6219 replies to this topic

[franbird]

I've used NSI-189 alongside both and haven't felt any bad interactions

[MetaphasicSystems]

Where can you buy NSI now?

Ditto.


Truly Blessed.

[Strangelove]

 

Where can you buy NSI now?

Ditto.


Truly Blessed.

 

 

I ship NSI-189 from a third party tested source (tested both from myself and another member) at $24-$16/gram depending on quantity. Shipping is included, it takes between 5-7 working days transit to USA and 3-4 working days to Europe, payment is through paypal.

 

I also have bulk PRL-8-53 available at $15/gram, half price from the cheapest on line seller. The only reason I bought it in bulk is that it seems a great combo with NSI-189 boosting many of its positives. I am getting increased motivation, be more present, and feel much calmer at the same time with this combination.

[Hungry Hippo]

I also have bulk PRL-8-53 available at $15/gram, half price from the cheapest on line seller. The only reason I bought it in bulk is that it seems a great combo with NSI-189 boosting many of its positives. I am getting increased motivation, be more present, and feel much calmer at the same time with this combination.

 

 

That's interesting Strangelove. In theory this compound could be a an exellent add on for people who are on antidepressives that have an anti-cholinergic action (that's about most of them). How strong is the effect on serotonin and dopamin? That would be important to know.

 

Furthermore, I wanted to give an update on my use of NSI untill now. I was really tired for the first two months. Right now, I sleep 6 hours. Before that I slept up to 16 hours a day. My vision is kind of restored. It's like someone turned up the resolution. Although I have a bit more backpain (and when I take 10 mg more, I take 20 mg I have a few hours later more backpain and shoulderpain) I have more endurance when exercising (in fact, I could not exercise at all). Memory is greatly improved. I socialise, and I lived for quite a long time in isolation, and I am funny again. At least I think I'm funny. And that's enjoyable enough.

 

So, I have my days and vocabulary back. That's good. Unfortunately NSI hightens the feeling of stress. It boosts energy, but doesn't make calm or mellow. The effect of stress is still there. And I experience more anxiety than before.

 

Maybe Moclobemide or Valdoxan or a low dose of serotonine inhibitor could be a good option. SSRI's kill me by the way. Those are no joke. At this moment I have a DNA research on the CYP enzymes that break down medication (and heavy metals). That could support future choices of the nice stuff that helps me to stand on my own feet.

 

Another option is to cut down the NSI to 10 mg and see if that calmes the stress and anxiety. For teh record, before taking NSI I managed anxiety and stress with Silexan, lavender oil. It's no miracle but it had a good reasonable effect. Even better than some prescribed medications. That effect is gone now.

 

If anyone recognise some of the effects above, I'm happy to read your respons.

 

O, before I forget. I use als NAC (N Acetyl-cysteine) and that works quite well. Since I use this with the NSI I made more progress than with NSI alone.

Edited by Hungry Hippo, 08 June 2016 - 07:02 AM.

[Shai Hulud]

Hungry Hippo, maybe try Gabapentin/Pregabalin for your anxiety, instead of a SSRI

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[Hungry Hippo]

Hungry Hippo, maybe try Gabapentin/Pregabalin for your anxiety, instead of a SSRI

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The side effects were no fun and Silexan had the same effect, a little less strong, but with no side effects at all. Alright, the burps have a lavender taste, but I liked that.
 

[psychejunkie]

 

I also have bulk PRL-8-53 available at $15/gram, half price from the cheapest on line seller. The only reason I bought it in bulk is that it seems a great combo with NSI-189 boosting many of its positives. I am getting increased motivation, be more present, and feel much calmer at the same time with this combination.

 

 

That's interesting Strangelove. In theory this compound could be a an exellent add on for people who are on antidepressives that have an anti-cholinergic action (that's about most of them). How strong is the effect on serotonin and dopamin? That would be important to know.

