6219 replies to this topic

[nicklesprout]

So how many people have felt permanent effects from nsi..personally even after 6 weeks of not using nsi I still feeler found effects on memory and mood

 

what was your dosing schedule and for how long did you take it? did you take it orally or sublingually? phosphate or freebase? did you stack it with anything else?

[thedarkbobo]

So how many people have felt permanent effects from nsi..personally even after 6 weeks of not using nsi I still feeler found effects on memory and mood

 

Personally after 1 week/1 off/1 week the memory effect ceased after around 4-5 days (I was learning Italian words every day in a train to work and really felt the decrease). Mood effect is a bit lower too (~30-50%). But thats just me.

 

Offtopic: Did anyone use phenibut with NSI? I need something to hammer my stress - like this or Propranolol or lithium orotate.

Edited by thedarkbobo, 01 May 2015 - 05:42 PM.

[Strangelove]

Some good options seems to be (according to previous posts and my experience also) ashwagandha and L-theanine.

 

I find there is a strong interaction with NSI-189 and phenibut not necesserily bad, but can be overwhelming, phenibut is a dopamine releaser and I feel this is the nature of the interaction. I would not recommend phenibut for everyday use anyway, there are many reviews about this online, best to try an adaptogen as ashwagandha.

 

This list is helpful for other ideas.

 

http://organicindiau...-overall-herbs/

Edited by Strangelove, 01 May 2015 - 06:59 PM.

[pdelw]

Hi there.

At the beginning I would just say that I started taking NSI-189 because of minor depression, social anxiety and concentration problems. I've never been on any prescribed anti-depressants. I used to take some Armodafinil for some time to stay more awake and concentrated - it was only causing sleepiness for me, no noticeable profits. I was trying original noopept for 2 months for cognitive purposes, still no noticeable profits so I stopped taking it as well.

Current dosage: 40mg/day of NSI-189 in the morning.

 

Day one:
I took 40mg of NSI-189 at 5 pm. Very bitter flavour. After some time I started to have tinnitus which scared me a bit. No improve at the first day, but as I was reading effects might be seen after few weeks.

Day two:
I had a good sleep even with little squeak in head. Another 40mg at 8am, before work. Feeling a little bit dizzy at the beginning but it passed after half an hour. Felt a little bit increased mood and more concentrated. Less noticing social anxiety, maybe because emotions were a little bit repressed. The only problem was that at 10 o'clock I felt enormous need to sleep. Generally all effects last till the rest of the day, still hearing mild squeak in head and kind of pressure. Because of pressure my vision has changed a little bit.

Day three:
Sleeping without any problems. 40mg in the morning. Effects same as yesterday. I started drinking coffe to stay more awake - I'm not used to drink coffe at all, but being on NSI-189 seems to have good cooperation with it.

Day four:
Day off. Lot of things in mind to do. Energy to do some exercises, but only in the morning. After lunch I felt quite tired. I'm hungry for most of the time.

Day five:
Day off. I slept almost 11 hours - crazy. Still having tinnitus - I'm getting a bit worried about that. Relaxing for most of the day, nothing productive.

Day six:
I woke up normally after 8 hours. I had mild headache for few hours. No visible improve comparing to last few days. Still carrying on, hope it gets better after some more time. Maybe my dosage is too low? Still drinking coffe and some energy drinks - I haven't been drinking coffe before because it was causing more sleepiness than energy boost for me, but now I even kind of like it.

 

I'll try to update every few days my progress with NSI-189.

 

[Strangelove]

I'm 5 days into it. The headaches have have been random but usually have been getting a headache for at least several hours each day...some lasting longer up to 4-5 hours. I rarely get headaches. They are mild headaches but definitely feel headachey. The headache does have a feeling of pressure that encompasses the entire head but the pressure is most noticeable across the temples and behind the ears. I also have developed noticeably worse tinnitus.

 

Unfortunately your experience has a similarity with tinnitus and headache that Hebbeh reported, you might want to contact him for further details, if you have not done already.

