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NSI-189

nsi-189

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#5671 greendholia

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Posted 30 October 2017 - 04:12 AM

 

Also just to add, 3rd day nsi 189

 

I just took a nap and the dreams were intense

 

I was dreaming of flying my hot air balloon through a jungle, chilling with different people, then the scenery shifted to a desert, nukes going off, then I was going to find a shaman, then I found a medicine woman, then I found people in a trailer, then I was randomly dating and talking to random women, saw gwyneth paltrow, ended up fighting some random guy. really amazing stuff, in really cool detail. haven't had such vivid dreams in a while, it felt like it itched some scratch in me that wanted to create inner worlds or something, i feel like the aftereffect of creating and having all those dreams was very healing. very interesting substance.

 

great to hear :)

 

how are your blocked emotions today?  still feeling effects? - i have emoitional flatness also. ive got nsi at home but im waiting cuz of my other stuff im trying atm

did u get free base or phosphate? and did u buy from strangelove?

 

 

They are still processing through although a little less so, the effects feel like slight mdma+lsd low dose. I got it from strangelove, dont know if freebase or phosphate, waiting for his response.



#5672 Strangelove

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Posted 30 October 2017 - 03:39 PM

Hi greendholia, Its the phosphate form, I think is best to try phosphate first at 20mg/40mg orally, a few have reported increased side effects with sublingual freebase. First I thought that it was dose related as sublingual freebase is more potent, but possibly its quick absorption also is what gives increased anxiety to few members that do not get from phosphate. 

 

There is no reason for anyone to get side effects, just start with a very low dose, you can always use more just a little later in the day. Great to hear about the good results some are getting, and others to be negative about their source. I could not know, possibly is NSI-189, but do not expect that it works for everyone, try a smaller amount first and give it some time.

 

I am still getting a number of benefits myself more than three years now. The one thing that really I do not want to miss, and I ll be taking NSI-189 for a long time (even in a as needed basis) its the positive state I am getting into, when I am out in social envinronments. I can connect at a deeper level with much more people, feeling that everyone is positive towards me, and I naturally reciprocate. This is with the addition of tianeptine, noopept or alcohol, as NSI-189 alone can put me in a positive but (even more) introspective state.

 

 


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#5673 ThreeKings12341

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Posted 30 October 2017 - 07:42 PM

good read streangelove!

 

s it ok to try sarcosine with nsi??



#5674 Water Buffalo

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Posted 31 October 2017 - 08:42 AM

good read streangelove!

s it ok to try sarcosine with nsi??


It is safe with d-serine, so presumably it's safe with sarcosine. Actually, they compliment each other very nicely.

#5675 Strangelove

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Posted 31 October 2017 - 02:30 PM

 

good read streangelove!

s it ok to try sarcosine with nsi??


It is safe with d-serine, so presumably it's safe with sarcosine. Actually, they compliment each other very nicely.

 

 

I would think similar, one of the things that I have found surprising is that so far (having read most online posts about NSI-189 and from PMs) I cannot think anything that is clearly contraindicated with NSI-189. Of course maybe this is not the case, but the large majority of combinations I have read, NSI-189 seems to boost and improve the effects of other "nootropics". Anyone that got a negative reaction with another chemical, except a boost in effects that requires a smaller dose from the chemicals in the combo?



#5676 bagbak

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Posted 01 November 2017 - 09:11 AM

Does anyone have any recommendations for dealing with NSI-induced anxiety? I can't seem to find any remedies. I believe it's augmenting Modafinil's anxiety-inducing effects... I've tried taking NSI without Moda, but the fatigue was too much. Caffeine does not seem to be strong enough and seems to be somewhat of a loop anyway (caffeine raises cortisol and NSI lowers it). I'm taking 40mg freebase everyday. I've tried taking it at night instead and that did not do much either.  Maybe 20mg am and 20mg pm?



#5677 Mind_Paralysis

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Posted 01 November 2017 - 09:47 AM

Does anyone have any recommendations for dealing with NSI-induced anxiety? I can't seem to find any remedies. I believe it's augmenting Modafinil's anxiety-inducing effects... I've tried taking NSI without Moda, but the fatigue was too much. Caffeine does not seem to be strong enough and seems to be somewhat of a loop anyway (caffeine raises cortisol and NSI lowers it). I'm taking 40mg freebase everyday. I've tried taking it at night instead and that did not do much either.  Maybe 20mg am and 20mg pm?

 

Dividing the dosages is one good idea - you can even divide it into THREE separate dosings, as that's been proven to be the best dosing-schedule in the studies - so,

 

20 mg morning +

10 mg lunch +

10 mg evening.

 

However, it sounds like you need to add a real-deal anxiolytic as well - I suggest adding Escitalopram, or high-dose Magnesium-L-Threonate.

 

It should be noted that some people are sensitive to the NMDA-antagonistic properties of MagLT though, and won't just get anxiolysis, but could also start experiencing depersonalisation/derealisation - so, keep that in mind.

 

As a rule, it should be ok as long as you're more SCT, ADHD or Autism than you are DP/DR or Schizoidal.