 

Furthermore, I wanted to give an update on my use of NSI untill now. I was really tired for the first two months. Right now, I sleep 6 hours. Before that I slept up to 16 hours a day. My vision is kind of restored. It's like someone turned up the resolution. Although I have a bit more backpain (and when I take 10 mg more, I take 20 mg I have a few hours later more backpain and shoulderpain) I have more endurance when exercising (in fact, I could not exercise at all). Memory is greatly improved. I socialise, and I lived for quite a long time in isolation, and I am funny again. At least I think I'm funny. And that's enjoyable enough.

 

So, I have my days and vocabulary back. That's good. Unfortunately NSI hightens the feeling of stress. It boosts energy, but doesn't make calm or mellow. The effect of stress is still there. And I experience more anxiety than before.

 

Maybe Moclobemide or Valdoxan or a low dose of serotonine inhibitor could be a good option. SSRI's kill me by the way. Those are no joke. At this moment I have a DNA research on the CYP enzymes that break down medication (and heavy metals). That could support future choices of the nice stuff that helps me to stand on my own feet.

 

Another option is to cut down the NSI to 10 mg and see if that calmes the stress and anxiety. For teh record, before taking NSI I managed anxiety and stress with Silexan, lavender oil. It's no miracle but it had a good reasonable effect. Even better than some prescribed medications. That effect is gone now.

 

If anyone recognise some of the effects above, I'm happy to read your respons.

 

O, before I forget. I use als NAC (N Acetyl-cysteine) and that works quite well. Since I use this with the NSI I made more progress than with NSI alone.

 

 

Hey,

 

Drop NAC! it elevates Dopamine and Norepinephrine; These are bad for your anxiety and stress! 

Maybe your stress are from NAC, not NSI-189 alone.

[Irishdude]

 

 

" have an anti-cholinergic action"

Arent you thinking of TCAs not SSRIs? I can't find anything reliable that shows me SSRI are anti cholinergic. Id appreciate a source

[Strangelove]

I think the very best "nootropic" to help with anxiety from NSI-189 is tianeptine sulfate.

 

PRL-8-53 is a dopamine agonist and seems to boost a lot some of the effects of NSI-189 . 

[Junk Master]

I'd be extremely curious to research GTS-21 combined with NSI-189 because GTS-21, while not apparently anxiolytic in the way benzo's, baclofen, and Phenibut/GHB are, really does seem to mitigate stressful situation induced anxiety in my case.  I've just finished a trial run of 3 grams of GTS-21 at 150 to 300 mg per day and have been through two, eight week "cycles" of NSI-189, and will be ordering more of both just to see how they "play" together.

 

I will say I've found GTS-21 to complement lower doses of Modafinil very well.  It removes some of the free floating anxiety and scattered thoughts that can accompany Moda, especially when dosed on successive days.

 

I did NOT find NSI-189 to complement Modafinil at all.  In fact, the combo seemed to cause too much anxiety and seemed to cancel out the inner calm/grounded/well being that NSI-189 produced for me.

[Valijon]

Strangelove is correct about Tianeptien with nsi-189. The two go together very well. I'm pleased with the results. I tried NAC for a while. It woke me up but, it made me feel tense mean, and increased anxiety. I wasn't a nice person on NAC.

After 2+ weeks the lethargy I first experienced with nsi-189 went away.

[Meggo]

Does anyone know how long the t1/2 and T/Cmax are of PRL-8-53?

[jaybird10 2]

I took nsi for 5 days (10mg) two weeks ago and stopped because I felt it was aggravating an old injury and it really intensified my already hightened anxiety. After having stopped nsi over 12 days ago Im still dealing with heightened anxiety along with body muscle twitching, indigestion problems. (bloating,stomach pangs). Has anyone experinced side effects long after coming off of nsi? Should I be worried?

[Lunast]

Does libido return upon discontinuation of NSI-189. I'm experiencing severe sexual anhedonia, which was present before cycling, but is pronounced upon my trial. While I'm more interested in well-being over libido, it would be reassururing to know that I still could perform if I wanted to in the future. Does,anyone have any experience?

