6219 replies to this topic

[Milkyway]

I am interested in getting NSI-189, so if anyone knows of any venues to do so please let me know. I would very much like tobe included in the next group buy of this so please contact me when planning this out.

[h2o]

Today the CEO of NeuralStem made an annoucement that the trial 1B results were "very encouraging" and the full results would be availabe in 1 -2 months from now. See
http://www.veracast....49237299345.cfm about 22 minutes in the video.

Edited by h2o, 12 February 2014 - 01:33 AM.

[sk_scientific]

I really want to get my hands on more of this stuff.

[manic_racetam]

The magic really started happening for me when I stopped taking this stuff. Took it for 30 days total and towards the end the sweet spot seemed to be 30mg in the morning which had the least side effects for me. An afternoon dose seemed to throw me off a bit.

Anyway, I was worried about stopping it because I felt quite a bit of improvement and thought it was an acute effect of the drug. But since stopping I feel like all my depression symptoms are gone. I'm fairly certain it was a direct effect of this substance. A spontaneous resolution of depression symptoms is definitely not typical for me at all in the middle of February. Last year at this time I was spending every day in my house, isolating and working on art projects. The summer was a bit better for me but I ended up spending most days in bed playing on my phone.

It's strange to feel a normal amount of motivation, positive thought processes, almost no brooding on the past or negative memories. And it was such a gradual process over the last couple of weeks that I didn't even notice it until I took a look at what I've been doing on a daily basis.

This is like nothing I've experienced in the past, I don't feel like I'm unnaturally forcing my brain to "feel" better. Even with tianeptine I felt different, or under the effect of some sort of chemical, but now I just feel better in general and unfiltered reality feels just fine.

Anyway, so far so good, would be amazing if this kept on lasting. Hopefully through reinforcing this state with some good habits will help the neurogenisis last, but I've still got a bit left for one more run of this stuff.

Any suggestions on how long of a break to take before a second cycle?

[di36]

The magic really started happening for me when I stopped taking this stuff. Took it for 30 days total and towards the end the sweet spot seemed to be 30mg in the morning which had the least side effects for me. An afternoon dose seemed to throw me off a bit.

Anyway, I was worried about stopping it because I felt quite a bit of improvement and thought it was an acute effect of the drug. But since stopping I feel like all my depression symptoms are gone. I'm fairly certain it was a direct effect of this substance. A spontaneous resolution of depression symptoms is definitely not typical for me at all in the middle of February. Last year at this time I was spending every day in my house, isolating and working on art projects. The summer was a bit better for me but I ended up spending most days in bed playing on my phone.

It's strange to feel a normal amount of motivation, positive thought processes, almost no brooding on the past or negative memories. And it was such a gradual process over the last couple of weeks that I didn't even notice it until I took a look at what I've been doing on a daily basis.

This is like nothing I've experienced in the past, I don't feel like I'm unnaturally forcing my brain to "feel" better. Even with tianeptine I felt different, or under the effect of some sort of chemical, but now I just feel better in general and unfiltered reality feels just fine.

Anyway, so far so good, would be amazing if this kept on lasting. Hopefully through reinforcing this state with some good habits will help the neurogenisis last, but I've still got a bit left for one more run of this stuff.

Any suggestions on how long of a break to take before a second cycle?

Thanks for your feedback manic.

-How long have you stopped taking nsi?
-Have you noticed any cognitive benefits?

[MizTen]

The magic really started happening for me when I stopped taking this stuff. Took it for 30 days total and towards the end the sweet spot seemed to be 30mg in the morning which had the least side effects for me. An afternoon dose seemed to throw me off a bit.

Anyway, I was worried about stopping it because I felt quite a bit of improvement and thought it was an acute effect of the drug. But since stopping I feel like all my depression symptoms are gone. I'm fairly certain it was a direct effect of this substance. A spontaneous resolution of depression symptoms is definitely not typical for me at all in the middle of February. Last year at this time I was spending every day in my house, isolating and working on art projects. The summer was a bit better for me but I ended up spending most days in bed playing on my phone.

It's strange to feel a normal amount of motivation, positive thought processes, almost no brooding on the past or negative memories. And it was such a gradual process over the last couple of weeks that I didn't even notice it until I took a look at what I've been doing on a daily basis.

