6219 replies to this topic

[xks201]

lol

[ovecta]

1 gram of NSI-189 should be arriving to me within the next few days, however at the the moment I'm taking 30mg Tianeptine and the mr.happy stack (uridine,dha, choline) should these compliment the NSI-189's anti-depressant effects or should I drop them while taking NSI?
Anyone have any experiences or opinions on how these may interact? The combination of Tianeptine+Mr happy stack has done wonders already for depression

[sparkk51]

anyone know how the 2nd group is going? I feel in the dark about it, even though I am in it.

Edited by sparkk51, 11 January 2014 - 04:57 PM.

[formergenius]

anyone know how the 2nd group is going? I feel in the dark about it, even though I am in it.

See this post and this post. We should all be growing our hippocampi soon.

While I'm posting I might as well add; 4th day on freebase NSI (20mg BID), no (adverse) effects seen yet, though I'd be inclined to say that it does have some kind of pharmacological activity. That statement however is quite useless; could very well be placebo.

Edited by formergenius, 11 January 2014 - 05:17 PM.

[chemicalambrosia]

Congratulations to everyone that invested in Neuralstem stock! It seems like the stock will go up about 10% on the last day of trading in 2013, and will have grown about 100% since most of the investors here at Longecity bought it. Hurrah!

Yeah, creds to Rior for the recommendation! I bought A LOT so I made a lot of money thanks to him!

Yup, thanks to the people that started this topic and everyone who mentioned that this company was publicly traded and had a treatment going into phase 2. I hope there is more good fortune for everyone involved, from the people that these potential medicines could help, to the owners of the stock.

[manic_racetam]

I asked for clarification about the stuff from ebay, he said he would assume that it was in freebase form but would have to contact the lab to make sure. He didn't want to make any definitive statements without knowing if it were true or not.

Fair enough, I appreciate his honesty. But for practical reasons I'm going to assume it is in freebase form in regards to dosage.

Yesterday was day 7 taking this stuff bidaily. I'd say I had positive effects on mood and energy all day yesterday. Felt almost like a familiar state of being from when I was still a teenager. These effects coincided with me upping the dosage from 20mg BID to 30mg BID. I'm gonna stick with 30mg BID through the end of this first gram.

The first morning I took 20mg I didn't notice anything at all. I took another 20mg that night and went over to a friends house. That first night I did notice a pretty obvious stimulating effect, felt more talkative for about 15 mins then had some acute anxiety. I checked my pulse as I usually do when experiencing anxiety and it was completely normal. It was more like a sensation of being very conscious of my circulatory system, but not in a pleasant way.

After that first night I didn't get any sort of effect at all from this compound. Yesterday was nice, but there's not enough experience yet to directly link that improved mood with this substance, especially since I'm not experiencing it at the moment.

Wish I had dropped some money into Neuralstem stock last year, lol

[ovecta]

1 gram of NSI-189 should be arriving to me within the next few days, however at the the moment I'm taking 30mg Tianeptine and the mr.happy stack (uridine,dha, choline) should these compliment the NSI-189's anti-depressant effects or should I drop them while taking NSI?
Anyone have any experiences or opinions on how these may interact? The combination of Tianeptine+Mr happy stack has done wonders already for depression

Just like to report I'm two days into my trial of NSI-189 (30mg daily) I didnt drop the above stack and continued on as usual, its too early to say but I do feel they potentiate nsi's effects in terms of antidepressant effects even at this early stage, it could be overkill but I'll keep posting progress, I should mention I do suffer depression and could never tolerate lexapro when prescribed even in small doses..here's to hoping I never have to touch such medication again...a posse ad esse

[CholinergiX]

Yesterday I received Nyles7's NSI and today I just took 10mg sublingualy... I will report effects after a few days.

