All you can do is try it, MedMad.
It has helped alot of people but there's no guarantee it'll work for you.
If you want to maximize your chances of response, theres some 'broscience' anecdotes that show it mixes well with MAOIs.
Posted 05 August 2018 - 02:47 PM
All you can do is try it, MedMad.
It has helped alot of people but there's no guarantee it'll work for you.
If you want to maximize your chances of response, theres some 'broscience' anecdotes that show it mixes well with MAOIs.
Posted 05 August 2018 - 04:55 PM
Posted 05 August 2018 - 05:05 PM
Thank you.. exelent post.. at the moment trying to take Lithium orotate 10/15mg a day with omega 3 high dose & NAC when needed .. it’s not working to well .. I wonder if NAC & LiO have this magic effect you mentioned .. also, for anyone interested in buying NSI-189 phosphate powder at very low cost, I did a packet of research & found a reputable supplier through a person on Reddit who has bought from this source.. it’s a company called Xi’an Lyphar Biotech Ltd .. can be found on Alibaba.com.. ask for Cathy.. price quoted, $75 for 10g or $40 for 5g + $15 for delivery.. hope it’s ok to put this info as it might help people.. if not just delete it from my post.. however I’m not sure how I’m going to mesure 20 or 40mg quantities without some very accurate scales & Ill have to buy some empty pills..
Posted 06 August 2018 - 09:07 PM
Q.D is once a day dosing. So 40mg QD means you take 40mg total in a day.
QD is latin for quaque die (Which in Latin means once a day)
You'll also come across BiD and TiD on these forums. They mean twice a day (BiD) and three times a day (TiD) respectively.
Thank you for the info.
But looking at these results it seems like it's better if you take it 3 times a day?
Posted 07 August 2018 - 12:01 AM
Posted 07 August 2018 - 02:17 PM
IRC.BIO got more NSI-189 Phosphate back in stock!
I can attest to it's authenticity and their reported high quality (≥99% purity).
Since they're closing down operations it's at considerable discount too. Maybe a good time for other NSI'ers to stock up
BTW: I am in no way affiliated with IRC.Bio, I only shared because MedMad posted his link to a Swedish supplier. So I checked my former source that I thought was sold out and was happily surprised.
Posted 10 August 2018 - 09:13 AM
IRC.BIO got more NSI-189 Phosphate back in stock!
I can attest to it's authenticity and their reported high quality (≥99% purity).
Since they're closing down operations it's at considerable discount too. Maybe a good time for other NSI'ers to stock up
BTW: I am in no way affiliated with IRC.Bio, I only shared because MedMad posted his link to a Swedish supplier. So I checked my former source that I thought was sold out and was happily surprised.
Sorry to bother you, but regarding my post above why do you think it seems to be better to take it once daily when the findings in the image suggested 3 times?
Posted 10 August 2018 - 01:52 PM
Sorry to bother you, but regarding my post above why do you think it seems to be better to take it once daily when the findings in the image suggested 3 times?
It's no bother at all Robin, I'm glad you asked.
For me personally:
The reason I'm working right now with a dose of 40mg once a day is from experience/experimentation and my outlook.
I tried a few different doses when starting with NSI. When I tried 40mg BiD (Once at waking once before bed) I was waking up with headaches after 4 days. With 40mg QD (at waking) I don't experience any headaches at all. So that's part of it; I don't experience any negative side effects this way.
Another part of the reason I'm dosing in the lower range is that I don't think taking more is going to lead to bigger gains in the long haul. I think it's safer (this is a untested chemical after all) to go low and slow for longer periods of time than take a risk with higher dosages and maybe short-circuit something. I'm about 2 months on now and I'm continuing to notice improvements in my mood and general cognitive abilities. It's not a race for me to get better or like some situation I cannot deal with psychically; so I'm just taking it easy and allowing the changes to come gradually while I can monitor them.
The images I think you're referring to (the ones showing brain activation sites, right?) demonstrated that at the lower dosage change is still happening and that's why I think my low and slow approach is a smart choice. It saves a bit of money too. If you're into that sort of thing.
I hope I answered your question Robin, but if not let me know and I'll try to explain better (I only had a few minutes before work to write this).
