6219 replies to this topic

[daouda]

fight club rules makes this very difficult to manage... things are rather stagnant now it seems or progressing very slowly. I think being out in the open would benefit.

Edited by daouda, 23 April 2013 - 09:10 PM.

[daouda]

remember, non-members have a limit of only TWO PMs per day!

[Xenix]

My idea is that people with the most amount of hippocampal damage/atrophy will notice the largest improvements.

[Major Legend]

We really have no idea what this compound will do, if it even does anything for a healthy person. Did some googling:

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.

Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R.

Source

Department of Neuroscience, Columbia University, New York, New York 10032, USA. as2619@columbia.edu

Abstract


Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout life. Neurons that arise in adults (adult-born neurons) show heightened synaptic plasticity during their maturation and can account for up to ten per cent of the entire granule cell population. Moreover, levels of adult hippocampal neurogenesis are increased by interventions that are associated with beneficial effects on cognition and mood, such as learning, environmental enrichment, exercise and chronic treatment with antidepressants. Together, these properties of adult neurogenesis indicate that this process could be harnessed to improve hippocampal functions. However, despite a substantial number of studies demonstrating that adult-born neurons are necessary for mediating specific cognitive functions, as well as some of the behavioural effects of antidepressants, it is unknown whether an increase in adult hippocampal neurogenesis is sufficient to improve cognition and mood. Here we show that inducible genetic expansion of the population of adult-born neurons through enhancing their survival improves performance in a specific cognitive task in which two similar contexts need to be distinguished. Mice with increased adult hippocampal neurogenesis show normal object recognition, spatial learning, contextual fear conditioning and extinction learning but are more efficient in differentiating between overlapping contextual representations, which is indicative of enhanced pattern separation. Furthermore, stimulation of adult hippocampal neurogenesis, when combined with an intervention such as voluntary exercise, produces a robust increase in exploratory behaviour. However, increasing adult hippocampal neurogenesis alone does not produce a behavioural response like that induced by anxiolytic agents or antidepressants. Together, our findings suggest that strategies that are designed to increase adult hippocampal neurogenesis specifically, by targeting the cell death of adult-born neurons or by other mechanisms, may have therapeutic potential for reversing impairments in pattern separation and dentate gyrus dysfunction such as those seen during normal ageing.

Note, nothing was different from the control group apart from pattern separation and exploratory behavior (complimented with exercise)

Also stress is known to lower natural hippocampal neurogenesis, and obviously depression is linked. There is I believe little evidence that neurogensis stops in the hippocampus in adult age, only that in advanced age structural problems occur leading to impairment of neurogensis. Therefore is is hard to access whether NSI on healthy individuals will do anything at all.

My sister who does research in virtual reality linked with psychology, says that she thinks that increased SYNAPTOGENSIS would more likely make people smarter (nootropic effect), rather than increasing the amount of brain cells in a healthy individual.

However NSI may be useful when combined with other nootropics such as CILTEP, those studying may see the most to benefit as they are constantly stimulated by novel information.

Edited by Major Legend, 24 April 2013 - 04:15 PM.

[megatron]

My sister who does research in virtual reality linked with psychology, says that she thinks that increased SYNAPTOGENSIS would more likely make people smarter (nootropic effect), rather than increasing the amount of brain cells in a healthy individual.

That's why we're going for a Dihexa group buy as well :P

[Xenix]

My sister who does research in virtual reality linked with psychology, says that she thinks that increased SYNAPTOGENSIS would more likely make people smarter (nootropic effect), rather than increasing the amount of brain cells in a healthy individual.

That's why we're going for a Dihexa group buy as well :P

I'm currently in the process of having my batch of (what I hope to be) Dihexa analysed. I should know by early next month if it's the real deal. If all goes well, we could use my source for a group buy.

[emckai]

Wish I could be part of this group buy, but unfortunately i'm a poor college student.
Hope to hear positive results from users soon!

[sunshinefrost]

We really have no idea what this compound will do, if it even does anything for a healthy person. Did some googling:

Increasing adult hippocampal neurogenesis is sufficient to improve pattern separation.

Sahay A, Scobie KN, Hill AS, O'Carroll CM, Kheirbek MA, Burghardt NS, Fenton AA, Dranovsky A, Hen R.