#5678 bagbak

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Posted 01 November 2017 - 10:23 PM

Thanks Stinkorninjor , I take magnesium regularly. I take L-theanine, and the occasional lithium.  They seem to level me out much more, it nor enough though and I do not take lithium/theanine every day... I might start to.  I was thinking about doing your dosing but I wouldn't be able to do the midday one due to work.  I was thinking about switching over to phosphate, splitting the dose, and using the lithium/theanine/magnesium and maybe Rhodiola for the fatigue. 



#5679 bialas55

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Posted 02 November 2017 - 07:20 AM

Has anyone tried to take phosphate sublingually, I am inclined towards this option. In the national forum a person who took phosphate this way and oral, wrote that she does not see the difference in action. On the other hand, all phosphate studies were conducted oral, phosphate compounds also reported to have better oral bioavailability



#5680 dmmbbs

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Posted 03 November 2017 - 04:08 AM

Does anybody know the pKa value of NSI-189 phosphate? Since sublingual pH is slightly acidic (about 6.5), the more the pKa,the less the absorption.

#5681 bagbak

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Posted 06 November 2017 - 01:43 AM

Just wanted to mention something in case it can help anyone here... I've been taking NSI-189 Freebase for 3 weeks at 40mg.  Taking 40mg first thing was a bit intense, so I now split it 20/20.  What I wanted to share is that I have been taking modafinil pretty regularly well before I started taking NSI.  I had some random rage episodes that I did not attribute to Modafinil at all. I have been taking Modafinil sporadically for years but never as consistently as I have in the last few months. 200mg a day about 4-5 days out of the week.  I feel like the Modafinil's side effects are augmented by the NSI. Modafinil has side effects of anger, depersonalization, and a plethora of other issues in many users (not all)... The "hyperemotional" side effect of NSI seems to augment the side effects of Modafinil for me. Just thought I'd share.



#5682 swegab

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Posted 06 November 2017 - 06:17 PM

Anyone that have experience taking this for ssri discontinuation syndrome,I haven't taken an ssri pill for six weeks but are having disturbing symptoms like bad sleep, brain zaps, fatigue, bad memory, myalgia.

Can nsi 189 help with these symptoms and heal the brain or is it gonna make it worse?

Edited by swegab, 06 November 2017 - 06:18 PM.


#5683 Mind_Paralysis

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Posted 06 November 2017 - 07:49 PM

Anyone that have experience taking this for ssri discontinuation syndrome,I haven't taken an ssri pill for six weeks but are having disturbing symptoms like bad sleep, brain zaps, fatigue, bad memory, myalgia.

Can nsi 189 help with these symptoms and heal the brain or is it gonna make it worse?

 

Some claim that it does, but there is NO proof that it would help with such symptoms.

 

Also, it's not a case of "healing the brain" when dealing with Serotonin-increasing discontinuation (it's not just SSRI's, ANY drug which increases extracellular serotonin seems to cause this effect, to one extent or another) - there's no damage to your brain, it's just an extreme over-reaction from your brain, trying to achieve homeostasis, balance, again - a more apt comparison would be like an allergic reaction, where your body overcompensates, causing bad symptoms.

 

I would suggest just going back on an SSRI again, to relieve the symptoms - preferably Fluoxetine, since that's the SSRI with the longest half-life, making it the easiest to discontinue. A small dosage of Fluoxetine for a while should sort you out.



#5684 bagbak

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Posted 08 November 2017 - 03:59 AM

Has anyone had worsening of depression on NSI? I feel like the last couple of days I've been very down in the dumps and in the "what's the point" kind of attitude about everything.  My anxiety has also increased quite a bit and I'm tense the majority of the time.  I'm on week 3 of freebase @40mg.  I'm far for apathetic and glum that I normally am.  It could be because I stopped modafinil, but I did not take it on weekends and did not feel like this. I thought it could be from the time change(SAD) but I use plenty of blue light which has helped me in the past. Any help would be appreciated... 



#5685 greendholia

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Posted 08 November 2017 - 05:35 PM

Has anyone had worsening of depression on NSI? I feel like the last couple of days I've been very down in the dumps and in the "what's the point" kind of attitude about everything.  My anxiety has also increased quite a bit and I'm tense the majority of the time.  I'm on week 3 of freebase @40mg.  I'm far for apathetic and glum that I normally am.  It could be because I stopped modafinil, but I did not take it on weekends and did not feel like this. I thought it could be from the time change(SAD) but I use plenty of blue light which has helped me in the past. Any help would be appreciated... 

 

Not really...but what I found from taking NSI 189 is that it doesn't seem to really be a supplement you take every single day, it seems to have more the dosing schedule of lsd or something where you can only take it 1 or 2 or 3 times max a week depending on the dosage.

 

I was taking it everyday and it was making me really tired...like the same tiredness I get if I am over-using a supplement. 