PS (At work now): I am considering upping the dosage to 50mg a day when I hit the two month mark and if I still havn't noticed adverse effects, but it will still be QD to avoid the overnight headache issue I had before.
-∞
Edited by 2Aleph Naught, 10 August 2018 - 02:35 PM.
Posted 11 August 2018 - 01:37 AM
Gotta brief field report to add to the thread. Ended up starting a regimen of NSI 189 Phosphate a few weeks ago. I started with a 5 mg test dose then started to titrate up starting at 20 mg by 5 mg a day until I reached 40 mg. I noticed a lift in mood pretty early on as well as a pressure headache but once I reached 40 mg I could barely function so I began to taper back down by 5 mg a day to see if I could find a sweet spot. On the day I reached 40 mg I noticed my hand was cramping which I thought was strange and also began to feel some tingling in my hands. I hoped reducing my dose would get rid of these symptoms as I had read about paresthesia being of the unusual negative side effects of this compound but even as I kept reducing my dose the tingling continued and began to turn into pain. I thought perhaps it would fade away if I persisted but eventually I erred on the side of caution and quit after 8 days of dosing (not including my 5 mg test dose). As I was tapering down I began having persistent pain in my arms, hands, knees, and feet and I began to get sore doing things I normally do.
For reference, I have been working in manual labor for the past three years and never had any real issues with soreness, yet now I began to get sore after walking around or doing a brief stint on the stationary bike. Also, I would wake up and my arms/elbows would be numb in the middle of the night and early morning and my sleep schedule was deeply disturbed since I couldn't fall asleep at night. It has been just over three weeks now since I quit my trial. The tingling has reduced and my arms are rarely falling asleep now but my legs and knees especially have persistent pain that gets worse when I do light exercise. I am hoping that my pain continues to lessen as at one point I was unsure if I would be able to play music or workout (two of the things that help me make it through my days) and now I have reached the point where I can play music with little pain (hands are better).
I really wish I could have tolerated this compound as I felt it had antidepressant effects on me despite its drawbacks. Unexpectedly, I noticed an increase in libido and noticed that I didn't feel so worn out post-orgasm which isn't an effect I have read too often (besides MizTen for the + in libido) at least from memory. I am going to take a long break and if in many months time my body is pain free I will try a very low dose trial of Freebase to see if I can handle that but I am quite paranoid about having persistent nerve pain.
On a related note to this post if anyone wants discounted NSI-189 Phosphate that I got my IRC.Bio, I have almost a gram that I will not be consuming and would be happy to sell to someone who can tolerate it. PM me for details, I am in the Bay Area also if anyone wants to save on shipping.
Anywho, thanks to all who have made this experiment possible with both its great benefits and its risks and good luck to all trying to reach the elusive state of happiness.
Edited by synkyr, 11 August 2018 - 01:38 AM.
Posted 12 August 2018 - 12:31 AM
I meant to say I have almost 15 grams also, not a gram.
Posted 13 August 2018 - 01:57 AM
Posted 13 August 2018 - 02:42 PM
Posted 14 August 2018 - 11:38 PM
Posted 15 August 2018 - 06:56 PM
Posted 15 August 2018 - 08:41 PM
Can you please tell me the best way to dose the powder phosphate version of NSI-189 ? I don’t have scales (yet) .. got 5g .. can I put it in a liquid of some kind or should I weight it or can someone send me a tiny 10 or 20mg scoop please.. of course I’ll pay for it. I need to start it fast.. can guessing work like a dab on the finger ? Probably not the best way
Hey MedMad I can tell you're anxious to get started with NSI but I have a bit of bad news for you. You're going to need a scale for proper dosing.
What you mentioned about using a liquid would only apply to make a measured solution. Like an amount of water + NSI-189 powder = mg/ml mixture. You'd need a scale to make this.
The other idea you had about scoops is also a no-go because of the different possible powder density. Mg is a measure of weight not one of volume. A scoop of powder can weigh differently depending on lots of things unfortunately.
You'll either have to wait for scales or risk it with a guessed at dose. If you choose to risk it I'd suggest at least keeping the scoop size the same and err on the side of caution with smallish amounts.
If you haven't got a scale on order I recommend this guy right here, it's accurate and fairly inexpensive.
-
∞
Edited by 2Aleph Naught, 15 August 2018 - 08:43 PM.
