Posted 22 August 2013 - 09:19 PM
Here's my version of an effect log for NSI-189. I've used something similar for a long time, usually once in the AM and once in the PM when I'm trying to determine if a healing or optimization strategy is helping or hurting. I am female, in my mid-fifties, moderate to high fitness level, physically healthy with back problems, and want to improve my brain health. I suspect some brain damage from toxins, lengthy course of IV antibiotics, heavy metals, pathogens, chronic stress, as well as a year-long course of chemotherapy. I have PTSD and SAD (definitely), ADD (probably), and GAD (maybe).
I am taking 40 mg of NSI-189 twice daily, usually after eating with 200 mg of Centrophenoxine and 100 mg of idebenone. Sometimes I take it on an empty stomach inside a small ball of coconut oil. It seems to absorb about the same either way. I do take other supplements but I don't think they're that important as they are pretty standard for health and I was already taking them before NSI-189.
10:10 am
8/22/13
Sleep hours — 7
Sleep quality — disturbed
Dreaming — no memory
Scaled from 0-6:
Health — 5
Fitness — 4
Mood — 4
Energy — 5
Focus — 5
Memory — 5
Libido — 4
Internal Stress (perceived, also known as anxiety) — 3
External Stressors (real life events that require significant responses and changes) — 4
Productivity — 4
Notes:
Huge abnormal increase in hunger, though I have not changed the diet (modified Paleo, intermittent fasting, and fitness protocols that I've followed for the last 18 months. I am seriously hungry a lot. I ate a massive fish and vegetable salad for breakfast, amounting to three lunch size portions for healthy active people. Maybe neurogenesis (in brain) is occurring and requiring a lot more nutrients?
Salivation: Once I tried taking NSI-189 sublingually. After a couple of minutes salivation was so copious that it became impossible not to swallow a lot, so that dose ended up being mostly oral due to swallowing the excess saliva. Effects did come on a little faster and stronger, but that's NOT what I wanted.
Digestive bile: I suspect that has increased because I can no longer tolerate digestive enzymes that I take regularly with good results (in the past).
Some mild nausea on a few occasions, almost unheard of for me.
A few times I felt the exact same kind of sudden body fatigue that I felt on low dose Deprenyl. Hard to drag my legs up the hill type fatigue, unique to Deprenyl when I am not doing hard exercise and one of two reasons I stopped taking Deprenyl. The other was increased anxiety.
I am sleeping pretty well which is very unusual, under the circumstances. Current situation would normally cause pretty bad insomnia.
Considering that the new major stressors that happened to occur at the beginning of my NSI-189 trial are still present, though a bit less intense, my current response to the stress is remarkable. Under these conditions I would normally be ready to pack my bags and drive off into the sunset or find a little cave to crawl into and stay there indefinitely. One certain response is that I would become much less productive and very emotionally numb, which provides some protection from PTSD symptoms, dysfunctional though that may be. But that hasn't happened this time at all.
I hesitated to include libido as a field to rate (mostly wanting to avoid perv-troll responses), but it is often a valuable marker of overall health. Plus, it is an item of great concern to many people here, so I've added it to this public log. Hopefully we can communicate and also keep our dignity on this topic. There has been a definite increase over what I thought was a normal sex drive. Also normally when stress escalates, my libido disappears. But not since starting NSI-189. This was one of the most noticeable first effects.
The headaches or head pressure feelings have been mild and infrequent. I know that these mild sensations are sometimes a sign of neurological repair and regeneration. Perhaps that is the cause...
I want to ramp up my optimization practices if possible before the NSI-189 is gone. Language learning, fitness challenges, memorization of boring but important stuff, new creative output, and meditation hacks are what I usually do to optimize my brain. Also enjoying some new adventure qualifies as an optimization activity for me. But right now maybe just avoiding a major episode of PTSD is a valuable goal under the current circumstances.
I had some mild come-downs from this initially, manifesting as very mild depression and anxiety. I think the half-life is probably around 6-8 hours. But dosing twice a day seems plenty. It also does seem to build up somewhat, I am reducing the dosage to 30 mg twice a day.
But I still think this this is a major and very unique drug. I have used various prescription drugs, many supplements and noots, and a number of mind hacks, such as meditation and self-hypnosis. I have radically changed my diet and fitness protocols. Some had very positive lasting effects (diet, exercise, supplements, mind hacks), and some were initially rather dramatic (Paleo diet, Adderall and Sunifiram). But none eliminated the brain changes that come with PTSD. The difference with NSI-189 is that it is so broad in scope and integrates pretty seamlessly into whatever else you're doing to help yourself. It seems to induce mindfulness and change the pre-cursor thought patterns that bring on PTSD when there is a real life triggering event. It isn't making me stupid or slow in responding to danger or extreme unpleasantness. It's making me a lot smarter in those conditions.
How to make the best use of this is the real question for me. But I also don't understand how it can change my brain so quickly without any apparent ill-effects. The only "bad" effects have been very mild and infrequent.
What if you could keep on taking it?
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