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NSI-189

nsi-189

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#1831 BrainFrost

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Posted 13 April 2014 - 03:59 PM

Week 5 for me and I've tapered down to 40mgx1 from the 40mgx2 i was on before due to supply amount. Honestly I don't feel anything anymore; I train competitively 4-5 hours a day, work in IT, and take my supplaments(5g fish oil, alpha pak, rhodiola rosea, occasional modafinil). But the effects of the first week are gone and I don't notice any more positive benefits in mood/cognitive effects/working memory/verbal fluency. I am holding out though hoping something clicks in my head and I become super awesome! :)



#1832 ModusOperandi

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Posted 14 April 2014 - 07:12 PM

 

 

Forgive me if it is a stupid question, but I was wondering about something with NSI-189. Many people have said they had positive effects for the first week or so, then got some adverse effects for a day or so after that, then the benefits really came once they stopped the 1 month cycle.
Would it be an idea to cycle NSI-189 for one week on/one week off? I know the clinical trial was for one month, but for what we are after, could a weekly cycle work?  . 


what are we after? im curing my depression symptoms, doesn't most people here?...and it helps pretty damn well. no headaches. im 8 days in. i'm for sure not going to cycle one week on/ off. 1 month minimum. it is a miracle molecule, if the effects lasts.

 

 

what dosing scheme are you using? i've been taking approximately 40mg daily for 5 days and haven't experienced anything noticeable yet
 

 

Can't say for sure, still waiting for my scale, supposed to be here 4 days ago. I started earlier cause i had this ring proposal thing at 4.4. and i didn't want to be D on that day. :laugh: Started 2X 15-30 mg(divided my stash until i got somewhat of "normal" dosage), went 3X day pretty soon as my D state returned. I take one just before i wake, then others with 5 h intervals. If i miss a dosage by an hour i feel physical symptoms of D surface, lack of energy, mood down, negative thinking, losing my mind, lack of concentration etc. Only sublingually, i like the quick effect.

 

Sleep feels better in quality. It is harder maybe to get up the bed, but when i do and get my first dosage, I'm back to normal state i.e. like i was way before D, quite energetic, motivated. Previosly, if i took a quick nap 15-45 min on a day, then following night i had a lousy sleep. Also i had  very bad mood and overall feeling after the nap. This is gone, i wake up like i did when i was younger, happy about the nap/still feeling normal and it's not reflecting my night sleep.

 

On cognitive side of things, i noticed that after first dosage, about hour or two later i had D symptoms leaving me and i did new score record on the first try in iPad game "electro trains", it's multitasking game. It could just be that i was so D and my concentration therefor was bad. Memory has not improved much, sometimes i feel it's gotten maybe worse. Not sure. Could it be that new neurons are so new, it could take some time to mature and function?

 

I don't feel the effect lasting. If i miss a dosage then i feel bad again, even though i'm having wonderful family thing/episode in my life, more sunlight etc etc.

 

Reporting in on one month, on creativity, libido, hunger etc. They feel the same now ie. quite normal if I'm not D. It should be noted that before this molecule i got pretty good relief for D from NAC and ALCAR+ magnesium, but even they had more side effects than NSI 189. Im going through milder D, i won against the rougher D years ago with ssri(Cymbalta). I didn't want to go back to ssri, especially when i had this opportunity to try NSI. My last hope!



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#1833 di36

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Posted 18 April 2014 - 12:21 PM

Have started nsi for about two weeks and i have great difficulty measuring with my mg scale.Does anyone know where i can buy online (in EU) milligram scoops?



#1834 sparkk51

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Posted 18 April 2014 - 04:59 PM

Have started nsi for about two weeks and i have great difficulty measuring with my mg scale.Does anyone know where i can buy online (in EU) milligram scoops?

You can't just buy a scoop designed for a specific mass as each substance will have a unique density. 



#1835 Hungry Hippo

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Posted 18 April 2014 - 05:13 PM

Has anyone an idea what compounds would be great combining with NSI-189 and which not? I have a friend who wants to try this and he's using Welbutrin. I gave him a week supply and he thought it's quite good together, but in the long run? I myself have some Selegiline left and I'm curious what would happen if combine this with NSI.



#1836 Lobotomy

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Posted 18 April 2014 - 05:17 PM

Is there anywhere I can still get some of this? Still in the process of arranging a group buy if all else fails.


Edited by Lobotomy, 18 April 2014 - 05:23 PM.


#1837 Flex

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Posted 18 April 2014 - 06:16 PM

Is there anywhere I can still get some of this? Still in the process of arranging a group buy if all else fails.

 

http://www.longecity...w-50gram/page-2


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#1838 di36

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Posted 18 April 2014 - 09:10 PM

 

Have started nsi for about two weeks and i have great difficulty measuring with my mg scale.Does anyone know where i can buy online (in EU) milligram scoops?

You can't just buy a scoop designed for a specific mass as each substance will have a unique density. 

 

yeah i know but what else can i do?