 

Maybe try not using it for a few days to recover, then you can get back on it



#5686 bagbak

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Posted 09 November 2017 - 02:52 AM

 

Has anyone had worsening of depression on NSI? I feel like the last couple of days I've been very down in the dumps and in the "what's the point" kind of attitude about everything.  My anxiety has also increased quite a bit and I'm tense the majority of the time.  I'm on week 3 of freebase @40mg.  I'm far for apathetic and glum that I normally am.  It could be because I stopped modafinil, but I did not take it on weekends and did not feel like this. I thought it could be from the time change(SAD) but I use plenty of blue light which has helped me in the past. Any help would be appreciated... 

 

Not really...but what I found from taking NSI 189 is that it doesn't seem to really be a supplement you take every single day, it seems to have more the dosing schedule of lsd or something where you can only take it 1 or 2 or 3 times max a week depending on the dosage.

 

I was taking it everyday and it was making me really tired...like the same tiredness I get if I am over-using a supplement. 

 

Maybe try not using it for a few days to recover, then you can get back on it

 

Thank you for the suggestion. I end my month this Sunday, and if only for completion, I'll continue that for now since it's only a couple more days. Afterward, if I feel better off of it, but markedly more less-depressed than when I started NSI...It will have been worth it to me. Maybe this is why not many people use the Freebase?



#5687 Mind_Paralysis

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Posted 09 November 2017 - 09:17 PM

 

 

Has anyone had worsening of depression on NSI? I feel like the last couple of days I've been very down in the dumps and in the "what's the point" kind of attitude about everything.  My anxiety has also increased quite a bit and I'm tense the majority of the time.  I'm on week 3 of freebase @40mg.  I'm far for apathetic and glum that I normally am.  It could be because I stopped modafinil, but I did not take it on weekends and did not feel like this. I thought it could be from the time change(SAD) but I use plenty of blue light which has helped me in the past. Any help would be appreciated... 

 

Not really...but what I found from taking NSI 189 is that it doesn't seem to really be a supplement you take every single day, it seems to have more the dosing schedule of lsd or something where you can only take it 1 or 2 or 3 times max a week depending on the dosage.

 

I was taking it everyday and it was making me really tired...like the same tiredness I get if I am over-using a supplement. 

 

Maybe try not using it for a few days to recover, then you can get back on it

 

Thank you for the suggestion. I end my month this Sunday, and if only for completion, I'll continue that for now since it's only a couple more days. Afterward, if I feel better off of it, but markedly more less-depressed than when I started NSI...It will have been worth it to me. Maybe this is why not many people use the Freebase?

 

 

There aren't many reports on worsened depression to my knowledge (on any form of NSI), however increasingly bad fatigue and somnolence (being tired) is commonly reported - there are also reports of more anxiety as a side-effect from Freebase.

 

It should be noted... the form which Neuralstem chose to use in its trials, is the Phosphate version - not the freebase.

 

That's why I myself chose Phosphate, since that's the tried and tested form - possibly, Neuralstem noted not just issues with bio-availability, but also with side-effects, prior to starting the official trials?
 



#5688 Kodiak

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Posted 09 November 2017 - 09:53 PM

Hi all,

 

I wanted to write a little about my initial experiences with NSI-189. I've been a member of this site for about 2 years now and check the main board/new posts pretty much daily while I'm in the office M-F. It's weird to me how this massive NSI thread was sitting right under my nose for so long without me checking it out to learn more about this interesting drug. I immersed myself in this thread about a month ago and read whatever I could find on Reddit too and finally secured a gram. Quick backstory, been on SSRIs in the past (Celexa and Paxil) and benzos, all of which were prescribed for anxiety. I've had many panic attacks in my past, as well. I walk around each day with a "knot" (tension) in the middle of my chest, which I think is a physical manifestation or response to my mind/thinking patterns which are always future-thinking of the what-if or worrying sort. I'm kind of always on high alert and definitely a perfectionist. I can't say I've ever been depressed but I wouldn't say I feel a lot of happiness either, if that makes sense. My father committed suicide in 2011, and after that I went into therapy hoping to sort through his death and my own issues and concerns, as he and I are/were wired the same. I imagine his anxiety and perfectionist tendencies rubbed off on me through the years. As I was undergoing therapy, I found Zen meditation and reiki, both of which helped and still help me tremendously. These two practices have definitely made life easier for me but that underlying tension and sense of doubt/fear/edginess is still present in me and runs pretty deep. After reading all of the NSI experiences, some calling this drug "life-changing" and "like a spot of sunshine deep in the brain" I couldn't help but wonder if NSI would flip some internal switch in me, too. I can remember only a handful of times in maybe the last 20 years where I didn't feel like I was carrying around this weight or tightness: 3 times were some pretty amazing openings from Zen experiences, one time after my first reiki session, and of course a few times after my first benzo uses. I guess, to sum things up, I'm looking for a degree of "ease" or "relief" or "lightness" in how I feel and, maybe more importantly, how I think.

 

I started with 20 mg last Tuesday, the 31st and kept at that amount for 7 days. Since I only purchased a gram and the consensus seems to keep on it for around 30 days, I wanted to start lower and eventually ramp up, which is good practice anyway when trying some thing new, I feel. Since this Tuesday, the 7th, I've increased my dosage to 30 mg/day. 