This is like nothing I've experienced in the past, I don't feel like I'm unnaturally forcing my brain to "feel" better. Even with tianeptine I felt different, or under the effect of some sort of chemical, but now I just feel better in general and unfiltered reality feels just fine.

Anyway, so far so good, would be amazing if this kept on lasting. Hopefully through reinforcing this state with some good habits will help the neurogenisis last, but I've still got a bit left for one more run of this stuff.

Any suggestions on how long of a break to take before a second cycle?

Thanks for posting this. Nice to hear such good results. That's very similar to what I experienced. Though it clearly was benefiting me while I took it, when I stopped I had a big extended surge of motivation that lasted for weeks. Though I took it for PTSD and it worked very well for that, there was some underlying depression that also disappeared. I know exactly what you mean about "unfiltered reality feels just fine."

I think that 10 days to 3 weeks is enough of a break before starting again. I plan to take lion's mane, as well as a few other things as potentiators. I would always cycle this due to that effect of high motivation when stopping. Difficult environmental circumstances are definitely affecting my mental state and will continue to do so for a long time, so in order to make the best use of this drug, there are a number of things I've got to do to hold the effects. My first two trials were mostly to figure out if and how it worked. The next one will be a lot more focused on optimizing and retaining the postitive results. I should have purchased 100 grams of it.

[sk_scientific]

Any suggestions on how long of a break to take before a second cycle?

There is much that is left to our imaginations as we've consumed this research chemical. The first item of confusion, as it would seem based upon available information, is that unlike most depression/anxiety/psychoactive drugs, NSI-189's action is not allopathic. That is, it isn't a treatment for a symptom in the sense that the vast majority of our drugs are. The molecule, unless it's a lie, in some way activate hippocampal stem cells, promoting neurological growth in at least one region of the brain.

The reason that the company is doing trials, and are submitting for longer trials of treatment, is to ascertain its safe administration longitudinally as well as its effaciousness. We simply do not know if it's a safe chemical to be taking for an extended duration of time, or even if it would be beneficial to do so.

We have this idea that we must continue our medications to be well, but this drug doesn't have a psychoactive action, per se. It is through the biological/structural changes that occur as a result of its ingestion that we see a result.

Perhaps a second cycle is not to be suggested.

With that said, and please don't do as I do, I can't wait to take more of the shit.

Edited by sk_scientific, 17 February 2014 - 06:53 AM.

[di36]

Any suggestions on how long of a break to take before a second cycle?

There is much that is left to our imaginations as we've consumed this research chemical. The first item of confusion, as it would seem based upon available information, is that unlike most depression/anxiety/psychoactive drugs, NSI-189's action is not allopathic. That is, it isn't a treatment for a symptom in the sense that the vast majority of our drugs are. The molecule, unless it's a lie, in some way activate hippocampal stem cells, promoting neurological growth in at least one region of the brain.

The reason that the company is doing trials, and are submitting for longer trials of treatment, is to ascertain its safe administration longitudinally as well as its effaciousness. We simply do not know if it's a safe chemical to be taking for an extended duration of time, or even if it would be beneficial to do so.

We have this idea that we must continue our medications to be well, but this drug doesn't have a psychoactive action, per se. It is through the biological/structural changes that occur as a result of its ingestion that we see a result.

Perhaps a second cycle is not to be suggested.

With that said, and please don't do as I do, I can't wait to take more of the shit.

But i think that the trials lasted 6 months.So maybe it is somehow safe to assume that at least this point could be reached.

[sk_scientific]

Any suggestions on how long of a break to take before a second cycle?

There is much that is left to our imaginations as we've consumed this research chemical. The first item of confusion, as it would seem based upon available information, is that unlike most depression/anxiety/psychoactive drugs, NSI-189's action is not allopathic. That is, it isn't a treatment for a symptom in the sense that the vast majority of our drugs are. The molecule, unless it's a lie, in some way activate hippocampal stem cells, promoting neurological growth in at least one region of the brain.

The reason that the company is doing trials, and are submitting for longer trials of treatment, is to ascertain its safe administration longitudinally as well as its effaciousness. We simply do not know if it's a safe chemical to be taking for an extended duration of time, or even if it would be beneficial to do so.

