)ketamine years ago and documented my experience on a message board. Got it off Silk Road just as its effects on depression were starting to make headlines. Even made a saline solution and bought this thing you could attach to a luer lock syringe to use it as a nasal spray, although just snorting it works better.

 

It's fantastic for a rapid reversal of depression by a few points, a nice motivating/anti-anhedonic effect the next day, but for me it ultimately proved to be insufficient.

 

I'd still recommend keeping some stored in case there's ever an emergency, if you're feeling seriously suicidal.

Edited by Bukujutsu, 04 March 2017 - 04:25 PM.

[wanderlust]

I actually tried (es)ketamine years ago and documented my experience on a message board. Got it off Silk Road just as its effects on depression were starting to make headlines. Even made a saline solution and bought this thing you could attach to a luer lock syringe to use it as a nasal spray, although just snorting it works better.

 

It's fantastic for a rapid reversal of depression by a few points, a nice motivating/anti-anhedonic effect the next day, but for me it ultimately proved to be insufficient.

 

I'd still recommend keeping some stored in case there's ever an emergency, if you're feeling seriously suicidal.

 

while sailing in the south china seas I used it for tooth ache , it worked well but was a little moreish.

 

if you happen to be in Peru or parts of the world where its legally permitted i would suggest trying ayahuasca.

 

it can really give one a higher perspective on ones life.

Edited by wanderlust, 04 March 2017 - 09:01 PM.

[Bukujutsu]

I think the doorway to psychedelics will remain shut for a very long time at least. It's a shame, I've read the works of Stanislav Grof and various other authors and believe they hold enormous potential for rapidly accelerating therapeutic progress when used properly.

 

Right now I just need more NSI-189 and hopefully my phenelzine source will come through. Found it from an unusual source ay a fair price. This could change everything if test results come back positive.

[Shai Hulud]

 

Did you find NSI-189 more effective than Nardil, bukujutsu?

 

I'm similar to you i'd say. Last time i was on NSI, as soon as i ran out it was an immediate fall into severe depression, almost as soon as the drug leaves my system. So it's fairly biologically based for some of us.

 

I feel for you Bukujutsu, hang in there. I'm waiting to hear back from Strangelove and asked him how he thought Nardil and NSI-189 might feel together since I'm on Nardil (75mg).

 

 

What dosages of NSI-189 did you guys use? A question applying for all of you who are falling back quickly in depression after stopping.

[Bukujutsu]

I was using 20mg 4 times a day.

[bugsbunny]

Ketamine, DMT, Psylocibin can be useful but hold high risk of increasing damage instead of healing. Ketamine on regular basis will cause braindamage. This stuff is too unusual in the effect to fit in society and wont be what people are searching for because the picture of these drugs are transfigured. The trip to much of a challenge for the standard human. I would call it a 50/50 change of damage/healing ratio and personally I would advise against it.

[Twindaddy37]

In an experiment I decided to double my dosage of NSI for a day, and experienced what some others have described as anxiety- it was more of a restless feeling, like restless mind and body. Interesting since nsi makes me more serene. Obviously this substance is dose dependent and those experiencing side effects should find the sweet spot. I  am sad to see others experiencing a rebound in depressive symptoms with discontinuation of this substance. The first time I used it for one month only, I seemed to feel more motivated when I stopped it but it could have been purely coincidental. I am planning on running it for about a full year, so I guess we will see what happens when I stop. 15-20 mg twice daily seems to be my sweet spot, I don't see the benefit in taking more than this.

[Twindaddy37]

Ketamine, DMT, Psylocibin can be useful but hold high risk of increasing damage instead of healing. Ketamine on regular basis will cause braindamage. This stuff is too unusual in the effect to fit in society and wont be what people are searching for because the picture of these drugs are transfigured. The trip to much of a challenge for the standard human. I would call it a 50/50 change of damage/healing ratio and personally I would advise against it.

 The research on psylocibin for treating depression seems positive. Ketamine does not seem safe. DMT and psylocibin for occasional use for the hormetic response seems appropriate.

Edited by Twindaddy37, 06 March 2017 - 03:43 PM.

[Twindaddy37]

A little off topic here, for those lurking this thread already taking NSI that aren't commenting in here much. What do you find pairs well with NSI and what else are you stacking for overall body health. I have tweaked my stack for 2 years and landed on one that gives me the most optimal mindset. Nsi 15-20mg twice daily, tianeptine sulfate 50mg once daily, polygala twice daily, lithium orotate 5mg at bedtime, vitamin d (for wintertime use) 5kiu, 1 gram fish oil, ocassional lions mane, 2 times a week 300mcg of melatonin, creatine,  uridine, multivitamin every 3 days, 2.5mg of iodine mon-fri and on Saturdays only phenibut 500mg 3xdaily. I have also recently added liposomal vitamin c, liposomal glutathione and astaxathin 12mg to blast for a month for a good detox, which I plan to do every 3 months or so. My mood and mental clarity are they best they have ever been on this stack, the only thing I have been itching to try is intranasal semax. I did a 4 week course of intranasal insulin which I feel had some lasting benefits.  I would like to hear any feedback or ideas, or other people routines that work very well for them.