 

I have a speedy thought, I like to research issues from many angles and I am naturally in a brain-storming state trying to be creative in writing fiction and non fiction, and been in a problem-solving state most of my time. When I first tried a small dose of NSI-189 I got a very calm feeling, and my previous state seemed like a subtle form of constant anxiety of positive or negative stress. I am saying this because you might experience something similar in a larger degree?

 

When I am getting larger doses, I am getting a good mood boost and feel increased confidence. I take a 40mg dose, adding the amount in the capsule of this ashwagandha brand I had a great experience in the past.

 

http://www.amazon.co...rds=ashwagandha

[pdelw]

 

I'm 5 days into it. The headaches have have been random but usually have been getting a headache for at least several hours each day...some lasting longer up to 4-5 hours. I rarely get headaches. They are mild headaches but definitely feel headachey. The headache does have a feeling of pressure that encompasses the entire head but the pressure is most noticeable across the temples and behind the ears. I also have developed noticeably worse tinnitus.

 

Unfortunately your experience has a similarity with tinnitus and headache that Hebbeh reported, you might want to contact him for further details, if you have not done already.

 

I have a speedy thought, I like to research issues from many angles and I am naturally in a brain-storming state trying to be creative in writing fiction and non fiction, and been in a problem-solving state most of my time. When I first tried a small dose of NSI-189 I got a very calm feeling, and my previous state seemed like a subtle form of constant anxiety of positive or negative stress. I am saying this because you might experience something similar in a larger degree?

 

When I am getting larger doses, I am getting a good mood boost and feel increased confidence. I take a 40mg dose, adding the amount in the capsule of this ashwagandha brand I had a great experience in the past.

 

http://www.amazon.co...rds=ashwagandha

 

 

Yes, I've been reading Hebbeh post before when I was looking for other people with tinnitus but I didn't speak to him yet.

 

Today I felt quite normal, a little bit increased confidence but nothing extremal.. I think it's getting more steady now. Will see during next few days/weeks...

 

For now I'm staying only on NSI-189, maybe with next order I'll get Ashwagandha or sth else to mix with

 

[Strangelove]

I am feeling much more social on NSI-189, is this a common effect?

 

I believe some people discussed this in the past.

 

I do not get more extroverted, but I have increased warm feelings towards others, especially when I restart a cycle. 

 

[pdelw]

I'm not sure about the social effect... I just find it easier to talk with people

 

A little update, after 12 days: Noticeable mood increase, slight motivation increase and willingness to do something. I find it much easier to deal with problems at work as well as personal ones. Hope it's not just placebo effect I'm still going to be 30 days on NSI-189, hope it will be only better now

[Blomj]

So I feel so silly writing this being that it's only day one of my taking 189, but I'm in such a different place mentally than I was yesterday, that I figured I post this.

 

I will say that I'm nearing the end of week 3 of taking 40mgs of strattera (I highly suspect I have SCT/CDD), so my mood today could be a result of the medication finally kicking in, but up until today I've been severely depressed. I've been ruminating on events and reliving horribly stupid, embarrassing and pathetic moments of my life more so than ever in the past. On top of that, I've been really down on myself for where I am in my life currently. This is an exercise in depression that compounds my usual self-deprecation about day-to-day life. It's not uncommon that I talk down to myself for long periods of time for doing something as simple as forgetting my coffee in the other room. I tend to ruminate on how faulty I am for being so forgetful... so that type of stuff. Needless to say, I'm good at at least one thing, and that's being depressed, lol.

 

Well, today I woke up at 3am and immediately the depressing ruminations started, and I laid in bed for about an hour before I said "F*ck it". I was waiting to see how strattera alone would help, but I was so low this morning, I didn't care about being scientific about taking the two at once. So, being in my reckless state, I took a 10mg scoop for sunifiram (that I never used) and used it to take 2 scoops of 189 orally. I should say the decision to use this scoop was after doing some research after the compounds structure and noting their similarity and visually inspecting the volume of the 5mg amounts I had of both. ***I don't recommend using this approach yourself! I do have a scale on order, currently*** After falling back to sleep and waking up around 11am, I tried to take another two scoops sublingually, but really just ended up taking it orally again. So at this point, maybe ~40gs.