We have this idea that we must continue our medications to be well, but this drug doesn't have a psychoactive action, per se. It is through the biological/structural changes that occur as a result of its ingestion that we see a result.

Perhaps a second cycle is not to be suggested.

With that said, and please don't do as I do, I can't wait to take more of the shit.

But i think that the trials lasted 6 months.So maybe it is somehow safe to assume that at least this point could be reached.

Volunteers were only medicated for 28 days each. They are planning to do another cohort at 90 days in the future, but that has not happened yet. Those who have taken this substance for longer, have done so on their own accord and outside of a research setting related to the company.

Edited by sk_scientific, 17 February 2014 - 02:33 PM.

[Flex]

just found via reddit this paper, which claims that stemcells are also located in the striatum (lateral ventricle).
http://de.reddit.com...d_hold_promise/
http://www.cell.com/...092867414001378

I wonder if NSI-189 (and Cerebrolysin?) does also increases Neurogenesis in this part.

[Puppeteer]

The magic really started happening for me when I stopped taking this stuff. Took it for 30 days total and towards the end the sweet spot seemed to be 30mg in the morning which had the least side effects for me. An afternoon dose seemed to throw me off a bit.

Anyway, I was worried about stopping it because I felt quite a bit of improvement and thought it was an acute effect of the drug. But since stopping I feel like all my depression symptoms are gone. I'm fairly certain it was a direct effect of this substance. A spontaneous resolution of depression symptoms is definitely not typical for me at all in the middle of February. Last year at this time I was spending every day in my house, isolating and working on art projects. The summer was a bit better for me but I ended up spending most days in bed playing on my phone.

It's strange to feel a normal amount of motivation, positive thought processes, almost no brooding on the past or negative memories. And it was such a gradual process over the last couple of weeks that I didn't even notice it until I took a look at what I've been doing on a daily basis.

This is like nothing I've experienced in the past, I don't feel like I'm unnaturally forcing my brain to "feel" better. Even with tianeptine I felt different, or under the effect of some sort of chemical, but now I just feel better in general and unfiltered reality feels just fine.

Anyway, so far so good, would be amazing if this kept on lasting. Hopefully through reinforcing this state with some good habits will help the neurogenisis last, but I've still got a bit left for one more run of this stuff.

Any suggestions on how long of a break to take before a second cycle?

Great to hear about such a positive experience. Do you think your memory has improved at all? Short-term, long-term, spatial, etc.?

[VERITAS INCORRUPTUS]

Has anyone reported effects from what would be a relatively low dose administration (2-10mg) or a dose protocol that was on a more intermittent basis that ED or similar such as E7D?

From briefly exploring this I surmise there may be superior effects from dosing that is of an overall reduced degree.

[sunshinefrost]

Anybody experienced any benefits on ligaments ? i felt that my reconstructed knee and hernias were healed/improved on this....

[Puppeteer]

Has anyone reported effects from what would be a relatively low dose administration (2-10mg) or a dose protocol that was on a more intermittent basis that ED or similar such as E7D?

From briefly exploring this I surmise there may be superior effects from dosing that is of an overall reduced degree.

I recall that ScienceGuy felt 5mg was the optimal dosage for him. Not sure if he elaborated on why at all anywhere; perhaps you could PM him.

[Posthuman]

Has anyone reported effects from what would be a relatively low dose administration (2-10mg) or a dose protocol that was on a more intermittent basis that ED or similar such as E7D?

From briefly exploring this I surmise there may be superior effects from dosing that is of an overall reduced degree.

I recall that ScienceGuy felt 5mg was the optimal dosage for him. Not sure if he elaborated on why at all anywhere; perhaps you could PM him.

He also said that he is very sensitive, a very good responder to virtually any compound he would take. So you could need more.

[ModusOperandi]

I have high hopes for this stuff, as i have depression+ cognitive problems, which one big cause was alcohol abuse back in the days. Im quite stunned the way i can read, in real time, about the human trials with this drug. I really hope the positive effect are long lasting, thats why all future post here are a great value. Anyway you all been great (except the suicide guy), I've read it through- 58 pages and now my hippo is hungry too!

[BigPapaChakra]

Can't wait to get my hands on some of this stuff. I wonder if I could get effects from only 10mg/day...