[civilizedsavage]

Let's say I am thoroughly impressed with NSI-189 during the trial, so much so that I'm willing to put down money for a 5-10 year supply. Would there be a possibility of future group buys to help individuals attain amounts that will cover their needs long term? This is assuming there is an individual as competent as either SG or VLK in organizing this sort of large scale operation. Anyways, just a thought. If this is my only chance to obtain NSI-189, its not the end of the world, there are other contenders that would suit my needs as well.

[tdmonster99]

Since we are having a slew of user reports, thought I would add mine as well. I became interested in NSI-189 as a means of treating symptoms of DP/DR I have had since 2009, depressive symptoms I have had dating back way before that, and I also used Accutane for about 6 months and there is some literature to suggest issues with suppression of hippocampal neurogenesis. I was not too interested in this compound for any nootropic purposes so I did not perform any objective cognitive tests. Also, this is my current regimen:

Fish oil 1500 mg EPA, 750 mg DHA
Liposomal Vit C 1 g
ALCAR 500 mg
NAC 1200 mg BID
Vit D 5,000 IU

I obtained Nyle's NSI-189 last Tuesday, 1/7, and started with a dose of 20 mg sublingually. In accordance with other reports, there definitely is a strong "pharmacological" effect that took onset within 20-30 minutes, which can best be subjectively described as a sense of wellness, whatever that means. I am not clinically depressed but do exhibit depressive symptoms fairly chronically, but I did notice a very rapid elevation in mood, but not a mania or euphoria, perhaps what should be a "normal" sense of well being.

I have been taking 20 mg sublingually, up until two days where I tried 30 mg, and then yesterday I tried 30 mg BID.

Bottom line thus far: I don't want to sound hyperbolic, but I really do enjoy this compound thus far. The first 3 days or so I noticed a greater increase in inner restlessness and anxiety which made me contemplate ceasing the trial but I stuck through it. By day 4-5, the anxiety subsided, I would say nearly completely by now. I just feel a sense of normalcy, not a heightened sense of well being. I did, and still do, feel an increased craving for carbohydrates, which was noted by other users. Also, my sleep feels a little disrupted, but my sleep patterns are poor to begin with and it is hard to say if it makes me feel more tired than usual. One other negative, this compound did provide a noticeable amount of gastric distress, and still does now, but its hard to say if its significant at this point. Overall, this compound, at 7 days in, is significantly better than any SSRI I have tried (citalopram, escitalopram, sertraline) with few to no serious side effects. Many of the initial side effects have abated by the 7th day and I imagine will continue to fade. Still to early to make any grand opinions, but I imagine by day 30 I should have a good grasp on the promise this compound holds. I look forward to receiving the sample from the 2nd group buy since it should be higher purity and phosphate form, at this time it is unknown exactly which form the ebay version is.

Edited by tdmonster99, 15 January 2014 - 12:49 AM.

[Rumpelstiltskin]

Why are some people getting the freebase form? Yes it's cheap, but it's not stable.

[violetechos]

The nsi-189 will stay more stable in the freebase form if kept from moisture (dessicants!). I believe moisture will start to increase the PH causing the molecular bonds to break...

It could probally be converted to the HCL salt by adding some sodium chloride. That or the chloride salt, which SHOULD be much more stable.

-l3nses

[chrismd465]

The nsi-189 will stay more stable in the freebase form if kept from moisture (dessicants!). I believe moisture will start to increase the PH causing the molecular bonds to break...

It could probally be converted to the HCL salt by adding some sodium chloride. That or the chloride salt, which SHOULD be much more stable.

-l3nses

I think you mean adding HCl will form the HCl salt. NaCl, itself being a salt, will not protonate the nitrogen(s) of the molecule particularly well.

One option would be to dissolve the substance in an appropriate nonpolar solvent and bubble HCl gas through, ideally causing the salt to "crash out" of solution to be collected by filtration. Somebody would have to experiment with various nonpolar solvents to find one with the best solubility profile, however.

An alternate option that would likely have a higher yield would be to acidify a polar solvent, add the freebase to form the soluble salt, and evaporate the solvent under reduced pressure.