 

At around 3pm my mood elevated significantly. A mother's day party I was going to avoid, due to my depression, I went to with a smile on my face. I was talking, joking and having a great time with family and friends. I was outside of my head, and I actually tried to depress myself on the drive over, but I really couldn't. During the party someone made a verbal jab at me, and where normally I would be hurt by it and get down, I made a joke and rolled with it and everyone responded well to my response. Nothing bothers me right now. It feels like I'm on ritalin and some sort of antidepressant. 

 

I almost hate that I feel this way after taking this for one day, because it just screams placebo effect. I'm usually one to roll my eyes at some user reports here that are similar to the one I just wrote, because it's not quantifiable, but I'm not one to usually get excited about trying new drugs. I've done a cycle of cerebrolysin, and not once did I feel a difference. There have been other nootropics that I've tried and not once felt anything. I'm almost afraid I'm going to regret writing this all after tomorrow, lol. I guess I'll see.

 

So that's my report out, now I need some tips on sublingually taking 189. Is there some trick that people here use? I tried to take a piece of paper with 189 on it and applied it under my tongue. I left the paper there for ~5mins but when I took it out, there was still some 189 on the paper. Is there another, better, method I should be using that someone could help me out with? Thanks!

[ceridwen]

This is probably the wrong method of application. I stick my middle finger in the powder get a tiny tiny bit of it stuck to my finger then stick it under my tongue and hope for the best

[Blomj]

Well, today I woke up at 3am and immediately the depressing ruminations started, and I laid in bed for about an hour before I said "F*ck it". I was waiting to see how strattera alone would help, but I was so low this morning, I didn't care about being scientific about taking the two at once. So, being in my reckless state, I took a 10mg scoop for sunifiram (that I never used) and used it to take 2 scoops of 189 orally. I should say the decision to use this scoop was after doing some research after the compounds structure and noting their similarity and visually inspecting the volume of the 5mg amounts I had of both. ***I don't recommend using this approach yourself! I do have a scale on order, currently*** After falling back to sleep and waking up around 11am, I tried to take another two scoops sublingually, but really just ended up taking it orally again. So at this point, maybe ~40gs.

 

Sorry, this is meant to be 40mgs. 

[Strangelove]

So I feel so silly writing this being that it's only day one of my taking 189, but I'm in such a different place mentally than I was yesterday, that I figured I post this.

 

I will say that I'm nearing the end of week 3 of taking 40mgs of strattera (I highly suspect I have SCT/CDD), so my mood today could be a result of the medication finally kicking in, but up until today I've been severely depressed. I've been ruminating on events and reliving horribly stupid, embarrassing and pathetic moments of my life more so than ever in the past. On top of that, I've been really down on myself for where I am in my life currently. This is an exercise in depression that compounds my usual self-deprecation about day-to-day life. It's not uncommon that I talk down to myself for long periods of time for doing something as simple as forgetting my coffee in the other room. I tend to ruminate on how faulty I am for being so forgetful... so that type of stuff. Needless to say, I'm good at at least one thing, and that's being depressed, lol.

 

Well, today I woke up at 3am and immediately the depressing ruminations started, and I laid in bed for about an hour before I said "F*ck it". I was waiting to see how strattera alone would help, but I was so low this morning, I didn't care about being scientific about taking the two at once. So, being in my reckless state, I took a 10mg scoop for sunifiram (that I never used) and used it to take 2 scoops of 189 orally. I should say the decision to use this scoop was after doing some research after the compounds structure and noting their similarity and visually inspecting the volume of the 5mg amounts I had of both. ***I don't recommend using this approach yourself! I do have a scale on order, currently*** After falling back to sleep and waking up around 11am, I tried to take another two scoops sublingually, but really just ended up taking it orally again. So at this point, maybe ~40gs.

 

At around 3pm my mood elevated significantly. A mother's day party I was going to avoid, due to my depression, I went to with a smile on my face. I was talking, joking and having a great time with family and friends. I was outside of my head, and I actually tried to depress myself on the drive over, but I really couldn't. During the party someone made a verbal jab at me, and where normally I would be hurt by it and get down, I made a joke and rolled with it and everyone responded well to my response. Nothing bothers me right now. It feels like I'm on ritalin and some sort of antidepressant. 