On a related note (but not solely to NSI-189), has anyone been looking into NSI-566 (I believe there was only one post on it way earlier which linked to an article speaking about it)? It looks pretty interesting. Here is a full length text on NSI-566 inducing motor neuron growth, differentiation, etc.

"The generation of MNs has been well explored with embryonic stem cells (Li et al., 2005; Shin et al., 2005; Lim et al., 2006; Lee et al., 2007). In our study, ~20% of the cells become MNs and this is comparable to similar studies with embryonic stem cells, in which the percentage of MNs achieved was ~ 21%, and 20–30% respectively for human and mouse embryonic stem cell studies (Li et al., 2005; Wichterle et al., 2002). However, with the fetal stem cell line utilized here, the differentiation period is much shorter (10 days compared to 40 days in Li et al., 2005). We speculate that the major reason for this difference could be that this is a spinal cord derived stem cell line, which is closer to spinal MNs in lineage compared to embryonic stem cells. Therefore, the induction procedure is simpler, in which only ventralization is the focus, whereas for the induction to MNs from embryonic stem cells, both neural induction and caudalization need to be considered. The differentiation period (~10 days) is comparable to the timeframe for ventralization in the previous study with embryonic stem cells (Li et al., 2005)."

[BrainFrost]

Can't wait to get my hands on some of this stuff. I wonder if I could get effects from only 10mg/day...

On a related note (but not solely to NSI-189), has anyone been looking into NSI-566 (I believe there was only one post on it way earlier which linked to an article speaking about it)? It looks pretty interesting. Here is a full length text on NSI-566 inducing motor neuron growth, differentiation, etc.

"The generation of MNs has been well explored with embryonic stem cells (Li et al., 2005; Shin et al., 2005; Lim et al., 2006; Lee et al., 2007). In our study, ~20% of the cells become MNs and this is comparable to similar studies with embryonic stem cells, in which the percentage of MNs achieved was ~ 21%, and 20–30% respectively for human and mouse embryonic stem cell studies (Li et al., 2005; Wichterle et al., 2002). However, with the fetal stem cell line utilized here, the differentiation period is much shorter (10 days compared to 40 days in Li et al., 2005). We speculate that the major reason for this difference could be that this is a spinal cord derived stem cell line, which is closer to spinal MNs in lineage compared to embryonic stem cells. Therefore, the induction procedure is simpler, in which only ventralization is the focus, whereas for the induction to MNs from embryonic stem cells, both neural induction and caudalization need to be considered. The differentiation period (~10 days) is comparable to the timeframe for ventralization in the previous study with embryonic stem cells (Li et al., 2005)."

I believe NSI-566 is used towards spinal reconstruction for patients who have broken their back.

[BigPapaChakra]

Yeah, upon further research it may not (though maybe it does) hold nootropic potential; but then again I'm sure some people on these boards have various (back/neck) injuries, as do I. Sorry to derail the thread, though.

[ovecta]

Took a very high dose (130mg) sublingually last night, the effects were very pronounced with a very quick onset, it felt very dopaminergic in its effects, I felt abit light headed yet my clarity of thought was very sharp and crisp.
I took my usually 1mg of melatonin and had no trouble sleeping, woke up today with a dull headache that has persisted right through the evening, its nothing too bothersome and it isn't causing me much of an issue while writing my thesis.
If any effects should manifest over the coming days I'll be sure to report them, might be hard to really identify any of them though as this drug is subtle in its effects.
I should note I'm using the freebase NSI-189

[Puppeteer]

The magic really started happening for me when I stopped taking this stuff. Took it for 30 days total and towards the end the sweet spot seemed to be 30mg in the morning which had the least side effects for me. An afternoon dose seemed to throw me off a bit.

Anyway, I was worried about stopping it because I felt quite a bit of improvement and thought it was an acute effect of the drug. But since stopping I feel like all my depression symptoms are gone. I'm fairly certain it was a direct effect of this substance. A spontaneous resolution of depression symptoms is definitely not typical for me at all in the middle of February. Last year at this time I was spending every day in my house, isolating and working on art projects. The summer was a bit better for me but I ended up spending most days in bed playing on my phone.

It's strange to feel a normal amount of motivation, positive thought processes, almost no brooding on the past or negative memories. And it was such a gradual process over the last couple of weeks that I didn't even notice it until I took a look at what I've been doing on a daily basis.