[drg]

So I had some nsi sitting in a clear plastic pill container for several months now it has hard lumps. It was fluffy and light for the longest time. Now also the taste is not the bitter taste I am used to. I am using new material but has this happened with anyone else.

[ikaros]

Finished 1 month on 40 mg of NSI-189 and I must say I'm fairly disappointed. I have MDD. First 2 weeks were sluggish, lethargic and more depressive for me. Then I felt my mood and energy return to somewhat a baseline state, which still is below normal functioning, but after this I did not notice any additional benefits. There might be some cognitive changes, but very difficult to tell. No anxiety, overt toxicity noted. Confounding factors might have been vortioxetine which I took along with 189 at 10 mg per day, but vortioxetine below 15 mg for me does very little. I also have recently added 20 mg 9-me-bc but this also seems to be very subtle.

 

From the recently published Neuralstem's phase 1 trial the most benefits were seen actually with 2x40 mg per day and maximal effects were somewhere after 1-2 months of use, so I don't understand where do people on this site came up with the idea that this should be done with 1 month cycles, it seems like just some farfetched non-evidence based logic that's very common to this board.

 

I will soon give it a try at 2x 40 mg for 2 months and then conclude whether it is worth continuing or not.

[Shai Hulud]

@ikaros dump vortioxetine. Basically just an SSRI sold as the pro cognitive alternative.
Try tranylcypromine.
If you get problems with high blood pressure, add Reboxetine.
If this is still not enough, see if adding NSi-189 works.
If you still have anxiety, try adding Gabapentin/Pregabalin

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[psychejunkie]

Hey guys,

 

I decided to post this experience as I think its from NSI-189.

Its been a week that I am taking NSI-189 10 mg/day (Sublingually);

I've noticed laughing at simple things like youngsters first few days; lowered nicotine cravings (or drug-seeking behavior in general); higher curiosity; better working memory and improved imagination.

 

But yesterday night I did experience something strange; I was in bed thinking about my last nights' dreams, I was thinking about if NSI-189 has made my dreams more vivid or not, then I noticed I can easily remember my old dreams (even from two years ago); I took the challenge and tried to remember my old dreams as much as I can;

I think I remembered 30-40% of my past seen dreams! maybe less, maybe more!

 

Has anyone experienced the similar effect from NSI-189???

[Babakk]

I too received mild mania-like on the first several days of using it orally.  

 

Yes Definitely true, the dosages in the study are only levels for testing that they've established so far, and official recommended dosages have not been established.  

 

And regardless, even so, sometimes medications are prescribed at higher/lower dosages than the "official" dosages to meet each patient's specific needs.  

 

Also, upon double checking,

what I received from IRC.bio does not have any clumps.  

 

The NSI-189 phosphate from buy-nsi-189.com (while they were running) is the only one I have that contains clumps.  

Hi,

 

Is there a list of suppliers of NSI-189 and why do they keep disappearing? Are they being shut down because of patent? 

 

Thanks

[Strangelove]

 

I too received mild mania-like on the first several days of using it orally.  

 

Yes Definitely true, the dosages in the study are only levels for testing that they've established so far, and official recommended dosages have not been established.  

 

And regardless, even so, sometimes medications are prescribed at higher/lower dosages than the "official" dosages to meet each patient's specific needs.  

 

Also, upon double checking,

what I received from IRC.bio does not have any clumps.  

 

The NSI-189 phosphate from buy-nsi-189.com (while they were running) is the only one I have that contains clumps.  

Hi,

 

Is there a list of suppliers of NSI-189 and why do they keep disappearing? Are they being shut down because of patent? 

 

Thanks

 

 

Yes, the patent holder shuts them down. I have been selling third party tested NSI-189 to other members for the last year for $24-$16gram depending on quantity, shipping is included.

 

[Babakk]

There seems to be quite a few reports of induced/increased anxiety(or related psychosomatic symptoms) as side effects of NSI-189. 

 

I wish people sharing their experience with this compound would include a full list of concurrent medication they are taking at the same time. This sort of data could really help others decide to try (or not try) it out. There could also emerge insights into how to mediate these side effects.