Source

Department of Neuroscience, Columbia University, New York, New York 10032, USA. as2619@columbia.edu

Abstract


Adult hippocampal neurogenesis is a unique form of neural circuit plasticity that results in the generation of new neurons in the dentate gyrus throughout life. Neurons that arise in adults (adult-born neurons) show heightened synaptic plasticity during their maturation and can account for up to ten per cent of the entire granule cell population. Moreover, levels of adult hippocampal neurogenesis are increased by interventions that are associated with beneficial effects on cognition and mood, such as learning, environmental enrichment, exercise and chronic treatment with antidepressants. Together, these properties of adult neurogenesis indicate that this process could be harnessed to improve hippocampal functions. However, despite a substantial number of studies demonstrating that adult-born neurons are necessary for mediating specific cognitive functions, as well as some of the behavioural effects of antidepressants, it is unknown whether an increase in adult hippocampal neurogenesis is sufficient to improve cognition and mood. Here we show that inducible genetic expansion of the population of adult-born neurons through enhancing their survival improves performance in a specific cognitive task in which two similar contexts need to be distinguished. Mice with increased adult hippocampal neurogenesis show normal object recognition, spatial learning, contextual fear conditioning and extinction learning but are more efficient in differentiating between overlapping contextual representations, which is indicative of enhanced pattern separation. Furthermore, stimulation of adult hippocampal neurogenesis, when combined with an intervention such as voluntary exercise, produces a robust increase in exploratory behaviour. However, increasing adult hippocampal neurogenesis alone does not produce a behavioural response like that induced by anxiolytic agents or antidepressants. Together, our findings suggest that strategies that are designed to increase adult hippocampal neurogenesis specifically, by targeting the cell death of adult-born neurons or by other mechanisms, may have therapeutic potential for reversing impairments in pattern separation and dentate gyrus dysfunction such as those seen during normal ageing.

Note, nothing was different from the control group apart from pattern separation and exploratory behavior (complimented with exercise)

Also stress is known to lower natural hippocampal neurogenesis, and obviously depression is linked. There is I believe little evidence that neurogensis stops in the hippocampus in adult age, only that in advanced age structural problems occur leading to impairment of neurogensis. Therefore is is hard to access whether NSI on healthy individuals will do anything at all.

My sister who does research in virtual reality linked with psychology, says that she thinks that increased SYNAPTOGENSIS would more likely make people smarter (nootropic effect), rather than increasing the amount of brain cells in a healthy individual.

However NSI may be useful when combined with other nootropics such as CILTEP, those studying may see the most to benefit as they are constantly stimulated by novel information.

Thanks for the info !!!
Pattern separation enhancemnt seems a lot related to working memory... For my part, that is really what i need to improve fluid intelligence. It would also be nice to better store info permanently.


Pattern Separation
For most people, memory is about time. It is easier to remember a set of items in a memory test if they are presented a few seconds before memory retrieval, than if they are presented several hours before. When memory fails, as it does normally in old age, or under pathological conditions such as Alzheimer’s disease, this failure is reflected in the inability to remember over an extended period of time – although the ability to remember over a few seconds may remain intact. Increasingly, however, memory researchers are becoming interested in the ability not to remember over time, but to keep memories distinct and resistant to confusion. If asked to remember where you parked your car this morning, yesterday morning and the day before, the task is difficult not because you need to remember over a long period – you can easily remember many things that happened three days ago – but because the similar memories of your car in that same parking lot are so easily confused. The ability to separate the components of memories into distinct complex memory representations that are unique and less easily confused has been simulated by computational models of memory and has been referred to as ‘pattern separation’. The psychological and neurobiological mechanisms underlying pattern separation are a particular interest of this lab.

http://www.tcnlab.ps...tern-separation

[sunshinefrost]

"therapeutic potential for reversing impairments in pattern separation and dentate gyrus dysfunction such as those seen during normal ageing."

Isn't that enough and amazing in itself ?

[sunshinefrost]

basically..... pattern separation is or can be refered to the separation of concerns (mostly used in It or telecom, math) and all of this boils down to being one and multiple-track minded simultaneously. Here is another interesting quote: "Through proper separation of concerns, complexity becomes manageable". Now that's a term i like... it's the working memory basically.

All of this is pointing towards ameliorating the working memory. Recently, the term "Working memory" can be seen as replacing the term "short term memory".

Dihexa also augments the hippocampus, it seems it works the same way but adds it synapses.... Adding more neurones first with NSI seems more logical. The thing that worries me about dihexa is that it simulates a lot of BDNF.... not sure too much BDNF is good.

Edited by sunshinefrost, 24 April 2013 - 09:27 PM.

[sunshinefrost]

I am considering lowering the group to 30 (we are at 28 at this time). I need scienceguy to confirm if he can get a fast quote for 30 x 2,5g = 75g

[NFP]

Wish I could be part of this group buy, but unfortunately i'm a poor college student.
Hope to hear positive results from users soon!

i plan on becoming a poor college student if this goes well

[NFP]

just searched NSI-189 on Google, and it seems the FDA just recently (2 days ago) approved Neuralstem to progress to the third and final phase of its ongoing NSI-189 trial.