#1839 Adaptogen

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Posted 18 April 2014 - 09:28 PM

 

 

Have started nsi for about two weeks and i have great difficulty measuring with my mg scale.Does anyone know where i can buy online (in EU) milligram scoops?

You can't just buy a scoop designed for a specific mass as each substance will have a unique density. 

 

yeah i know but what else can i do?

 

Depending on the scale you're using, sometimes adding a small piece of paper or something helps, and then just subtracting that from the total weight. sometimes the cheaper scales seem to have trouble registering lower weights. I've been taring half a gel cap, then filling that with nsi until it reaches the desired dosage.

 

this is the one i bought

http://www.ebay.com/...=item2a34a0b703


Edited by Adaptogen, 18 April 2014 - 09:53 PM.


#1840 Hungry Hippo

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Posted 18 April 2014 - 09:47 PM

Have started nsi for about two weeks and i have great difficulty measuring with my mg scale.Does anyone know where i can buy online (in EU) milligram scoops?

 

Look for a diamond/gold scale, they have a 0.001 scale. I have one myself and it works pretty good. In the Netherlands you can buy one here (and you can select also your own country):

 

http://nl.aliexpress.../482644520.html

 

http://www.battal.nl...-20gr-j112.html

(the same but you pay more for it.)
 



#1841 DamnedOwl

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Posted 18 April 2014 - 09:55 PM

Also, if you're willing to splash out a little more (and I heartily recommend doing so), then there's also this: http://www.weegschaa...l101-p-133.html

 

I bought that same model from that shop two years ago. Worth every cent!



#1842 Flex

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Posted 19 April 2014 - 04:56 AM

 

 

Have started nsi for about two weeks and i have great difficulty measuring with my mg scale.Does anyone know where i can buy online (in EU) milligram scoops?

You can't just buy a scoop designed for a specific mass as each substance will have a unique density. 

 

yeah i know but what else can i do?

 

 

Ok how about the Stoneage method.

I gonna weight something up and place it on e.g. a 1 euro cent coin.

Then i can "roughly" tell You how much to take, so e,g, a half of the coin etc..

 

Otherwise You can find a cheap one for ca. 25 euros on amazon, like mine.
 


Edited by Flex, 19 April 2014 - 04:58 AM.

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#1843 Amorphous

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Posted 20 April 2014 - 03:10 AM

I've finished my 4th week, and there was nothing major going on. I still felt like I needed more sleep and waking up was still difficult. Appetite increased so did my weight; hopefully, I'll be back to normal after I stop NSI. I'll be taking my last NSI dose on this Sunday for the first cycle.  



#1844 verticalVagabond

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Posted 20 April 2014 - 01:39 PM

has nyles7 permanently stopped selling NSI 189 on ebay? I can't believe how quickly a year has passed and I've yet to try this stuff.

I feel like NSI 189 has become my bitcoin of longecity (although hopefully NSI 189 is a bit less speculative!). I missed out on the early mover advantage and now I've found myself experiencing the sensation vicariously 
 

I don't know why I miss these things - this seemed like one of the more important things in my life. Anyone notice improved decision making from NSI 189? How does that work?



#1845 ModusOperandi

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Posted 20 April 2014 - 05:42 PM

the dividing and scoop seems not to work for me. I got the long waited scale from hong kong, cheap ebay stuff but only off by 2-3 mg or 0.003 g. I divided before that in my previous overview for 2 weeks and apparently i was taking only 10-15 mg. I'm upping my dose, yesterday 40 mg 3Xday and my sleep was disrupted little bit, backing it down to 30. No headache whatsover, i beginning to worry whats wrong with me lol. Pretty strong taste having 40mg of it under your tongue, but nothing too big to worry about.

#1846 Hungry Hippo

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Posted 20 April 2014 - 07:05 PM

has nyles7 permanently stopped selling NSI 189 on ebay? I can't believe how quickly a year has passed and I've yet to try this stuff.
 

Nyles7 is still selling.



#1847 foreseason

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Posted 20 April 2014 - 07:12 PM

I've heard this twice now. So how come I can't find him/NSI on eBay?


has nyles7 permanently stopped selling NSI 189 on ebay? I can't believe how quickly a year has passed and I've yet to try this stuff.
 

Nyles7 is still selling.

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#1848 Maxpower

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Posted 20 April 2014 - 10:17 PM

I've finished my 4th week, and there was nothing major going on. I still felt like I needed more sleep and waking up was still difficult. Appetite increased so did my weight; hopefully, I'll be back to normal after I stop NSI. I'll be taking my last NSI dose on this Sunday for the first cycle.  

 

A few people have reported improvements after they stop the cycle, hopefully you will feel the benefits after Sunday. Can you let us know how you feel after you have finished the cycle and maybe some follow up a few weeks later?



#1849 Maxpower

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Posted 20 April 2014 - 10:24 PM

Not sure how long it's been since I stopped taking this stuff. Took it for approximately a month at 20-40mg per day. Depression still gone but did notice one side effect that correlates with me taking this substance.