[CholinergiX]

So... I was taking NSI for 2 days, both days 10mg sublingualy and got headache as a result. I am very sensitive to nootropic substances (for example:suni 0.5mg, noopept 5mg dosages). I will wait some time to washout and will start on lower dosage.

sorry for my english

[formergenius]

Has anyone tried mega-dosing NSI-189? I've upped my dose to 30mg BID, and will up to 40mg BID tomorrow (seeing as I'm experiencing no (side-)effects, why not right?).
From what I've read, 40mg TID is the max dose researched. Would it be unwise to surpass this?

[Flex]

@ formergenius,

Did You noticed anything after taking NSI-189 ?

[zeroskater6979]

Any follow up on experiences from those who were in the first group buy?

[ovecta]

When nsi-189 is released onto the market I wonder if it will intended to be used as a stand alone medication or will it be augmented with other anti-depressants to boost their effectiveness... I'm also wondering what It could be contraindicated with

[Flex]

Does anybody know why NSI-189 is proposed for various diesases like Traumatic Brain Injury etc. ?

As from my understanding NSI-189 does only increase the regeneration/growth of the Hippocampus.
So how could a improved Hippocampus compensate a injured Cortex ?
(Altough I know that the Hippocampus is responsible for the Brainwave modulation.)

Or is this just a claim to get more Investors ?

Edited by Flex, 24 January 2014 - 05:02 PM.

[Puppeteer]

Presumably they're just referring to TBIs that have damaged the hippocampus in some way... See this study: http://www.ncbi.nlm....pubmed/21931758

[di36]

Can i ask something i don't understand?
Does NSI promotes neurogenesis or hippocambus growth?

[formergenius]

di36: both.

I tried 40mg again yesterday and it's too much for me. I've decided to stop today and will probably start my Cerebrolysin cycle in an hour or so. I'll save what little NSI-189 I have left for the off days.

[spookytooth]

Just a small update: I continue using Cerebrolysin 5ml/day with NSI at 5mg/day atm to continue using it for as long as I ca, hopefully until I receive new NSI.
Even this small dose seems to boost my focus a little and gives me a certain clearheaded feeling. The memory benefits I had at 20mg bid are gone though.

[di36]

formergenius:How long have you used NSI?

And generally (i know it is experimental) is it considered safe?

Edited by di36, 26 January 2014 - 04:13 PM.

[formergenius]

2,5 weeks.

[Flex]

@ Puppeteer
Thx

@ Di36

This is what I´m asking myself too.
But its allready tested to humans in a small trial and maybe to animal prior to this
and it didnt seem that some got Cancer or any impairments,
so this seems enough ,at least, for me.

[manic_racetam]

I'm starting to doubt this stuff is in freebase form, mainly due to the taste being completely bland. Correct me if I'm wrong, but wouldn't a base be bitter? And what kind of chemical supply companies would send out a chemical in freebase form without being requested to do so. If it's not in phosphate form probably HCl salt or some other salt that is easy to accomplish.

Anyway, I was taking 30mg BID for a couple weeks, then realized that the second dose was making me feel kind of weird. So I started doing 25mg am and 20mg pm. I've tried quite a few variations and currently feeling the best with a single 30mg dose in the morning as soon as I wake up.

I don't think taking a lot of this stuff at one time will be a very pleasant experience. Each time I've over-shot it on dosage even by a small margin I've felt pretty uncomfortable, mainly weird uneasiness, not full-on anxiety or anything, but just not feeling totally emotionally or mentally "well". Hard to put into words.

Many symptoms of depression have already gone though. As depression leaves me it's always a pretty gradual process that I don't realize happening until I look at behavior changes that have been taking place. I've been waking up everyday at 8:30am, even on my days off. I used to sleep as late as possible on my days off and lay around till the evening time, but recently realized I always felt terrible after doing that. Not sure if its the NSI-189 that offered a slight shift in motivation and perception in that respect or if I would have come to that conclusion on my own.