 

So far:

-No negative side effects. At all. No tiredness, no increased anxiety, no pins and needles in my extremities, no headaches, no changes in libido. 

-I use smokeless tobacco and nicotine gum while at work, and one strange thing I notice is that while I still crave nicotine, when I put a dip in or pop a piece of gum, I feel that the effects of nicotine are severely blunted so I don't get as much of a kick from it. Then, after a few minutes of not getting any "rush" from the nicotine, I end up spitting the dip or gum out. I think I could quit nicotine much easier with NSI on my side.

-I feel more motivated. My girlfriend and I had a baby last December, so sleeping, getting to the gym, keeping up with my consistent meditation practice, pretty much all aspects of the life I used to have before the birth have gone out the window. After starting NSI, something kicked in mentally. Maybe it's subliminal in the sense that after reading a lot of posts on here encouraging exercise and meditation while on NSI, I started up again, but I don't think that's it, more like something lit the fire again.

-I've taken a lot of research chems, supplements and herbs over the years, along with a decent amount of PEDs. I've never really questioned who's making all of this stuff or of what quality is it. Yet, some mornings when I'm weighing out my NSI on the digital scale, I catch myself questioning just what the hell I'm doing taking some unapproved white powder out of this little ziplock bag from some guy I never met. I mean I shake my head at myself out of both excitement AND a little fear because, unlike say a vial of GHRP or HCG, NSI is allegedly affecting my brain. It's a little funny to me what it's come down to in an effort to find a little happiness, if anyone can relate.

-I feel a bit more sure of myself. Daily stressors and life in general has gotten just a little bit easier.

-Lastly, and most important, I find myself getting these random little insights, almost on a daily basis, insights that open up my thinking a bit. NSI is almost like meditation in powdered form. I wish I could elaborate more but I get these minor epiphanies (is any epiphany minor?) and my thinking is adjusted just a notch to "the better side" if that makes sense. I know I've just started but I'm optimistic about what the next few weeks bring as I increase the dose. I may order more once my gram supply runs out so I can see where else it takes me. 

 

The edginess/low-grade anxiety I feel and what I think is the resulting tightness in my chest still persist. If I could get rid of that I'd be grateful. If anyone has any suggestions I'd love to hear them. But, as a meditator, part of me thinks it's "just my energy" as my Zen teacher always tells me, and that I should embrace it and smile at it. Easier said than done, right? :)

 

Thanks for reading!


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#5689 Mind_Paralysis

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Posted 10 November 2017 - 12:03 PM

Hi all,

 

I wanted to write a little about my initial experiences with NSI-189. I've been a member of this site for about 2 years now and check the main board/new posts pretty much daily while I'm in the office M-F. It's weird to me how this massive NSI thread was sitting right under my nose for so long without me checking it out to learn more about this interesting drug. I immersed myself in this thread about a month ago and read whatever I could find on Reddit too and finally secured a gram. Quick backstory, been on SSRIs in the past (Celexa and Paxil) and benzos, all of which were prescribed for anxiety. I've had many panic attacks in my past, as well. I walk around each day with a "knot" (tension) in the middle of my chest, which I think is a physical manifestation or response to my mind/thinking patterns which are always future-thinking of the what-if or worrying sort. I'm kind of always on high alert and definitely a perfectionist. I can't say I've ever been depressed but I wouldn't say I feel a lot of happiness either, if that makes sense. My father committed suicide in 2011, and after that I went into therapy hoping to sort through his death and my own issues and concerns, as he and I are/were wired the same. I imagine his anxiety and perfectionist tendencies rubbed off on me through the years. As I was undergoing therapy, I found Zen meditation and reiki, both of which helped and still help me tremendously. These two practices have definitely made life easier for me but that underlying tension and sense of doubt/fear/edginess is still present in me and runs pretty deep. After reading all of the NSI experiences, some calling this drug "life-changing" and "like a spot of sunshine deep in the brain" I couldn't help but wonder if NSI would flip some internal switch in me, too. I can remember only a handful of times in maybe the last 20 years where I didn't feel like I was carrying around this weight or tightness: 3 times were some pretty amazing openings from Zen experiences, one time after my first reiki session, and of course a few times after my first benzo uses. I guess, to sum things up, I'm looking for a degree of "ease" or "relief" or "lightness" in how I feel and, maybe more importantly, how I think.

 

I started with 20 mg last Tuesday, the 31st and kept at that amount for 7 days. Since I only purchased a gram and the consensus seems to keep on it for around 30 days, I wanted to start lower and eventually ramp up, which is good practice anyway when trying some thing new, I feel. Since this Tuesday, the 7th, I've increased my dosage to 30 mg/day. 

 

So far:

-No negative side effects. At all. No tiredness, no increased anxiety, no pins and needles in my extremities, no headaches, no changes in libido. 