 

I almost hate that I feel this way after taking this for one day, because it just screams placebo effect. I'm usually one to roll my eyes at some user reports here that are similar to the one I just wrote, because it's not quantifiable, but I'm not one to usually get excited about trying new drugs. I've done a cycle of cerebrolysin, and not once did I feel a difference. There have been other nootropics that I've tried and not once felt anything. I'm almost afraid I'm going to regret writing this all after tomorrow, lol. I guess I'll see.

 

So that's my report out, now I need some tips on sublingually taking 189. Is there some trick that people here use? I tried to take a piece of paper with 189 on it and applied it under my tongue. I left the paper there for ~5mins but when I took it out, there was still some 189 on the paper. Is there another, better, method I should be using that someone could help me out with? Thanks!

 

I do not think its placebo, although it might have to do with a good interaction with strattera. Did you feel any overstimulation at all from the combination? 

[Blomj]

I would say yes, Strangelove. At one point, on my ride home with my father, I was talking a million miles a minute. It felt like I had a rapid swing from depressed to manic.

 

 

I'll keep a log of my use. Any suggestions for testing I could do before and after? I know of n-back, but other suggestions would be appreciated.

[Strangelove]

As I have gone through a similar state and speaking from my personal experience, I would try for a sustainable effect over time and not a constant euphoria.

I find NSI-189 very benign in side effects, but you should carefully try to measure its dose using a scale

 

http://www.ebay.com/...=item5d5394c7b2

 

or a 10mg measuring spoon (the only small size you could find I believe).

 

Again from my experience (and what I see from experiences on line) people get side effects, from getting larger doses from what is optimal, without probably realizing it.

 

I find cycling regular doses with much smaller doses an effective strategy for me.

 

 

[jaiho]

I've been using 40mg phosphate a day for the past two months, increased to 2x a day for the past 2-3 weeks.

 

The anti depressant effect for me is substantial.

My symptoms are:

 

Anhedonia / DP

No emotions

No physical pleasure / orgasm pleasure

Sometimes down mood but mostly flat.

 

NSI has reduced my DP, and increased pleasure & emotions from music & activites. The only thing im still chasing is more dopamine, which ill give Tramadol a go of

[stillwater]

I'm trying this for the second time, and as noted much earlier in this thread, I had to quit two weeks in due to extreme anxiety. I couldn't bring myself to throw it out though and after looking at it in my cupboard enough times, I've decide to try it again while throwing every anxiolytic I have at it to reduce the anxiety side effects.  I'm on day 4 now, and the only side I'm getting is an increase of an already existing case of tinnitus, this is a bit worrisome because well tinnitus sucks, I've noticed others have mentioned it as well. Perhaps stupidly I am going to keep taking it and hope that it's not permanent or gets even worse.

 

 

[Strangelove]

I'm trying this for the second time, and as noted much earlier in this thread, I had to quit two weeks in due to extreme anxiety. I couldn't bring myself to throw it out though and after looking at it in my cupboard enough times, I've decide to try it again while throwing every anxiolytic I have at it to reduce the anxiety side effects.  I'm on day 4 now, and the only side I'm getting is an increase of an already existing case of tinnitus, this is a bit worrisome because well tinnitus sucks, I've noticed others have mentioned it as well. Perhaps stupidly I am going to keep taking it and hope that it's not permanent or gets even worse.

 

They are many people in reddit, that combine NSI-189 with noopept to help with the anxiety. I do not get anxiety myself (maybe you should try a smaller dose?) but I have noopept and going to try to see if there is some kind of a synergistic effect. 

Edited by Strangelove, 12 May 2015 - 06:11 PM.

[stillwater]

 

I'm trying this for the second time, and as noted much earlier in this thread, I had to quit two weeks in due to extreme anxiety. I couldn't bring myself to throw it out though and after looking at it in my cupboard enough times, I've decide to try it again while throwing every anxiolytic I have at it to reduce the anxiety side effects.  I'm on day 4 now, and the only side I'm getting is an increase of an already existing case of tinnitus, this is a bit worrisome because well tinnitus sucks, I've noticed others have mentioned it as well. Perhaps stupidly I am going to keep taking it and hope that it's not permanent or gets even worse.