Feel motivation coming back into my life after a pretty long drag of not feeling like doing much of anything with my life. Don't notice any acute effects from a single dose of this stuff unless I over-shoot it and end up with mild negative sides. But thankful I've experienced no headaches so far.

Also in regards to PTSD and negative emotional memories that continue to resurface, I feel there is great therapeutic potential for this substance. I noticed an acutal increase in recurring negative emotional memories in the first couple of weeks of use, stuff I thought I had fully repressed. It freaked me out at first but I've realized that I'm able to view and revisit these memories without the emotional burden they usually bring. Not sure, maybe those areas of my brain are repairing or something and bringing those memories up to actually deal with them.... anyway enough psuedoscience. Into the second gram now, around 20 or so days into the trial.

[lourdaud]

I'm starting to doubt this stuff is in freebase form, mainly due to the taste being completely bland. Correct me if I'm wrong, but wouldn't a base be bitter? And what kind of chemical supply companies would send out a chemical in freebase form without being requested to do so. If it's not in phosphate form probably HCl salt or some other salt that is easy to accomplish.

Anyway, I was taking 30mg BID for a couple weeks, then realized that the second dose was making me feel kind of weird. So I started doing 25mg am and 20mg pm. I've tried quite a few variations and currently feeling the best with a single 30mg dose in the morning as soon as I wake up.

I don't think taking a lot of this stuff at one time will be a very pleasant experience. Each time I've over-shot it on dosage even by a small margin I've felt pretty uncomfortable, mainly weird uneasiness, not full-on anxiety or anything, but just not feeling totally emotionally or mentally "well". Hard to put into words.

Many symptoms of depression have already gone though. As depression leaves me it's always a pretty gradual process that I don't realize happening until I look at behavior changes that have been taking place. I've been waking up everyday at 8:30am, even on my days off. I used to sleep as late as possible on my days off and lay around till the evening time, but recently realized I always felt terrible after doing that. Not sure if its the NSI-189 that offered a slight shift in motivation and perception in that respect or if I would have come to that conclusion on my own.

Feel motivation coming back into my life after a pretty long drag of not feeling like doing much of anything with my life. Don't notice any acute effects from a single dose of this stuff unless I over-shoot it and end up with mild negative sides. But thankful I've experienced no headaches so far.

Also in regards to PTSD and negative emotional memories that continue to resurface, I feel there is great therapeutic potential for this substance. I noticed an acutal increase in recurring negative emotional memories in the first couple of weeks of use, stuff I thought I had fully repressed. It freaked me out at first but I've realized that I'm able to view and revisit these memories without the emotional burden they usually bring. Not sure, maybe those areas of my brain are repairing or something and bringing those memories up to actually deal with them.... anyway enough psuedoscience. Into the second gram now, around 20 or so days into the trial.

Very interesting, manic_racetam!

I've had experienced something similar and maybe it is the NSI-189 working. I can't be sure since I also started taking hydergine, bacopa and kelp some time ago (and recently BPAP as well) but something is definitely at work here. I've been in a deep deep black hole ever since this summer, when I got off moclobemide after years of serotonergic drugs. I don't think I've ever been this depressed and I was starting to seriously consider just giving up and start doing drugs instead of getting on with my life.

The most significant difference now is that I have a more positive outlook and look forward to getting back on track again. I'm generally quite optimistic and future-oriented and I believe that the fact that my motivation is coming back may be a sign that I'm getting out of this long slump.

I've been taking about 20 mg a day (fingerballing it) so my 5 gram bag will hopefully last still for a while. I just hope I won't slide back when I run out!

[Godof Smallthings]

I just hope I won't slide back when I run out!

When you feel increased motivation, use it to build daily healthy habits that help to fight depression. I am sure you know which ones can help.

[BigPapaChakra]

I don't know if this is the wrong time to ask or anything, or if this was answered earlier (got to about page 40 in this thread, reading every comment up until that point), but I'd like to find a way into the second group buy if it's still going on, or, at least be added to any future group buy for this compound. Unless of course there is some way for me to obtain some NSI-189 in phosphate form for myself.