-I use smokeless tobacco and nicotine gum while at work, and one strange thing I notice is that while I still crave nicotine, when I put a dip in or pop a piece of gum, I feel that the effects of nicotine are severely blunted so I don't get as much of a kick from it. Then, after a few minutes of not getting any "rush" from the nicotine, I end up spitting the dip or gum out. I think I could quit nicotine much easier with NSI on my side.

-I feel more motivated. My girlfriend and I had a baby last December, so sleeping, getting to the gym, keeping up with my consistent meditation practice, pretty much all aspects of the life I used to have before the birth have gone out the window. After starting NSI, something kicked in mentally. Maybe it's subliminal in the sense that after reading a lot of posts on here encouraging exercise and meditation while on NSI, I started up again, but I don't think that's it, more like something lit the fire again.

-I've taken a lot of research chems, supplements and herbs over the years, along with a decent amount of PEDs. I've never really questioned who's making all of this stuff or of what quality is it. Yet, some mornings when I'm weighing out my NSI on the digital scale, I catch myself questioning just what the hell I'm doing taking some unapproved white powder out of this little ziplock bag from some guy I never met. I mean I shake my head at myself out of both excitement AND a little fear because, unlike say a vial of GHRP or HCG, NSI is allegedly affecting my brain. It's a little funny to me what it's come down to in an effort to find a little happiness, if anyone can relate.

-I feel a bit more sure of myself. Daily stressors and life in general has gotten just a little bit easier.

-Lastly, and most important, I find myself getting these random little insights, almost on a daily basis, insights that open up my thinking a bit. NSI is almost like meditation in powdered form. I wish I could elaborate more but I get these minor epiphanies (is any epiphany minor?) and my thinking is adjusted just a notch to "the better side" if that makes sense. I know I've just started but I'm optimistic about what the next few weeks bring as I increase the dose. I may order more once my gram supply runs out so I can see where else it takes me. 

 

The edginess/low-grade anxiety I feel and what I think is the resulting tightness in my chest still persist. If I could get rid of that I'd be grateful. If anyone has any suggestions I'd love to hear them. But, as a meditator, part of me thinks it's "just my energy" as my Zen teacher always tells me, and that I should embrace it and smile at it. Easier said than done, right? :)

 

Thanks for reading!

 

Thank you for the report.

 

I know of another fellow with a persistent anxiety-disorder, PTSD, which took NSI-189 and actually described it similar to you - according to him, it's "mindfulness in powdered form".

 

I've usually had one such experience as well, mostly at the start of each NSI-cycle. It's nothing consistent for me though, unlike what it is for you and him.

 

 

I suppose it makes some sense, that some would respond like that, since the drug was developed by DARPA, presumably to get shell-shocked, aka PTSD-stricken soldiers with trauma-induced Depression back on their feet. (and ready to literally kick ass)

 

As for the anxiety - the physical symptoms can be removed by medications which lower activity in the peripheral nervous system, norepinephrine-modulators - there are two which are indicated in anxiety and have shown good effects through the years - they also, dose-dependently, inhibit signalling from the AMYGDALA, the center of the brain which handles fear and response to outward stimuli.

 

Guanfacine

Propranolol

 

Both of those drugs are also used for high blood-pressure - but get the dosage right... and they might just work on your symptoms as well.


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#5690 bialas55

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Posted 11 November 2017 - 02:57 PM

I read posts from 100 to 190 and I did not find a clear statement someone that phosphate taken sublingually also works properly, there was another 100. I also read that they were organized Groupbuy, or are they still organized, I suspect not?



#5691 Charles Thompson

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Posted 14 November 2017 - 12:39 PM

Does anyone know anybody selling this at an affordable price?

#5692 Strangelove

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Posted 15 November 2017 - 01:25 PM

Does anyone know anybody selling this at an affordable price?

 

I have been sending 5grams NSI-189 / $90 (including registered shipping) to other members for more than two years now, with a further discount for more. Right now I am in a trip outside my country and I did not think was a good idea to get a lot with me. I have already shipped all the prepackaged amount I had, but If nothing changes, I ll be back in one week.



#5693 ThreeKings12341

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Posted 15 November 2017 - 08:26 PM

double post


Edited by ThreeKings12341, 15 November 2017 - 08:26 PM.


#5694 ThreeKings12341

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Posted 15 November 2017 - 08:28 PM

 

hey! are u still seeing improvements? And are the improvements u mentioned still present?   u take the nsi with water or...?


Edited by ThreeKings12341, 15 November 2017 - 08:28 PM.


#5695 bialas55

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Posted 18 November 2017 - 06:11 PM

Which vendor of alibaby is most trustworthy? I suspect that from there it is best not to order from here, but in the near future it maybe my only option. I see there are signs at 1YR, 2YR, how about something on private mail, not in the main thread.