This is like nothing I've experienced in the past, I don't feel like I'm unnaturally forcing my brain to "feel" better. Even with tianeptine I felt different, or under the effect of some sort of chemical, but now I just feel better in general and unfiltered reality feels just fine.

Anyway, so far so good, would be amazing if this kept on lasting. Hopefully through reinforcing this state with some good habits will help the neurogenisis last, but I've still got a bit left for one more run of this stuff.

Any suggestions on how long of a break to take before a second cycle?

Thanks for posting this. Nice to hear such good results. That's very similar to what I experienced. Though it clearly was benefiting me while I took it, when I stopped I had a big extended surge of motivation that lasted for weeks. Though I took it for PTSD and it worked very well for that, there was some underlying depression that also disappeared. I know exactly what you mean about "unfiltered reality feels just fine."

I think that 10 days to 3 weeks is enough of a break before starting again. I plan to take lion's mane, as well as a few other things as potentiators. I would always cycle this due to that effect of high motivation when stopping. Difficult environmental circumstances are definitely affecting my mental state and will continue to do so for a long time, so in order to make the best use of this drug, there are a number of things I've got to do to hold the effects. My first two trials were mostly to figure out if and how it worked. The next one will be a lot more focused on optimizing and retaining the postitive results. I should have purchased 100 grams of it.

Hey MizTen, can I ask what you're planning to stack with NSI for potentiation?

[MizTen]

...
Hey MizTen, can I ask what you're planning to stack with NSI for potentiation?

Something like this, which I'm already taking:

Morning:
Vitamin K
Curcumin extract
Uridine
Lithium orotate
Ubiquinol 100 mg
DHA/EPAGinkgo Biloba w\ vinpocetine
Hawthorn extract
Silymarin 250 mg
St. John's Wort
NAC
B-complex
PRL-8-53

Noon:
DHA\EPA
Pycnogenol
Idebenone 300 mg
NAC
Astaxanthin
Centrophenoxine 350 mg
St. John's Wort 300 mg

Afternoon:
Hawthorn extract
Pycnogenol
DHA
Ubiquinol 100 mgSt. John's Wort 300 mg

Night:
Lion's Mane
Hawthorn extract
Immune Boost 77
Magnesium & Potassium aspartate
Jiaogulan Extract 250 mgL-Glutathione Reduced 500 mg
Schisandra extract 250 mg
St. John's Wort 300 mg
Milk Thistle 150 mg
Pregnenolone 100 mg
DHA
Melatonin
C6o

There's more, but I left them out or edited to avoid posting brand names. Dosages are changing, I don't need to take as much stuff, some are cycled and I stop the St. John's Wort once spring starts and the daylight hours have increased.

The supplements and noots do make a huge difference. But other brain health supports are really just as important and I may get some very amplified effects, as I am already experiencing that now with what I'm doing (without the NSI-189 or the PRL-8-53). The binaural beats, self-hypnosis, and meditation are starting to really make a difference. Exercise, brain training, outdoor activities, and socializing are foundational for me.

I also stated a while back in this thread that NSI-189 did not have any significant effect on my memory. Having recently gone through my own notes during my 2 trials of NSI-189 (not posted here) that is definitely not true. I actually did get a rather large memory improvement right after the end of the first trial, around the same time as the motivational surge came charging in. I just didn't notice it as much because the motivation boost was so big. So NSI-189 did improve my memory quite a bit.

Interestingly, the memory improvement has stayed, though not as strong, despite the fact that I'm not taking NSI-189 or PRL-8-53 and life has been very challenging lately, pushing me into some old dark places with PTSD, though I can manage it better now. I think the next round of NSI-189 along with my other practices will do the trick.

I wish I knew more about neuroscience in terms of the natural cycles of the body and brain. I'm sure they exist, but I have not found much information about that.

I'd like to try cerebrolysin in some cycled fashion with my new plan, but I haven't figured out how to do that yet.