 

Anyway, has anyone out there used NSI-189 concurrently with an SSRI specially Paroxetine? There are a few reports but none of them say anything about subsequent change in the effects/side effects. But it does appear that that the could be used concurrently at least at low doses.

 

I am thinking that SSRIs in general and Paroxetine in particular could mediate side effects like anxiety.

 

 

Edited by Babak Kamali, 13 June 2016 - 11:39 AM.

[Babakk]

 

I also have bulk PRL-8-53 available at $15/gram, half price from the cheapest on line seller. The only reason I bought it in bulk is that it seems a great combo with NSI-189 boosting many of its positives. I am getting increased motivation, be more present, and feel much calmer at the same time with this combination.

 

 

That's interesting Strangelove. In theory this compound could be a an exellent add on for people who are on antidepressives that have an anti-cholinergic action (that's about most of them). How strong is the effect on serotonin and dopamin? That would be important to know.

 

Furthermore, I wanted to give an update on my use of NSI untill now. I was really tired for the first two months. Right now, I sleep 6 hours. Before that I slept up to 16 hours a day. My vision is kind of restored. It's like someone turned up the resolution. Although I have a bit more backpain (and when I take 10 mg more, I take 20 mg I have a few hours later more backpain and shoulderpain) I have more endurance when exercising (in fact, I could not exercise at all). Memory is greatly improved. I socialise, and I lived for quite a long time in isolation, and I am funny again. At least I think I'm funny. And that's enjoyable enough.

 

So, I have my days and vocabulary back. That's good. Unfortunately NSI hightens the feeling of stress. It boosts energy, but doesn't make calm or mellow. The effect of stress is still there. And I experience more anxiety than before.

 

Maybe Moclobemide or Valdoxan or a low dose of serotonine inhibitor could be a good option. SSRI's kill me by the way. Those are no joke. At this moment I have a DNA research on the CYP enzymes that break down medication (and heavy metals). That could support future choices of the nice stuff that helps me to stand on my own feet.

 

Another option is to cut down the NSI to 10 mg and see if that calmes the stress and anxiety. For teh record, before taking NSI I managed anxiety and stress with Silexan, lavender oil. It's no miracle but it had a good reasonable effect. Even better than some prescribed medications. That effect is gone now.

 

If anyone recognise some of the effects above, I'm happy to read your respons.

 

O, before I forget. I use als NAC (N Acetyl-cysteine) and that works quite well. Since I use this with the NSI I made more progress than with NSI alone.

Anxiety (back pain) and sleepiness seem contradictory. How would you account for that. Or were the anticholinergic effects just your body's initial reaction as an attempt to block the drug's effects? 

[Water Buffalo]

Finished 1 month on 40 mg of NSI-189 and I must say I'm fairly disappointed. I have MDD. First 2 weeks were sluggish, lethargic and more depressive for me. Then I felt my mood and energy return to somewhat a baseline state, which still is below normal functioning, but after this I did not notice any additional benefits. There might be some cognitive changes, but very difficult to tell. No anxiety, overt toxicity noted. Confounding factors might have been vortioxetine which I took along with 189 at 10 mg per day, but vortioxetine below 15 mg for me does very little. I also have recently added 20 mg 9-me-bc but this also seems to be very subtle.

 

From the recently published Neuralstem's phase 1 trial the most benefits were seen actually with 2x40 mg per day and maximal effects were somewhere after 1-2 months of use, so I don't understand where do people on this site came up with the idea that this should be done with 1 month cycles, it seems like just some farfetched non-evidence based logic that's very common to this board.

 

I will soon give it a try at 2x 40 mg for 2 months and then conclude whether it is worth continuing or not.

 

From one of Neuralstem's updates on NSI-189 "Data further showed that results continued for eight weeks, despite the fact that there was no accumulation of the drug in the patients' system." If you read through the thread most people recommend continuing NSI-189 for around 3-4 months for more significant changes to occur. The 28 day recommendation was probably what some people thought was the most effective or safest path.