 

They are many people in reddit, that combine NSI-189 with noopept to help with the anxiety. I do not get anxiety myself (maybe you should try a smaller dose?) but I have noopept and going to try to see if there is some kind of a synergistic effect. 

 

 

Thanks for the suggestion, I might try it at some point.  I did lower the dose to 10mg a day this time around, and it seems to be working, plus I am beginning to notice some of the good effects. Also I'm using small doses of tianeptine, passionflower, cat's claw and baclofen at night. I'm not sure yet what to do with this tinnitus though.

[pdelw]

@stillwater

10mg? It's very low dose. I'm waiting for some opinions then if lower dose is enough for you. I'm going to finish current stack on 40mg dose, then I have holidays abroad and it might be risky to take it on the plane so probably I'll have 2 weeks brake.

Did the tinnitus disappear for you on lower dose?
 

[stillwater]

@stillwater

10mg? It's very low dose. I'm waiting for some opinions then if lower dose is enough for you. I'm going to finish current stack on 40mg dose, then I have holidays abroad and it might be risky to take it on the plane so probably I'll have 2 weeks brake.

Did the tinnitus disappear for you on lower dose?
 

 

 

My first round of NSi was done last Sept, at 40mg, it was too much, and a few others at that time lowered their doses also. Before he disappeared ScienceGuy who was one of the first users, mentioned that after trial and error, 5mg was the optimal dose for him to receive benefits with less sides. I may push it to 20mg if the anxiety stays in check. But even at 10mg I'm feeling something.

 

My tinnutis got worse the second day of this second trial.  I can't remember if it came on the first time I tried NSI and went away when I stopped. Oh well.

[atomical]

Why do you continue to use a substance that gives you horrible side effects?  The whole point of taking a cutting edge compound is to alleviate a problem and make your life better.  Talking about dosage isn't even worth discussing if it falls outside the dosing protocol of one of the clinical studies.  You are alone when you take a research chemical.

[stillwater]

Why do you continue to use a substance that gives you horrible side effects?  The whole point of taking a cutting edge compound is to alleviate a problem and make your life better.  Talking about dosage isn't even worth discussing if it falls outside the dosing protocol of one of the clinical studies.  You are alone when you take a research chemical.

 

I fail to see the logic in any of your statements. The whole point of this forum and this thread is to discuss experiences and some level of support.

 

 

Pretty much any established anti-depressant of the last 50 years,  gives way worse side effects than simply anxiety alone, and anxiety is the only side I've experienced with NSI.  

 

We all metabolize substances differently and we all have varied heights, weights, composition, genetics, enzyme makeup etc.  If some see improvements at 5mg, great. If some see nothing until 80mg so be it. It's interesting to hear what the range is for positive or negative results. 

 

101 pages of discussion and comparisons and experiences is no more alone than say a ssri survivors forum. Not to mention to this day there is no clear cut science or agreed upon data as to how must commercial psychiatric meds actually work or don't work or the exact side effects every patient is going to experience.   

[atomical]

Why do you continue to use a substance that gives you horrible side effects? The whole point of taking a cutting edge compound is to alleviate a problem and make your life better. Talking about dosage isn't even worth discussing if it falls outside the dosing protocol of one of the clinical studies. You are alone when you take a research chemical.

I fail to see the logic in any of your statements. The whole point of this forum and this thread is to discuss experiences and some level of support.


Pretty much any established anti-depressant of the last 50 years, gives way worse side effects than simply anxiety alone, and anxiety is the only side I've experienced with NSI.

We all metabolize substances differently and we all have varied heights, weights, composition, genetics, enzyme makeup etc. If some see improvements at 5mg, great. If some see nothing until 80mg so be it. It's interesting to hear what the range is for positive or negative results.

101 pages of discussion and comparisons and experiences is no more alone than say a ssri survivors forum. Not to mention to this day there is no clear cut science or agreed upon data as to how must commercial psychiatric meds actually work or don't work or the exact side effects every patient is going to experience.

There are studies on the effectiveness of psychiatric meds.