[BigPapaChakra]

I'm glad this was brought up - I've been inquiring to various groups as to whether certain nutrient/mineral/macros/calories should be consumed in far greater quantities when undergoing something that should cause a large amount synapto/neuro/myelinogenesis. Theoretically, it makes sense: besides having to ingest or do something that induces these processes, all these 'micro-structures' are made of 'stuff' (oleic acid in myelin, for instance). I've been starting to follow both Dr. Ray Peat and Paul Jaminet, and it seems that when metabolism is increased (mitochondrial respiration, OXPHOS/uncoupling, thyroid hormone, etc), nutrients begin to get depleted at a faster rate than previously. Wouldn't something such as NSI do the same? I know Cerebrolysin increases GLUT1 expression in the brain, thus it makes sense to consume more carbs when using it. In the case that this is true, what nutrients can aid in the facilitation of these processes (not necessarily induce them, but facilitate the induction caused by NSI)?

[8bitmore]

I'm glad this was brought up - I've been inquiring to various groups as to whether certain nutrient/mineral/macros/calories should be consumed in far greater quantities when undergoing something that should cause a large amount synapto/neuro/myelinogenesis. Theoretically, it makes sense: besides having to ingest or do something that induces these processes, all these 'micro-structures' are made of 'stuff' (oleic acid in myelin, for instance). I've been starting to follow both Dr. Ray Peat and Paul Jaminet, and it seems that when metabolism is increased (mitochondrial respiration, OXPHOS/uncoupling, thyroid hormone, etc), nutrients begin to get depleted at a faster rate than previously. Wouldn't something such as NSI do the same? I know Cerebrolysin increases GLUT1 expression in the brain, thus it makes sense to consume more carbs when using it. In the case that this is true, what nutrients can aid in the facilitation of these processes (not necessarily induce them, but facilitate the induction caused by NSI)?

First thing that comes to my mind is chicken broth / soup home made on organic components. There is already research out on the cognitive benefits of chicken extract by itself and then there's huge historical backlog of chicken soup used to improve healing and immune system so reckon the balance is right in that particular animal. I don't know about effective veggie alternative but would love to hear ideas..

[zeroskater6979]

How are people administering their nsi? making your own capsules or dissolving in water, empty or full stomach? thanks.

[ModusOperandi]

How are people administering their nsi? making your own capsules or dissolving in water, empty or full stomach? thanks.

sublingually, as i read somewhere in this topic. Im so noob that i have no glue how to you do it properly. But redy to try when mine gets here, if any one have any tips, im all ears.

[Puppeteer]

It's very simple: measure out however much you intend to take and just place it underneath your tongue and allow it to dissolve. Hold it there for a few minutes being careful not to swallow it. That's all there is to it. Its the same principle as using dipping tobacco or LSD blotters.

[VP.]

Yeah, upon further research it may not (though maybe it does) hold nootropic potential; but then again I'm sure some people on these boards have various (back/neck) injuries, as do I. Sorry to derail the thread, though.

NSI-566 does have nootrpoic potential. Research is in preclinical phase. Not something self hackers could do though.

• Alzheimer’s Disease

Preclinical phase with NSI-566. Further clinical development on Alzheimer’s disease application pending NSI-566 ALS ongoing trial.

• Traumatic Brain Injury

Preclinical phase with NSI-566. Further clinical development on traumatic brain injury application pending NSI-566 ALS

ongoing trial.

http://www.neuralste...-development#ad

[Nattzor]

Curing brain damage is not nootropic potential for healthy people.

And I doubt anyone will ever (or well, in the coming decades) play around with fetal stem cells at home.

[BigPapaChakra]

Yeah, upon further research it may not (though maybe it does) hold nootropic potential; but then again I'm sure some people on these boards have various (back/neck) injuries, as do I. Sorry to derail the thread, though.

NSI-566 does have nootrpoic potential. Research is in preclinical phase. Not something self hackers could do though.

• Alzheimer’s Disease

Preclinical phase with NSI-566. Further clinical development on Alzheimer’s disease application pending NSI-566 ALS ongoing trial.

• Traumatic Brain Injury

Preclinical phase with NSI-566. Further clinical development on traumatic brain injury application pending NSI-566 ALS

ongoing trial.

http://www.neuralste...-development#ad

Yeah I forgot about seeing that information when I was reading the study I posted; glad to see that there is some brain building/restoration properties to NSI-566, though. I'll dig into it further after I actually get to trial NSI-189. My eagerness is growing with every passing day, haha.