 

Someone mentioned that their future trials would be longer in duration, maybe 90 days? I couldn't find any data on this, but it may have been in one of their videos.

[Water Buffalo]

 

I would not be surprised if NSI ended up doing "nothing at all" lol. I'm just in it for the overal endeavor of trying cutting edge science.

People might not see results right away, but that doesn't mean that it's not effective. You would think neurogenesis takes time. This isn't piracetam here. This is regenerative medicine. The NeuralStem CEO has said hinted that future trials of NSI-189 will be 90 days where in his words there would "certainly" be hippocampal growth.

He starts talking about NSI-189 at around 17:40 and mentions the 90 day trial specifically at around 20:15 minutes in:

 

 

This is the post I was looking for. Maybe you should wait until 90 days ikaros.
 

Edited by Water Buffalo, 15 June 2016 - 10:07 AM.

[ikaros]

I'm running it again for a longer period and with a higher dose. I have a supply for 250 days at 2x40 mg, confirmed it with mass-spec to be the genuine product.

[Strangelove]

A member I have been talking for a while started writting his experience below, but for reasons of anonymity he preffered to post it myself. 

 

 

I thought I would chime back in since this thread seems to be getting a little less active as the fame has died down between press releases. I would say that the lack of posting or the lack of availability are, in fact, inversely correlated with the effectiveness of NSI-189 when placed in context.

It has been reported before by various posters that there are numerous people who take NSI-189 and do not feel the need to post any longer because of the positive effects. Thus, the only messages or notices of their activity that are outwardly visible are limited to direct messages between users. Such as the case with myself and many others. Why post in a thread that in some ways is focused on mostly negative topics – what went wrong when taking it, or highlights of individual scenarios brought on by extenuating circumstances part of either normal life events or disease (ie: lyme disease)?

I’m a bit hesitant to believe all of the negative side effects that some users have reported, as I have not had any of them - such as neuropathy, tinnitus, headaches, or generalized fatigue. Not that anyone is disingenuous, it is just that I have taken what would be considered an above average dose the entire time I have been exposed to NSI-189 and I have nothing but glowing reports about it. I should preface that this journey has never been quite a scientific process since I’m not focused on precision as much as I am expediency.

 

 

 

While I started with the phosphate form – which is not my favorite due to the taste – I was able to find some effectiveness with it very early on. In fact, you could say as of Day 1 I was sold on its effects. That Day 1 was a little over 2 months ago. It was not quite like a switch being flipped, but it was profound enough that I felt like I was getting to a higher plane of control over my life and wellbeing. In other words, it had a profound impact on anhedonia and general frustrations or aggravations. Tedious activities and things that were once “grueling” or somewhat tortuous became mundane activities that just rolled off my shoulders. In general, life became much more enjoyable all around.

 

 

 

The first three days or so were a little rough in that I found myself adjusting to the effects of mild anxiety and more vivid emotionality that was accentuated by the use of cannabis. Especially those that are dominant Sativas. However, this went away thereafter and I only find it to be a very mild occurrence if I smoke a very strong Sativa and delay my doses of NSI-189 freebase well past the half life – in other words waiting a full 24-32+ hours between dosages. The coming on / off of NSI-189 is where you find yourself dealing with a transitional emotional state that can be challenging for some, but it is very manageable.

 

 

 

Once you look past the mild anxiety predisposition issues that some have, if you happen to be a respondent to NSI-189 without issues of anxiety you are going to be in for some truly great benefits. Though, it is not a magic bullet. It is a tool part of a more elaborate toolkit that must be used fully and respected in order to gain the results most are seeking. But if you do use it properly, you may find yourself with positive effects like my own: I find myself cooking a lot these days, exercising much more regularly, I’m much more constructive socially, have fewer scattered thoughts, and I’ve had a dramatic increase in my overall intellectual productivity across the board. You could say for me, the stack I am now taking is the equivalent of NZT.