#5696 CaptainJ

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Posted 19 November 2017 - 10:08 AM

I may not be a legend here yet, but I can vouch from StrangeLove.  The guy lives up to his name, really.  At any rate, I can vouch that he sends the stuff.  I am not familiar with it and havent experimented much yet, so that's all I'll clearly say for now, but I have a good feeling whatever quality he represents, he fulfills. I feel I have spoken as much as I can without overspeaking.  I am in the middle of an experiment with something else now, but this thread has inspired me to add this in, even though I accidentally experimented with St John's Wort earlier to help induce the cyp3A4 enzyme that would help eliminate something more quickly.  I now wish I hadn't, because it turned out after checking my voicemail that it was completely unnecessary, and has prevented me from eating pizza, cheese, and other things I would have partaken of tonight...even though Ive read the maoi thing supposedly isnt that real, I have had really bad night sweats once when using SJW very short term for this same purpose when I had a small window of time...

 

So while I am here, and it may be too late once I see an answer, would St John's Wort for whatever reason have an adverse reaction with either NSI-189 or Noopept?(in the search from the web that led me hear, I saw the brief description claiming a POSITIVE reaction, though I couldnt find the actual post(pg 189) while skimming the thread.   Thanks, I appreciate your help, folks.  And I also appreciate StrangeLove for giving me this oppportunity, whatever I make of it.  While I understand folks' concerns about the gentleman, I hope to assuage you of them.  I suppose I could also add some real combination data for one sitting, even more than I mentioned, if anyone is interested.  I haven't really read this thread yet, so let me know if that is something folks want us to share.  I'm not sure how we should word things about stuff that's not for human consumption, I want to do right by StrangeLove and by this great forum.   


Edited by CaptainJ, 19 November 2017 - 10:23 AM.

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#5697 Mind_Paralysis

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Posted 19 November 2017 - 10:54 AM

I may not be a legend here yet, but I can vouch from StrangeLove.  The guy lives up to his name, really.  At any rate, I can vouch that he sends the stuff.  I am not familiar with it and havent experimented much yet, so that's all I'll clearly say for now, but I have a good feeling whatever quality he represents, he fulfills. I feel I have spoken as much as I can without overspeaking.  I am in the middle of an experiment with something else now, but this thread has inspired me to add this in, even though I accidentally experimented with St John's Wort earlier to help induce the cyp3A4 enzyme that would help eliminate something more quickly.  I now wish I hadn't, because it turned out after checking my voicemail that it was completely unnecessary, and has prevented me from eating pizza, cheese, and other things I would have partaken of tonight...even though Ive read the maoi thing supposedly isnt that real, I have had really bad night sweats once when using SJW very short term for this same purpose when I had a small window of time...

 

So while I am here, and it may be too late once I see an answer, would St John's Wort for whatever reason have an adverse reaction with either NSI-189 or Noopept?(in the search from the web that led me hear, I saw the brief description claiming a POSITIVE reaction, though I couldnt find the actual post(pg 189) while skimming the thread.   Thanks, I appreciate your help, folks.  And I also appreciate StrangeLove for giving me this oppportunity, whatever I make of it.  While I understand folks' concerns about the gentleman, I hope to assuage you of them.  I suppose I could also add some real combination data for one sitting, even more than I mentioned, if anyone is interested.  I haven't really read this thread yet, so let me know if that is something folks want us to share.  I'm not sure how we should word things about stuff that's not for human consumption, I want to do right by StrangeLove and by this great forum.   

 

I would be very interested in hearing your results from taking NSI-189 with various compounds... every bit of data can be useful, in the end.

 

I wouldn't combine NSI-189 with SJW though... because there IS NO official data on this - we have NO idea how NSI-189 metabolises - or if it even metabolises at all. (some medications, like Gabapentin for instance, hardly metabolises at all, leaving the body almost untouched.)
 

When it comes to the metabolism of NSI-189, I suggest having a look at the compounds its related too, and try to see if there's any connection between how THEY metabolise:
 

Nicotinamide

Pyrazine

Momelotinib

 

Are some of the substances which have chemical similarities to NSI-189.

 

It could very well be that SJW would interfere a LOT with NSI-189, since it interferes with nearly anything under the sun - we just don't know... In essence, I wouldn't use SJW with any kind of research chemical - it's too dangerous!

 

 

In closing, why do you even want to try SJW? It's generally considered weak-sauce for actual depression, you know - there's studies to back this up. You're better off with low-dose Tianeptine if you want something without SSRI-style effects, for dysthymia.



#5698 CaptainJ

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Posted 19 November 2017 - 11:21 AM

 

I may not be a legend here yet, but I can vouch from StrangeLove.  The guy lives up to his name, really.  At any rate, I can vouch that he sends the stuff.  I am not familiar with it and havent experimented much yet, so that's all I'll clearly say for now, but I have a good feeling whatever quality he represents, he fulfills. I feel I have spoken as much as I can without overspeaking.  I am in the middle of an experiment with something else now, but this thread has inspired me to add this in, even though I accidentally experimented with St John's Wort earlier to help induce the cyp3A4 enzyme that would help eliminate something more quickly.  I now wish I hadn't, because it turned out after checking my voicemail that it was completely unnecessary, and has prevented me from eating pizza, cheese, and other things I would have partaken of tonight...even though Ive read the maoi thing supposedly isnt that real, I have had really bad night sweats once when using SJW very short term for this same purpose when I had a small window of time...