Posted 16 August 2018 - 01:54 PM
Can you please tell me the best way to dose the powder phosphate version of NSI-189 ? I don’t have scales (yet) .. got 5g .. can I put it in a liquid of some kind or should I weight it or can someone send me a tiny 10 or 20mg scoop please.. of course I’ll pay for it. I need to start it fast.. can guessing work like a dab on the finger ? Probably not the best way
Why didn't you order some scoops and some pill-capsules at the same time you ordered the NSI-189? They're everywhere on Amazon and ebay, man.
Anyways, if you have something else to mix the powder with, another 5 grams of, say, corn starch, then that would be great - because then you can more easily divide it into dosages. Remember, the bigger the amount of total powder, the more accurate the dosage of NSI-189.
(cornstarch is used in many, many official medications)
https://www.drugs.co...-starch-30.html
Here's a more detailed description of how to cap powders:
https://nootropicsci...pplement-blend/
Note that many other ingredients can be used, like protein powder - it depends a bit on the compound though, not all fillers are inactive enough for some medical substances.
https://www.braintro...ropic-capsules/
Anyways, here's a quick run-down of how many dosages you can at least eyeball the powder to be divided into:
5000 mg / 40 mg = 125 dosages.
5000 mg / 20 mg = 250 dosages.
If you have some way of dividing the powder up, you can just try and make a 125 reasonably equal piles of powder (for 40 mg per dosage), and then you take a pile every time you dose.
If you decide to mix it with cornstarch, to make it easier to divide, then the amount of piles is the same, just twice the size. (if you have 5000 mg nsi + 5000 mg cornstarch in one big pile)
Here, I recommend you just buy some caps and a scoop and get to it:
https://purebulk.com...hines-capsules/
Corn starch you can either get from amazon or from your local convenience store.
Posted 16 August 2018 - 02:58 PM
Posted 16 August 2018 - 03:43 PM
thank you so much.. I received scales & empty pills I bought on aliexpress (it’s a platform for buying single items from China).. 1000 empty caps was €8 & scales were $11 though not the same as u showed.. they are not perfect but hope they will do.. it’s still incredibly difficult to dose correctly the pills.. I’m starting with 10mg pills no filler just the phosphate powder.. can i ask how long it took before the effects can be felt ? I’m really in a bad way, I hope this stuff helps.
I'm afraid it seems to vary quite a bit, the onset of effect - for some of us, like me, the effect can be felt after but a few days, for others it takes several weeks - for yet another group, I've seen them mention NO EFFECT, except side-effects, until they DISCONTINUE the drug after a few weeks - if one has then followed the recommended one-month dosing schedule, then one suddenly realizes ones mood is going up dramatically.
If you're lucky, you'll feel it fairly quickly.
BTW, you're not bipolar, are you? If you are, you might go into mania very quickly - some have mentioned how it only took them a few hours to go full manic from NSI-189 - only with the addition of Lithium did the drug have the correct effect. This is logical, since mood-stabilizers are usually required for every other form of antidepressant, when bipolar patients are treated.
Edited by Mind_Paralysis, 16 August 2018 - 03:45 PM.
Posted 17 August 2018 - 09:26 AM
Posted 17 August 2018 - 11:45 AM
I’ve never been diagnosed as bi-polar, but since coming off certain drugs the withdrawals resemble mania sometimes.. I’ve always been treated for depression & anxiety.. but I must admit my symptoms are resembling bi-polar & giving me ADs the past year makes me aggressive.. but there were times in the past that I took only an AD (was a tricyclic) & was ok, so I don’t think I’m manic depressive.. infact i suspect my brain has been screwed by 20 years of drugs.. if I have got a perminant disfunction I don’t know what it is exactly.. all I know is the front of my brain feels totally numb, like it does not function anymore. I’m on 2nd day of NSI.. started at 20mg.. will see how it goes.. took 10mg this morning will take another 10mg this afternoon.. I’ve got headaches, confusion, crippling anxiety & fatigue/depression.. can NSI make you worse, especially at start of treatment ?
It can make anxiety worse, that's a common side-effect.
It usually takes a few days for those effects to take hold though. As far as I know, NSI-189 has, as of yet, unlike other antidepressants, not been reported or proven to worsen depressive thoughts or induce suicidality.