 

 

 

My current vitamin intake is somewhat similar to what some others are already taking, such as: Vitamin D3 (5000 IU x2/day), Vitamin E (400 IU x2/day), CoQ10 (300mg x2-3/day), 450mg Circuminoids with 15mg Black Pepper Extract, General Multivitamin with B-complexes, etc.

 

 

 

I supplement the vitamins with a high protein diet that includes daily smoothies which are filled with Pure Spring Water (No Fluorides Added), Vanilla Almond Milk, Organic Plant Protein Mix (Hemp/Brown Rice/Chia mix), Copious amounts of Fruit (Strawberries, Mango, Raspberries, Blackberries, and Blueberries; sometimes Banana), Vanilla Extract, Cinnamon (lower blood sugar), Raw Agave Syrup, 4 Tbsp+ of 100% Pure Cocoa, Ovaltine, and sometimes an additional fiber additive. Best way to complement the high level of carbohydrates and simple sugars is to supplement with equally copious amounts of freshly made thick cut bacon to ensure you don’t have any sugar crash.

 

 

 

After a long day, or even before a long one begins, the smoothies are probably the most essential component to maintaining peak performance. No drug is going to replace the nutrition your body needs to keep functioning. A lot of what some would consider negative side effects are really just your body’s blood sugar levels in flux or the craving for raw calories. The metabolic demands on your body go up with NSI-189 – like any stimulant, so it is essential to meet the demand head on. Just as D3 is essential for maintaining proper neurotransmitter levels – among the many other benefits, the maintenance of your caloric intake helps your brain sustain a high levels of glucose demand without skipping a beat.

 

 

 

My daily dosing regimen is roughly similar to the following:

 

• 5mg Dexedrine tablet soon after waking with 40-50mg NSI-189 Freebase (sublingual then swallowed) soon after.

• Breakfast / short interim, then 12-15mg PRL-8-53 with or without ~10mg Tianeptine Sulfate.

• 4-5 hour interim, then 10-15mg Tianeptine Sulfate with 12-15mg PRL-8-53 with a meal or snack.

• Interim of 3-4 hours, then 40-50mg NSI-189 Freebase (sublingual then swallowed).

• Meal or other short break, then 10-15mg Tianeptine Sulfate with 10-12mg PRL-8-53.

• Benadryl at bedtime.

 

 

 

Some days I take a second Dexedrine tablet, or use more tianeptine since it helps with my asthma in response to some pollen allergies. However, I should point out that overdoing the tianeptine (as in 20mg+) can cause excessive fatigue that is hard to counter unless you drink some coffee. This appears to cause some mild clouding and can impact your cognitive performance, however if you limit your dosage to the therapeutic levels of around 12.5mg you can stay sharp.

 

A few points I want to highlight:

 

 

 

Anxiety: I think for many, the issue of anxiety is that they are unable to process the logical induction of the anxiety and attribute it to the chemical. In other words, they have an issue rationalizing what is happening and thus go into more of a panic state than letting their mind overcome the situation on its own. You control your mind, but sometimes the mind has a way of controlling you. But in the sense of NSI-189 attributable anxiety, I feel it is highly manageable and not at all unexpected given the pathways it is affecting.

 

 

 

Any dopamine modulator will find itself touching on anxiety potential due to the way dopamine regulates anxiety responses in the brain normally. Which is why you see excess dopamine being a factor in psychosis, paranoia, and schizophrenic disturbances – antipsychotics work against dopamine activity by binding competitively, downregulating expression of receptors, increasing reuptake, or influencing specific transporters that are part of pathways that control the flow of dopamine in/out of the synapses, etc. When you have a sudden surge or change in the availability of dopamine you can shift the balance for individuals one way or the other depending on their individual biochemical makeup. Some people are more able to deal with the balance shifts. I think this is a much more complicated question than I have time to address in this post, but it is one you can hopefully draw inspiration from in continuing your reading.