 

So while I am here, and it may be too late once I see an answer, would St John's Wort for whatever reason have an adverse reaction with either NSI-189 or Noopept?(in the search from the web that led me hear, I saw the brief description claiming a POSITIVE reaction, though I couldnt find the actual post(pg 189) while skimming the thread.   Thanks, I appreciate your help, folks.  And I also appreciate StrangeLove for giving me this oppportunity, whatever I make of it.  While I understand folks' concerns about the gentleman, I hope to assuage you of them.  I suppose I could also add some real combination data for one sitting, even more than I mentioned, if anyone is interested.  I haven't really read this thread yet, so let me know if that is something folks want us to share.  I'm not sure how we should word things about stuff that's not for human consumption, I want to do right by StrangeLove and by this great forum.   

 

I would be very interested in hearing your results from taking NSI-189 with various compounds... every bit of data can be useful, in the end.

 

I wouldn't combine NSI-189 with SJW though... because there IS NO official data on this - we have NO idea how NSI-189 metabolises - or if it even metabolises at all. (some medications, like Gabapentin for instance, hardly metabolises at all, leaving the body almost untouched.)
 

When it comes to the metabolism of NSI-189, I suggest having a look at the compounds its related too, and try to see if there's any connection between how THEY metabolise:
 

Nicotinamide

Pyrazine

Momelotinib

 

Are some of the substances which have chemical similarities to NSI-189.

 

It could very well be that SJW would interfere a LOT with NSI-189, since it interferes with nearly anything under the sun - we just don't know... In essence, I wouldn't use SJW with any kind of research chemical - it's too dangerous!

 

 

In closing, why do you even want to try SJW? It's generally considered weak-sauce for actual depression, you know - there's studies to back this up. You're better off with low-dose Tianeptine if you want something without SSRI-style effects, for dysthymia.

 

 

(please forgive my penmanship, I'm not completely myself at the moment for various reasons)

Oh, I completely agree!  I was using it short term(2 doses of 300mg x .3, then stopped because it was no longer needed) to induce the cyp3A4 enzyme that would help eliminate something more quickly.  it was maybe 6 and a half hours ago, the 2nd of the 2 capsules.  The nsi-189 was about 20mg, and maybe 8-10mg of Noopept with it, and that was an hour ago.  No noticable effects yet, nor no I really expect any, and that may play a part....nocebo effect?  Things dont seem to effect me as much as the average person(I think it is subconscious programming), or at least I dont seem sensitive enough to notice them...  I am not sure you can imagine the frustration of reading about all these "miracles" on here, and actually being the "non-healthy" people they are actually spposed to have an effect on, and every rarely noticing anything, let alone miracles. 

 

I admit I can get impatient and know full well it would have been more prudent to wait until the SJW was flushed, but due to personal reasons I felt like taking a small dose, and adding to the anecdotal data.  If the sponsor(I do studies sometimes, so Im used to referring to them that way) is reading this, maybe they will appreciate the free legwork we're putting in for them.   

 

I avoided some marked down nice looking cheese I bought tonight, as well as the frozen pizza I had planned to eat due to the SJW, but being I'd actually measured out the noopept and nsi-189 earlier, added to personal reasons, I felt alright doing it being I had only dosed twice and the last one was a decent bit ago, despite the long half life.  I want to state I clearly dont encourage anyone imitate me in any way or take this data as anything other than how it worked out for one person.  I do believe I saw someone in the search engine results claim a positive interaction, but did not see it in the actual forum.

 

I dont want to go back into hiding, It took much "experimenting" tonight to get me to post...that and encouragement to speak up for Strangelove when I saw others questioning his character.  I did not want to see his name besmirched, and it prompted me to actually post, lol.  I hope I dont return to "shunned" mode, lol.  Cheers to the whole lot of ya!  


Edited by CaptainJ, 19 November 2017 - 11:28 AM.


#5699 Mind_Paralysis

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Posted 19 November 2017 - 04:28 PM

 

 

I may not be a legend here yet, but I can vouch from StrangeLove.  The guy lives up to his name, really.  At any rate, I can vouch that he sends the stuff.  I am not familiar with it and havent experimented much yet, so that's all I'll clearly say for now, but I have a good feeling whatever quality he represents, he fulfills. I feel I have spoken as much as I can without overspeaking.  I am in the middle of an experiment with something else now, but this thread has inspired me to add this in, even though I accidentally experimented with St John's Wort earlier to help induce the cyp3A4 enzyme that would help eliminate something more quickly.  I now wish I hadn't, because it turned out after checking my voicemail that it was completely unnecessary, and has prevented me from eating pizza, cheese, and other things I would have partaken of tonight...even though Ive read the maoi thing supposedly isnt that real, I have had really bad night sweats once when using SJW very short term for this same purpose when I had a small window of time...