It does cause more fatigue though - anxiety and fatigue are two very common side-effects.
Posted 17 August 2018 - 05:43 PM
Posted 17 August 2018 - 05:45 PM
Posted 17 August 2018 - 06:03 PM
Can anyone tell me, does NSI-189 increase levels of serotonin, dopamine, noradrenaline or other neurotransmitters ?
Not to any extent that's plausible to have a noticeable (or be the source of AD) effect - the only possible exception is Norepinephrine, which is the highest affinity it has - this affinity is still very, very low.
At the moment, the main mechanism behind the drug is... completely unknown.
There are some ideas that it alters metabolism of amino-acids through some unknown pathway, but those are just speculations.
The company making the drug, Neuralstem, have claimed, and published, that they've done extensive testing on many, many systems of neurotransmitters, enzymes and activities in the body which NSI-189 does not appear to affect, concluding that the mechanism is unknown.
It's generally considered that they DO know how it works though, they just don't want to reveal it to their competitors, whom could then immediately start developing drugs with similar targets, potentially even more effective or tolerable.
Posted 17 August 2018 - 06:12 PM
Edited by bialas55, 17 August 2018 - 06:15 PM.
Posted 17 August 2018 - 06:29 PM
Posted 18 August 2018 - 06:36 PM
Posted 18 August 2018 - 08:13 PM
Posted 18 August 2018 - 09:36 PM
Don't think there is any danger when you take MDMA when on a NSI-189 cycle. Although other people might have more information about it.
Gotta say that am very happy with the effect of the NSI I've received. The one thing that is sometimes a bit weird is that I can be happy and confident for a few days and than on another day I feel a bit down again. Could it be because I started smoking weed again in the weekend?
There are a few previous reports that marijuana use can negate the benefits of NSI-189. The user Jaiho (among a few others) is probably one example.
Posted 18 August 2018 - 09:42 PM
Quick questions for you knowledgeable folks:
1. When using NSI and Tianeptine for social anxiety, what dose of Tianeptine do you use? Is that dose different than if Tianeptine were taken solo?
2. Similarly, when using NSI and Noopept, does it make much sense to dose Noopept in excess of 5-6 mg, or is that sufficient?
Thanks so much, in advance, for your thoughtful replies!
A rule of thumb would be to use half the amount of tianeptine from your NSI-189 dose.
A 5-6mg noopept dose, if it is sublingual it might be a little too much, for oral use, might be OK for many, but you can try a larger dose also.
Posted 18 August 2018 - 09:47 PM
Sorry for all the late replies in PMs, customs once again withhold my last batch, and I could not manage to release it this time. Nevertheless, I placed a new smaller order for the members I owe some with a new name/address. I have about 30 grams left from the same lab, that I have third party test three times these last four years. Having posted results in the past it is the only place I have not detected impurities (I have tested three labs). I will give contact details to any member that will contact me after I send the small amount I have on hand. I would have to stop shipping to others for good this time, both having the stress with customs and be very busy on my full-time day job.
Anyone that is interested could send any of the cryptocurrencies below, or an Amazon gift card. If you are an Amazon customer it takes literary a few seconds to send the gift card, you just fill in the amount and my email, just contact me to arrange it.
NSI-189 phosphate.
$20/1 gram
$80/ 5 grams
Tianeptine Sulfate.
$9/1 gram
Tianeptine Sodium
$9/1 gram
Please add a 10% on this if you want to send an Amazon gift card.
Honestly, for anyone trying NSI-189 for mood/anxiety/social boost, tianeptine according to a large reddit post is the best combination with NSI-189.
Due to a very busy schedule, I have had to give replies in PMs over 3-4 o clock in the morning, I cannot wait the date that my schedule will be a regular 8 days work day to read on new chemicals here, and enjoy some of my long-term hobbies now that my mood is better. I have been "surprised" how smooth all this went for the last past four years speaking with over 1000 members. Somehow I have more "chemistry" and mutual interests, with a majority of the members here than I have not had in my everyday life. This is a subject for another thread, but (hint) are we the majority here INTJ/P MBTI personalities, with a possible Enneagram 5. I will get back to this in another thread, not very scientific concepts, but great fun, and good tools for self-improvement nevertheless! I again have a one-week summer vacation, so I will reply to all (starting from tomorrow) very soon.
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