 

 

 

Stimulant Respondents: I’m starting to believe that the profile of NSI-189 is best suited by matching it with the dosing patterns of other chemicals like Dextro-Amphetamine. For instance, at very low doses (around 2.5-10mg) Dextro-Amphetamine actually can induce fatigue, cramps, headaches, brain fog, and mild acute tinnitus – which is seen in individuals who are respondents (ADHD-subtypes). These respondents generally will not have the same stimulant effects that others get when they take Dextro-Amphetamine or its more commonly available counterpart (the racemic mixture of d/dl/l-amphetamine salts in Adderall). In fact, some if you give them a 10mg Adderall tablet may in fact fall asleep. This is a clear sign of a respondent that will likely get very quality effects from NSI-189.

 

 

 

Sleep: It is vital that you get proper sleep and do not skip on getting as much as possible. You have a higher demand for not only nutrition due to metabolic functions being heightened, you also have a higher demand to post-process the day’s information. If you do not get the right amount of sleep you only cost yourself time later whether it is productivity, attentiveness, emotional connectedness (feeling like a zombie due to fatigue), or even undue stress to the body (higher cortisol levels, etc) which can lead to an earlier death or heightened risk for dementia due to the lack of clearance of toxins and free radicals.

 

 

 

Stress: If you do not exercise your heightened stimulation or activity while on NSI-189 will only exacerbate the stress and anxiety. You MUST work your muscles to some degree every day otherwise you are not getting the most out of the therapeutic dosages. NSI-189 will not replace the need to physically exert yourself to manage built up energy or feeling “wound up” that is in part due to thoughts that are plaguing you or feelings of being overwhelmed by your schedule. Taking the time to do other mundane and trivial activities that are relaxing yet exerting – such as doing dishes, gardening, playing sports, or cleaning up the house.

 

 

 

Slump: I think that after about a month the effects drop off slightly before returning around the start of Month 2. You just have to stick with it through that stretch to see the better outcome on the other side.

 

 

 

Cognition / Learning: I taught myself an entirely new programming language from thin air (not knowing anything about it) to recognized expert level competency in about 4-6 weeks. I can now, when in combination with PRL-8-53, overcome ADD tendencies to be unable to read more than a few sentences without getting distracted or losing focus on what I had just read, in fact, I can now read through 100-150 pages in a very dense book about computer architecture or design while remembering the context and information vividly. The long-term-potentiation that is heightened helps to keep those new memories in place and accessible even a day or two into the future and beyond. When in normal conversations, I frequently find myself on a higher level than anyone I’m speaking with because I can breakdown and recall specific phrases verbatim that had been spoken in much early parts of a discussion. It is amazing how much simply forgetting what was said influences a debate – not anymore! I’m able to catch even the faintest hints and recall them with utmost precision and speed. In terms of general performance on most tasks, my critical thinking and task planning / goal orientation is heightened to the point where I now have people working for me. I’m a different person these days, for the better. I should point out that Dexedrine has a large influence on this as it affects a dopamine transporter that for me may be the reverse as others – this is supported by some studies that go back to Vanderbilt but were highly vague and limited to a pair of brothers, but they claimed that the flow of dopamine out of the neurons for some respondents with a genetic marker had “sputtered” or sporadic flow, but when exposed to dextro-amphetamine the transporter acted in a normal consistent manner. This sporadic vs consistent flow may also be thought of as a potential complexing factor in relation to effects described by those coming on/off NSI-189.

 

 

 