Yes, this is a thread that discusses a research chemical. That doesnt mean we have to entertain crack pot theories. There are people doing all sorts of crazy shit such as not having a proper scale and eye balling it.

Also, what sort of support do you expect here? All you are going to get is anecdotes. Maybe that gives you hope, but it isn't scientific or rationale.

[stillwater]

 

There are studies on the effectiveness of psychiatric meds.

Yes, this is a thread that discusses a research chemical. That doesnt mean we have to entertain crack pot theories. There are people doing all sorts of crazy shit such as not having a proper scale and eye balling it.

Also, what sort of support do you expect here? All you are going to get is anecdotes. Maybe that gives you hope, but it isn't scientific or rationale.

 

 

 

I'm not really seeing your point here. Did you expect that people wouldn't come in and report their varied experiences with this drug? That some wouldn't would describe getting positive results from less than the trial amount or even more? Why wouldn't  they?  This, for a lot of people, myself included is a chance for relief from a level of mental illness, when many other things have failed including researched psych meds, that also have a high risk factor and come with warnings on their boxes such as risk for suicidality, etc. People take those risks because they want to feel better, sometimes desperately. I'm not sure what brings you into this.   

 

 

If had gone through the trouble to obtain this drug, tried the drug trial dose and found I couldn't handle a particular side effect, but someone came along and said give a lower dose a shot , it worked for me, I would be thankful of the suggestion and yes give it a shot. I don't see that as being "crackpot".  Many Dr.'s and Psych's have told their patients to try  adjusting their meds if they lost their sex drives, felt suicidal, fatigued, manic, anxious,etc.  

[Milkyway]

To everyone reporting positive experiences with NSI 189, whose brew are you taking?  Currently I am taking it with Coluracetam and the combination  increases drowsiness but in so doing help with sleep.  I get to really feeling better with dopamine agonists in excess of prescribed doses.  This is scaring me because I want to avoid dependency and abuse.  So, most days when I take the prescribed dose of my psychiatric meds. and the NSI and Coluracetam, I just make it through.  I want to sail through life and not drag my feet. Anyway, trying to keep it all under control.  For those of you who are having a beneficial response to the NSI I would like to know whose it is, if indeed it might be better. 

[citizen81]

I have severe afternoon depression and just tried NSI for the first time today. I actually felt an initial calming effect from it. Maybe even reduced some of my anxiety (and I was anxious about trying this). Wouldn't say I feel particularly clear headed, but a bit more than usual.

 

Hoping for a cure...

I have severe afternoon depression and just tried NSI for the first time today. I actually felt an initial calming effect from it. Maybe even reduced some of my anxiety (and I was anxious about trying this). Wouldn't say I feel particularly clear headed, but a bit more than usual.

 

Hoping for a cure...

[crazepharmacist]

Anyone experience headaches while on NSI-189? I've been noticing a pulsating headache just above my right eyebrow, in the temple region. It's gone away now but I'm wondering if it's related as I just started my trial a few days ago. 

[MetaMind]

@crazypharmacist:

The "strange headache" youre experiencing is a common sideeffect of NSI many users have mentioned before.

I m also starting a "trial" now with 40mg twice a day.

I combined NSI with the mr happy stack (uridine,fishoil capsules,b-complex vitamin, cdp-choline(<--not introduced now)) and I had to stop taking uridine  coz I got a very strange interaction yesterday... it was kinda like an anxiety attack mixed with the  "strange headache" which felt very unpleasant (30min). 

Anyone else experienced this "special" anxiety attack or took the "mr happy stack" with NSI?

 

 

Also for harnessing the maximum potential outcome follow those guidelines:

- eat blueberrys   (has been proven to ignite neurogenisis in the hippocampus)

- excersise

- "act of learning"

- pleasant enviroment

 

 

 

[Blomj]

@Metamind

 

What is this "act of learning"? Are you talking about learning more in general, or is it some type of program?

 

 

Edited by Blomj, 16 May 2015 - 10:22 PM.

[Blomj]

For people following this thread:

 

My post #2989 may be misleading. After being on NSI-189 for one week, it seems something was likely responsible for my mood that day, because I've felt normal since then. I will say I've been in a slightly better mood than normal, but that could be due to the fact that the sun has been shining .