 

So while I am here, and it may be too late once I see an answer, would St John's Wort for whatever reason have an adverse reaction with either NSI-189 or Noopept?(in the search from the web that led me hear, I saw the brief description claiming a POSITIVE reaction, though I couldnt find the actual post(pg 189) while skimming the thread.   Thanks, I appreciate your help, folks.  And I also appreciate StrangeLove for giving me this oppportunity, whatever I make of it.  While I understand folks' concerns about the gentleman, I hope to assuage you of them.  I suppose I could also add some real combination data for one sitting, even more than I mentioned, if anyone is interested.  I haven't really read this thread yet, so let me know if that is something folks want us to share.  I'm not sure how we should word things about stuff that's not for human consumption, I want to do right by StrangeLove and by this great forum.   

 

I would be very interested in hearing your results from taking NSI-189 with various compounds... every bit of data can be useful, in the end.

 

I wouldn't combine NSI-189 with SJW though... because there IS NO official data on this - we have NO idea how NSI-189 metabolises - or if it even metabolises at all. (some medications, like Gabapentin for instance, hardly metabolises at all, leaving the body almost untouched.)
 

When it comes to the metabolism of NSI-189, I suggest having a look at the compounds its related too, and try to see if there's any connection between how THEY metabolise:
 

Nicotinamide

Pyrazine

Momelotinib

 

Are some of the substances which have chemical similarities to NSI-189.

 

It could very well be that SJW would interfere a LOT with NSI-189, since it interferes with nearly anything under the sun - we just don't know... In essence, I wouldn't use SJW with any kind of research chemical - it's too dangerous!

 

 

In closing, why do you even want to try SJW? It's generally considered weak-sauce for actual depression, you know - there's studies to back this up. You're better off with low-dose Tianeptine if you want something without SSRI-style effects, for dysthymia.

 

 

(please forgive my penmanship, I'm not completely myself at the moment for various reasons)

Oh, I completely agree!  I was using it short term(2 doses of 300mg x .3, then stopped because it was no longer needed) to induce the cyp3A4 enzyme that would help eliminate something more quickly.  it was maybe 6 and a half hours ago, the 2nd of the 2 capsules.  The nsi-189 was about 20mg, and maybe 8-10mg of Noopept with it, and that was an hour ago.  No noticable effects yet, nor no I really expect any, and that may play a part....nocebo effect?  Things dont seem to effect me as much as the average person(I think it is subconscious programming), or at least I dont seem sensitive enough to notice them...  I am not sure you can imagine the frustration of reading about all these "miracles" on here, and actually being the "non-healthy" people they are actually spposed to have an effect on, and every rarely noticing anything, let alone miracles. 

 

I admit I can get impatient and know full well it would have been more prudent to wait until the SJW was flushed, but due to personal reasons I felt like taking a small dose, and adding to the anecdotal data.  If the sponsor(I do studies sometimes, so Im used to referring to them that way) is reading this, maybe they will appreciate the free legwork we're putting in for them.   

 

I avoided some marked down nice looking cheese I bought tonight, as well as the frozen pizza I had planned to eat due to the SJW, but being I'd actually measured out the noopept and nsi-189 earlier, added to personal reasons, I felt alright doing it being I had only dosed twice and the last one was a decent bit ago, despite the long half life.  I want to state I clearly dont encourage anyone imitate me in any way or take this data as anything other than how it worked out for one person.  I do believe I saw someone in the search engine results claim a positive interaction, but did not see it in the actual forum.

 

I dont want to go back into hiding, It took much "experimenting" tonight to get me to post...that and encouragement to speak up for Strangelove when I saw others questioning his character.  I did not want to see his name besmirched, and it prompted me to actually post, lol.  I hope I dont return to "shunned" mode, lol.  Cheers to the whole lot of ya!  

 

 

I think you penned fairly well, considering the circumstances. = )

 

Anyways, I think you did the right thing with coming out of lurking and giving us your two cents! I hope to see more of you on the forums, perhaps you can even start a thread of your own, for your particular, unique issues? (I'm sensing a long history of some form or another, in you)

I think many people do report quite a bit of placebo btw, so don't take every report too unskeptically - the overall pattern I've seen, is that NSI-189 seems to mostly be effective for a specific type of depression, and not necessarily more so than SSRI's or MAOI's are for other forms of depression. (this is more or less what the trials have concluded as well, as far as I can tell)

 

Where it really shines, is in those of us whom have lighter, or harsher, cognitive damage of some kind.

 

 

PS: Many have reported that the benefits can take up to a month, similar to other forms of antidepressants - so there's miles to go, mate!

 

(personally, when I first used it and was the most impaired, depressed and burnt out, I'd say I noticed benefits about... 5 days into it - then it grew, until it plateaued about 3 weeks in)


Edited by Stinkorninjor, 19 November 2017 - 04:31 PM.


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#5700 normalizing

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Posted 20 November 2017 - 05:31 AM

hi i was trying to purchase NSI 189 from this UK guy on the forum who opened his own site selling powders and for some reason his site is defective so anyway i couldnt get anything. i have to ask, where else to go to purchase some of this at this desperate point??







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