Synergy: Caffeine can be enhanced significantly. However, if you get issues with blood pressure or chest pressure make sure you take CoQ10 as your heart’s natural demand for it goes up over time, especially when under the influence of stimulants. Dextro-amphetamine, as has been described, is highly beneficial with the two. You find a more even response with less of an edge to the Dexedrine. That said, if you do not take Tianeptine or balance your diet well with exercise added, you may find the NSI-189 and Dexedrine combination to be a little bit of enhancer to anxiety or general moodiness if you do not time the NSI-189 doses properly – as you come off the dex without redosing NSI-189 this can be seen. When anxiety is an issue, a small amount of Tianeptine can rapidly and dramatically eliminate all anxiety with extreme anxiolytic activity. However, overdoing it can cause fatigue and cloudiness. You could also think of it as somewhat a blissful ignorance state – in which you are distracted by how not-depressed you are, or rather how happy you are. Thus, you can somewhat decrease performance if you take too much, but when in combination with NSI-189 it is fantastic for getting the tasks you hate doing done. It should be pointed out that if you have asthma, taking Tianeptine will help dramatically, however when you mix PRL-8-53 in, the PRL-8-53 can reverse some of the antispasmodic tendencies of Tianeptine. This can also be used as a marker to gauge redosing without using a clock. The anti-bronchiospasm effects can be most pronounced when in combination with cannabis or allergies. You will find yourself not using your inhaler or relying on antihistamines.

 

 

[Babakk]

Does anyone remember ALKS 5461?

 

This was a drug that was hailed to be a cure for depression and the trials kept giving promising results pushing the share prices soaring at each stage. It was even given permission to fast forward it to get to the market. But on the last of the phase III clinical trials it was suddenly found to be no better than placebo (in once case it was even worse) leading to 90% drop in share prices. Off course some two years before that there were repeated reports of the top management selling their shares is small tranches.  

 

I wonder if NSI-189 is yet another scam to push up the stock price. Either that or the stuff on market  is not genuine. I have noticed that all the more positive/glowing reports/experiences are from people that are sh** load of other stuff and not even on a regular regiment. So how can any of their experiences be considered objective, never mind quantified?

 

I have tried this stuff or at least what was sold to me as NSI-189 (e.g. through ebay). I took 40mg sublingually and it just felt like bad speed. It drove up my blood pressure to 198/101 and my heart beat to 98pbm. I also felt a mild anxiety and headache for which I had to take an aspirin. 48 hours later the headache has been replaced by back pain and I still have higher than normal blood pressure. And yet according to Nuralstem this stuff is well tolerated with little or no side effects.

 

The only other medication I take is 10mg Paroxetine which I have been taking for years.

 

 

 

 

Edited by Babak Kamali, 16 June 2016 - 10:25 AM.

[Baten]

I wonder if NSI-189 is yet another scam to push up the stock price. Either that or the stuff on market  is not genuine. I have noticed that all the more positive/glowing reports/experiences are from people that are sh** load of other stuff and not even on a regular regiment. So how can any of their experiences be considered objective, never mind quantified?

 

Neuralstem has been actively stopping big nootropic stores from selling their proprietary compound though, so these positive reports are all from third-party people buying it against neuralstem's 'wishes'. I'd find it hard to believe that these anecdotal reports would be doctored.

[Babakk]

 

I wonder if NSI-189 is yet another scam to push up the stock price. Either that or the stuff on market  is not genuine. I have noticed that all the more positive/glowing reports/experiences are from people that are sh** load of other stuff and not even on a regular regiment. So how can any of their experiences be considered objective, never mind quantified?

 

Neuralstem has been actively stopping big nootropic stores from selling their proprietary compound though, so these positive reports are all from third-party people buying it against neuralstem's 'wishes'. I'd find it hard to believe that these anecdotal reports would be doctored.

 

I don't see a contradiction here.

As I said most of the positive reports are either from people who are loads of other stuff already or from people who report a positive results within hours for a drug that is supposed to have a half life of 120 hours.

Besides, there are at least just as many negative reports as there are positive ones and increasingly there are reports of side effects with very little discernible positive results of a compound that is supposed to be well tolerated. It is time to call the spade a spade.

If I were on such a scam, I would too be stopping other third party suppliers in order to delay exposure. The longer it takes for the truth to come out the higher the stock prices will rise.  If I were Neuralstem, I too wouldn't want people to find out too soon before the stocks were risen on the basis of my own reports. In fact if I were so confident about the compound I wouldn't be so zealous about shutting others down as they would be considered as free advertising. 

Edited by Babak Kamali, 16 June 2016 - 12:25 PM.

[neuralis]

May I ask what is your own personal experience with NSI-189?