FDA Approves Neuralstem To Treat Final Cohort In NSI-189 Phase Ib Trial

→ source (external link)

[Passion]

I'm interested in joining the group buy if it's not too late.

[Steve Zissou]

What is the price for the group buy?

[golden1]

Sorry I won't be able to participate as I had thought. I look forward to seeing other people's results and hope for the best!

[Reformed-Redan]

Well I couldn't miss out on such a chance and bit in.

Anyone read about GLYX-13 from Naurex?

Edited by yadayada, 26 April 2013 - 06:36 AM.

[Izan]

.

Edited by izan82, 26 April 2013 - 01:46 PM.

[lostfalco]

I'm super interested in GLYX-13. Effects take 20 minutes and last for two weeks. Neuropeptides are a fascinating new area of research. Sounds like GLYX is a partial NMDA agonist which, of course, is one of the major learning and memory pathways. I'm already in on the first two group buys...why not a third?

[OpaqueMind]

I'm super interested in GLYX-13. Effects take 20 minutes and last for two weeks. Neuropeptides are a fascinating new area of research. Sounds like GLYX is a partial NMDA agonist which, of course, is one of the major learning and memory pathways. I'm already in on the first two group buys...why not a third?

Your brain might explode?!

That'd be a mess

Edited by OpaqueMind, 26 April 2013 - 03:06 PM.

[Reformed-Redan]

I'm super interested in GLYX-13. Effects take 20 minutes and last for two weeks. Neuropeptides are a fascinating new area of research. Sounds like GLYX is a partial NMDA agonist which, of course, is one of the major learning and memory pathways. I'm already in on the first two group buys...why not a third?

It would cost a fortune to synthesize. Its really interesting since I've never seen NMDA modulators. Plus, this would obliterate any positive symptoms of schizo.

I was also hoping to synthesize IDRA-21 after all these group buys. Might have to put it on the backburner.

[Metagene]

1mg of GLYX-13 for $115

http://www.tocris.co...p?ItemId=221742

Ouch.

[therein]

@izan82
I am born and raised in Turkey and Turkish is my first language. I live in the US but I can contact them if you guys decide to buy from them instead. I can even give them a call.

[therein]

We wouldn't even need to do an international money transfer this way. I have bank accounts and assets in Turkey.

[DamnedOwl]

I think it's almost certain to be a scam, to be honest, however much I'd love deals like this to be true!

By the way, you may want to follow this thread too: http://www.longecity...780#entry582527
In particularly the last few posts.

[therein]

I think it's almost certain to be a scam, to be honest, however much I'd love deals like this to be true!

By the way, you may want to follow this thread too: http://www.longecity...780#entry582527
In particularly the last few posts.

Interesting. I wrote a reply to that thread. Let me know if I can help you guys out in any way. I'll be flying to Turkey in three weeks for summer and I can even go check it out.

[Izan]

@izan82
I am born and raised in Turkey and Turkish is my first language. I live in the US but I can contact them if you guys decide to buy from them instead. I can even give them a call.

hoşgeldiniz! i have lot's of turkish friends. but i also believe it's a scam.

[therein]

Tesekkurler, izan82.

I didn't get a chance to look at all the evidence. Why do you think it is a scam? It seems like the company actually has a branch in Turkey and it isn't that unseen for someone to reply back from their personal email address. I can call the phone number on their corporate website and ask them to confirm through more official channels.

Edited by therein, 26 April 2013 - 11:50 PM.

[1thoughtMaze1]

what is this NSI-189? i wish i could see molecular structure.


Im confused, it is a SSRI?

How do you know this structure is the NSI-186... The original reference to it mentioned its was proprietary, where did you get it?

Sorry if in missed the answer skimming the thread.

It is not a SSRI

The present invention relates, to compounds that promote neurogenesis in vivo, More particularly, the present invention is related to classes of compound structures that are shown to be particularly effective in promoting neurogenesis including compounds of the type, fused imidazoles, aminopyrimidines, nicotinamides, aminomethyl phenoxypiperidines and aryloxypiperidines, These compounds are shown to promote neurogenesis by proliferation and/or differentiation of human hippocampus multipotent stem cells and/or progenitor cells and neuronal progenitors. Moreonver the present invention relates to these angents as therapeutics for prevention and treatment of neurological diseases in mammals and as reagents for detecting neurogenesis and proliferation.

http://www.google.co...nsi 189&f=false

[Reformed-Redan]

We're not changing suppliers for sure. These guys are as legit as they come and the quality will be great. Maybe another time.