[Yaguare44]

@twindaddy37: for me it's not so much a question of what i stack with it, rather what i don't. for example, i find an nsi-cycle is better without much of caffeine usage.

tianeptine and phenibut and stuff like that i dont take with the nsi...

on the other hand i use a lot of stuff for overall body health, but it does not have anything to do with the nsi... magnesium, zinc, vitamin d, iodine... i use up to 10 grams fishoil per day... i use gynostemme extract 2-3 times a day.  creatine daily...

occasional liposomal vitamin c, i use citrulline-malate a few times per week. fasoracetam a few times per month... niacin (the flush version, 500mg on empty stomach with orangejuice) 1-2 times per week.  MSM daily... ALCAR, NAC daily (!!)... chlorella... and guess what i also use MMS now...

 

maybe look into citrulline, fasoracetam and gynostemma extract... 1g of fish oil is not a lot.

 

why do you take the uridine ?

Edited by Yaguare44, 06 March 2017 - 06:37 PM.

[Mind_Paralysis]

@twindaddy37: for me it's not so much a question of what i stack with it, rather what i don't. for example, i find an nsi-cycle is better without much of caffeine usage.

tianeptine and phenibut and stuff like that i dont take with the nsi...

on the other hand i use a lot of stuff for overall body health, but it does not have anything to do with the nsi... magnesium, zinc, vitamin d, iodine... i use up to 10 grams fishoil per day... i use gynostemme extract 2-3 times a day.  creatine daily...

occasional liposomal vitamin c, i use citrulline-malate a few times per week. fasoracetam a few times per month... niacin (the flush version, 500mg on empty stomach with orangejuice) 1-2 times per week.  MSM daily... ALCAR, NAC daily (!!)... chlorella... and guess what i also use MMS now...

 

maybe look into citrulline, fasoracetam and gynostemma extract... 1g of fish oil is not a lot.

 

why do you take the uridine ?

 

 

No, 1 gram ain't a lot - but TEN grams, that's pushing it...!

We've got several threads about people who have been using such dosages, over a long period of time (admittedly, some also while supplementing Alpha-GPC and such), and whom have been struck with what can only be described as "persistent Acetacholinergic Syndrome" - a state where your choline-methylation seems to become stuck in overdrive, causing severe depression, anxiety, and above all - crushing brain-fog.

 

You might want to consider lowering that limit of yours a bit - 6-8 grams should easily be enough.
 

Edited by Stinkorninjor, 06 March 2017 - 08:11 PM.

[jaiho]

I was using 20mg 4 times a day.

 

Never heard anyone dosing this often.

What effects did you notice? Remission or partial response to your depression?

[Twindaddy37]

@twindaddy37: for me it's not so much a question of what i stack with it, rather what i don't. for example, i find an nsi-cycle is better without much of caffeine usage.

tianeptine and phenibut and stuff like that i dont take with the nsi...

on the other hand i use a lot of stuff for overall body health, but it does not have anything to do with the nsi... magnesium, zinc, vitamin d, iodine... i use up to 10 grams fishoil per day... i use gynostemme extract 2-3 times a day.  creatine daily...

occasional liposomal vitamin c, i use citrulline-malate a few times per week. fasoracetam a few times per month... niacin (the flush version, 500mg on empty stomach with orangejuice) 1-2 times per week.  MSM daily... ALCAR, NAC daily (!!)... chlorella... and guess what i also use MMS now...

 

maybe look into citrulline, fasoracetam and gynostemma extract... 1g of fish oil is not a lot.

 

why do you take the uridine ?

 

My mission is one of creating a highly resilient mental space so that my mind can heal from past damages (8 years of heavy narcotic abuse, and lots of them while living an extremely fast paced lifestyle that was filled with chronic stress that beat my body and mind into the ground). I have experimented for two years to find the perfect combination of substances that has made me most resilient to my life stressors- and i take the appropriate actions to grow both spiritually, emotionally and mentally. The damage left me with some pretty gnarly imbalances, namely alot of constant worrying, a flat mood and alot of negative self talk. I did manage to fix this and live in a pretty decent headspace for about 7 months, without anything. Then i was living on own and stress was little. Out of blue i was blessed with twin girls, and my life became VERY hectic again- so i needed fortification. My mission to fix the physical, nutritional and mental imbalances led me to finding an appropriate stack that works best with my chemistry, that gives me no side effects- and this is what i have settled on. I have used most of the adaptogenic herbs, gynostemma ect. I find that anything over 1 gram of fish oil hurts my libido and it is afterall a PUFA, which is why i limit my dosage of fish oil. Also like stinkornijor said, i found that fish oil in excess hurts mood. I also take MCT oil, which i think is healthier. I have not tried fasoracetam whats the benefit of this substance? Doesnt NSI have a niacin like component to it? The only niacin i get is in a multi. MSM did nothing for me. I do take mag citrate every three days before bedtime. I try not to overdo anything and strive for balance. My goal is to build stress resilience, which is why i also do some cold exposure therapy. I figure if i can create a headspace where i am simply (mostly) living in the present, my mind will have the optimum potential to grow and rewire where there was damage from the past. I cut out all media, social media, news, politics, groups of people with opinions, commercials and just INFORMATION in general, aside from this forum, so that i can learn to live through my intuition again, and i find there has been ALOT of growth in doing so.I also "minimized"- got rid of shit i didnt need or use basically to simplify.  Uridine i use for dopamine receptor modulation. I use phenibut on the weekend one day as a tool to be as social as possible, so i can flex the social muscles. 

Edited by Twindaddy37, 07 March 2017 - 04:02 PM.