I developed a very slight "stutter" or "stammer" in my speech. Would got caught up mid sentence and have to pause and start the word over again. Never experienced anything like that before so figure it's possible that the nsi caused it.

Has since gone away almost completely, I'm thinking I took two months off. Started my second run of it today. Will be taking 25mg each morning. Found that two doses were too much for me. But the magic is def back in full swing already on the first day. Can't wait to end this run to get the motivation from last time I stopped. Got 2-3 weeks of serious motivation last time when I stopped taking it. Gotta run.

 

Any updates on how your 2nd cycle went? Did you still get the dip in mental performance in week 2-3?



#1850 verticalVagabond

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Posted 20 April 2014 - 10:44 PM

I've finished my 4th week, and there was nothing major going on. I still felt like I needed more sleep and waking up was still difficult. Appetite increased so did my weight; hopefully, I'll be back to normal after I stop NSI. I'll be taking my last NSI dose on this Sunday for the first cycle.  

 

We could do a poll or something to figure out how long on average before people see results. 

 

I wonder if the efficacy depends on the relative size of the hippocampus before administering NSI 189. 

 

I've heard this helps to some degree with multitasking. Has anyone with add/adhd tried this? 



#1851 fairy

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Posted 21 April 2014 - 01:38 AM

Don't know if this has been pointed out or is just dumb: for the NSI-189 to increase the hippocampal volume of a mice by 20%, is the same amount of *free* volume needed or the remaining part of the brain shrinks to add some space? I mean, like a sponge.



#1852 sparkk51

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Posted 21 April 2014 - 01:59 AM

Don't know if this has been pointed out or is just dumb: for the NSI-189 to increase the hippocampal volume of a mice by 20%, is the same amount of *free* volume needed or the remaining part of the brain shrinks to add some space? I mean, like a sponge.

 

We've discussed this before a while back, but it is a large thread. There was no definitive answer, and I don't think we'll ever get one.


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#1853 DamnedOwl

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Posted 21 April 2014 - 10:05 AM

 

Don't know if this has been pointed out or is just dumb: for the NSI-189 to increase the hippocampal volume of a mice by 20%, is the same amount of *free* volume needed or the remaining part of the brain shrinks to add some space? I mean, like a sponge.

 

We've discussed this before a while back, but it is a large thread. There was no definitive answer, and I don't think we'll ever get one.

 

 

Unless our heads explode!  :-D



#1854 nootropicsandsarms

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Posted 21 April 2014 - 10:35 AM

which product effect like nsi189?



#1855 Nattzor

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Posted 21 April 2014 - 10:46 AM

Don't know if this has been pointed out or is just dumb: for the NSI-189 to increase the hippocampal volume of a mice by 20%, is the same amount of *free* volume needed or the remaining part of the brain shrinks to add some space? I mean, like a sponge.

 

Can anyone link me the rat study? It would make sense a small volume increase, but a bigger density increase.



#1856 Flex

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Posted 21 April 2014 - 04:43 PM

which product effect like nsi189?

 

 

maybe ECGC to some degree.

 

Green tea epigallocatechin-3-gallate (EGCG) promotes neural progenitor cell proliferation and sonic hedgehog pathway activation during adult hippocampal neurogenesis.

http://www.ncbi.nlm....pubmed/22692966

 

But from my sole Intuition, I doubt somewhat that its compareble to NSI-189 or Cerebrolysin --> (when only looking it´s effects on the Hippocampus).

 

If so, it could be a treatment for Down syndrome, and Btw Cerebrolysine aswell

 

Hedgehog Agonist Therapy Corrects Structural and Cognitive Deficits in a Down Syndrome Mouse Model

http://stm.sciencema.../5/201/201ra120

 

But I´m no Doctor, therefore I just dont know..


Edited by Flex, 21 April 2014 - 04:44 PM.


#1857 mait

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Posted 21 April 2014 - 06:14 PM

Melatonin should help in replentishing neural prgenitor stemm cells - will add citation later.



#1858 Lobotomy

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Posted 21 April 2014 - 09:45 PM

Has anyone been taking this with other nootropic drugs?



#1859 VP.

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Posted 21 April 2014 - 10:33 PM

 

Don't know if this has been pointed out or is just dumb: for the NSI-189 to increase the hippocampal volume of a mice by 20%, is the same amount of *free* volume needed or the remaining part of the brain shrinks to add some space? I mean, like a sponge.

 

Can anyone link me the rat study? It would make sense a small volume increase, but a bigger density increase.

 

 

Lot's of info in Neuralstem's patent application.

https://www.google.c...tents/US8030492



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#1860 JASOG888

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Posted 22 April 2014 - 02:52 AM

Has anyone been taking this with other nootropic drugs?

 

Yes, cerebrolysin. I initially started with 40mg in the morning(the same dosing I used with Nyles' NSI), but it caused brain fog for a few hours, then the cere took effect again. Now I take my daily 40mg dose before bed.







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